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Illumina Body Map 2 (GSE30611)

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Results for ISL2

Z-value: 0.80

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Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ISL2
ENSG00000159556.10 ISL LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg38_v1_chr15_+_76336755_763367790.154.1e-01Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_55182442 1.91 ENST00000545075.3
MTRNR2L10
MT-RNR2 like 10
chr5_+_40909490 1.76 ENST00000313164.10
C7
complement C7
chr1_-_237945275 1.69 ENST00000604646.1
MTRNR2L11
MT-RNR2 like 11
chr11_-_13495984 1.64 ENST00000282091.6
PTH
parathyroid hormone
chr10_-_29634964 1.64 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr11_-_13496018 1.34 ENST00000529816.1
PTH
parathyroid hormone
chrX_-_85379659 1.32 ENST00000262753.9
POF1B
POF1B actin binding protein
chr2_+_233760265 1.31 ENST00000305208.10
ENST00000360418.4
UGT1A1
UDP glucuronosyltransferase family 1 member A1
chr2_-_189582012 1.31 ENST00000427419.5
ENST00000455320.5
SLC40A1
solute carrier family 40 member 1
chr17_-_66229380 1.25 ENST00000205948.11
APOH
apolipoprotein H
chr1_+_62597510 1.22 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr21_+_38272410 1.20 ENST00000398934.5
ENST00000398930.5
KCNJ15
potassium inwardly rectifying channel subfamily J member 15
chr1_-_178871022 1.13 ENST00000367629.1
ANGPTL1
angiopoietin like 1
chr1_-_178871060 1.12 ENST00000234816.7
ANGPTL1
angiopoietin like 1
chr8_+_91249307 1.11 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr4_+_112647059 1.06 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr2_+_233671879 1.05 ENST00000354728.5
UGT1A9
UDP glucuronosyltransferase family 1 member A9
chr7_+_123601815 1.05 ENST00000451215.6
ASB15
ankyrin repeat and SOCS box containing 15
chr2_-_162152239 1.05 ENST00000418842.7
GCG
glucagon
chr2_+_167135901 1.05 ENST00000628543.2
XIRP2
xin actin binding repeat containing 2
chr8_+_132897674 1.03 ENST00000518505.1
TG
thyroglobulin
chr7_+_123601836 1.03 ENST00000434204.5
ASB15
ankyrin repeat and SOCS box containing 15
chr2_-_162152404 1.01 ENST00000375497.3
GCG
glucagon
chr7_-_120857124 0.97 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
TSPAN12
tetraspanin 12
chr15_+_58410543 0.95 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr14_-_67412112 0.94 ENST00000216446.9
PLEK2
pleckstrin 2
chr10_-_93482326 0.92 ENST00000359263.9
MYOF
myoferlin
chr7_+_123601859 0.87 ENST00000437535.5
ASB15
ankyrin repeat and SOCS box containing 15
chr10_-_93482194 0.84 ENST00000358334.9
ENST00000371488.3
MYOF
myoferlin
chr19_+_14583076 0.83 ENST00000547437.5
ENST00000417570.6
CLEC17A
C-type lectin domain containing 17A
chrX_-_85379703 0.82 ENST00000373145.3
POF1B
POF1B actin binding protein
chr4_+_94207596 0.82 ENST00000359052.8
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr7_-_16804987 0.81 ENST00000401412.5
ENST00000419304.7
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr10_-_93482287 0.80 ENST00000371489.5
MYOF
myoferlin
chr5_+_132873660 0.80 ENST00000296877.3
LEAP2
liver enriched antimicrobial peptide 2
chr15_+_90191913 0.79 ENST00000559792.5
SEMA4B
semaphorin 4B
chr20_+_31514410 0.78 ENST00000335574.10
ENST00000340852.9
ENST00000398174.9
ENST00000466766.2
ENST00000498035.5
ENST00000344042.5
HM13
histocompatibility minor 13
chrX_-_21658324 0.71 ENST00000379499.3
KLHL34
kelch like family member 34
chr2_+_233917371 0.70 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chr6_+_130018565 0.68 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr2_-_10447771 0.68 ENST00000405333.5
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr15_+_64387828 0.66 ENST00000261884.8
TRIP4
thyroid hormone receptor interactor 4
chr5_+_40841308 0.63 ENST00000381677.4
ENST00000254691.10
CARD6
caspase recruitment domain family member 6
chr12_+_130953898 0.61 ENST00000261654.10
ADGRD1
adhesion G protein-coupled receptor D1
chr4_-_174263080 0.60 ENST00000615392.4
FBXO8
F-box protein 8
chr16_+_28553908 0.59 ENST00000317058.8
SGF29
SAGA complex associated factor 29
chr3_-_122022122 0.59 ENST00000393631.5
ENST00000273691.7
ENST00000344209.10
ILDR1
immunoglobulin like domain containing receptor 1
chrX_-_31266857 0.58 ENST00000378702.8
ENST00000361471.8
DMD
dystrophin
chr11_-_8871385 0.56 ENST00000527516.5
ENST00000533471.5
DENND2B
DENN domain containing 2B
chr4_+_85604146 0.56 ENST00000512201.5
ARHGAP24
Rho GTPase activating protein 24
chr3_+_136930469 0.56 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr2_+_87748087 0.56 ENST00000359481.9
PLGLB2
plasminogen like B2
chr2_-_157439403 0.55 ENST00000418920.5
CYTIP
cytohesin 1 interacting protein
chrX_-_15314543 0.55 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chrX_-_31266925 0.54 ENST00000680557.1
ENST00000378680.6
ENST00000378723.7
ENST00000680768.2
ENST00000681870.1
ENST00000680355.1
ENST00000682322.1
ENST00000682600.1
ENST00000680162.2
ENST00000681153.1
ENST00000681334.1
DMD
dystrophin
chr14_+_21997531 0.54 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr7_-_120858066 0.51 ENST00000222747.8
TSPAN12
tetraspanin 12
chr13_+_48976597 0.51 ENST00000541916.5
FNDC3A
fibronectin type III domain containing 3A
chr20_-_35147285 0.50 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr2_+_86441995 0.49 ENST00000427678.1
KDM3A
lysine demethylase 3A
chrX_-_32155462 0.49 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
DMD
dystrophin
chr21_-_30492008 0.46 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr4_-_48114523 0.46 ENST00000506073.1
TXK
TXK tyrosine kinase
chr3_-_142029108 0.45 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr11_-_28108109 0.45 ENST00000263181.7
KIF18A
kinesin family member 18A
chr4_+_168497044 0.44 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr7_+_16661182 0.44 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr19_-_45730861 0.44 ENST00000317683.4
FBXO46
F-box protein 46
chr6_+_54099538 0.43 ENST00000447836.6
MLIP
muscular LMNA interacting protein
chr7_-_116030750 0.43 ENST00000265440.12
ENST00000320239.11
TFEC
transcription factor EC
chr2_-_40453438 0.42 ENST00000455476.5
SLC8A1
solute carrier family 8 member A1
chr19_+_3185911 0.42 ENST00000246117.9
ENST00000588428.5
NCLN
nicalin
chr14_+_22202561 0.42 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr7_-_116030735 0.42 ENST00000393485.5
TFEC
transcription factor EC
chr12_-_56741535 0.42 ENST00000647707.1
ENSG00000285625.1
novel protein
chr1_-_225428813 0.41 ENST00000338179.6
ENST00000425080.1
LBR
lamin B receptor
chr12_-_57818704 0.41 ENST00000549994.1
AVIL
advillin
chr2_-_169031317 0.41 ENST00000650372.1
ABCB11
ATP binding cassette subfamily B member 11
chr4_+_168497066 0.41 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr17_-_49709014 0.40 ENST00000511657.1
SLC35B1
solute carrier family 35 member B1
chr11_+_28108248 0.40 ENST00000406787.7
ENST00000403099.5
ENST00000407364.8
METTL15
methyltransferase like 15
chr3_+_186974957 0.40 ENST00000438590.5
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr4_-_67963441 0.39 ENST00000508048.6
TMPRSS11A
transmembrane serine protease 11A
chr12_+_64405046 0.37 ENST00000540203.5
XPOT
exportin for tRNA
chr6_+_31137646 0.37 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr19_+_49513353 0.36 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr4_+_25160631 0.36 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS-AS1
PI4K2B
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chrX_+_83861126 0.36 ENST00000621735.4
ENST00000329312.5
CYLC1
cylicin 1
chr8_-_123729211 0.36 ENST00000520519.1
ANXA13
annexin A13
chr4_+_94207845 0.36 ENST00000457823.6
ENST00000354268.9
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr20_-_52105644 0.35 ENST00000371523.8
ZFP64
ZFP64 zinc finger protein
chr7_-_45111673 0.34 ENST00000461363.1
ENST00000258770.8
ENST00000495078.1
ENST00000494076.5
ENST00000478532.5
ENST00000361278.7
TBRG4
transforming growth factor beta regulator 4
chr19_+_48695952 0.34 ENST00000522966.2
ENST00000425340.3
ENST00000391876.5
FUT2
fucosyltransferase 2
chr9_+_72577369 0.33 ENST00000651183.1
TMC1
transmembrane channel like 1
chr8_+_69492793 0.33 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
SULF1
sulfatase 1
chr5_+_102865244 0.33 ENST00000511477.5
ENST00000506006.1
ENST00000509832.5
PAM
peptidylglycine alpha-amidating monooxygenase
chr20_+_45420585 0.32 ENST00000639239.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr2_-_87021844 0.32 ENST00000355705.4
ENST00000409310.6
PLGLB1
plasminogen like B1
chr6_+_54099565 0.31 ENST00000511678.5
MLIP
muscular LMNA interacting protein
chr12_-_110499546 0.30 ENST00000552130.6
VPS29
VPS29 retromer complex component
chr10_-_114144599 0.30 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr6_+_63635792 0.29 ENST00000262043.8
ENST00000506783.5
ENST00000481385.6
ENST00000515594.5
ENST00000494284.6
PHF3
PHD finger protein 3
chr11_-_26723361 0.29 ENST00000533617.5
SLC5A12
solute carrier family 5 member 12
chr16_+_86566821 0.29 ENST00000649859.1
FOXC2
forkhead box C2
chr2_-_84881238 0.29 ENST00000335459.9
TRABD2A
TraB domain containing 2A
chr14_+_34993240 0.29 ENST00000677647.1
SRP54
signal recognition particle 54
chr5_+_58491451 0.28 ENST00000513924.2
ENST00000515443.2
GAPT
GRB2 binding adaptor protein, transmembrane
chr12_+_4720395 0.28 ENST00000252318.7
GALNT8
polypeptide N-acetylgalactosaminyltransferase 8
chr4_-_103019634 0.28 ENST00000510559.1
ENST00000296422.12
ENST00000394789.7
SLC9B1
solute carrier family 9 member B1
chr6_-_49964160 0.28 ENST00000322066.4
DEFB114
defensin beta 114
chr5_+_58491427 0.28 ENST00000396776.6
ENST00000502276.6
ENST00000511930.2
GAPT
GRB2 binding adaptor protein, transmembrane
chr1_-_17439657 0.27 ENST00000375436.9
RCC2
regulator of chromosome condensation 2
chr7_-_33100886 0.27 ENST00000448915.1
RP9
RP9 pre-mRNA splicing factor
chr13_-_46142834 0.27 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr1_-_169703329 0.27 ENST00000497295.1
SELL
selectin L
chr22_-_28711931 0.27 ENST00000434810.5
ENST00000456369.5
CHEK2
checkpoint kinase 2
chrM_+_9207 0.26 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_-_111483700 0.26 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr4_-_137532452 0.26 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
PCDH18
protocadherin 18
chr12_-_95551417 0.26 ENST00000258499.8
USP44
ubiquitin specific peptidase 44
chr14_+_60982358 0.26 ENST00000526105.5
SLC38A6
solute carrier family 38 member 6
chr17_-_10469558 0.25 ENST00000255381.2
MYH4
myosin heavy chain 4
chr2_+_127419686 0.25 ENST00000427769.5
PROC
protein C, inactivator of coagulation factors Va and VIIIa
chr1_-_247760556 0.25 ENST00000641256.1
OR1C1
olfactory receptor family 1 subfamily C member 1
chr15_+_78077798 0.25 ENST00000409568.6
SH2D7
SH2 domain containing 7
chr7_-_42152396 0.24 ENST00000642432.1
ENST00000647255.1
ENST00000677288.1
GLI3
GLI family zinc finger 3
chr6_-_155455830 0.24 ENST00000159060.3
NOX3
NADPH oxidase 3
chr3_-_150703965 0.23 ENST00000498386.1
ERICH6
glutamate rich 6
chr4_+_155854758 0.22 ENST00000506072.5
ENST00000507590.5
TDO2
tryptophan 2,3-dioxygenase
chr17_+_10697576 0.22 ENST00000379774.5
ADPRM
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr17_-_7404039 0.21 ENST00000576017.1
ENST00000302422.4
TMEM256
transmembrane protein 256
chr3_-_186544377 0.21 ENST00000307944.6
CRYGS
crystallin gamma S
chr11_+_55723776 0.21 ENST00000641440.1
OR5D3P
olfactory receptor family 5 subfamily D member 3 pseudogene
chr17_-_40999903 0.20 ENST00000391587.3
KRTAP3-2
keratin associated protein 3-2
chr11_+_5389377 0.20 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr12_-_118190510 0.20 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr14_+_22096017 0.20 ENST00000390452.2
TRDV1
T cell receptor delta variable 1
chrM_+_10055 0.19 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
chr7_-_111392915 0.19 ENST00000450877.5
IMMP2L
inner mitochondrial membrane peptidase subunit 2
chr17_+_7252502 0.19 ENST00000570322.5
ENST00000576496.5
ENST00000574841.2
ELP5
elongator acetyltransferase complex subunit 5
chrY_-_23694579 0.19 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr17_+_1771688 0.18 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin family F member 1
chr2_-_206213430 0.18 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr1_-_152806628 0.18 ENST00000606576.1
ENST00000607093.2
LCE1C
late cornified envelope 1C
chr17_-_8210203 0.18 ENST00000578549.5
ENST00000582368.5
AURKB
aurora kinase B
chr9_+_108862255 0.18 ENST00000333999.5
ACTL7A
actin like 7A
chr2_+_108239965 0.18 ENST00000681802.2
ENST00000329106.3
SULT1C3
sulfotransferase family 1C member 3
chr3_-_191282383 0.17 ENST00000427544.6
UTS2B
urotensin 2B
chr4_-_119322128 0.17 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr17_-_64390592 0.17 ENST00000563523.5
PECAM1
platelet and endothelial cell adhesion molecule 1
chr20_-_31390483 0.16 ENST00000376315.2
DEFB119
defensin beta 119
chrY_+_18546691 0.16 ENST00000309834.8
ENST00000307393.3
ENST00000382856.2
HSFY1
heat shock transcription factor Y-linked 1
chr4_+_168497113 0.16 ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr19_-_44529687 0.16 ENST00000621342.4
ENST00000617951.1
CEACAM20
CEA cell adhesion molecule 20
chr11_-_5548540 0.15 ENST00000322653.7
OR52H1
olfactory receptor family 52 subfamily H member 1
chr13_+_30422487 0.15 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr10_+_94762673 0.15 ENST00000480405.2
ENST00000371321.9
CYP2C19
cytochrome P450 family 2 subfamily C member 19
chr14_+_21621801 0.15 ENST00000542354.1
TRAV1-1
T cell receptor alpha variable 1-1
chr4_+_70242583 0.15 ENST00000304954.3
CSN3
casein kappa
chr15_-_75455767 0.15 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chr3_+_169911566 0.14 ENST00000428432.6
ENST00000335556.7
SAMD7
sterile alpha motif domain containing 7
chr7_-_84492718 0.14 ENST00000424555.5
SEMA3A
semaphorin 3A
chr16_+_53099100 0.14 ENST00000565832.5
CHD9
chromodomain helicase DNA binding protein 9
chr16_-_1488764 0.13 ENST00000447419.7
ENST00000440447.2
PTX4
pentraxin 4
chr5_-_131165231 0.13 ENST00000675100.1
ENST00000304043.10
ENST00000513012.2
HINT1
histidine triad nucleotide binding protein 1
chr11_-_124320197 0.13 ENST00000624618.2
OR8D2
olfactory receptor family 8 subfamily D member 2
chr17_+_7428831 0.12 ENST00000636696.4
ENST00000651079.1
SPEM3
SPEM family member 3
chr14_+_19719015 0.12 ENST00000557414.1
OR4N2
olfactory receptor family 4 subfamily N member 2
chr14_-_55440616 0.12 ENST00000247219.5
TBPL2
TATA-box binding protein like 2
chr6_-_138512493 0.12 ENST00000533765.1
NHSL1
NHS like 1
chr11_+_35186820 0.11 ENST00000531110.6
ENST00000525685.6
CD44
CD44 molecule (Indian blood group)
chr11_-_16397521 0.10 ENST00000533411.5
SOX6
SRY-box transcription factor 6
chr3_+_40477107 0.10 ENST00000314686.9
ENST00000447116.6
ENST00000429348.6
ENST00000432264.4
ENST00000456778.5
ZNF619
zinc finger protein 619
chr12_+_55444069 0.10 ENST00000641516.1
ENST00000641202.1
OR6C2
olfactory receptor family 6 subfamily C member 2
chr1_+_98661666 0.09 ENST00000529992.5
SNX7
sorting nexin 7
chr12_+_1970772 0.09 ENST00000682544.1
CACNA1C
calcium voltage-gated channel subunit alpha1 C
chr12_+_69825273 0.09 ENST00000547771.6
MYRFL
myelin regulatory factor like
chr17_-_7315312 0.08 ENST00000577040.2
ENST00000389167.9
ENST00000380728.7
GPS2
G protein pathway suppressor 2
chr1_+_112718880 0.08 ENST00000361886.4
TAFA3
TAFA chemokine like family member 3
chrX_-_101617921 0.08 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr1_+_13303539 0.08 ENST00000437300.2
PRAMEF33
PRAME family member 33
chr1_+_149899561 0.08 ENST00000369152.6
BOLA1
bolA family member 1
chr10_-_5003850 0.08 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
AKR1C2
aldo-keto reductase family 1 member C2
chrX_-_72808210 0.07 ENST00000419795.6
ENST00000458170.1
FAM236D
family with sequence similarity 236 member D
chr2_-_206213362 0.07 ENST00000442134.1
GPR1
G protein-coupled receptor 1
chr15_+_48191648 0.07 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
SLC12A1
CTXN2
solute carrier family 12 member 1
cortexin 2
chr5_+_111092172 0.07 ENST00000612402.4
WDR36
WD repeat domain 36
chr13_+_23570370 0.07 ENST00000403372.6
ENST00000248484.9
TNFRSF19
TNF receptor superfamily member 19
chr11_-_56614874 0.07 ENST00000641076.1
OR5M1
olfactory receptor family 5 subfamily M member 1
chr2_-_158380960 0.07 ENST00000409187.5
CCDC148
coiled-coil domain containing 148
chr1_-_13056575 0.06 ENST00000436041.6
PRAMEF27
PRAME family member 27
chr11_-_62754141 0.06 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chr11_-_75089754 0.06 ENST00000305159.3
OR2AT4
olfactory receptor family 2 subfamily AT member 4
chr12_+_55492378 0.06 ENST00000548615.1
OR6C68
olfactory receptor family 6 subfamily C member 68
chr11_-_63608542 0.06 ENST00000540943.1
PLAAT3
phospholipase A and acyltransferase 3
chr1_+_149899618 0.06 ENST00000369150.1
BOLA1
bolA family member 1
chr12_-_54295748 0.06 ENST00000540264.2
ENST00000312156.8
NFE2
nuclear factor, erythroid 2
chr1_-_223665723 0.06 ENST00000366873.6
CAPN8
calpain 8
chr12_+_1970809 0.06 ENST00000683781.1
ENST00000682462.1
CACNA1C
calcium voltage-gated channel subunit alpha1 C
chr6_-_24358036 0.05 ENST00000378454.8
DCDC2
doublecortin domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.4 1.3 GO:1903988 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.3 2.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.3 1.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.3 0.8 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 0.6 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.2 0.5 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.2 0.8 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 2.6 GO:0001778 plasma membrane repair(GO:0001778)
0.1 1.1 GO:0051552 flavone metabolic process(GO:0051552)
0.1 0.5 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.1 0.4 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.7 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 1.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 1.2 GO:0051005 negative regulation of phospholipase activity(GO:0010519) negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.4 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 1.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.6 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 0.7 GO:0050955 thermoception(GO:0050955)
0.1 0.3 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.6 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.1 1.8 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.0 GO:0015705 iodide transport(GO:0015705)
0.1 0.9 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.5 GO:0072011 glomerular endothelium development(GO:0072011)
0.1 0.3 GO:1904806 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.1 0.3 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 1.1 GO:0019532 oxalate transport(GO:0019532)
0.1 0.4 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.2 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 0.2 GO:0060875 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.3 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.3 GO:0018032 protein amidation(GO:0018032)
0.0 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.4 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.1 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.0 1.0 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.4 GO:0071313 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.0 0.6 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.0 0.3 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.2 GO:0048840 otolith development(GO:0048840)
0.0 1.5 GO:0010842 retina layer formation(GO:0010842)
0.0 1.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.1 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 0.2 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.3 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.3 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.7 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.8 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.4 GO:0033150 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.1 1.6 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.6 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 1.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.6 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.2 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.0 2.6 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0043203 axon hillock(GO:0043203)
0.0 0.4 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0097689 iron channel activity(GO:0097689)
0.2 1.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.2 0.6 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.4 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.1 0.8 GO:0042806 fucose binding(GO:0042806)
0.1 0.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 3.0 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.4 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 2.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 2.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 1.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 3.3 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.3 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 4.5 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 1.8 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 1.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 3.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins