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Illumina Body Map 2 (GSE30611)
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Results for KLF12
Z-value: 1.09
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Transcription factors associated with KLF12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF12 | hg38_v1_chr13_-_74133892_74133941 | -0.37 | 3.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.4 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.2 | 4.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.4 | 4.0 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.2 | 3.7 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.4 | 3.3 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.2 | 3.3 | GO:0044849 | estrous cycle(GO:0044849) |
| 0.1 | 3.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 1.0 | 3.1 | GO:0002194 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.4 | 3.1 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.3 | 3.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 7.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.3 | 6.4 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 3.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 3.7 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.5 | 3.5 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 3.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 3.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 3.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 3.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 6.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.3 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 4.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 3.6 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 3.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.4 | 3.1 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 3.1 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.2 | 3.0 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.5 | 2.9 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 4.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 2.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.0 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 4.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.3 | 4.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 4.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 3.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.9 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 2.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 2.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.1 | 2.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 2.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |