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Illumina Body Map 2 (GSE30611)

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Results for LHX3

Z-value: 0.87

Motif logo

Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
ENSG00000107187.17 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg38_v1_chr9_-_136205122_136205133-0.232.2e-01Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_48191648 3.45 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
solute carrier family 12 member 1
cortexin 2
chr4_+_154563003 2.65 ENST00000302068.9
ENST00000509493.1
fibrinogen beta chain
chr12_-_10130143 2.46 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr3_+_151873634 2.17 ENST00000362032.6
succinate receptor 1
chr12_-_10130241 2.00 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr5_-_39274515 1.92 ENST00000510188.1
FYN binding protein 1
chr19_-_51417791 1.84 ENST00000353836.9
sialic acid binding Ig like lectin 10
chr19_-_51417700 1.82 ENST00000529627.1
ENST00000439889.6
sialic acid binding Ig like lectin 10
chr18_+_74534493 1.82 ENST00000358821.8
carnosine dipeptidase 1
chr7_-_87713287 1.79 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ATP binding cassette subfamily B member 1
chr2_+_134838610 1.72 ENST00000356140.10
ENST00000392928.5
aminocarboxymuconate semialdehyde decarboxylase
chr12_+_40310431 1.71 ENST00000681696.1
leucine rich repeat kinase 2
chr18_+_74534594 1.69 ENST00000582365.1
carnosine dipeptidase 1
chr5_-_88824266 1.52 ENST00000509373.1
ENST00000636541.1
myocyte enhancer factor 2C
chr12_-_10130082 1.51 ENST00000533022.5
C-type lectin domain containing 7A
chr2_+_218129277 1.49 ENST00000428565.1
C-X-C motif chemokine receptor 2
chr4_+_157221598 1.45 ENST00000505888.1
glutamate ionotropic receptor AMPA type subunit 2
chr7_-_36724457 1.44 ENST00000617537.5
ENST00000435386.1
acyloxyacyl hydrolase
chr3_+_68006224 1.43 ENST00000496687.1
TAFA chemokine like family member 1
chr6_+_122996227 1.38 ENST00000275162.10
clavesin 2
chr8_-_109974688 1.32 ENST00000297404.1
potassium voltage-gated channel modifier subfamily V member 1
chr7_-_36724543 1.30 ENST00000612871.4
acyloxyacyl hydrolase
chr1_-_150971935 1.16 ENST00000368949.8
ceramide synthase 2
chr17_+_70075317 1.12 ENST00000589377.1
potassium inwardly rectifying channel subfamily J member 16
chr9_-_6605338 1.07 ENST00000638654.1
glycine decarboxylase
chr1_-_150235972 1.06 ENST00000534220.1
acidic nuclear phosphoprotein 32 family member E
chr18_-_3845321 1.04 ENST00000539435.5
ENST00000400147.6
DLG associated protein 1
chr1_-_150236064 1.04 ENST00000532744.2
ENST00000369114.9
ENST00000369115.3
ENST00000583931.6
acidic nuclear phosphoprotein 32 family member E
chr3_+_186974957 1.00 ENST00000438590.5
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr1_-_160579439 1.00 ENST00000368054.8
ENST00000368048.7
ENST00000311224.8
ENST00000368051.3
ENST00000534968.5
CD84 molecule
chr4_+_157220691 0.99 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
glutamate ionotropic receptor AMPA type subunit 2
chr16_-_28623560 0.99 ENST00000350842.8
sulfotransferase family 1A member 1
chr2_+_184598520 0.97 ENST00000302277.7
zinc finger protein 804A
chr1_-_150235995 0.96 ENST00000436748.6
acidic nuclear phosphoprotein 32 family member E
chr1_+_66354375 0.92 ENST00000480109.2
phosphodiesterase 4B
chr2_-_2324323 0.90 ENST00000648339.1
ENST00000647694.1
myelin transcription factor 1 like
chr13_-_83882456 0.89 ENST00000674365.1
SLIT and NTRK like family member 1
chr5_+_127649018 0.86 ENST00000379445.7
cortexin 3
chr1_+_240245260 0.85 ENST00000441342.1
formin 2
chr19_+_14583076 0.82 ENST00000547437.5
ENST00000417570.6
C-type lectin domain containing 17A
chr4_-_23890070 0.80 ENST00000617484.4
ENST00000612355.1
PPARG coactivator 1 alpha
chr12_+_118981531 0.80 ENST00000267260.5
serine/arginine repetitive matrix 4
chr6_-_159045104 0.79 ENST00000326965.7
T cell activation RhoGTPase activating protein
chr11_-_790062 0.79 ENST00000330106.5
cell cycle exit and neuronal differentiation 1
chr12_-_7503841 0.78 ENST00000359156.8
CD163 molecule
chr7_+_30145789 0.78 ENST00000324489.5
maturin, neural progenitor differentiation regulator homolog
chr18_+_57352541 0.77 ENST00000324000.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr12_-_7503744 0.76 ENST00000396620.7
ENST00000432237.3
CD163 molecule
chr13_-_83882390 0.75 ENST00000377084.3
SLIT and NTRK like family member 1
chr7_-_123199960 0.75 ENST00000194130.7
solute carrier family 13 member 1
chr5_-_88824334 0.75 ENST00000506716.5
myocyte enhancer factor 2C
chr10_-_72523936 0.75 ENST00000398763.8
ENST00000418483.6
ENST00000489666.2
mitochondrial calcium uptake 1
chr1_-_150235943 0.74 ENST00000533654.5
acidic nuclear phosphoprotein 32 family member E
chr2_-_144521042 0.73 ENST00000637267.2
zinc finger E-box binding homeobox 2
chr18_-_3845292 0.73 ENST00000400145.6
DLG associated protein 1
chr14_+_34993240 0.72 ENST00000677647.1
signal recognition particle 54
chrM_-_14669 0.72 ENST00000361681.2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr19_-_3557563 0.72 ENST00000389395.7
ENST00000355415.7
major facilitator superfamily domain containing 12
chr3_+_122183664 0.71 ENST00000639785.2
calcium sensing receptor
chr4_-_36243939 0.70 ENST00000506189.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_2324642 0.70 ENST00000650485.1
ENST00000649207.1
myelin transcription factor 1 like
chr10_-_114144599 0.68 ENST00000428953.1
coiled-coil domain containing 186
chr2_-_98663464 0.68 ENST00000414521.6
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
chr9_+_79573162 0.67 ENST00000425506.5
TLE family member 4, transcriptional corepressor
chr12_-_118190510 0.67 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr1_+_244051275 0.66 ENST00000358704.4
zinc finger and BTB domain containing 18
chr1_+_177170916 0.64 ENST00000361539.5
BMP/retinoic acid inducible neural specific 2
chr8_-_131040890 0.64 ENST00000286355.10
adenylate cyclase 8
chr4_-_23890035 0.64 ENST00000507380.1
ENST00000264867.7
PPARG coactivator 1 alpha
chr1_+_197268204 0.64 ENST00000535699.5
ENST00000538660.5
crumbs cell polarity complex component 1
chr6_+_106360668 0.62 ENST00000633556.3
crystallin beta-gamma domain containing 1
chr19_-_48646155 0.60 ENST00000084798.9
carbonic anhydrase 11
chr7_-_14974773 0.60 ENST00000437998.1
diacylglycerol kinase beta
chr7_-_116159886 0.59 ENST00000484212.5
transcription factor EC
chr7_+_138460238 0.58 ENST00000343526.9
tripartite motif containing 24
chr6_+_72216442 0.58 ENST00000425662.6
ENST00000453976.6
regulating synaptic membrane exocytosis 1
chr4_+_41935114 0.57 ENST00000508448.5
ENST00000513702.5
ENST00000325094.9
transmembrane protein 33
chr10_-_27240505 0.56 ENST00000375888.5
ENST00000676732.1
acyl-CoA binding domain containing 5
chr3_+_63967738 0.56 ENST00000484332.1
ataxin 7
chr1_-_23799533 0.56 ENST00000429356.5
UDP-galactose-4-epimerase
chr10_-_88851809 0.55 ENST00000371930.5
ankyrin repeat domain 22
chr11_-_75089754 0.53 ENST00000305159.3
olfactory receptor family 2 subfamily AT member 4
chr10_+_87357720 0.52 ENST00000412718.3
ENST00000381697.7
NUT family member 2D
chr7_-_105691637 0.52 ENST00000472195.1
ataxin 7 like 1
chr1_-_23799561 0.52 ENST00000445705.1
UDP-galactose-4-epimerase
chr2_-_2324968 0.51 ENST00000649641.1
myelin transcription factor 1 like
chr15_+_65550819 0.49 ENST00000569894.5
3-hydroxyacyl-CoA dehydratase 3
chr11_-_129024157 0.49 ENST00000392657.7
Rho GTPase activating protein 32
chr17_-_66229380 0.49 ENST00000205948.11
apolipoprotein H
chrX_-_13817027 0.48 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr1_+_197268222 0.47 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
crumbs cell polarity complex component 1
chr4_+_157220795 0.47 ENST00000506284.5
glutamate ionotropic receptor AMPA type subunit 2
chr7_+_38977904 0.47 ENST00000518318.7
ENST00000403058.6
POU class 6 homeobox 2
chr6_-_138512493 0.47 ENST00000533765.1
NHS like 1
chr8_-_56211257 0.45 ENST00000316981.8
ENST00000423799.6
ENST00000429357.2
PLAG1 zinc finger
chr11_+_60056587 0.44 ENST00000395032.6
ENST00000358152.6
membrane spanning 4-domains A3
chr10_-_126670686 0.44 ENST00000488181.3
chromosome 10 open reading frame 90
chr14_+_61697622 0.44 ENST00000539097.2
hypoxia inducible factor 1 subunit alpha
chr2_-_2324935 0.42 ENST00000649709.1
myelin transcription factor 1 like
chr1_-_111488795 0.41 ENST00000472933.2
transmembrane and immunoglobulin domain containing 3
chr1_+_196888014 0.41 ENST00000367416.6
ENST00000608469.6
ENST00000251424.8
ENST00000367418.2
complement factor H related 4
chr5_-_88823763 0.41 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
myocyte enhancer factor 2C
chr18_-_5197241 0.41 ENST00000434239.4
A-kinase anchor inhibitor 1
chr11_-_117316230 0.40 ENST00000313005.11
ENST00000528053.5
beta-secretase 1
chr14_+_21997531 0.39 ENST00000390445.2
T cell receptor alpha variable 17
chr4_+_94207596 0.37 ENST00000359052.8
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr5_+_68290637 0.37 ENST00000336483.9
phosphoinositide-3-kinase regulatory subunit 1
chr18_+_616672 0.35 ENST00000338387.11
clusterin like 1
chr18_+_616711 0.35 ENST00000579494.1
clusterin like 1
chr12_+_49346911 0.35 ENST00000395069.3
DnaJ heat shock protein family (Hsp40) member C22
chr3_+_46877705 0.34 ENST00000449590.6
parathyroid hormone 1 receptor
chr1_-_74512611 0.34 ENST00000294635.5
leucine rich repeat containing 53
chr8_-_30812867 0.32 ENST00000518243.5
protein phosphatase 2 catalytic subunit beta
chr19_+_11346499 0.31 ENST00000458408.6
ENST00000586451.5
ENST00000588592.5
coiled-coil domain containing 159
chr3_-_191282383 0.30 ENST00000427544.6
urotensin 2B
chr3_+_101724633 0.30 ENST00000494050.5
centrosomal protein 97
chr17_-_30334050 0.30 ENST00000328886.5
ENST00000538566.6
transmembrane and immunoglobulin domain containing 1
chr11_+_60056653 0.29 ENST00000278865.8
membrane spanning 4-domains A3
chr3_+_46612525 0.27 ENST00000640551.3
family with sequence similarity 240 member A
chr2_-_96505345 0.27 ENST00000310865.7
ENST00000451794.6
neuralized E3 ubiquitin protein ligase 3
chr19_-_11346486 0.27 ENST00000590482.5
transmembrane protein 205
chr3_-_64019334 0.27 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr5_+_148312416 0.27 ENST00000274565.5
serine peptidase inhibitor Kazal type 7
chr6_+_26103922 0.26 ENST00000377803.4
H4 clustered histone 3
chr4_-_86357722 0.26 ENST00000641341.1
ENST00000642038.1
ENST00000641116.1
ENST00000641767.1
ENST00000639242.1
ENST00000638313.1
mitogen-activated protein kinase 10
chrX_+_85003863 0.26 ENST00000373173.7
apolipoprotein O like
chr9_-_113303271 0.26 ENST00000297894.5
ENST00000489339.2
ring finger protein 183
chr7_+_92057602 0.26 ENST00000491695.2
A-kinase anchoring protein 9
chr3_+_138621225 0.25 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr19_+_9185594 0.25 ENST00000344248.4
olfactory receptor family 7 subfamily D member 2
chr3_-_47475811 0.25 ENST00000265565.10
ENST00000428413.5
SREBF chaperone
chr15_+_64387828 0.24 ENST00000261884.8
thyroid hormone receptor interactor 4
chr1_-_92486916 0.24 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr15_-_55408245 0.24 ENST00000563171.5
ENST00000425574.7
ENST00000442196.8
ENST00000564092.1
cell cycle progression 1
chrX_+_109535775 0.23 ENST00000218004.5
nuclear transport factor 2 like export factor 2
chr8_-_109680812 0.23 ENST00000528716.5
ENST00000527600.5
ENST00000531230.5
ENST00000532189.5
ENST00000534184.5
ENST00000408889.7
ENST00000533171.5
syntabulin
chr16_-_28623330 0.23 ENST00000677940.1
novel protein
chr3_+_101724602 0.23 ENST00000341893.8
centrosomal protein 97
chr1_-_19923617 0.23 ENST00000375116.3
phospholipase A2 group IIE
chr14_+_55027576 0.22 ENST00000339298.2
suppressor of cytokine signaling 4
chrX_+_123963164 0.22 ENST00000394478.1
stromal antigen 2
chr17_+_37491464 0.21 ENST00000613659.1
dual specificity phosphatase 14
chr3_-_142029108 0.20 ENST00000497579.5
transcription factor Dp-2
chr22_+_23145366 0.19 ENST00000341989.9
ENST00000263116.8
RAB36, member RAS oncogene family
chr1_-_182671853 0.18 ENST00000367556.5
regulator of G protein signaling 8
chr19_+_11346556 0.17 ENST00000587531.5
coiled-coil domain containing 159
chr5_-_79514127 0.17 ENST00000334082.11
homer scaffold protein 1
chr8_-_30812773 0.16 ENST00000221138.9
protein phosphatase 2 catalytic subunit beta
chr15_-_75455802 0.16 ENST00000568431.5
ENST00000568309.5
ENST00000568190.1
ENST00000570115.5
ENST00000564778.5
SIN3 transcription regulator family member A
chr15_-_75455767 0.15 ENST00000360439.8
SIN3 transcription regulator family member A
chr1_-_182671902 0.15 ENST00000483095.6
regulator of G protein signaling 8
chr11_-_63608542 0.13 ENST00000540943.1
phospholipase A and acyltransferase 3
chr16_+_67570741 0.11 ENST00000644753.1
ENST00000642819.1
ENST00000645306.1
CCCTC-binding factor
chr12_-_52367478 0.11 ENST00000257901.7
keratin 85
chr12_+_55444069 0.11 ENST00000641516.1
ENST00000641202.1
olfactory receptor family 6 subfamily C member 2
chr16_-_1488764 0.11 ENST00000447419.7
ENST00000440447.2
pentraxin 4
chr7_+_120273129 0.11 ENST00000331113.9
potassium voltage-gated channel subfamily D member 2
chr3_+_158110052 0.11 ENST00000295930.7
ENST00000471994.5
ENST00000482822.3
ENST00000476899.6
ENST00000683899.1
ENST00000684604.1
ENST00000682164.1
ENST00000464171.5
ENST00000611884.5
ENST00000312179.10
ENST00000475278.6
arginine and serine rich coiled-coil 1
chr2_-_50656384 0.10 ENST00000625891.2
neurexin 1
chr8_+_106726115 0.10 ENST00000521592.5
oxidation resistance 1
chr18_-_5197502 0.09 ENST00000580650.1
A-kinase anchor inhibitor 1
chr12_+_55330043 0.09 ENST00000641364.1
olfactory receptor family 6 subfamily C member 3
chr6_-_31120437 0.09 ENST00000376288.3
corneodesmosin
chr3_+_41194741 0.08 ENST00000643541.1
ENST00000426215.5
ENST00000645210.1
ENST00000646381.1
ENST00000405570.6
ENST00000642248.1
ENST00000433400.6
catenin beta 1
chr3_-_20012250 0.08 ENST00000389050.5
protein phosphatase 2C like domain containing 1
chr9_+_69145463 0.07 ENST00000636438.1
tight junction protein 2
chr1_-_158426237 0.07 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr1_+_115029823 0.06 ENST00000256592.3
thyroid stimulating hormone subunit beta
chrX_+_108045050 0.06 ENST00000458383.1
ENST00000217957.10
V-set and immunoglobulin domain containing 1
chr11_-_5778667 0.06 ENST00000317093.2
olfactory receptor family 52 subfamily N member 5
chr1_-_158570580 0.06 ENST00000641540.1
olfactory receptor family 6 subfamily P member 1
chr5_+_55853314 0.04 ENST00000354961.8
ENST00000297015.7
interleukin 31 receptor A
chr14_+_55027200 0.04 ENST00000395472.2
ENST00000555846.2
suppressor of cytokine signaling 4
chr1_-_45522870 0.02 ENST00000424390.2
peroxiredoxin 1
chr10_-_45307838 0.01 ENST00000536058.1
olfactory receptor family 13 subfamily A member 1
chr3_+_138621207 0.00 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr1_+_207325629 0.00 ENST00000618707.2
CD55 molecule (Cromer blood group)
chr5_+_167284799 0.00 ENST00000518659.5
teneurin transmembrane protein 2
chr13_-_70108441 0.00 ENST00000377844.9
ENST00000545028.2
kelch like family member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:1902688 regulation of NAD metabolic process(GO:1902688)
0.6 1.7 GO:1903123 regulation of thioredoxin peroxidase activity(GO:1903123) negative regulation of thioredoxin peroxidase activity(GO:1903124) negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation(GO:1903125) Wnt signalosome assembly(GO:1904887) negative regulation of peroxidase activity(GO:2000469)
0.5 1.4 GO:0071250 cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) glomerular visceral epithelial cell apoptotic process(GO:1903210) regulation of glomerular visceral epithelial cell apoptotic process(GO:1904633) positive regulation of glomerular visceral epithelial cell apoptotic process(GO:1904635) response to resveratrol(GO:1904638) cellular response to resveratrol(GO:1904639) positive regulation of progesterone biosynthetic process(GO:2000184)
0.4 1.1 GO:1903442 response to methylamine(GO:0036255) response to lipoic acid(GO:1903442)
0.3 1.0 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
0.3 1.2 GO:1900148 Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045)
0.2 1.5 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.2 2.7 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 6.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.2 2.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.7 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.2 0.9 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.2 1.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 0.5 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.6 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.1 0.8 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.3 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)
0.1 1.1 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.7 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.5 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.1 3.8 GO:0043486 histone exchange(GO:0043486)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.0 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 2.5 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.5 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 2.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.7 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 1.0 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.5 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.5 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.7 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.5 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.4 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 3.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.3 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 1.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.5 GO:0006953 acute-phase response(GO:0006953)
0.0 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584) regulation of molecular function, epigenetic(GO:0040030)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 1.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 1.4 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0007403 glial cell fate determination(GO:0007403) fungiform papilla formation(GO:0061198) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.0 1.6 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0032473 cytoplasmic side of mitochondrial outer membrane(GO:0032473) caveola neck(GO:0099400)
0.5 1.4 GO:1990843 subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844)
0.4 2.9 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 1.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 2.6 GO:0005577 fibrinogen complex(GO:0005577)
0.2 3.8 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.4 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.7 GO:1990246 uniplex complex(GO:1990246)
0.1 0.7 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 0.3 GO:0044307 dendritic branch(GO:0044307)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 1.5 GO:0042629 mast cell granule(GO:0042629)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.4 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.9 2.7 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.6 1.8 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.6 1.7 GO:0036479 GTP-dependent protein kinase activity(GO:0034211) peroxidase inhibitor activity(GO:0036479)
0.4 1.1 GO:0070279 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642) vitamin B6 binding(GO:0070279) pyridoxal binding(GO:0070280)
0.3 1.1 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.2 1.5 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.2 0.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 2.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.2 1.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 6.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.8 GO:0042806 fucose binding(GO:0042806)
0.1 2.7 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 3.5 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.7 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.8 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 1.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.5 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.3 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.0 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 3.8 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 1.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.6 GO:0051087 chaperone binding(GO:0051087)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.0 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 3.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 3.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.9 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 1.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis