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Illumina Body Map 2 (GSE30611)
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Results for LHX8
Z-value: 0.88
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Transcription factors associated with LHX8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX8 | hg38_v1_chr1_+_75134382_75134411 | 0.53 | 1.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of LHX8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.2 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 0.0 | 5.0 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.2 | 4.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 3.6 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.5 | 3.0 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.1 | 2.9 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.1 | 2.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.5 | 2.7 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 0.0 | 2.7 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 2.4 | GO:0005977 | glycogen metabolic process(GO:0005977) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.8 | 5.0 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.1 | 4.4 | GO:0032982 | myosin filament(GO:0032982) |
| 0.4 | 3.0 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 2.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 2.7 | GO:0033018 | junctional membrane complex(GO:0030314) sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 2.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.4 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.2 | 1.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 1.6 | GO:0036128 | CatSper complex(GO:0036128) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 5.9 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 5.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 4.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 3.0 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 2.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 2.0 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 1.8 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 1.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.8 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.7 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.5 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.1 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |