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Illumina Body Map 2 (GSE30611)
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Results for MBD2
Z-value: 0.75
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Transcription factors associated with MBD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MBD2 | hg38_v1_chr18_-_54224578_54224689 | -0.44 | 1.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_17617326 Show fit | 1.43 |
ENST00000326961.6
ENST00000361271.8 |
3-hydroxyacyl-CoA dehydratase 1 |
|
| chr4_-_6472548 Show fit | 1.17 |
ENST00000382599.9
|
protein phosphatase 2 regulatory subunit Bgamma |
|
| chr2_+_219434825 Show fit | 1.17 |
ENST00000312358.12
|
striated muscle enriched protein kinase |
|
| chr1_+_109466527 Show fit | 1.17 |
ENST00000369872.4
|
synaptophysin like 2 |
|
| chr9_-_109498251 Show fit | 1.12 |
ENST00000374541.4
ENST00000262539.7 |
protein tyrosine phosphatase non-receptor type 3 |
|
| chr18_-_28177934 Show fit | 1.12 |
ENST00000676445.1
|
cadherin 2 |
|
| chrX_+_69504320 Show fit | 1.10 |
ENST00000252338.5
|
family with sequence similarity 155 member B |
|
| chr10_-_17617235 Show fit | 1.07 |
ENST00000466335.1
|
3-hydroxyacyl-CoA dehydratase 1 |
|
| chr11_-_46918522 Show fit | 1.03 |
ENST00000378623.6
ENST00000534404.1 |
LDL receptor related protein 4 |
|
| chr17_-_39197696 Show fit | 1.02 |
ENST00000394310.7
ENST00000622445.4 ENST00000344140.5 |
calcium voltage-gated channel auxiliary subunit beta 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MBD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.3 | 1.7 | GO:0061034 | olfactory bulb mitral cell layer development(GO:0061034) |
| 0.0 | 1.7 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 1.6 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.0 | 1.6 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.4 | 1.4 | GO:0045212 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.0 | 1.2 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 1.1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 1.1 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.1 | 1.1 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 1.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 1.2 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 1.1 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 1.1 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 1.0 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 1.0 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0051286 | cell tip(GO:0051286) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.8 | 2.5 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 0.0 | 1.7 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.3 | 1.4 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.0 | 1.3 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.2 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.4 | 1.1 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
| 0.1 | 1.1 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 1.0 | GO:0086059 | voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059) |
| 0.1 | 1.0 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.9 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 1.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.1 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 1.0 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.6 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |