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Illumina Body Map 2 (GSE30611)

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Results for MEF2B

Z-value: 1.56

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Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
MEF2B
ENSG00000213999.17 myocyte enhancer factor 2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg38_v1_chr19_-_19192122_19192165-0.476.9e-03Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_26067622 13.30 ENST00000374272.4
TRIM63
tripartite motif containing 63
chr2_+_169509693 13.22 ENST00000284669.2
KLHL41
kelch like family member 41
chr12_-_110920568 11.60 ENST00000548438.1
ENST00000228841.15
MYL2
myosin light chain 2
chr12_-_48999363 11.24 ENST00000421952.3
DDN
dendrin
chr16_-_31428325 11.18 ENST00000287490.5
COX6A2
cytochrome c oxidase subunit 6A2
chrX_-_21758097 10.73 ENST00000379494.4
SMPX
small muscle protein X-linked
chr11_-_19201976 9.84 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
CSRP3
cysteine and glycine rich protein 3
chr5_+_54455661 9.76 ENST00000302005.3
HSPB3
heat shock protein family B (small) member 3
chr2_+_88067818 9.72 ENST00000444564.2
ENST00000419482.7
SMYD1
SET and MYND domain containing 1
chr4_+_119135825 9.51 ENST00000307128.6
MYOZ2
myozenin 2
chr2_-_210303608 9.49 ENST00000341685.8
MYL1
myosin light chain 1
chr3_+_42685535 9.22 ENST00000287777.5
KLHL40
kelch like family member 40
chrX_-_21758021 8.56 ENST00000646008.1
SMPX
small muscle protein X-linked
chr3_-_52452828 8.16 ENST00000496590.1
TNNC1
troponin C1, slow skeletal and cardiac type
chr2_+_238138661 7.99 ENST00000409223.2
KLHL30
kelch like family member 30
chr2_+_167187283 7.72 ENST00000409605.1
ENST00000409273.6
XIRP2
xin actin binding repeat containing 2
chr8_+_2045037 7.60 ENST00000262113.9
MYOM2
myomesin 2
chr11_+_1839602 7.12 ENST00000617947.4
ENST00000252898.11
TNNI2
troponin I2, fast skeletal type
chr8_+_2045058 6.87 ENST00000523438.1
MYOM2
myomesin 2
chr14_-_93955577 6.70 ENST00000555507.5
ASB2
ankyrin repeat and SOCS box containing 2
chr2_+_88067849 6.66 ENST00000438570.1
SMYD1
SET and MYND domain containing 1
chr7_-_113919000 6.61 ENST00000284601.4
PPP1R3A
protein phosphatase 1 regulatory subunit 3A
chr11_+_1838970 6.59 ENST00000381911.6
TNNI2
troponin I2, fast skeletal type
chr2_+_167187364 6.58 ENST00000672671.1
XIRP2
xin actin binding repeat containing 2
chr6_-_123636923 6.56 ENST00000334268.9
TRDN
triadin
chr1_+_167094049 6.53 ENST00000361200.7
STYXL2
serine/threonine/tyrosine interacting like 2
chr3_-_39192584 6.15 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin binding repeat containing 1
chr11_+_1839452 6.06 ENST00000381906.5
TNNI2
troponin I2, fast skeletal type
chr16_+_31214088 5.99 ENST00000613872.1
TRIM72
tripartite motif containing 72
chr15_+_42359454 5.90 ENST00000349748.8
ENST00000318023.11
ENST00000397163.8
CAPN3
calpain 3
chr5_+_191477 5.87 ENST00000328278.4
LRRC14B
leucine rich repeat containing 14B
chr16_+_31214111 5.80 ENST00000322122.8
TRIM72
tripartite motif containing 72
chr10_-_73655984 5.20 ENST00000394810.3
SYNPO2L
synaptopodin 2 like
chr14_-_93955258 5.19 ENST00000556062.5
ASB2
ankyrin repeat and SOCS box containing 2
chr11_-_19202004 5.13 ENST00000648719.1
CSRP3
cysteine and glycine rich protein 3
chr5_-_16508812 5.09 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr3_+_179653032 5.08 ENST00000680587.1
ENST00000681064.1
ENST00000263966.8
ENST00000681358.1
ENST00000679749.1
USP13
ubiquitin specific peptidase 13
chr12_+_119178920 5.07 ENST00000281938.7
HSPB8
heat shock protein family B (small) member 8
chr5_-_16508990 5.01 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr12_-_110920710 4.96 ENST00000546404.1
MYL2
myosin light chain 2
chr12_+_119178953 4.93 ENST00000674542.1
HSPB8
heat shock protein family B (small) member 8
chr3_+_179653129 4.91 ENST00000680008.1
USP13
ubiquitin specific peptidase 13
chr15_+_84817346 4.90 ENST00000258888.6
ALPK3
alpha kinase 3
chr5_-_16508788 4.76 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr5_-_16508858 4.76 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr6_-_123636906 4.75 ENST00000628709.2
TRDN
triadin
chr17_-_9791586 4.73 ENST00000571134.2
DHRS7C
dehydrogenase/reductase 7C
chr5_-_16508951 4.64 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr1_-_146021724 4.58 ENST00000475797.1
ENST00000497365.5
ENST00000336751.11
ENST00000634927.1
ENST00000421822.2
HJV
hemojuvelin BMP co-receptor
chr8_-_123653794 4.57 ENST00000684634.1
KLHL38
kelch like family member 38
chr17_+_7281711 4.54 ENST00000317370.13
ENST00000571308.5
SLC2A4
solute carrier family 2 member 4
chr15_+_42359577 4.48 ENST00000357568.8
CAPN3
calpain 3
chr19_-_39834127 4.37 ENST00000601972.1
ENST00000430012.6
ENST00000323039.10
ENST00000348817.7
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr17_-_29140373 4.34 ENST00000533420.3
MYO18A
myosin XVIIIA
chrX_-_64230600 4.29 ENST00000362002.3
ASB12
ankyrin repeat and SOCS box containing 12
chr2_+_219434825 4.27 ENST00000312358.12
SPEG
striated muscle enriched protein kinase
chrX_-_15314543 3.61 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr18_-_3219849 3.52 ENST00000261606.11
MYOM1
myomesin 1
chr6_-_123636966 3.50 ENST00000542443.5
TRDN
triadin
chr1_-_115768702 3.45 ENST00000261448.6
CASQ2
calsequestrin 2
chr18_-_3219961 3.44 ENST00000356443.9
MYOM1
myomesin 1
chr10_-_67696115 3.42 ENST00000433211.7
CTNNA3
catenin alpha 3
chr1_-_23424692 3.38 ENST00000374601.7
ENST00000450454.7
TCEA3
transcription elongation factor A3
chr3_+_159852933 3.19 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr22_-_50578417 3.13 ENST00000312108.12
ENST00000395650.6
CPT1B
carnitine palmitoyltransferase 1B
chr1_-_23424618 3.02 ENST00000476978.2
TCEA3
transcription elongation factor A3
chr3_-_57292676 3.01 ENST00000389601.3
ENST00000487349.6
ASB14
ankyrin repeat and SOCS box containing 14
chr3_-_192727500 2.88 ENST00000430714.5
ENST00000418610.1
ENST00000445105.7
ENST00000684728.1
ENST00000448795.5
ENST00000683935.1
ENST00000684282.1
ENST00000683451.1
FGF12
fibroblast growth factor 12
chr9_+_97501622 2.64 ENST00000259365.9
TMOD1
tropomodulin 1
chr10_-_75073627 2.63 ENST00000338487.6
DUSP29
dual specificity phosphatase 29
chr20_+_45407207 2.49 ENST00000372712.6
DBNDD2
dysbindin domain containing 2
chr17_+_44170695 2.39 ENST00000293414.6
ASB16
ankyrin repeat and SOCS box containing 16
chr14_+_24132050 2.33 ENST00000559294.1
FITM1
fat storage inducing transmembrane protein 1
chr19_-_39833615 2.26 ENST00000593685.5
ENST00000600611.5
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr20_+_10218948 2.24 ENST00000430336.1
SNAP25
synaptosome associated protein 25
chr3_+_35642159 2.20 ENST00000187397.8
ARPP21
cAMP regulated phosphoprotein 21
chr14_-_70080180 2.15 ENST00000394330.6
ENST00000533541.1
ENST00000216568.11
SLC8A3
solute carrier family 8 member A3
chr3_+_127915226 2.12 ENST00000405109.5
KBTBD12
kelch repeat and BTB domain containing 12
chr7_+_143316105 2.10 ENST00000343257.7
ENST00000650516.1
CLCN1
chloride voltage-gated channel 1
chr10_-_95441015 2.05 ENST00000371241.5
ENST00000354106.7
ENST00000371239.5
ENST00000361941.7
ENST00000277982.9
ENST00000371245.7
SORBS1
sorbin and SH3 domain containing 1
chr17_-_44111253 2.01 ENST00000591714.5
HDAC5
histone deacetylase 5
chrX_-_143635081 1.99 ENST00000338017.8
SLITRK4
SLIT and NTRK like family member 4
chr12_+_78863962 1.98 ENST00000393240.7
SYT1
synaptotagmin 1
chr5_+_156326735 1.94 ENST00000435422.7
SGCD
sarcoglycan delta
chr2_-_219253145 1.89 ENST00000456818.5
ENST00000447205.1
TUBA4A
tubulin alpha 4a
chr9_-_83267230 1.87 ENST00000328788.5
FRMD3
FERM domain containing 3
chr11_-_47352693 1.85 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
MYBPC3
myosin binding protein C3
chr5_-_88883701 1.81 ENST00000636998.1
MEF2C
myocyte enhancer factor 2C
chr3_+_127915469 1.79 ENST00000407609.7
KBTBD12
kelch repeat and BTB domain containing 12
chr20_+_10218808 1.63 ENST00000254976.7
ENST00000304886.6
SNAP25
synaptosome associated protein 25
chr8_+_141417902 1.60 ENST00000681443.1
PTP4A3
protein tyrosine phosphatase 4A3
chr14_-_20436161 1.46 ENST00000636854.3
KLHL33
kelch like family member 33
chr5_-_161547735 1.35 ENST00000675773.1
ENST00000274547.7
GABRB2
gamma-aminobutyric acid type A receptor subunit beta2
chr1_-_156490599 1.28 ENST00000360595.7
MEF2D
myocyte enhancer factor 2D
chr13_+_38687068 1.25 ENST00000280481.9
FREM2
FRAS1 related extracellular matrix 2
chrX_-_139222777 1.22 ENST00000448673.1
FGF13
fibroblast growth factor 13
chr14_-_21025000 1.20 ENST00000554489.5
ENST00000555657.5
ENST00000557274.5
ENST00000555158.5
ENST00000554833.5
ENST00000555384.5
ENST00000556420.5
ENST00000554893.5
ENST00000553503.5
ENST00000555733.5
ENST00000397856.7
ENST00000553867.5
ENST00000556147.6
ENST00000556008.5
ENST00000557182.5
ENST00000554483.5
ENST00000556688.5
ENST00000397853.7
ENST00000556329.6
ENST00000397851.6
ENST00000554143.5
ENST00000555142.5
ENST00000557676.5
ENST00000556924.5
NDRG2
NDRG family member 2
chr4_+_41360759 1.18 ENST00000508501.5
ENST00000512946.5
ENST00000313860.11
ENST00000512632.5
ENST00000512820.5
LIMCH1
LIM and calponin homology domains 1
chr18_-_50266481 1.10 ENST00000398545.5
CFAP53
cilia and flagella associated protein 53
chr3_+_54123452 1.07 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr14_-_21025490 1.04 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG2
NDRG family member 2
chr17_-_44123628 1.04 ENST00000587135.1
ENST00000225983.10
ENST00000682912.1
ENST00000588703.5
HDAC5
histone deacetylase 5
chr12_+_25052663 0.97 ENST00000556887.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr4_+_44678412 0.93 ENST00000281543.6
GUF1
GTP binding elongation factor GUF1
chr12_+_25052694 0.86 ENST00000554942.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr10_+_84424919 0.85 ENST00000543283.2
ENST00000494586.5
CCSER2
coiled-coil serine rich protein 2
chr12_+_52037232 0.83 ENST00000553200.1
NR4A1
nuclear receptor subfamily 4 group A member 1
chr1_+_170664121 0.82 ENST00000239461.11
PRRX1
paired related homeobox 1
chr10_+_116590956 0.76 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr17_-_44123590 0.71 ENST00000336057.9
HDAC5
histone deacetylase 5
chr8_-_27258386 0.66 ENST00000350889.8
ENST00000519997.5
ENST00000519614.5
ENST00000522908.1
ENST00000265770.11
STMN4
stathmin 4
chrX_+_71301742 0.64 ENST00000373829.8
ENST00000538820.1
ITGB1BP2
integrin subunit beta 1 binding protein 2
chr10_+_116591010 0.62 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr20_-_63951122 0.60 ENST00000369908.9
UCKL1
uridine-cytidine kinase 1 like 1
chr10_+_84425148 0.59 ENST00000493409.5
CCSER2
coiled-coil serine rich protein 2
chr17_-_29140400 0.58 ENST00000528564.2
MYO18A
myosin XVIIIA
chr17_+_20155989 0.53 ENST00000395530.6
ENST00000581399.6
ENST00000679819.1
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_-_145910031 0.50 ENST00000369304.8
ITGA10
integrin subunit alpha 10
chr20_+_59676661 0.48 ENST00000355648.8
PHACTR3
phosphatase and actin regulator 3
chr1_-_145910066 0.43 ENST00000539363.2
ITGA10
integrin subunit alpha 10
chr8_-_27258414 0.43 ENST00000523048.5
STMN4
stathmin 4
chr1_-_145962581 0.42 ENST00000619813.1
ANKRD34A
ankyrin repeat domain 34A
chr13_-_44437214 0.39 ENST00000622051.1
TSC22D1
TSC22 domain family member 1
chr10_+_116590407 0.33 ENST00000531984.5
PNLIPRP1
pancreatic lipase related protein 1
chr11_+_72223688 0.28 ENST00000540973.1
INPPL1
inositol polyphosphate phosphatase like 1
chr20_+_58907981 0.28 ENST00000656419.1
GNAS
GNAS complex locus
chr1_-_145962955 0.26 ENST00000619519.1
ANKRD34A
ankyrin repeat domain 34A
chr4_-_106368772 0.25 ENST00000638719.4
GIMD1
GIMAP family P-loop NTPase domain containing 1
chr1_+_212608628 0.23 ENST00000613954.4
ENST00000341491.9
ENST00000366985.5
ATF3
activating transcription factor 3
chr3_+_8501807 0.19 ENST00000426878.2
ENST00000397386.7
ENST00000415597.5
ENST00000157600.8
LMCD1
LIM and cysteine rich domains 1
chr12_-_7747339 0.15 ENST00000543765.1
ENST00000360345.8
ENST00000540085.5
CLEC4C
C-type lectin domain family 4 member C
chr1_-_150720842 0.15 ENST00000442853.5
ENST00000368995.8
ENST00000322343.11
ENST00000361824.7
HORMAD1
HORMA domain containing 1
chr1_+_160081529 0.14 ENST00000368088.4
KCNJ9
potassium inwardly rectifying channel subfamily J member 9
chr7_+_87152599 0.14 ENST00000579592.5
ENST00000434534.5
DMTF1
cyclin D binding myb like transcription factor 1
chr1_+_76867469 0.12 ENST00000477717.6
ST6GALNAC5
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr15_+_68054308 0.11 ENST00000249636.11
PIAS1
protein inhibitor of activated STAT 1
chr22_+_19719435 0.09 ENST00000395109.6
SEPTIN5
septin 5
chr7_-_37449174 0.07 ENST00000445322.1
ENST00000448602.5
ELMO1
engulfment and cell motility 1
chr1_-_150720829 0.06 ENST00000368987.5
HORMAD1
HORMA domain containing 1
chr14_-_21537064 0.05 ENST00000541965.1
SALL2
spalt like transcription factor 2
chr5_-_132011580 0.04 ENST00000651250.1
ENST00000434099.6
ENST00000296869.9
ENST00000651356.1
ENST00000651883.2
ACSL6
acyl-CoA synthetase long chain family member 6
chr6_+_27957241 0.02 ENST00000244623.1
OR2B6
olfactory receptor family 2 subfamily B member 6

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 24.3 GO:0061709 reticulophagy(GO:0061709)
3.0 14.8 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
2.7 21.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
2.5 10.0 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
2.2 13.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
2.0 8.2 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
1.5 9.2 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
1.5 15.0 GO:0035995 detection of muscle stretch(GO:0035995)
1.3 16.6 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
1.0 10.4 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
1.0 4.9 GO:1903028 positive regulation of opsonization(GO:1903028)
1.0 11.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.0 3.9 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.9 13.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.7 2.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.6 1.8 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.5 3.5 GO:0071313 cellular response to caffeine(GO:0071313)
0.4 11.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 31.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.4 18.2 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.3 3.4 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.3 2.0 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.3 2.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.2 2.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 1.2 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 13.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 13.6 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 3.7 GO:2000615 regulation of histone H3-K9 acetylation(GO:2000615)
0.1 3.1 GO:0006853 carnitine shuttle(GO:0006853)
0.1 2.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 2.1 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 6.5 GO:0007520 myoblast fusion(GO:0007520)
0.1 4.5 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 1.6 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.1 18.7 GO:0006941 striated muscle contraction(GO:0006941)
0.1 4.7 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.1 6.8 GO:0030239 myofibril assembly(GO:0030239)
0.1 0.6 GO:0044211 CTP salvage(GO:0044211)
0.1 0.2 GO:0051598 meiotic recombination checkpoint(GO:0051598)
0.1 1.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 10.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 5.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 1.4 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:0048664 neuron fate determination(GO:0048664)
0.0 3.8 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 3.7 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 29.3 GO:0016567 protein ubiquitination(GO:0016567)
0.0 1.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.4 GO:0060047 heart contraction(GO:0060047)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 19.3 GO:0005927 muscle tendon junction(GO:0005927)
2.2 8.8 GO:0005863 striated muscle myosin thick filament(GO:0005863)
1.4 16.6 GO:0097512 cardiac myofibril(GO:0097512)
1.4 8.2 GO:1990584 cardiac Troponin complex(GO:1990584)
1.3 19.8 GO:0005861 troponin complex(GO:0005861)
1.3 18.3 GO:0030314 junctional membrane complex(GO:0030314) sarcoplasmic reticulum lumen(GO:0033018)
1.0 11.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.6 41.0 GO:0031430 M band(GO:0031430)
0.6 11.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.6 3.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.4 11.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.4 2.1 GO:0005899 insulin receptor complex(GO:0005899)
0.4 4.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 9.5 GO:0005859 muscle myosin complex(GO:0005859)
0.3 9.2 GO:0031672 A band(GO:0031672)
0.3 3.4 GO:0005916 fascia adherens(GO:0005916)
0.3 24.3 GO:0005801 cis-Golgi network(GO:0005801)
0.2 2.0 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 1.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 54.8 GO:0030018 Z disc(GO:0030018)
0.2 17.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.9 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 2.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 4.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 10.6 GO:0042383 sarcolemma(GO:0042383)
0.0 3.7 GO:0042641 actomyosin(GO:0042641)
0.0 1.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.4 GO:0000151 ubiquitin ligase complex(GO:0000151)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 27.9 GO:0031014 troponin T binding(GO:0031014)
1.4 24.5 GO:0031433 telethonin binding(GO:0031433)
1.2 10.0 GO:1904288 BAT3 complex binding(GO:1904288)
0.9 21.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.9 25.5 GO:0031432 titin binding(GO:0031432)
0.7 16.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 3.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 3.7 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 3.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.3 11.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 14.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 4.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 11.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 2.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 16.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 1.6 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.2 4.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 2.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 8.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 3.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 56.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 2.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 6.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 4.9 GO:0043531 ADP binding(GO:0043531)
0.1 0.6 GO:0004849 uridine kinase activity(GO:0004849)
0.0 1.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 15.3 GO:0030674 protein binding, bridging(GO:0030674)
0.0 2.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 16.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 5.5 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.1 PID INSULIN PATHWAY Insulin Pathway
0.0 1.8 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 56.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 5.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 4.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 4.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 35.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 2.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 2.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation