ISMARA results: MEF2B

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Illumina Body Map 2 (GSE30611)

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Results for MEF2B

Z-value: 1.56

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Transcription factors associated with MEF2B

Gene Symbol	Gene ID	Gene Info
MEF2B Ensembl NCBI GeneCards UniProt	ENSG00000213999.17	myocyte enhancer factor 2B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEF2B	hg38_v1_chr19_-_19192122_19192165	-0.47	6.9e-03	Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_26067622 Show fit	13.30	ENST00000374272.4	TRIM63 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 63
chr2_+_169509693 Show fit	13.22	ENST00000284669.2	KLHL41 Ensembl NCBI GeneCards UniProt Show fit	kelch like family member 41
chr12_-_110920568 Show fit	11.60	ENST00000548438.1 ENST00000228841.15	MYL2 Ensembl NCBI GeneCards UniProt Show fit	myosin light chain 2
chr12_-_48999363 Show fit	11.24	ENST00000421952.3	DDN Ensembl NCBI GeneCards UniProt Show fit	dendrin
chr16_-_31428325 Show fit	11.18	ENST00000287490.5	COX6A2 Ensembl NCBI GeneCards UniProt Show fit	cytochrome c oxidase subunit 6A2
chrX_-_21758097 Show fit	10.73	ENST00000379494.4	SMPX Ensembl NCBI GeneCards UniProt Show fit	small muscle protein X-linked
chr11_-_19201976 Show fit	9.84	ENST00000647990.1 ENST00000649235.1 ENST00000265968.9 ENST00000649842.1	CSRP3 Ensembl NCBI GeneCards UniProt Show fit	cysteine and glycine rich protein 3
chr5_+_54455661 Show fit	9.76	ENST00000302005.3	HSPB3 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 3
chr2_+_88067818 Show fit	9.72	ENST00000444564.2 ENST00000419482.7	SMYD1 Ensembl NCBI GeneCards UniProt Show fit	SET and MYND domain containing 1
chr4_+_119135825 Show fit	9.51	ENST00000307128.6	MYOZ2 Ensembl NCBI GeneCards UniProt Show fit	myozenin 2

Showing 1 to 10 of 142 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	31.9	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0	29.3	GO:0016567	protein ubiquitination(GO:0016567)
3.0	24.3	GO:0061709	reticulophagy(GO:0061709)
2.7	21.4	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	18.7	GO:0006941	striated muscle contraction(GO:0006941)
0.4	18.2	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
1.3	16.6	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
1.5	15.0	GO:0035995	detection of muscle stretch(GO:0035995)
3.0	14.8	GO:1901846	positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
0.1	13.6	GO:0055008	cardiac muscle tissue morphogenesis(GO:0055008)

Showing 1 to 10 of 51 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	54.8	GO:0030018	Z disc(GO:0030018)
0.6	41.0	GO:0031430	M band(GO:0031430)
0.3	24.3	GO:0005801	cis-Golgi network(GO:0005801)
1.3	19.8	GO:0005861	troponin complex(GO:0005861)
3.2	19.3	GO:0005927	muscle tendon junction(GO:0005927)
1.3	18.3	GO:0030314	junctional membrane complex(GO:0030314) sarcoplasmic reticulum lumen(GO:0033018)
0.2	17.9	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
1.4	16.6	GO:0097512	cardiac myofibril(GO:0097512)
1.0	11.9	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.6	11.2	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	56.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
2.0	27.9	GO:0031014	troponin T binding(GO:0031014)
0.9	25.5	GO:0031432	titin binding(GO:0031432)
1.4	24.5	GO:0031433	telethonin binding(GO:0031433)
0.9	21.4	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.7	16.6	GO:0032036	myosin heavy chain binding(GO:0032036)
0.2	16.4	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	15.3	GO:0030674	protein binding, bridging(GO:0030674)
0.2	14.3	GO:0051393	alpha-actinin binding(GO:0051393)
0.2	11.8	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	16.6	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	5.5	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	3.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	2.1	PID INSULIN PATHWAY	Insulin Pathway
0.0	2.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.8	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	1.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	1.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	56.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	35.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	5.8	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1	4.9	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	4.5	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	3.1	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1	2.2	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	2.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.9	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	1.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation

Showing 1 to 10 of 10 entries

Results for MEF2B

Z-value: 1.56

Motif logo

Transcription factors associated with MEF2B

Activity-expression correlation:

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: