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Illumina Body Map 2 (GSE30611)

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Results for MEF2D_MEF2A

Z-value: 5.45

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Transcription factors associated with MEF2D_MEF2A

Gene Symbol Gene ID Gene Info
ENSG00000116604.18 myocyte enhancer factor 2D
ENSG00000068305.17 myocyte enhancer factor 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Ahg38_v1_chr15_+_99566066_995660870.503.7e-03Click!
MEF2Dhg38_v1_chr1_-_156490599_1564906250.431.3e-02Click!

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_19201976 78.07 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
cysteine and glycine rich protein 3
chr17_+_39665340 76.53 ENST00000578283.1
ENST00000309889.3
titin-cap
chr12_-_110920568 63.31 ENST00000548438.1
ENST00000228841.15
myosin light chain 2
chr16_-_31428325 61.40 ENST00000287490.5
cytochrome c oxidase subunit 6A2
chr10_-_113664033 57.65 ENST00000359988.4
ENST00000369360.7
ENST00000360478.7
ENST00000369358.8
nebulin related anchoring protein
chr7_-_113919000 55.51 ENST00000284601.4
protein phosphatase 1 regulatory subunit 3A
chr2_+_88067818 54.28 ENST00000444564.2
ENST00000419482.7
SET and MYND domain containing 1
chr2_+_167187283 52.18 ENST00000409605.1
ENST00000409273.6
xin actin binding repeat containing 2
chr6_-_123636923 50.39 ENST00000334268.9
triadin
chr3_-_39192584 48.24 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
xin actin binding repeat containing 1
chrX_-_21758097 46.94 ENST00000379494.4
small muscle protein X-linked
chr11_-_19202004 46.84 ENST00000648719.1
cysteine and glycine rich protein 3
chr12_+_101594849 46.23 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
myosin binding protein C1
chr5_+_54455661 44.61 ENST00000302005.3
heat shock protein family B (small) member 3
chr2_+_167187364 43.81 ENST00000672671.1
xin actin binding repeat containing 2
chr8_-_123653794 43.30 ENST00000684634.1
kelch like family member 38
chr2_-_210303608 42.14 ENST00000341685.8
myosin light chain 1
chr6_-_123636906 41.70 ENST00000628709.2
triadin
chr10_-_73655984 41.09 ENST00000394810.3
synaptopodin 2 like
chr3_-_52452828 38.32 ENST00000496590.1
troponin C1, slow skeletal and cardiac type
chrX_-_21758021 38.09 ENST00000646008.1
small muscle protein X-linked
chr22_-_35617321 37.94 ENST00000397326.7
ENST00000442617.1
myoglobin
chr2_+_88067849 37.67 ENST00000438570.1
SET and MYND domain containing 1
chr8_+_2045037 37.53 ENST00000262113.9
myomesin 2
chr10_+_49299159 37.24 ENST00000374144.8
chromosome 10 open reading frame 71
chr10_+_86668501 36.73 ENST00000623056.4
ENST00000263066.11
ENST00000429277.7
ENST00000361373.9
ENST00000372066.8
ENST00000372056.8
ENST00000623007.3
LIM domain binding 3
chr4_+_119135825 36.52 ENST00000307128.6
myozenin 2
chr8_+_2045058 33.93 ENST00000523438.1
myomesin 2
chr6_-_123636966 33.28 ENST00000542443.5
triadin
chr3_+_121593363 33.08 ENST00000338040.6
F-box protein 40
chr22_-_35622521 32.80 ENST00000419229.1
ENST00000406324.5
myoglobin
chr18_-_3219849 31.63 ENST00000261606.11
myomesin 1
chr11_+_1838970 31.19 ENST00000381911.6
troponin I2, fast skeletal type
chr12_-_110920710 30.75 ENST00000546404.1
myosin light chain 2
chr1_-_26067622 30.71 ENST00000374272.4
tripartite motif containing 63
chr17_-_29140373 29.72 ENST00000533420.3
myosin XVIIIA
chr5_+_191477 29.60 ENST00000328278.4
leucine rich repeat containing 14B
chr10_-_73651013 29.24 ENST00000372873.8
synaptopodin 2 like
chr5_+_79689825 29.10 ENST00000446378.3
cardiomyopathy associated 5
chr17_+_7281711 28.96 ENST00000317370.13
ENST00000571308.5
solute carrier family 2 member 4
chr14_-_23408265 28.60 ENST00000405093.9
myosin heavy chain 6
chr22_+_25742141 28.47 ENST00000536101.5
ENST00000335473.12
ENST00000407587.6
myosin XVIIIB
chr1_-_100178215 27.90 ENST00000370138.1
ENST00000370137.6
ENST00000342895.7
ENST00000620882.4
leucine rich repeat containing 39
chr2_+_169509693 27.40 ENST00000284669.2
kelch like family member 41
chr18_-_3219961 26.96 ENST00000356443.9
myomesin 1
chr15_+_42359454 26.91 ENST00000349748.8
ENST00000318023.11
ENST00000397163.8
calpain 3
chr4_+_118888918 26.37 ENST00000434046.6
synaptopodin 2
chr2_-_210315160 25.49 ENST00000352451.4
myosin light chain 1
chr6_-_123636997 25.14 ENST00000546248.5
triadin
chr6_-_123636979 24.88 ENST00000662930.1
triadin
chr1_+_160190567 24.83 ENST00000368078.8
calsequestrin 1
chr12_-_48999363 24.37 ENST00000421952.3
dendrin
chr17_+_4951758 22.66 ENST00000518175.1
enolase 3
chr2_+_102761963 22.48 ENST00000640575.2
ENST00000412401.3
transmembrane protein 182
chr17_-_9791586 22.40 ENST00000571134.2
dehydrogenase/reductase 7C
chr1_-_146021724 21.67 ENST00000475797.1
ENST00000497365.5
ENST00000336751.11
ENST00000634927.1
ENST00000421822.2
hemojuvelin BMP co-receptor
chr15_+_42359577 21.30 ENST00000357568.8
calpain 3
chr16_+_31214088 21.05 ENST00000613872.1
tripartite motif containing 72
chr17_-_10518536 20.75 ENST00000226207.6
myosin heavy chain 1
chr16_+_31214111 20.44 ENST00000322122.8
tripartite motif containing 72
chr7_-_44065541 20.38 ENST00000297283.4
phosphoglycerate mutase 2
chr1_-_982086 20.37 ENST00000341290.6
PPARGC1 and ESRR induced regulator, muscle 1
chr1_-_114695533 20.32 ENST00000520113.7
adenosine monophosphate deaminase 1
chr4_+_118888829 20.29 ENST00000448416.6
ENST00000307142.9
ENST00000429713.7
synaptopodin 2
chr22_-_50578417 20.17 ENST00000312108.12
ENST00000395650.6
carnitine palmitoyltransferase 1B
chr1_-_114695613 19.66 ENST00000369538.4
adenosine monophosphate deaminase 1
chr11_+_1839602 19.15 ENST00000617947.4
ENST00000252898.11
troponin I2, fast skeletal type
chr3_-_155293665 19.12 ENST00000489090.2
small transmembrane regulator of ion transport 1
chr2_+_219434825 18.92 ENST00000312358.12
striated muscle enriched protein kinase
chr9_-_94593810 18.81 ENST00000375337.4
fructose-bisphosphatase 2
chr6_+_54083423 18.31 ENST00000460844.6
ENST00000370876.6
muscular LMNA interacting protein
chr11_-_47352693 18.27 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
myosin binding protein C3
chrX_-_64230600 18.27 ENST00000362002.3
ankyrin repeat and SOCS box containing 12
chr1_-_115768702 18.13 ENST00000261448.6
calsequestrin 2
chr6_+_41053194 17.34 ENST00000244669.3
apolipoprotein B mRNA editing enzyme catalytic subunit 2
chr14_+_24132050 17.24 ENST00000559294.1
fat storage inducing transmembrane protein 1
chr7_-_151187212 17.18 ENST00000420175.3
ENST00000275838.5
ankyrin repeat and SOCS box containing 10
chr1_-_201421718 16.99 ENST00000367312.5
ENST00000555340.6
ENST00000361379.9
ENST00000622580.4
troponin I1, slow skeletal type
chr19_+_3933059 16.96 ENST00000616156.4
ENST00000168977.6
ENST00000599576.5
nicotinamide riboside kinase 2
chr15_+_84817346 16.81 ENST00000258888.6
alpha kinase 3
chr3_+_42685535 16.45 ENST00000287777.5
kelch like family member 40
chr3_+_35642159 16.37 ENST00000187397.8
cAMP regulated phosphoprotein 21
chr15_-_82806054 16.34 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
fibronectin type III and SPRY domain containing 2
chr1_-_31373067 16.24 ENST00000373713.7
fatty acid binding protein 3
chr2_+_238138661 16.18 ENST00000409223.2
kelch like family member 30
chr1_+_160115715 16.07 ENST00000361216.8
ATPase Na+/K+ transporting subunit alpha 2
chr11_+_1839452 15.51 ENST00000381906.5
troponin I2, fast skeletal type
chrX_-_15314543 15.50 ENST00000344384.8
ankyrin repeat and SOCS box containing 11
chr19_-_49072699 15.41 ENST00000221444.2
potassium voltage-gated channel subfamily A member 7
chr16_-_4242068 15.40 ENST00000399609.7
sarcalumenin
chr1_+_228208054 15.32 ENST00000284548.16
ENST00000422127.5
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr11_-_64759967 15.22 ENST00000377432.7
ENST00000164139.4
glycogen phosphorylase, muscle associated
chr1_+_160115777 15.14 ENST00000392233.7
ATPase Na+/K+ transporting subunit alpha 2
chr11_+_1919694 15.11 ENST00000278317.11
ENST00000453458.5
ENST00000381557.6
ENST00000381579.7
ENST00000381589.7
ENST00000381563.8
ENST00000344578.8
ENST00000381558.6
troponin T3, fast skeletal type
chr4_+_185143258 14.90 ENST00000281456.11
solute carrier family 25 member 4
chr1_+_228208024 14.88 ENST00000570156.7
ENST00000680850.1
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr10_-_75073627 14.78 ENST00000338487.6
dual specificity phosphatase 29
chr2_-_96844012 14.74 ENST00000318357.9
ENST00000331001.2
ankyrin repeat domain 23
chr7_-_151187772 14.51 ENST00000377867.7
ankyrin repeat and SOCS box containing 10
chr12_+_119178920 14.50 ENST00000281938.7
heat shock protein family B (small) member 8
chr19_+_3933581 14.29 ENST00000593949.1
nicotinamide riboside kinase 2
chrX_+_153781033 14.25 ENST00000370104.5
ENST00000370108.7
ENST00000370101.8
ENST00000430541.5
ENST00000370100.5
SRSF protein kinase 3
chr16_+_7332744 13.99 ENST00000436368.6
ENST00000311745.9
ENST00000340209.8
ENST00000620507.4
RNA binding fox-1 homolog 1
chr12_+_119178953 13.89 ENST00000674542.1
heat shock protein family B (small) member 8
chr3_+_127915226 13.86 ENST00000405109.5
kelch repeat and BTB domain containing 12
chr5_-_16508990 13.77 ENST00000399793.6
reticulophagy regulator 1
chr5_-_16508812 13.63 ENST00000683414.1
reticulophagy regulator 1
chr12_+_101568350 13.44 ENST00000550514.5
myosin binding protein C1
chr5_-_16508788 13.28 ENST00000682142.1
reticulophagy regulator 1
chr3_+_136022734 13.22 ENST00000334546.6
protein phosphatase 2 regulatory subunit B''alpha
chr17_-_29622893 13.19 ENST00000345068.9
ENST00000584602.1
ENST00000388767.8
ENST00000580212.6
coronin 6
chr3_+_179653032 12.99 ENST00000680587.1
ENST00000681064.1
ENST00000263966.8
ENST00000681358.1
ENST00000679749.1
ubiquitin specific peptidase 13
chr10_-_67665642 12.96 ENST00000682945.1
ENST00000330298.6
ENST00000682758.1
catenin alpha 3
chr9_+_97501622 12.86 ENST00000259365.9
tropomodulin 1
chr2_-_96843992 12.63 ENST00000418232.5
ankyrin repeat domain 23
chr5_-_16508858 12.52 ENST00000684456.1
reticulophagy regulator 1
chr16_+_30064142 12.45 ENST00000562168.5
ENST00000569545.5
aldolase, fructose-bisphosphate A
chr5_-_142698004 12.41 ENST00000407758.5
ENST00000441680.6
ENST00000419524.6
ENST00000621536.4
fibroblast growth factor 1
chr16_+_30064274 12.39 ENST00000563060.6
aldolase, fructose-bisphosphate A
chr8_-_33599935 12.18 ENST00000523956.1
ENST00000256261.9
dual specificity phosphatase 26
chr3_-_46863435 12.08 ENST00000395869.5
ENST00000653454.1
ENST00000292327.6
myosin light chain 3
chr5_-_16508951 12.00 ENST00000682628.1
reticulophagy regulator 1
chr3_+_179653129 11.94 ENST00000680008.1
ubiquitin specific peptidase 13
chr12_-_57251169 11.75 ENST00000554578.5
ENST00000546246.2
ENST00000332782.7
ENST00000553489.1
SH3 and cysteine rich domain 3
chr2_+_219418369 11.71 ENST00000373960.4
desmin
chr3_-_196515315 11.70 ENST00000397537.3
single-pass membrane protein with coiled-coil domains 1
chr5_+_156326735 11.70 ENST00000435422.7
sarcoglycan delta
chr8_+_141417902 11.60 ENST00000681443.1
protein tyrosine phosphatase 4A3
chr9_-_127877665 11.43 ENST00000644144.2
adenylate kinase 1
chr3_+_127915469 11.36 ENST00000407609.7
kelch repeat and BTB domain containing 12
chr12_+_80707625 11.35 ENST00000228641.4
myogenic factor 6
chr4_+_94451857 11.13 ENST00000318007.9
ENST00000380180.7
ENST00000437932.5
ENST00000615540.4
ENST00000359265.8
ENST00000512274.1
ENST00000503974.5
ENST00000504489.3
ENST00000317968.9
ENST00000542407.5
PDZ and LIM domain 5
chr16_+_30064462 10.98 ENST00000412304.6
aldolase, fructose-bisphosphate A
chr16_+_30064731 10.56 ENST00000563987.5
aldolase, fructose-bisphosphate A
chr5_+_173889337 10.37 ENST00000520867.5
ENST00000334035.9
cytoplasmic polyadenylation element binding protein 4
chr17_-_29622732 10.04 ENST00000683819.1
ENST00000492276.7
coronin 6
chr3_-_192727500 9.99 ENST00000430714.5
ENST00000418610.1
ENST00000445105.7
ENST00000684728.1
ENST00000448795.5
ENST00000683935.1
ENST00000684282.1
ENST00000683451.1
fibroblast growth factor 12
chr1_+_150282526 9.85 ENST00000447007.5
ENST00000369095.5
ENST00000369094.5
ENST00000290363.6
circadian associated repressor of transcription
chr6_-_75493629 9.54 ENST00000393004.6
filamin A interacting protein 1
chr13_+_75804169 9.54 ENST00000526371.1
ENST00000526528.1
LIM domain 7
chr1_-_39672080 9.50 ENST00000235628.2
5'-nucleotidase, cytosolic IA
chr17_+_67044530 9.28 ENST00000226021.5
calcium voltage-gated channel auxiliary subunit gamma 1
chr13_+_75636311 9.16 ENST00000377499.9
ENST00000377534.8
LIM domain 7
chr3_-_57292676 8.92 ENST00000389601.3
ENST00000487349.6
ankyrin repeat and SOCS box containing 14
chr20_+_58907981 8.92 ENST00000656419.1
GNAS complex locus
chr9_-_83267230 8.71 ENST00000328788.5
FERM domain containing 3
chr19_+_35138778 8.62 ENST00000351325.9
ENST00000586871.5
ENST00000592174.1
FXYD domain containing ion transport regulator 1
novel transcript
chr15_+_65076744 8.54 ENST00000432196.5
kelch repeat and BTB domain containing 13
chr17_+_44170695 8.51 ENST00000293414.6
ankyrin repeat and SOCS box containing 16
chr8_+_66127043 8.48 ENST00000276573.11
ENST00000350034.4
ENST00000315962.9
tripartite motif containing 55
chr17_-_44111253 8.44 ENST00000591714.5
histone deacetylase 5
chr19_+_35138993 8.41 ENST00000612146.4
ENST00000589209.5
FXYD domain containing ion transport regulator 1
chr14_-_21025490 8.31 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG family member 2
chr11_+_112961247 8.26 ENST00000621518.4
ENST00000618266.4
ENST00000615112.4
ENST00000615285.4
ENST00000619839.4
ENST00000401611.6
ENST00000621128.4
neural cell adhesion molecule 1
chr2_-_218831791 8.19 ENST00000439262.6
ENST00000430489.1
protein kinase AMP-activated non-catalytic subunit gamma 3
chrX_+_153781001 8.17 ENST00000393786.7
SRSF protein kinase 3
chr14_-_21025000 8.16 ENST00000554489.5
ENST00000555657.5
ENST00000557274.5
ENST00000555158.5
ENST00000554833.5
ENST00000555384.5
ENST00000556420.5
ENST00000554893.5
ENST00000553503.5
ENST00000555733.5
ENST00000397856.7
ENST00000553867.5
ENST00000556147.6
ENST00000556008.5
ENST00000557182.5
ENST00000554483.5
ENST00000556688.5
ENST00000397853.7
ENST00000556329.6
ENST00000397851.6
ENST00000554143.5
ENST00000555142.5
ENST00000557676.5
ENST00000556924.5
NDRG family member 2
chr20_+_45407207 8.10 ENST00000372712.6
dysbindin domain containing 2
chr8_-_17676484 7.77 ENST00000634613.1
ENST00000519066.5
microtubule associated scaffold protein 1
chr9_+_121286115 7.74 ENST00000477104.2
ENST00000394353.7
gelsolin
chr1_-_201377652 7.72 ENST00000455702.6
ENST00000367320.6
ENST00000421663.6
ENST00000412633.3
ENST00000367318.10
ENST00000422165.6
ENST00000656932.1
ENST00000438742.6
ENST00000367322.6
ENST00000458432.6
ENST00000509001.5
ENST00000660295.1
troponin T2, cardiac type
chr13_+_75804270 7.69 ENST00000447038.5
LIM domain 7
chr11_+_112961480 7.57 ENST00000621850.4
neural cell adhesion molecule 1
chr4_-_99657820 7.55 ENST00000511828.2
chromosome 4 open reading frame 54
chr16_+_7332839 7.51 ENST00000355637.9
RNA binding fox-1 homolog 1
chr10_-_67696115 7.46 ENST00000433211.7
catenin alpha 3
chr6_-_46015812 7.34 ENST00000544153.3
ENST00000339561.12
chloride intracellular channel 5
chr7_+_95485934 7.22 ENST00000325885.6
ankyrin repeat and SOCS box containing 4
chr4_-_23890070 7.17 ENST00000617484.4
ENST00000612355.1
PPARG coactivator 1 alpha
chr1_-_203175783 7.13 ENST00000621380.1
ENST00000255416.9
myosin binding protein H
chr1_-_23424692 7.12 ENST00000374601.7
ENST00000450454.7
transcription elongation factor A3
chrX_-_72714181 7.02 ENST00000339490.7
ENST00000541944.5
ENST00000373539.3
phosphorylase kinase regulatory subunit alpha 1
chr1_-_205813177 6.98 ENST00000367137.4
solute carrier family 41 member 1
chr11_+_3645105 6.96 ENST00000250693.2
ADP-ribosyltransferase 1
chr4_+_41360759 6.93 ENST00000508501.5
ENST00000512946.5
ENST00000313860.11
ENST00000512632.5
ENST00000512820.5
LIM and calponin homology domains 1
chr12_-_21941402 6.84 ENST00000326684.8
ENST00000682068.1
ENST00000621589.2
ENST00000261200.9
ENST00000683676.1
ATP binding cassette subfamily C member 9
chr3_+_138348592 6.78 ENST00000621127.4
ENST00000494949.5
muscle RAS oncogene homolog
chr10_-_14838003 6.71 ENST00000465530.2
cerebral dopamine neurotrophic factor
chr2_+_178284907 6.63 ENST00000409631.5
oxysterol binding protein like 6
chr1_-_216723437 6.59 ENST00000459955.5
ENST00000366937.5
ENST00000391890.7
estrogen related receptor gamma
chr1_-_23424618 6.54 ENST00000476978.2
transcription elongation factor A3
chr11_+_112961402 6.51 ENST00000613217.4
ENST00000316851.12
ENST00000620046.4
ENST00000531044.5
ENST00000529356.5
neural cell adhesion molecule 1
chr6_-_46015607 6.49 ENST00000644878.1
ENST00000644324.1
ENST00000672327.1
chloride intracellular channel 5
chr1_+_170664121 6.48 ENST00000239461.11
paired related homeobox 1
chr4_-_23890035 6.44 ENST00000507380.1
ENST00000264867.7
PPARG coactivator 1 alpha
chrX_-_72714278 6.43 ENST00000373542.9
ENST00000373545.7
phosphorylase kinase regulatory subunit alpha 1
chr19_+_35139440 6.22 ENST00000455515.6
FXYD domain containing ion transport regulator 1
chrM_+_7586 6.21 ENST00000361739.1
mitochondrially encoded cytochrome c oxidase II
chr2_-_178672418 6.17 ENST00000448510.2
titin
chr15_+_78266181 6.09 ENST00000446172.2
DnaJ heat shock protein family (Hsp40) member A4
chr2_-_105438503 5.95 ENST00000393352.7
ENST00000607522.1
four and a half LIM domains 2
chr13_+_75804221 5.88 ENST00000489941.6
ENST00000525373.5
LIM domain 7
chr17_-_42979993 5.88 ENST00000409103.5
ENST00000360221.8
ENST00000454303.1
ENST00000591916.7
ENST00000451885.3
PTGES3L-AARSD1 readthrough
prostaglandin E synthase 3 like
chr3_+_159852933 5.82 ENST00000482804.1
schwannomin interacting protein 1
chr12_-_21941300 5.75 ENST00000684084.1
ATP binding cassette subfamily C member 9
chr13_+_75760659 5.71 ENST00000526202.5
ENST00000465261.6
LIM domain 7
chrX_+_71301742 5.68 ENST00000373829.8
ENST00000538820.1
integrin subunit beta 1 binding protein 2
chr7_+_143316105 5.63 ENST00000343257.7
ENST00000650516.1
chloride voltage-gated channel 1
chr8_-_61689768 5.58 ENST00000517847.6
ENST00000389204.8
ENST00000517661.5
ENST00000517903.5
ENST00000522603.5
ENST00000541428.5
ENST00000522349.5
ENST00000522835.5
ENST00000518306.5
aspartate beta-hydroxylase
chr15_-_70702273 5.57 ENST00000558758.5
ENST00000379983.6
ENST00000560441.5
uveal autoantigen with coiled-coil domains and ankyrin repeats

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
35.1 175.4 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
20.8 207.6 GO:0035995 detection of muscle stretch(GO:0035995)
16.3 130.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
11.5 46.0 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
10.4 31.2 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
8.1 65.2 GO:0061709 reticulophagy(GO:0061709)
7.9 70.7 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
7.4 44.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
7.2 94.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
7.1 85.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
6.4 32.1 GO:1903028 positive regulation of opsonization(GO:1903028)
6.2 24.9 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
5.0 24.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
4.8 48.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
4.7 18.8 GO:0005986 sucrose biosynthetic process(GO:0005986)
3.6 40.0 GO:0032264 IMP salvage(GO:0032264)
3.5 41.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
3.4 20.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
3.3 23.2 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
3.3 234.8 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
3.1 46.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
3.0 12.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
3.0 18.1 GO:0071313 cellular response to caffeine(GO:0071313)
2.7 16.5 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
2.7 16.2 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
2.6 33.2 GO:0036309 protein localization to M-band(GO:0036309)
2.5 67.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
2.5 10.0 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
2.5 14.9 GO:0015853 adenine transport(GO:0015853)
2.2 30.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
2.1 101.2 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
2.0 20.4 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.9 17.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.7 27.4 GO:0060297 regulation of sarcomere organization(GO:0060297)
1.7 5.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
1.7 5.0 GO:0006059 hexitol metabolic process(GO:0006059)
1.6 17.3 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
1.5 7.7 GO:0044855 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
1.4 4.2 GO:0070256 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.2 8.5 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
1.2 7.3 GO:0003139 secondary heart field specification(GO:0003139)
1.2 5.9 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
1.1 21.7 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.1 12.4 GO:0071286 cellular response to magnesium ion(GO:0071286)
1.1 3.2 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
1.1 2.1 GO:0042704 uterine wall breakdown(GO:0042704)
1.1 117.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
1.0 36.7 GO:0045214 sarcomere organization(GO:0045214)
1.0 19.9 GO:0043117 positive regulation of vascular permeability(GO:0043117)
1.0 32.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.0 93.3 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
1.0 18.4 GO:0006853 carnitine shuttle(GO:0006853)
1.0 12.4 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.9 5.6 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.8 20.4 GO:0014850 response to muscle activity(GO:0014850)
0.8 3.3 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.8 3.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.8 13.8 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.7 5.1 GO:0051012 microtubule sliding(GO:0051012)
0.7 9.5 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128)
0.7 3.5 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.7 6.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.7 7.2 GO:0015793 glycerol transport(GO:0015793)
0.6 87.1 GO:0005977 glycogen metabolic process(GO:0005977)
0.6 26.1 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.6 5.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.6 12.5 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.6 31.1 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.6 3.6 GO:0015862 uridine transport(GO:0015862)
0.6 24.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 1.7 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.6 5.6 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 2.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.6 8.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.5 3.3 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.5 11.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.5 22.9 GO:0061620 NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.5 1.0 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.5 2.6 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.5 3.5 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.5 4.9 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.5 3.8 GO:0006021 inositol biosynthetic process(GO:0006021)
0.5 10.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.5 88.7 GO:0006941 striated muscle contraction(GO:0006941)
0.5 2.3 GO:0033058 directional locomotion(GO:0033058)
0.5 1.9 GO:1903984 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.5 5.4 GO:0006013 mannose metabolic process(GO:0006013)
0.4 17.5 GO:0030239 myofibril assembly(GO:0030239)
0.4 8.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.4 17.4 GO:0010107 potassium ion import(GO:0010107)
0.4 1.7 GO:0002188 formation of cytoplasmic translation initiation complex(GO:0001732) translation reinitiation(GO:0002188)
0.4 2.1 GO:1903525 regulation of membrane tubulation(GO:1903525) positive regulation of membrane tubulation(GO:1903527)
0.4 6.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 3.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.3 4.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.3 1.6 GO:0006574 valine catabolic process(GO:0006574)
0.2 4.4 GO:0019532 oxalate transport(GO:0019532)
0.2 21.9 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.2 1.2 GO:0032571 response to vitamin K(GO:0032571)
0.2 20.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 5.9 GO:0003334 keratinocyte development(GO:0003334)
0.2 3.5 GO:0000733 DNA strand renaturation(GO:0000733)
0.2 160.7 GO:0043687 post-translational protein modification(GO:0043687)
0.2 3.6 GO:0045475 locomotor rhythm(GO:0045475)
0.2 4.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 5.6 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.2 23.4 GO:0032091 negative regulation of protein binding(GO:0032091)
0.2 25.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.2 11.4 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.2 7.0 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.2 2.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 3.5 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.1 2.9 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 2.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 15.6 GO:0061337 cardiac conduction(GO:0061337)
0.1 3.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 22.3 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 10.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.8 GO:0007512 adult heart development(GO:0007512)
0.1 5.8 GO:0070570 regulation of neuron projection regeneration(GO:0070570)
0.1 1.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 1.8 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 9.3 GO:0060047 heart contraction(GO:0060047)
0.1 0.4 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 15.8 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 1.3 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 2.2 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 1.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 23.7 GO:0006986 response to unfolded protein(GO:0006986)
0.1 2.2 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.8 GO:0030222 eosinophil differentiation(GO:0030222)
0.1 2.0 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 1.0 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.9 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 2.0 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.3 GO:0015886 heme transport(GO:0015886)
0.1 1.4 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.1 16.2 GO:0006936 muscle contraction(GO:0006936)
0.1 5.6 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.1 4.6 GO:0034605 cellular response to heat(GO:0034605)
0.1 3.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.4 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 64.4 GO:0016567 protein ubiquitination(GO:0016567)
0.1 2.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 2.3 GO:0019228 neuronal action potential(GO:0019228)
0.1 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 7.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 0.5 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 1.6 GO:0048265 response to pain(GO:0048265)
0.0 1.9 GO:0015682 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 9.1 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 1.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.5 GO:0034214 protein hexamerization(GO:0034214)
0.0 4.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.5 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.0 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 2.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.0 GO:0007143 female meiotic division(GO:0007143)
0.0 0.3 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 2.5 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.8 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.6 GO:0051491 positive regulation of filopodium assembly(GO:0051491)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
23.8 142.7 GO:0005927 muscle tendon junction(GO:0005927)
19.2 76.9 GO:0005863 striated muscle myosin thick filament(GO:0005863)
16.7 233.8 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
9.2 110.3 GO:0097512 cardiac myofibril(GO:0097512)
7.7 46.0 GO:1990584 cardiac Troponin complex(GO:1990584)
6.9 186.3 GO:0032982 myosin filament(GO:0032982)
6.5 97.9 GO:0005861 troponin complex(GO:0005861)
4.5 13.6 GO:1990844 subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844)
3.8 67.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
3.6 172.8 GO:0031430 M band(GO:0031430)
3.2 22.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
3.1 85.9 GO:0005859 muscle myosin complex(GO:0005859)
2.3 27.3 GO:0032593 insulin-responsive compartment(GO:0032593)
2.2 638.3 GO:0031674 I band(GO:0031674)
2.1 54.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
1.7 19.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
1.7 20.4 GO:0005916 fascia adherens(GO:0005916)
1.3 11.7 GO:0016012 sarcoglycan complex(GO:0016012)
1.2 13.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
1.1 21.2 GO:0016461 unconventional myosin complex(GO:0016461)
1.0 5.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.9 24.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.8 94.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.8 8.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.8 68.9 GO:0005801 cis-Golgi network(GO:0005801)
0.8 12.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.7 47.5 GO:0031941 filamentous actin(GO:0031941)
0.6 39.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.6 9.4 GO:0030478 actin cap(GO:0030478)
0.6 1.9 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.5 25.7 GO:0016459 myosin complex(GO:0016459)
0.5 21.3 GO:0016528 sarcoplasm(GO:0016528)
0.4 2.5 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.4 1.7 GO:0043614 multi-eIF complex(GO:0043614)
0.3 3.5 GO:0016589 NURF complex(GO:0016589)
0.3 43.1 GO:0042383 sarcolemma(GO:0042383)
0.3 15.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 13.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 10.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 3.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 5.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 93.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.2 2.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 4.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 10.3 GO:0030673 axolemma(GO:0030673)
0.1 28.2 GO:0016605 PML body(GO:0016605)
0.1 15.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 4.5 GO:0030686 90S preribosome(GO:0030686)
0.1 0.3 GO:0032437 cuticular plate(GO:0032437)
0.1 24.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.9 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 3.3 GO:0001891 phagocytic cup(GO:0001891)
0.1 7.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 13.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 18.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 11.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.6 GO:0071564 npBAF complex(GO:0071564)
0.1 1.6 GO:0005922 connexon complex(GO:0005922)
0.1 17.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.5 GO:0005921 gap junction(GO:0005921)
0.0 6.3 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.8 GO:0097225 sperm midpiece(GO:0097225)
0.0 22.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 5.1 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 16.8 GO:0005769 early endosome(GO:0005769)
0.0 7.1 GO:0043209 myelin sheath(GO:0043209)
0.0 2.6 GO:0035580 specific granule lumen(GO:0035580)
0.0 5.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0030175 filopodium(GO:0030175)
0.0 0.0 GO:0005592 collagen type XI trimer(GO:0005592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 113.1 GO:0051373 FATZ binding(GO:0051373)
10.9 131.1 GO:0031433 telethonin binding(GO:0031433)
10.6 362.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
7.8 31.2 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
7.4 104.2 GO:0031014 troponin T binding(GO:0031014)
6.4 146.1 GO:0032036 myosin heavy chain binding(GO:0032036)
5.9 140.6 GO:0031432 titin binding(GO:0031432)
5.7 22.8 GO:0030172 troponin C binding(GO:0030172)
5.4 16.2 GO:0070538 oleic acid binding(GO:0070538)
4.7 18.8 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
4.1 20.4 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
3.8 15.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
3.7 29.8 GO:0017018 myosin phosphatase activity(GO:0017018)
3.7 14.9 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
3.6 46.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
3.2 19.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
3.1 24.9 GO:1904288 BAT3 complex binding(GO:1904288)
3.0 69.3 GO:0005344 oxygen transporter activity(GO:0005344)
2.5 20.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
2.2 19.9 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
2.0 20.4 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
2.0 95.6 GO:0051393 alpha-actinin binding(GO:0051393)
2.0 12.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.9 67.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.9 22.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.7 17.3 GO:0004126 cytidine deaminase activity(GO:0004126)
1.7 31.2 GO:1990239 steroid hormone binding(GO:1990239)
1.2 13.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
1.2 8.5 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.1 11.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
1.1 24.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
1.1 11.0 GO:0050682 AF-2 domain binding(GO:0050682)
1.1 5.4 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
1.0 7.1 GO:0015254 glycerol channel activity(GO:0015254)
1.0 91.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.9 91.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.8 4.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.8 3.3 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.8 7.0 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.8 21.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.7 41.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.7 5.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 7.7 GO:0045159 myosin II binding(GO:0045159)
0.7 11.1 GO:0042805 actinin binding(GO:0042805)
0.7 12.9 GO:0005523 tropomyosin binding(GO:0005523)
0.6 3.8 GO:0031403 lithium ion binding(GO:0031403)
0.6 2.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.6 5.0 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.5 11.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.5 8.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.5 32.1 GO:0043531 ADP binding(GO:0043531)
0.5 2.0 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.5 152.7 GO:0044325 ion channel binding(GO:0044325)
0.5 9.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.5 8.9 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.4 9.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 2.6 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.4 6.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 12.4 GO:0044548 S100 protein binding(GO:0044548)
0.4 1.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.4 278.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 2.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.4 3.5 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 1.0 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 1.6 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.3 7.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.3 2.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.3 15.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 2.5 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.3 4.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 3.3 GO:0015250 water channel activity(GO:0015250)
0.2 3.5 GO:0036310 annealing helicase activity(GO:0036310)
0.2 4.7 GO:0070411 I-SMAD binding(GO:0070411)
0.2 3.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.4 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 185.5 GO:0003779 actin binding(GO:0003779)
0.2 15.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 21.1 GO:0070888 E-box binding(GO:0070888)
0.2 5.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 26.1 GO:0001618 virus receptor activity(GO:0001618)
0.2 2.0 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.5 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 13.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 4.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 13.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 15.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 3.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 3.2 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.3 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.7 GO:0005499 vitamin D binding(GO:0005499)
0.1 8.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.3 GO:0004807 triose-phosphate isomerase activity(GO:0004807)
0.1 4.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 5.9 GO:0050681 androgen receptor binding(GO:0050681)
0.1 1.3 GO:0015232 heme transporter activity(GO:0015232)
0.1 27.9 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 0.3 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.4 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.3 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 2.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 0.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 13.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 3.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.5 GO:0022832 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 94.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.6 35.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.5 25.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 19.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 34.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 28.6 PID FGF PATHWAY FGF signaling pathway
0.2 7.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 13.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 26.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 10.3 PID CMYB PATHWAY C-MYB transcription factor network
0.2 1.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 11.0 PID AURORA B PATHWAY Aurora B signaling
0.1 2.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 4.7 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 12.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 4.4 PID IFNG PATHWAY IFN-gamma pathway
0.1 1.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 2.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 2.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.6 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.9 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 493.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.5 40.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
1.2 94.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.9 28.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.9 36.9 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.9 24.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.7 35.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.6 12.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.5 9.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.5 31.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.4 7.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 17.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.3 11.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 22.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.2 14.4 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 30.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 80.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 7.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 15.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 4.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.9 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 4.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 4.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 5.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 5.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 3.3 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 7.5 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.1 1.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.7 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 2.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 5.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.9 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.7 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 1.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.4 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.5 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.8 REACTOME DEFENSINS Genes involved in Defensins