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Illumina Body Map 2 (GSE30611)
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Results for NFATC4
Z-value: 1.63
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Transcription factors associated with NFATC4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC4 | hg38_v1_chr14_+_24368020_24368341 | 0.72 | 4.1e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_100846405 Show fit | 6.74 |
ENST00000495591.5
ENST00000466947.5 |
ABI family member 3 binding protein |
|
| chr1_+_162632454 Show fit | 6.57 |
ENST00000367921.8
ENST00000367922.7 |
discoidin domain receptor tyrosine kinase 2 |
|
| chr14_-_91946989 Show fit | 6.29 |
ENST00000556154.5
|
fibulin 5 |
|
| chr19_-_4517600 Show fit | 6.25 |
ENST00000301286.4
|
perilipin 4 |
|
| chr12_+_12785652 Show fit | 6.20 |
ENST00000356591.5
|
apolipoprotein L domain containing 1 |
|
| chr1_+_99646025 Show fit | 5.96 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr7_-_120858066 Show fit | 5.45 |
ENST00000222747.8
|
tetraspanin 12 |
|
| chr12_+_13196718 Show fit | 5.22 |
ENST00000431267.2
ENST00000542474.5 ENST00000544053.5 ENST00000256951.10 |
epithelial membrane protein 1 |
|
| chr17_+_43847168 Show fit | 4.82 |
ENST00000317310.5
|
CD300 molecule like family member g |
|
| chr3_+_186842687 Show fit | 4.58 |
ENST00000444204.2
ENST00000320741.7 |
adiponectin, C1Q and collagen domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 10.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.4 | 10.3 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.8 | 10.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 9.3 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.3 | 9.1 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 1.1 | 8.9 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.0 | 8.0 | GO:0031638 | zymogen activation(GO:0031638) |
| 0.2 | 7.8 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 1.5 | 7.7 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 16.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.3 | 11.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 11.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 11.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 10.8 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.1 | 8.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.6 | 8.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 7.6 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.7 | 7.0 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.2 | 7.0 | GO:0043218 | compact myelin(GO:0043218) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 12.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 11.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 8.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.3 | 8.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 8.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 8.0 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 1.2 | 7.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 1.1 | 6.8 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.4 | 6.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 19.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.5 | 9.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 5.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 5.3 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 5.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.7 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 3.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 9.5 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.3 | 6.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 6.4 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 4.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 4.4 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 4.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 3.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 3.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |