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Illumina Body Map 2 (GSE30611)
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Results for NFE2L1
Z-value: 0.94
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Transcription factors associated with NFE2L1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L1 | hg38_v1_chr17_+_48055945_48055986 | -0.57 | 6.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_59019397 Show fit | 3.73 |
ENST00000217133.2
|
tubulin beta 1 class VI |
|
| chr1_+_192158448 Show fit | 3.07 |
ENST00000367460.4
|
regulator of G protein signaling 18 |
|
| chr2_-_157488829 Show fit | 2.71 |
ENST00000435117.1
ENST00000439355.5 |
cytohesin 1 interacting protein |
|
| chr7_+_142352802 Show fit | 2.66 |
ENST00000634605.1
|
T cell receptor beta variable 7-2 |
|
| chr7_+_142469521 Show fit | 2.61 |
ENST00000390371.3
|
T cell receptor beta variable 6-6 |
|
| chr4_+_73740541 Show fit | 2.39 |
ENST00000401931.1
ENST00000307407.8 |
C-X-C motif chemokine ligand 8 |
|
| chr1_-_183569186 Show fit | 2.34 |
ENST00000420553.5
ENST00000419402.1 |
neutrophil cytosolic factor 2 |
|
| chr12_-_122716790 Show fit | 2.23 |
ENST00000528880.3
|
hydroxycarboxylic acid receptor 3 |
|
| chr3_-_27722699 Show fit | 2.06 |
ENST00000461503.2
|
eomesodermin |
|
| chr12_-_14951106 Show fit | 2.02 |
ENST00000541644.5
ENST00000545895.5 |
Rho GDP dissociation inhibitor beta |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFE2L1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.8 | GO:2000332 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.5 | 7.5 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 4.3 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.7 | 4.0 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.0 | 3.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 3.4 | GO:0070268 | cornification(GO:0070268) |
| 0.6 | 3.0 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.1 | 3.0 | GO:0050869 | negative regulation of B cell activation(GO:0050869) |
| 0.2 | 2.8 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.2 | 2.4 | GO:2000535 | regulation of entry of bacterium into host cell(GO:2000535) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.6 | 7.5 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 7.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 5.2 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 4.3 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 3.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 3.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 2.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 2.3 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 2.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.6 | 7.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 5.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 4.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.4 | 4.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 3.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 3.0 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 3.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 2.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.7 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 4.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 3.4 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 3.3 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 3.2 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 3.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 2.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.3 | 8.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 5.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 4.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 4.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 3.9 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.2 | 3.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 3.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 2.9 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |