ISMARA results: NKX2-2

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Illumina Body Map 2 (GSE30611)

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Results for NKX2-2

Z-value: 1.12

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Transcription factors associated with NKX2-2

Gene Symbol	Gene ID	Gene Info
NKX2-2 Ensembl NCBI GeneCards UniProt	ENSG00000125820.6	NK2 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-2	hg38_v1_chr20_-_21514046_21514070	0.27	1.4e-01	Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_16600703 Show fit	2.59	ENST00000616247.4	LMO3 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 3
chr2_+_102337148 Show fit	2.16	ENST00000311734.6 ENST00000409584.5	IL1RL1 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor like 1
chr3_+_159273235 Show fit	1.90	ENST00000638749.1	IQCJ-SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	IQCJ-SCHIP1 readthrough
chr3_-_33645433 Show fit	1.65	ENST00000635664.1 ENST00000485378.6 ENST00000313350.10 ENST00000487200.5	CLASP2 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic linker associated protein 2
chrX_+_136205982 Show fit	1.48	ENST00000628568.1	FHL1 Ensembl NCBI GeneCards UniProt Show fit	four and a half LIM domains 1
chr16_+_23182737 Show fit	1.47	ENST00000300061.3	SCNN1G Ensembl NCBI GeneCards UniProt Show fit	sodium channel epithelial 1 subunit gamma
chr2_+_79120474 Show fit	1.46	ENST00000233735.2	REG1A Ensembl NCBI GeneCards UniProt Show fit	regenerating family member 1 alpha
chr7_+_97732046 Show fit	1.31	ENST00000350485.8 ENST00000346867.4 ENST00000319273.10	TAC1 Ensembl NCBI GeneCards UniProt Show fit	tachykinin precursor 1
chrX_+_106201724 Show fit	1.28	ENST00000372552.1	PWWP3B Ensembl NCBI GeneCards UniProt Show fit	PWWP domain containing 3B
chrX_+_153687918 Show fit	1.26	ENST00000253122.10	SLC6A8 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3	2.6	GO:0097338	response to clozapine(GO:0097338)
0.2	2.6	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1	2.5	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.3	2.2	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.1	2.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.1	2.0	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	2.0	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.2	1.8	GO:0036371	protein localization to T-tubule(GO:0036371)
0.4	1.7	GO:0072134	nephrogenic mesenchyme morphogenesis(GO:0072134)

Showing 1 to 10 of 152 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	2.7	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	2.6	GO:0055037	recycling endosome(GO:0055037)
0.1	2.4	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	2.4	GO:0030315	T-tubule(GO:0030315)
0.0	2.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	2.0	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	2.0	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	1.9	GO:0005796	Golgi lumen(GO:0005796)
0.1	1.8	GO:0016580	Sin3 complex(GO:0016580)

Showing 1 to 10 of 65 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0047485	protein N-terminus binding(GO:0047485)
0.1	3.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	2.8	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	2.6	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	2.4	GO:0044325	ion channel binding(GO:0044325)
0.1	2.3	GO:0002162	dystroglycan binding(GO:0002162)
0.7	2.2	GO:0002113	interleukin-33 binding(GO:0002113)
0.3	2.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	1.8	GO:0030507	spectrin binding(GO:0030507)
0.0	1.8	GO:0008565	protein transporter activity(GO:0008565)

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	3.1	ST GAQ PATHWAY	G alpha q Pathway
0.1	2.1	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	1.7	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.1	1.5	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.5	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	1.4	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.3	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.6	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	3.8	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	2.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	2.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	1.8	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	1.7	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	1.6	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	1.3	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	1.2	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 42 entries

Results for NKX2-2

Z-value: 1.12

Motif logo

Transcription factors associated with NKX2-2

Activity-expression correlation:

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: