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Illumina Body Map 2 (GSE30611)

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Results for NKX2-4

Z-value: 1.48

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
NKX2-4
ENSG00000125816.5 NK2 homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-4hg38_v1_chr20_-_21397513_213975310.531.9e-03Click!

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_19201976 8.90 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
CSRP3
cysteine and glycine rich protein 3
chr10_+_97572771 6.22 ENST00000370655.6
ENST00000455090.1
ANKRD2
ankyrin repeat domain 2
chr11_-_19202004 5.43 ENST00000648719.1
CSRP3
cysteine and glycine rich protein 3
chr2_-_178804623 4.49 ENST00000359218.10
ENST00000342175.11
TTN
titin
chr1_+_152878312 4.39 ENST00000368765.4
SMCP
sperm mitochondria associated cysteine rich protein
chr8_-_7463452 3.75 ENST00000528943.5
ENST00000359758.9
ENST00000361111.6
ENST00000398462.7
ENST00000297498.6
ENST00000317900.7
SPAG11B
sperm associated antigen 11B
chr1_-_75932392 3.69 ENST00000284142.7
ASB17
ankyrin repeat and SOCS box containing 17
chr20_+_45722329 3.45 ENST00000279058.4
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr8_+_7847870 3.36 ENST00000400125.6
ENST00000434307.6
ENST00000642566.1
SPAG11A
sperm associated antigen 11A
chr9_+_100578071 3.06 ENST00000307584.6
CAVIN4
caveolae associated protein 4
chr5_+_137867868 2.92 ENST00000515645.1
MYOT
myotilin
chr10_+_68109433 2.88 ENST00000613327.4
ENST00000358913.10
ENST00000373675.3
MYPN
myopalladin
chr1_-_205449924 2.83 ENST00000367154.5
LEMD1
LEM domain containing 1
chr1_-_100178215 2.78 ENST00000370138.1
ENST00000370137.6
ENST00000342895.7
ENST00000620882.4
LRRC39
leucine rich repeat containing 39
chrX_+_49551278 2.59 ENST00000639028.1
ENST00000381698.4
GAGE12F
GAGE12E
G antigen 12F
G antigen 12E
chr1_+_156338455 2.50 ENST00000368253.6
ENST00000470342.5
ENST00000368254.6
TSACC
TSSK6 activating cochaperone
chrX_+_30243715 2.45 ENST00000378981.8
ENST00000397550.6
MAGEB1
MAGE family member B1
chr5_+_150660841 2.44 ENST00000297130.4
MYOZ3
myozenin 3
chr19_-_41844629 2.43 ENST00000609812.6
LYPD4
LY6/PLAUR domain containing 4
chr18_-_27990256 2.42 ENST00000675173.1
CDH2
cadherin 2
chr1_+_202462730 2.37 ENST00000290419.9
ENST00000491336.5
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr7_+_29194861 2.33 ENST00000409350.5
ENST00000495789.6
CHN2
chimerin 2
chr2_-_201619144 2.32 ENST00000439802.5
ENST00000286195.7
ENST00000439140.6
ENST00000450242.1
C2CD6
C2 calcium dependent domain containing 6
chr19_-_41844697 2.20 ENST00000601246.5
LYPD4
LY6/PLAUR domain containing 4
chrX_-_135120526 2.17 ENST00000423661.1
ETDB
embryonic testis differentiation homolog B
chr15_-_82806054 2.15 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr20_+_4721901 2.12 ENST00000305817.3
PRND
prion like protein doppel
chr2_+_36696686 2.12 ENST00000379242.7
ENST00000389975.7
VIT
vitrin
chrX_+_74304173 2.10 ENST00000339534.4
ZCCHC13
zinc finger CCHC-type containing 13
chr1_+_160127672 2.07 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chrX_+_106201724 2.06 ENST00000372552.1
PWWP3B
PWWP domain containing 3B
chr9_+_35042213 2.06 ENST00000378745.3
ENST00000312292.6
C9orf131
chromosome 9 open reading frame 131
chr8_+_7848000 2.05 ENST00000326558.9
ENST00000351436.8
ENST00000528033.3
SPAG11A
sperm associated antigen 11A
chr1_+_156338619 1.98 ENST00000481479.5
ENST00000368252.5
ENST00000466306.5
ENST00000368251.1
TSACC
TSSK6 activating cochaperone
chr18_-_58629084 1.97 ENST00000361673.4
ALPK2
alpha kinase 2
chrX_+_49829260 1.88 ENST00000376141.5
ENST00000218068.7
PAGE4
PAGE family member 4
chr15_+_44956683 1.87 ENST00000340827.4
TERB2
telomere repeat binding bouquet formation protein 2
chr2_+_1413456 1.84 ENST00000539820.5
ENST00000382269.7
ENST00000345913.8
ENST00000329066.9
ENST00000382201.7
TPO
thyroid peroxidase
chr11_+_104036624 1.80 ENST00000302259.5
DDI1
DNA damage inducible 1 homolog 1
chrX_-_52520803 1.77 ENST00000518075.1
XAGE1B
X antigen family member 1B
chr12_+_48122574 1.76 ENST00000549022.5
ENST00000547587.5
ENST00000312352.11
PFKM
phosphofructokinase, muscle
chr12_+_18738102 1.76 ENST00000317658.5
CAPZA3
capping actin protein of muscle Z-line subunit alpha 3
chrX_+_30235894 1.73 ENST00000620842.1
MAGEB3
MAGE family member B3
chr11_+_57338344 1.73 ENST00000263314.3
ENST00000616487.4
P2RX3
purinergic receptor P2X 3
chr17_-_45262084 1.71 ENST00000331780.5
SPATA32
spermatogenesis associated 32
chr5_+_173918216 1.67 ENST00000519467.1
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr18_-_46920139 1.65 ENST00000589917.1
ENST00000587810.1
PIAS2
protein inhibitor of activated STAT 2
chr5_-_79512794 1.64 ENST00000282260.10
ENST00000508576.5
ENST00000535690.1
HOMER1
homer scaffold protein 1
chr16_+_77788554 1.63 ENST00000302536.3
VAT1L
vesicle amine transport 1 like
chr6_-_36024493 1.63 ENST00000394602.6
ENST00000355574.6
SLC26A8
solute carrier family 26 member 8
chr2_+_102736903 1.62 ENST00000639249.1
ENST00000454536.5
ENST00000409528.5
ENST00000409173.5
ENST00000488134.5
TMEM182
transmembrane protein 182
chrX_-_48356688 1.61 ENST00000298396.7
ENST00000376893.7
SSX3
SSX family member 3
chr2_+_36696790 1.59 ENST00000497382.5
ENST00000404084.5
ENST00000379241.7
ENST00000401530.5
VIT
vitrin
chr12_-_13095628 1.56 ENST00000457134.6
ENST00000537302.5
GSG1
germ cell associated 1
chr5_+_173918186 1.54 ENST00000657000.1
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr22_-_29061831 1.54 ENST00000216071.5
C22orf31
chromosome 22 open reading frame 31
chr10_-_67696115 1.52 ENST00000433211.7
CTNNA3
catenin alpha 3
chr11_-_111512339 1.50 ENST00000525791.5
ENST00000456861.2
ENST00000356018.6
BTG4
BTG anti-proliferation factor 4
chr2_-_105396943 1.50 ENST00000409807.5
FHL2
four and a half LIM domains 2
chr2_+_1414382 1.48 ENST00000423320.5
ENST00000346956.7
ENST00000382198.5
TPO
thyroid peroxidase
chr19_+_41845029 1.45 ENST00000269945.8
ENST00000596258.5
DMRTC2
DMRT like family C2
chrX_-_135119746 1.44 ENST00000426364.5
ETDB
embryonic testis differentiation homolog B
chr7_+_116954391 1.44 ENST00000421345.5
ENST00000471110.5
ENSG00000288635.1
ST7-OT4
novel protein, readthrough ST7-OT4 - ST7
ST7 overlapping transcript 4
chr2_+_149118169 1.43 ENST00000450639.5
LYPD6B
LY6/PLAUR domain containing 6B
chrX_-_15854791 1.42 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr5_-_88824334 1.42 ENST00000506716.5
MEF2C
myocyte enhancer factor 2C
chr2_+_206939515 1.42 ENST00000272852.4
CPO
carboxypeptidase O
chr12_-_18738006 1.41 ENST00000266505.12
ENST00000543242.5
ENST00000539072.5
ENST00000541966.5
ENST00000648272.1
PLCZ1
phospholipase C zeta 1
chrX_-_15854743 1.39 ENST00000450644.2
AP1S2
adaptor related protein complex 1 subunit sigma 2
chr5_+_102808057 1.39 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr1_+_44739805 1.35 ENST00000452259.5
KIF2C
kinesin family member 2C
chr12_+_57782742 1.35 ENST00000540550.6
ENST00000323833.12
ENST00000652027.2
ENST00000550559.5
ENST00000548851.5
ENST00000543727.5
ENST00000434359.5
ENST00000457189.1
TSFM
Ts translation elongation factor, mitochondrial
chr6_-_36024635 1.35 ENST00000490799.6
SLC26A8
solute carrier family 26 member 8
chr2_+_178451598 1.34 ENST00000644554.1
ENST00000647226.1
PJVK
pejvakin
chr9_-_86259604 1.34 ENST00000376001.7
ENST00000339137.7
C9orf153
chromosome 9 open reading frame 153
chr19_-_39934626 1.33 ENST00000616721.6
FCGBP
Fc fragment of IgG binding protein
chr21_+_37420299 1.32 ENST00000455097.6
ENST00000643854.1
ENST00000645424.1
ENST00000642309.1
ENST00000645774.1
ENST00000398956.2
DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
chr9_+_131190131 1.30 ENST00000531600.1
NUP214
nucleoporin 214
chr3_+_50617119 1.29 ENST00000430409.5
ENST00000621469.5
ENST00000357955.6
MAPKAPK3
MAPK activated protein kinase 3
chr12_-_122400005 1.26 ENST00000535290.5
CLIP1
CAP-Gly domain containing linker protein 1
chr16_+_57976435 1.24 ENST00000290871.10
ENST00000441824.4
TEPP
testis, prostate and placenta expressed
chr6_-_11779606 1.24 ENST00000506810.1
ADTRP
androgen dependent TFPI regulating protein
chr16_+_30023198 1.22 ENST00000681219.1
ENST00000300575.6
C16orf92
chromosome 16 open reading frame 92
chr19_+_41845018 1.22 ENST00000596827.5
DMRTC2
DMRT like family C2
chr15_+_42402375 1.21 ENST00000397200.8
ENST00000569827.5
CAPN3
calpain 3
chr2_-_224569782 1.20 ENST00000409096.5
CUL3
cullin 3
chr5_-_147906530 1.17 ENST00000318315.5
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chr15_+_36594868 1.17 ENST00000566807.5
ENST00000643612.1
ENST00000567389.5
ENST00000562877.5
CDIN1
CDAN1 interacting nuclease 1
chr7_-_29195186 1.16 ENST00000449801.5
ENST00000409850.5
CPVL
carboxypeptidase vitellogenic like
chr3_-_14556046 1.14 ENST00000637939.1
ENST00000637182.1
GRIP2
glutamate receptor interacting protein 2
chr5_+_167284799 1.14 ENST00000518659.5
TENM2
teneurin transmembrane protein 2
chr12_+_49295138 1.13 ENST00000257860.9
PRPH
peripherin
chr8_-_18854355 1.13 ENST00000519851.5
PSD3
pleckstrin and Sec7 domain containing 3
chr11_-_65089025 1.13 ENST00000524632.1
ENST00000530719.6
TMEM262
transmembrane protein 262
chr1_+_147902789 1.10 ENST00000369235.2
GJA8
gap junction protein alpha 8
chr7_+_157336988 1.08 ENST00000262177.9
ENST00000417758.5
ENST00000443280.5
DNAJB6
DnaJ heat shock protein family (Hsp40) member B6
chr3_-_108058361 1.07 ENST00000398258.7
CD47
CD47 molecule
chr19_+_50203607 1.07 ENST00000642316.2
ENST00000425460.6
ENST00000440075.6
ENST00000376970.6
ENST00000599920.5
MYH14
myosin heavy chain 14
chr18_+_11851404 1.07 ENST00000526991.3
CHMP1B
charged multivesicular body protein 1B
chr12_-_113221087 1.06 ENST00000299732.6
ENST00000416617.3
IQCD
IQ motif containing D
chr5_+_156326735 1.05 ENST00000435422.7
SGCD
sarcoglycan delta
chr2_+_219434825 1.04 ENST00000312358.12
SPEG
striated muscle enriched protein kinase
chr1_-_56819365 1.04 ENST00000343433.7
FYB2
FYN binding protein 2
chr11_+_34977778 1.04 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex component X
chr17_-_73227700 1.02 ENST00000579872.1
ENST00000580032.1
FAM104A
family with sequence similarity 104 member A
chr1_-_224437028 1.01 ENST00000445239.1
WDR26
WD repeat domain 26
chr7_+_6031376 1.00 ENST00000409061.2
ANKRD61
ankyrin repeat domain 61
chr11_+_62208665 1.00 ENST00000244930.6
SCGB2A1
secretoglobin family 2A member 1
chr14_-_33951052 0.98 ENST00000250457.9
ENST00000547327.2
EGLN3
egl-9 family hypoxia inducible factor 3
chr2_+_37950432 0.97 ENST00000407257.5
ENST00000417700.6
ENST00000234195.7
ENST00000442857.5
RMDN2
regulator of microtubule dynamics 2
chr15_-_78234513 0.97 ENST00000558130.1
ENST00000258873.9
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr18_-_31760864 0.97 ENST00000269205.7
ENST00000672005.1
SLC25A52
solute carrier family 25 member 52
chr5_+_175871570 0.97 ENST00000512824.5
ENST00000393745.8
CPLX2
complexin 2
chr7_-_107803215 0.96 ENST00000340010.10
ENST00000453332.1
SLC26A3
solute carrier family 26 member 3
chr14_-_77423517 0.95 ENST00000555603.1
NOXRED1
NADP dependent oxidoreductase domain containing 1
chr15_-_58014097 0.95 ENST00000559517.5
ALDH1A2
aldehyde dehydrogenase 1 family member A2
chr2_+_207550261 0.95 ENST00000414681.1
CREB1
cAMP responsive element binding protein 1
chr19_+_41844946 0.94 ENST00000600017.5
DMRTC2
DMRT like family C2
chr11_-_106022209 0.94 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr8_+_116938180 0.94 ENST00000378279.4
AARD
alanine and arginine rich domain containing protein
chr3_+_189631373 0.92 ENST00000264731.8
ENST00000418709.6
ENST00000320472.9
ENST00000392460.7
ENST00000440651.6
TP63
tumor protein p63
chr5_-_132543513 0.92 ENST00000231454.6
IL5
interleukin 5
chr19_+_40611863 0.92 ENST00000601032.5
LTBP4
latent transforming growth factor beta binding protein 4
chr9_-_28670285 0.91 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
LINGO2
leucine rich repeat and Ig domain containing 2
chr2_+_190180835 0.90 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr17_+_48841563 0.90 ENST00000502761.1
CALCOCO2
calcium binding and coiled-coil domain 2
chr14_+_64214136 0.89 ENST00000557084.1
ENST00000458046.6
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr17_-_65826445 0.88 ENST00000317442.12
CEP112
centrosomal protein 112
chr17_+_8002610 0.88 ENST00000254854.5
GUCY2D
guanylate cyclase 2D, retinal
chr1_+_241652275 0.87 ENST00000366552.6
ENST00000437684.7
WDR64
WD repeat domain 64
chr3_+_9362971 0.86 ENST00000417036.1
ENST00000419437.5
ENST00000345094.7
ENST00000452837.7
ENST00000515662.6
THUMPD3
THUMP domain containing 3
chr2_+_100974849 0.86 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr7_-_8262668 0.86 ENST00000446305.1
ICA1
islet cell autoantigen 1
chr17_-_40417873 0.86 ENST00000423485.6
TOP2A
DNA topoisomerase II alpha
chr22_-_18936142 0.84 ENST00000438924.5
ENST00000457083.1
ENST00000357068.11
ENST00000420436.5
ENST00000334029.6
ENST00000610940.4
PRODH
proline dehydrogenase 1
chr6_+_31706866 0.83 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr17_+_44899695 0.82 ENST00000410006.6
ENST00000357776.6
ENST00000417826.3
ENST00000410027.5
ENST00000412523.3
CCDC103
FAM187A
coiled-coil domain containing 103
family with sequence similarity 187 member A
chr2_+_102761963 0.82 ENST00000640575.2
ENST00000412401.3
TMEM182
transmembrane protein 182
chr14_+_55611977 0.82 ENST00000395309.7
ENST00000413890.6
KTN1
kinectin 1
chr2_+_36696758 0.79 ENST00000457137.6
VIT
vitrin
chr5_+_43602648 0.78 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
NNT
nicotinamide nucleotide transhydrogenase
chr3_+_32695535 0.78 ENST00000454516.7
CNOT10
CCR4-NOT transcription complex subunit 10
chr1_-_197775633 0.78 ENST00000422998.1
DENND1B
DENN domain containing 1B
chr16_+_81037187 0.77 ENST00000564241.5
ENST00000565237.1
ATMIN
ATM interactor
chr14_+_80955043 0.77 ENST00000541158.6
TSHR
thyroid stimulating hormone receptor
chr10_+_58334998 0.76 ENST00000373910.9
UBE2D1
ubiquitin conjugating enzyme E2 D1
chr10_+_58334976 0.76 ENST00000615793.1
UBE2D1
ubiquitin conjugating enzyme E2 D1
chr15_-_32888239 0.76 ENST00000559610.1
FMN1
formin 1
chr12_-_49094792 0.75 ENST00000649637.2
DHH
desert hedgehog signaling molecule
chr9_-_92404690 0.75 ENST00000447356.1
OGN
osteoglycin
chr9_+_125748175 0.74 ENST00000491787.7
ENST00000447726.6
PBX3
PBX homeobox 3
chr7_-_13988863 0.74 ENST00000405358.8
ETV1
ETS variant transcription factor 1
chr6_-_149648693 0.74 ENST00000367411.7
KATNA1
katanin catalytic subunit A1
chr5_-_151303760 0.74 ENST00000335230.8
SLC36A3
solute carrier family 36 member 3
chrX_-_134658450 0.74 ENST00000359237.9
PLAC1
placenta enriched 1
chr3_-_109337572 0.74 ENST00000335658.6
DPPA4
developmental pluripotency associated 4
chr19_+_48993864 0.73 ENST00000595090.6
RUVBL2
RuvB like AAA ATPase 2
chr10_+_100535927 0.71 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr15_-_92655712 0.70 ENST00000327355.6
FAM174B
family with sequence similarity 174 member B
chr1_+_222713352 0.69 ENST00000426638.1
BROX
BRO1 domain and CAAX motif containing
chr9_-_92404559 0.68 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr8_+_42541775 0.67 ENST00000416469.6
SMIM19
small integral membrane protein 19
chr2_-_182427014 0.65 ENST00000409365.5
ENST00000351439.9
PDE1A
phosphodiesterase 1A
chr10_+_22316445 0.65 ENST00000448361.5
COMMD3
COMM domain containing 3
chr10_-_102241502 0.65 ENST00000370002.8
PITX3
paired like homeodomain 3
chr9_+_95004954 0.65 ENST00000445181.5
AOPEP
aminopeptidase O (putative)
chr11_-_11353241 0.64 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr10_+_22316375 0.64 ENST00000376836.8
ENST00000456711.5
ENST00000444869.5
ENST00000475460.6
ENST00000602390.5
ENST00000489125.2
COMMD3
COMMD3-BMI1
COMM domain containing 3
COMMD3-BMI1 readthrough
chr3_+_173584433 0.64 ENST00000361589.8
NLGN1
neuroligin 1
chr17_-_44899368 0.64 ENST00000591382.5
ENST00000593072.5
ENST00000592576.5
ENST00000426333.7
ENST00000402521.7
EFTUD2
elongation factor Tu GTP binding domain containing 2
chr6_-_52909666 0.63 ENST00000370968.5
ENST00000211122.4
GSTA3
glutathione S-transferase alpha 3
chr11_+_19117123 0.63 ENST00000399351.7
ENST00000446113.7
ZDHHC13
zinc finger DHHC-type palmitoyltransferase 13
chr6_-_149648735 0.63 ENST00000335643.12
ENST00000444282.5
KATNA1
katanin catalytic subunit A1
chr21_-_33491386 0.63 ENST00000617313.4
ENST00000314399.3
DNAJC28
DnaJ heat shock protein family (Hsp40) member C28
chr5_+_141969190 0.62 ENST00000506004.5
ENST00000507291.1
RNF14
ring finger protein 14
chr17_-_51747788 0.62 ENST00000575097.1
CA10
carbonic anhydrase 10
chr8_+_135457442 0.61 ENST00000355849.10
KHDRBS3
KH RNA binding domain containing, signal transduction associated 3
chr20_-_23605917 0.61 ENST00000376971.4
CST9
cystatin 9
chr1_-_217076889 0.61 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chr5_-_88824266 0.60 ENST00000509373.1
ENST00000636541.1
MEF2C
myocyte enhancer factor 2C
chr3_-_49191822 0.60 ENST00000432035.2
ENST00000545770.7
C3orf84
chromosome 3 open reading frame 84
chr7_-_38631356 0.57 ENST00000356264.7
ENST00000325590.9
AMPH
amphiphysin
chr5_-_59216826 0.57 ENST00000638939.1
PDE4D
phosphodiesterase 4D
chr20_-_41300116 0.57 ENST00000432768.6
ZHX3
zinc fingers and homeoboxes 3
chr4_+_109912877 0.57 ENST00000265171.10
ENST00000509793.5
ENST00000652245.1
EGF
epidermal growth factor
chr18_-_12377200 0.56 ENST00000269143.8
AFG3L2
AFG3 like matrix AAA peptidase subunit 2
chr10_+_19489054 0.56 ENST00000377265.3
MALRD1
MAM and LDL receptor class A domain containing 1
chr5_+_68239815 0.56 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr11_+_22668101 0.55 ENST00000630668.2
ENST00000278187.7
GAS2
growth arrest specific 2
chr7_+_134127299 0.55 ENST00000645682.1
ENST00000285928.2
LRGUK
leucine rich repeats and guanylate kinase domain containing
chr9_-_32573150 0.55 ENST00000379847.8
ENST00000350021.2
NDUFB6
NADH:ubiquinone oxidoreductase subunit B6
chr9_+_37667997 0.55 ENST00000539465.5
FRMPD1
FERM and PDZ domain containing 1
chr4_+_8592750 0.55 ENST00000315782.6
ENST00000360986.9
CPZ
carboxypeptidase Z
chr15_+_40695423 0.55 ENST00000526763.6
ENST00000532743.6
RAD51
RAD51 recombinase
chr15_-_43106076 0.55 ENST00000546274.6
UBR1
ubiquitin protein ligase E3 component n-recognin 1
chr10_-_28282086 0.54 ENST00000375719.7
ENST00000375732.5
MPP7
membrane palmitoylated protein 7
chr5_+_160009113 0.54 ENST00000522793.5
ENST00000682719.1
ENST00000684137.1
ENST00000683219.1
ENST00000684018.1
ENST00000231238.10
ENST00000682131.1
TTC1
tetratricopeptide repeat domain 1
chr19_+_48756067 0.54 ENST00000222157.5
FGF21
fibroblast growth factor 21
chr11_-_19241598 0.53 ENST00000532666.1
ENST00000527884.5
ENST00000620009.4
E2F8
E2F transcription factor 8
chr2_-_219160540 0.53 ENST00000457600.2
NHEJ1
non-homologous end joining factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 18.8 GO:0035995 detection of muscle stretch(GO:0035995)
0.9 3.6 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.7 4.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.7 2.1 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
0.3 6.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.3 1.6 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.3 0.9 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.3 1.2 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.3 1.8 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.2 0.9 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.2 2.4 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.2 3.9 GO:0019532 oxalate transport(GO:0019532)
0.2 1.7 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.2 1.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.2 0.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 0.6 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.2 1.0 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414) homologous recombination-dependent replication fork processing(GO:1990426)
0.2 1.4 GO:0007343 egg activation(GO:0007343)
0.2 1.4 GO:0018032 protein amidation(GO:0018032)
0.2 2.1 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 0.8 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.2 1.5 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.2 0.7 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.2 0.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 0.5 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.2 0.6 GO:0097115 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.2 2.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 0.9 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.2 1.5 GO:0086073 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 0.7 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 3.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.9 GO:1904640 response to methionine(GO:1904640)
0.1 0.6 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.1 0.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0044335 neural crest cell fate commitment(GO:0014034) canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335)
0.1 0.4 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 1.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.1 1.1 GO:0044211 CTP salvage(GO:0044211)
0.1 0.8 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.6 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 1.9 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.1 GO:0060717 chorion development(GO:0060717)
0.1 0.7 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.5 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.1 1.4 GO:0051013 microtubule severing(GO:0051013)
0.1 1.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.5 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 1.0 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 3.3 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.3 GO:0035928 mitochondrial RNA 5'-end processing(GO:0000964) rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.1 0.3 GO:2000439 regulation of monocyte extravasation(GO:2000437) positive regulation of monocyte extravasation(GO:2000439)
0.1 0.9 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 1.0 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 0.8 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.4 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.1 1.0 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.3 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.9 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.3 GO:0048058 compound eye corneal lens development(GO:0048058)
0.1 0.4 GO:1904021 negative regulation of G-protein coupled receptor internalization(GO:1904021)
0.1 0.3 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.1 0.9 GO:0030473 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear migration along microfilament(GO:0031022)
0.1 1.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.8 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.5 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.1 0.4 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 1.1 GO:0097264 self proteolysis(GO:0097264)
0.1 0.4 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 0.8 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.1 0.4 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.1 1.4 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.1 0.5 GO:0002784 regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) negative regulation of defense response to bacterium(GO:1900425)
0.1 0.7 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.2 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 1.1 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 1.1 GO:0044351 macropinocytosis(GO:0044351)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.2 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.1 0.5 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.1 0.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0030961 peptidyl-arginine hydroxylation(GO:0030961)
0.0 6.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 1.0 GO:0071397 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.0 1.1 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.7 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 1.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.8 GO:0051775 response to redox state(GO:0051775)
0.0 0.9 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.7 GO:0033327 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.1 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 1.1 GO:0008228 opsonization(GO:0008228)
0.0 0.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.4 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.4 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.9 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 1.6 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 1.3 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.7 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.5 GO:0031274 regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.0 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 0.2 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.6 GO:0002003 angiotensin maturation(GO:0002003)
0.0 1.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.1 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.0 2.4 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.2 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.6 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.9 GO:0060004 reflex(GO:0060004)
0.0 0.6 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.8 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0035853 chromosome passenger complex localization to spindle midzone(GO:0035853)
0.0 0.2 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.3 GO:0015886 heme transport(GO:0015886)
0.0 0.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 1.0 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.5 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 1.0 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 1.1 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.5 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.1 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.5 GO:0014002 astrocyte development(GO:0014002)
0.0 2.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0046963 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 GO:0005916 fascia adherens(GO:0005916)
0.3 1.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 1.3 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 1.1 GO:0097513 myosin II filament(GO:0097513)
0.2 3.6 GO:0001741 XY body(GO:0001741)
0.1 0.6 GO:0005745 m-AAA complex(GO:0005745)
0.1 1.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.3 GO:0005827 polar microtubule(GO:0005827)
0.1 45.7 GO:0031674 I band(GO:0031674)
0.1 0.5 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.1 0.9 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 3.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.9 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 3.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 0.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.1 0.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.7 GO:0097255 R2TP complex(GO:0097255)
0.1 1.4 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.1 GO:0000815 ESCRT III complex(GO:0000815)
0.1 1.6 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.1 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.0 GO:0000800 lateral element(GO:0000800)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.0 GO:0071920 cleavage body(GO:0071920)
0.0 0.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 5.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 3.7 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.7 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.2 21.3 GO:0031433 telethonin binding(GO:0031433)
0.7 3.3 GO:0004447 iodide peroxidase activity(GO:0004447)
0.3 0.9 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.3 1.2 GO:0031208 POZ domain binding(GO:0031208)
0.3 0.9 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.3 0.8 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 3.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 1.4 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.2 1.8 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 1.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 0.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 1.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 1.6 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 1.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.4 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.1 1.0 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.5 GO:0050567 amidase activity(GO:0004040) glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.1 0.9 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 1.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 2.0 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.4 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.1 0.7 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.8 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.1 1.1 GO:0004849 uridine kinase activity(GO:0004849)
0.1 2.1 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.1 1.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.4 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 3.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.4 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.1 3.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.7 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.1 2.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.5 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.0 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 1.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.7 GO:0015180 hydrogen:amino acid symporter activity(GO:0005280) L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 1.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.9 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.7 GO:0071532 oxygen sensor activity(GO:0019826) ankyrin repeat binding(GO:0071532)
0.1 1.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 1.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.9 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 2.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 0.9 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.2 GO:0031432 titin binding(GO:0031432)
0.0 0.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.7 GO:0005113 patched binding(GO:0005113)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 1.3 GO:0048156 tau protein binding(GO:0048156)
0.0 0.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.5 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.4 GO:0089720 caspase binding(GO:0089720)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 5.0 GO:0051087 chaperone binding(GO:0051087)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.6 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 2.1 GO:0005507 copper ion binding(GO:0005507)
0.0 3.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.7 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.8 GO:0071949 FAD binding(GO:0071949)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 1.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.0 0.2 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 3.8 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.8 PID IL5 PATHWAY IL5-mediated signaling events
0.0 2.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 2.6 PID AURORA B PATHWAY Aurora B signaling
0.0 1.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.9 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 2.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 3.1 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 0.8 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.0 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 3.1 REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 2.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 2.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.4 REACTOME KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.3 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 5.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors