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Illumina Body Map 2 (GSE30611)

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Results for NKX2-5

Z-value: 1.17

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
ENSG00000183072.10 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg38_v1_chr5_-_173235300_173235317-0.096.4e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_79560386 3.71 ENST00000372327.9
ENST00000417041.1
ENST00000640627.1
ENST00000372325.7
surfactant protein A2
chr2_-_85668172 2.97 ENST00000428225.5
ENST00000519937.7
surfactant protein B
chr1_-_160070102 2.65 ENST00000638728.1
ENST00000637644.1
potassium inwardly rectifying channel subfamily J member 10
chr1_-_160070150 2.59 ENST00000644903.1
potassium inwardly rectifying channel subfamily J member 10
chr4_-_167234426 2.55 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr14_-_106771020 2.38 ENST00000617374.2
immunoglobulin heavy variable 2-70
chr10_+_79610932 2.37 ENST00000428376.6
ENST00000398636.8
ENST00000419470.6
ENST00000429958.5
surfactant protein A1
chr4_-_167234579 2.24 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chrX_-_13817027 2.16 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr4_-_167234266 2.12 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr15_-_74433942 1.98 ENST00000543145.6
ENST00000261918.9
semaphorin 7A (John Milton Hagen blood group)
chr15_+_42404719 1.92 ENST00000569136.6
ENST00000673936.1
ENST00000673890.1
ENST00000674149.1
ENST00000673771.1
ENST00000337571.9
ENST00000673743.1
ENST00000674146.1
ENST00000674119.1
ENST00000356316.7
ENST00000673692.1
ENST00000674052.1
calpain 3
chr4_-_46124046 1.86 ENST00000295452.5
gamma-aminobutyric acid type A receptor subunit gamma1
chr22_-_50085414 1.74 ENST00000311597.10
modulator of VRAC current 1
chr15_+_42404793 1.69 ENST00000561817.5
ENST00000674018.1
ENST00000397204.9
ENST00000673886.1
ENST00000674139.1
ENST00000673851.1
calpain 3
chr4_-_167234552 1.69 ENST00000512648.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr7_+_100177897 1.66 ENST00000317296.9
ENST00000615138.5
ENST00000620100.5
ENST00000422690.5
ENST00000439782.1
stromal antigen 3
chr22_-_50085331 1.66 ENST00000395876.6
modulator of VRAC current 1
chr11_-_18791563 1.64 ENST00000396168.1
protein tyrosine phosphatase non-receptor type 5
chr15_+_42404820 1.59 ENST00000673839.1
ENST00000673978.1
calpain 3
chr12_-_48865863 1.56 ENST00000309739.6
Rho family GTPase 1
chr14_+_80955577 1.53 ENST00000642209.1
ENST00000298171.7
thyroid stimulating hormone receptor
chr14_-_106724093 1.51 ENST00000390634.3
immunoglobulin heavy variable 2-70D
chr1_-_237945275 1.50 ENST00000604646.1
MT-RNR2 like 11
chr14_-_106038355 1.46 ENST00000390597.3
immunoglobulin heavy variable 2-5
chr7_-_108243234 1.42 ENST00000417701.5
neuronal cell adhesion molecule
chr22_-_50085378 1.34 ENST00000442311.1
modulator of VRAC current 1
chr14_-_106507476 1.33 ENST00000390621.3
immunoglobulin heavy variable 1-45
chr17_-_58544315 1.31 ENST00000671766.1
ENST00000672673.2
ENST00000321691.3
septin 4
chr14_-_106130061 1.28 ENST00000390602.3
immunoglobulin heavy variable 3-13
chrX_-_13817279 1.26 ENST00000475307.1
glycoprotein M6B
chr17_-_7929793 1.22 ENST00000303790.3
potassium voltage-gated channel subfamily A regulatory beta subunit 3
chr7_+_100177743 1.19 ENST00000394018.6
ENST00000416412.5
stromal antigen 3
chr1_+_65309517 1.16 ENST00000371069.5
DnaJ heat shock protein family (Hsp40) member C6
chr8_+_132866948 1.14 ENST00000220616.9
thyroglobulin
chr3_-_155745016 1.14 ENST00000460012.7
phospholipase C eta 1
chr3_+_108602776 1.13 ENST00000497905.5
ENST00000463306.1
DAZ interacting zinc finger protein 3
chr1_-_25906457 1.13 ENST00000426559.6
stathmin 1
chr1_+_161706949 1.11 ENST00000350710.3
ENST00000367949.6
ENST00000367959.6
ENST00000540521.5
ENST00000546024.5
ENST00000674251.1
ENST00000674323.1
Fc receptor like A
chr12_-_51028234 1.10 ENST00000547688.7
ENST00000394904.9
solute carrier family 11 member 2
chr20_-_43189733 1.09 ENST00000373187.5
ENST00000356100.6
ENST00000373184.5
ENST00000373190.5
protein tyrosine phosphatase receptor type T
chr11_-_18791768 1.09 ENST00000358540.7
protein tyrosine phosphatase non-receptor type 5
chr4_-_46993520 1.07 ENST00000264318.4
gamma-aminobutyric acid type A receptor subunit alpha4
chr3_-_187670385 1.03 ENST00000287641.4
somatostatin
chr1_-_101996919 1.02 ENST00000370103.9
olfactomedin 3
chr15_+_42404700 1.02 ENST00000674093.1
calpain 3
chrX_+_87517784 1.01 ENST00000373119.9
ENST00000373114.4
kelch like family member 4
chr1_-_160070125 1.01 ENST00000639408.1
potassium inwardly rectifying channel subfamily J member 10
chr17_+_4932248 0.99 ENST00000329125.6
glycoprotein Ib platelet subunit alpha
chr13_-_52848632 0.98 ENST00000377942.7
ENST00000338862.5
protocadherin 8
chr14_+_94174284 0.98 ENST00000304338.8
protein phosphatase 4 regulatory subunit 4
chr2_-_174634566 0.97 ENST00000392547.6
WAS/WASL interacting protein family member 1
chr1_-_101846957 0.96 ENST00000338858.9
olfactomedin 3
chr5_-_88884525 0.96 ENST00000502983.5
myocyte enhancer factor 2C
chr9_-_114930508 0.95 ENST00000223795.3
ENST00000618336.4
TNF superfamily member 8
chr22_-_38181772 0.94 ENST00000430886.5
ENST00000667521.1
ENST00000663895.1
ENST00000402064.5
ENST00000332509.8
ENST00000664587.1
phospholipase A2 group VI
chr5_+_170353480 0.93 ENST00000377360.8
potassium voltage-gated channel interacting protein 1
chr7_-_14902743 0.92 ENST00000402815.6
diacylglycerol kinase beta
chr14_+_80955366 0.92 ENST00000342443.10
thyroid stimulating hormone receptor
chr14_+_80955043 0.91 ENST00000541158.6
thyroid stimulating hormone receptor
chr2_-_166149120 0.90 ENST00000641575.1
ENST00000641603.1
sodium voltage-gated channel alpha subunit 1
chr15_+_90265634 0.89 ENST00000379095.5
neugrin, neurite outgrowth associated
chr14_+_21887848 0.89 ENST00000390437.2
T cell receptor alpha variable 12-2
chr14_+_80955650 0.89 ENST00000554263.5
ENST00000554435.1
thyroid stimulating hormone receptor
chr17_-_31314066 0.87 ENST00000577894.1
ecotropic viral integration site 2B
chr11_+_99020940 0.87 ENST00000524871.6
contactin 5
chr1_+_161707244 0.84 ENST00000349527.8
ENST00000294796.8
ENST00000309691.10
ENST00000367953.7
ENST00000367950.2
Fc receptor like A
chr13_-_72727600 0.84 ENST00000377818.4
mitotic spindle organizing protein 1
chr5_+_147878703 0.83 ENST00000296694.5
secretoglobin family 3A member 2
chr17_-_31314040 0.81 ENST00000330927.5
ecotropic viral integration site 2B
chr16_+_8720706 0.80 ENST00000425191.6
ENST00000569156.5
4-aminobutyrate aminotransferase
chr7_-_14902842 0.78 ENST00000407950.5
diacylglycerol kinase beta
chr7_+_129368123 0.78 ENST00000460109.5
ENST00000474594.5
adenosylhomocysteinase like 2
chr6_-_158819355 0.77 ENST00000367075.4
ezrin
chr4_+_80197493 0.76 ENST00000415738.3
PR/SET domain 8
chr12_+_4809176 0.75 ENST00000280684.3
potassium voltage-gated channel subfamily A member 6
chr1_+_69568398 0.73 ENST00000310961.9
ENST00000370958.5
leucine rich repeat containing 7
chr1_-_24930263 0.73 ENST00000308873.11
RUNX family transcription factor 3
chr2_+_135531460 0.72 ENST00000683871.1
ENST00000409478.5
ENST00000264160.8
ENST00000438014.5
R3H domain containing 1
chr11_+_99021066 0.71 ENST00000527185.5
ENST00000528682.5
contactin 5
chr1_+_50105666 0.71 ENST00000651347.1
ELAV like RNA binding protein 4
chr10_-_126670686 0.70 ENST00000488181.3
chromosome 10 open reading frame 90
chr12_-_262828 0.70 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
solute carrier family 6 member 13
chr20_+_54475647 0.69 ENST00000395939.5
docking protein 5
chr4_+_46993708 0.68 ENST00000513567.5
gamma-aminobutyric acid type A receptor subunit beta1
chr22_-_38181707 0.68 ENST00000668949.1
ENST00000335539.7
phospholipase A2 group VI
chr14_-_106875069 0.67 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chrX_-_143635081 0.66 ENST00000338017.8
SLIT and NTRK like family member 4
chr11_+_60971777 0.65 ENST00000542157.5
ENST00000433107.6
ENST00000352009.9
ENST00000452451.6
CD6 molecule
chr20_+_58651228 0.63 ENST00000361830.7
ENST00000458280.5
ENST00000355957.9
ENST00000312283.12
ENST00000412911.5
ENST00000359617.8
ENST00000371141.8
syntaxin 16
chr7_-_24918080 0.62 ENST00000441059.5
ENST00000415162.5
oxysterol binding protein like 3
chr2_-_166149204 0.62 ENST00000635750.1
sodium voltage-gated channel alpha subunit 1
chr14_-_21048431 0.61 ENST00000555026.5
NDRG family member 2
chr19_-_48170323 0.61 ENST00000263274.12
ENST00000427526.6
DNA ligase 1
chr12_+_101568350 0.60 ENST00000550514.5
myosin binding protein C1
chr2_-_179746040 0.59 ENST00000409343.5
zinc finger protein 385B
chr9_-_20382461 0.58 ENST00000380321.5
ENST00000629733.3
MLLT3 super elongation complex subunit
chr7_-_37449174 0.56 ENST00000445322.1
ENST00000448602.5
engulfment and cell motility 1
chr3_-_111595339 0.55 ENST00000317012.5
zinc finger BED-type containing 2
chr19_+_10836575 0.55 ENST00000592854.5
chromosome 19 open reading frame 38
chr8_+_47960883 0.54 ENST00000648407.1
ENST00000649838.1
ENST00000649919.1
ENST00000262105.6
ENST00000649973.1
minichromosome maintenance complex component 4
chr20_+_54475584 0.54 ENST00000262593.10
docking protein 5
chr17_+_60677822 0.54 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3 microtubule associated cell migration factor
chr9_+_33264848 0.53 ENST00000419016.6
charged multivesicular body protein 5
chr12_-_112382363 0.53 ENST00000682272.1
ENST00000377560.9
HECT domain E3 ubiquitin protein ligase 4
chr5_+_141350081 0.53 ENST00000523390.2
ENST00000611598.1
protocadherin gamma subfamily B, 1
chr8_-_113436883 0.53 ENST00000455883.2
ENST00000297405.10
CUB and Sushi multiple domains 3
chr11_-_19201976 0.52 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
cysteine and glycine rich protein 3
chr7_-_81770122 0.52 ENST00000423064.7
hepatocyte growth factor
chr20_+_58651785 0.51 ENST00000358029.8
syntaxin 16
chr19_+_14562356 0.49 ENST00000596073.6
trans-2,3-enoyl-CoA reductase
chr2_-_96208815 0.48 ENST00000443962.1
ENST00000337288.10
StAR related lipid transfer domain containing 7
chr7_-_87713287 0.48 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ATP binding cassette subfamily B member 1
chr4_-_46388713 0.48 ENST00000507069.5
gamma-aminobutyric acid type A receptor subunit alpha2
chr9_+_33265013 0.47 ENST00000223500.9
charged multivesicular body protein 5
chr3_+_45943455 0.47 ENST00000304552.5
C-X-C motif chemokine receptor 6
chr1_+_19882374 0.47 ENST00000375120.4
OTU deubiquitinase 3
chr1_-_109389886 0.47 ENST00000493736.5
sortilin 1
chrX_+_14529516 0.46 ENST00000218075.9
glycine receptor alpha 2
chr4_+_143433491 0.46 ENST00000512843.1
GRB2 associated binding protein 1
chr3_-_39192584 0.45 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
xin actin binding repeat containing 1
chr7_+_48924559 0.45 ENST00000650262.1
cell division cycle 14C
chr1_-_54887161 0.44 ENST00000535035.6
ENST00000371269.9
ENST00000436604.2
24-dehydrocholesterol reductase
chr19_+_5681000 0.44 ENST00000581893.5
ENST00000411793.6
ENST00000301382.8
ENST00000581773.5
ENST00000339423.7
ENST00000423665.6
ENST00000583928.5
ENST00000342970.6
ENST00000422535.6
ENST00000581521.5
hydroxysteroid 11-beta dehydrogenase 1 like
chr1_-_202889099 0.43 ENST00000367262.4
RAB interacting factor
chr12_+_123233420 0.43 ENST00000253233.6
ENST00000366329.7
ENST00000546132.2
ENST00000536130.2
chromosome 12 open reading frame 65
chr19_-_48170295 0.43 ENST00000596549.5
DNA ligase 1
chr19_-_38388020 0.43 ENST00000334928.11
ENST00000587676.1
gametogenetin
chr12_+_110614027 0.42 ENST00000550703.6
ENST00000551590.5
tectonic family member 1
chr4_-_73988179 0.42 ENST00000296028.4
pro-platelet basic protein
chr2_-_201071579 0.41 ENST00000453765.5
ENST00000452799.5
ENST00000446678.5
ENST00000418596.7
ENST00000681958.1
family with sequence similarity 126 member B
chr9_-_5833014 0.41 ENST00000339450.10
endoplasmic reticulum metallopeptidase 1
chr16_+_715092 0.40 ENST00000568223.7
meteorin, glial cell differentiation regulator
chr9_+_131111393 0.40 ENST00000372301.2
allograft inflammatory factor 1 like
chr1_+_14924100 0.40 ENST00000361144.9
kazrin, periplakin interacting protein
chrX_+_151396566 0.39 ENST00000370361.5
vacuolar ATPase assembly factor VMA21
chrX_+_11759678 0.38 ENST00000649797.1
ENST00000648614.1
MSL complex subunit 3
chr15_+_82809618 0.37 ENST00000286760.5
WASP homolog associated with actin, golgi membranes and microtubules
chr1_+_76074698 0.37 ENST00000328299.4
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr14_-_67692435 0.37 ENST00000554035.5
retinol dehydrogenase 11
chr16_+_81651186 0.35 ENST00000566462.2
c-Maf inducing protein
chr17_+_76265332 0.35 ENST00000327490.8
ENST00000587913.1
UBA like domain containing 2
chr15_-_72271244 0.35 ENST00000287196.13
poly(ADP-ribose) polymerase family member 6
chr1_+_161707222 0.33 ENST00000236938.12
Fc receptor like A
chr11_-_47594399 0.33 ENST00000302514.4
C1q and TNF related 4
chr1_+_150282526 0.33 ENST00000447007.5
ENST00000369095.5
ENST00000369094.5
ENST00000290363.6
circadian associated repressor of transcription
chr1_+_161707205 0.33 ENST00000367957.7
Fc receptor like A
chr7_+_130266847 0.32 ENST00000222481.9
carboxypeptidase A2
chrX_+_11759604 0.32 ENST00000649602.1
ENST00000650215.1
ENST00000649685.1
ENST00000649649.1
ENST00000380693.8
ENST00000380692.7
ENST00000650628.1
ENST00000649851.1
ENST00000421368.3
MSL complex subunit 3
chr4_+_113049616 0.32 ENST00000504454.5
ENST00000357077.9
ENST00000394537.7
ENST00000672779.1
ENST00000264366.10
ankyrin 2
chr7_-_81769971 0.31 ENST00000354224.10
ENST00000643024.1
hepatocyte growth factor
chr9_-_135501734 0.30 ENST00000371791.5
chromosome 9 open reading frame 116
chr14_+_22040576 0.30 ENST00000390448.3
T cell receptor alpha variable 20
chr2_-_27322564 0.30 ENST00000233545.6
mitochondrial inner membrane protein MPV17
chr1_+_161721563 0.30 ENST00000367948.6
Fc receptor like B
chr17_-_27893339 0.29 ENST00000460380.6
ENST00000379102.8
ENST00000508862.5
ENST00000582441.1
LYR motif containing 9
novel protein
chr17_+_47971136 0.28 ENST00000583352.5
CDK5 regulatory subunit associated protein 3
chr14_+_21841182 0.28 ENST00000390433.1
T cell receptor alpha variable 12-1
chr14_+_93927259 0.28 ENST00000556222.1
ENST00000554404.1
family with sequence similarity 181 member A
chr16_-_30123120 0.28 ENST00000395200.5
mitogen-activated protein kinase 3
chr5_-_139395096 0.28 ENST00000434752.4
proline rich basic protein 1
chr10_+_73744346 0.28 ENST00000345254.9
ENST00000339365.2
SEC24 homolog C, COPII coat complex component
chr4_+_113049479 0.28 ENST00000671727.1
ENST00000671762.1
ENST00000672366.1
ENST00000672502.1
ENST00000672045.1
ENST00000672251.1
ENST00000672854.1
ankyrin 2
chr6_+_33410961 0.28 ENST00000374512.7
ENST00000374516.8
PHD finger protein 1
chr10_-_48605032 0.27 ENST00000249601.9
Rho GTPase activating protein 22
chr11_-_84437800 0.27 ENST00000527466.1
discs large MAGUK scaffold protein 2
chr19_+_54451290 0.27 ENST00000610347.1
leukocyte receptor cluster member 8
chr6_-_134052594 0.27 ENST00000275230.6
solute carrier family 2 member 12
chr17_-_81656532 0.27 ENST00000331056.10
phosphodiesterase 6G
chr1_+_113929600 0.26 ENST00000369558.5
ENST00000369561.8
homeodomain interacting protein kinase 1
chr6_-_111793900 0.25 ENST00000462598.7
FYN proto-oncogene, Src family tyrosine kinase
chr11_+_108223027 0.25 ENST00000675843.1
ENST00000683468.1
ENST00000532931.5
ENST00000530958.5
ATM serine/threonine kinase
chr8_-_119638780 0.25 ENST00000522826.5
ENST00000520066.5
ENST00000259486.10
ENST00000075322.11
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr7_-_81770013 0.24 ENST00000465234.2
hepatocyte growth factor
chr8_-_71547626 0.24 ENST00000647540.1
ENST00000644229.1
EYA transcriptional coactivator and phosphatase 1
chr16_-_30122944 0.24 ENST00000484663.5
ENST00000478356.5
mitogen-activated protein kinase 3
chr17_+_50547089 0.23 ENST00000619622.4
ENST00000356488.8
ENST00000006658.11
spermatogenesis associated 20
chr3_+_42160160 0.23 ENST00000341421.7
ENST00000396175.5
trafficking kinesin protein 1
chrX_-_84188148 0.23 ENST00000262752.5
ribosomal protein S6 kinase A6
chrX_+_11760087 0.23 ENST00000649271.1
MSL complex subunit 3
chrX_+_11760035 0.23 ENST00000482871.6
ENST00000648013.1
MSL complex subunit 3
chr11_+_108223112 0.22 ENST00000452508.6
ENST00000683914.1
ENST00000683150.1
ENST00000639953.1
ENST00000640388.1
ENST00000639240.1
ATM serine/threonine kinase
chr9_-_20382448 0.22 ENST00000491137.5
MLLT3 super elongation complex subunit
chr2_-_175168159 0.22 ENST00000392544.5
ENST00000409499.5
ENST00000409833.5
ENST00000264110.7
ENST00000409635.5
ENST00000345739.9
ENST00000426833.7
activating transcription factor 2
chr4_+_109848102 0.22 ENST00000594814.6
leucine rich repeat, Ig-like and transmembrane domains 3
chr3_+_121567924 0.21 ENST00000334384.5
arginine-fifty homeobox
chr5_-_160685379 0.21 ENST00000642502.1
ATPase phospholipid transporting 10B (putative)
chr13_+_108596152 0.21 ENST00000356711.7
ENST00000251041.10
myosin XVI
chr2_-_175168338 0.21 ENST00000437522.5
activating transcription factor 2
chr17_+_28728781 0.20 ENST00000268766.11
NIMA related kinase 8
chr7_-_100177336 0.20 ENST00000292377.4
glypican 2
chr22_+_39926591 0.20 ENST00000420971.5
GRB2 related adaptor protein 2
chr22_+_38057200 0.20 ENST00000404072.7
ENST00000424694.5
protein interacting with PRKCA 1
chr11_+_26332117 0.20 ENST00000531646.1
ENST00000256737.8
anoctamin 3
chr14_+_93927358 0.20 ENST00000557000.2
family with sequence similarity 181 member A
chr5_+_141430565 0.19 ENST00000613314.1
protocadherin gamma subfamily A, 12
chr11_-_19202004 0.18 ENST00000648719.1
cysteine and glycine rich protein 3
chr12_+_110614097 0.17 ENST00000471804.7
ENST00000377654.5
ENST00000614115.5
ENST00000397655.7
ENST00000549123.6
ENST00000679401.1
ENST00000397659.9
ENST00000680445.1
tectonic family member 1
chr19_-_38387992 0.17 ENST00000586599.1
gametogenetin
chr10_+_18340821 0.17 ENST00000612743.1
ENST00000612134.4
calcium voltage-gated channel auxiliary subunit beta 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.8 6.3 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.6 5.7 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.4 8.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.1 GO:1903461 Okazaki fragment processing involved in mitotic DNA replication(GO:1903461)
0.3 3.4 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 5.2 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 0.6 GO:2000656 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.2 1.6 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.2 1.1 GO:0015692 lead ion transport(GO:0015692)
0.2 1.0 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.2 2.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.8 GO:1902896 terminal web assembly(GO:1902896)
0.1 1.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.5 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.1 0.8 GO:0061528 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 0.4 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.8 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 1.1 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 2.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.4 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.5 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 1.1 GO:0015705 iodide transport(GO:0015705)
0.1 2.4 GO:0008228 opsonization(GO:0008228)
0.1 1.0 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 1.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.4 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 1.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 0.7 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 2.4 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 0.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 1.6 GO:0016322 neuron remodeling(GO:0016322)
0.1 1.0 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 6.7 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 0.2 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 8.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.6 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 1.2 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 3.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.4 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 1.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.6 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.8 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.0 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.6 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.7 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 1.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 2.0 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.3 GO:0071569 protein ufmylation(GO:0071569)
0.0 1.0 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.5 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 3.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.0 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0031627 telomeric loop formation(GO:0031627)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.2 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.3 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.7 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.6 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.2 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.7 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.4 GO:0006677 glycosylceramide metabolic process(GO:0006677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.0 GO:0042599 lamellar body(GO:0042599)
0.3 2.8 GO:0030893 meiotic cohesin complex(GO:0030893)
0.2 0.8 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.1 GO:0070826 paraferritin complex(GO:0070826)
0.2 0.8 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.1 0.8 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 1.1 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 1.0 GO:0072487 MSL complex(GO:0072487)
0.1 2.9 GO:0043194 axon initial segment(GO:0043194)
0.1 7.0 GO:0030315 T-tubule(GO:0030315)
0.1 3.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 2.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 5.2 GO:0005901 caveola(GO:0005901)
0.0 2.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 2.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 8.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.6 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 2.2 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.5 6.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 8.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 6.8 GO:0031432 titin binding(GO:0031432)
0.2 1.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.2 0.5 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 0.5 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.5 GO:0030379 neurotensin receptor activity, non-G-protein coupled(GO:0030379)
0.1 1.6 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.8 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 1.1 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 0.8 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.5 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 2.8 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.5 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 0.7 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 3.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.5 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 3.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 0.7 GO:0031433 telethonin binding(GO:0031433)
0.0 1.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.5 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 1.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 4.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 5.7 GO:0003823 antigen binding(GO:0003823)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.9 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.0 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 2.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 2.6 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.1 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 3.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 6.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.9 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 2.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.1 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 2.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.6 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 1.0 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis