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Illumina Body Map 2 (GSE30611)
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Results for NKX2-5
Z-value: 1.17
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Transcription factors associated with NKX2-5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-5 | hg38_v1_chr5_-_173235300_173235317 | -0.09 | 6.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.6 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 8.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 6.7 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.8 | 6.3 | GO:0051935 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 0.6 | 5.7 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 0.2 | 5.2 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 1.1 | 4.2 | GO:1904588 | cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229) |
| 0.0 | 3.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.3 | 3.4 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 3.0 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 8.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 8.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 7.0 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 5.2 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 3.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 3.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 2.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.3 | 2.8 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.0 | 2.3 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 6.8 | GO:0031432 | titin binding(GO:0031432) |
| 0.5 | 6.3 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 5.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 4.7 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.5 | 4.2 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.0 | 3.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 3.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 2.8 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 2.6 | GO:0005319 | lipid transporter activity(GO:0005319) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 3.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.3 | 4.2 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 2.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 2.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 2.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 1.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.2 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |