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Illumina Body Map 2 (GSE30611)

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Results for NKX2-6

Z-value: 1.24

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.8 NK2 homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-6hg38_v1_chr8_-_23706756_23706756-0.144.6e-01Click!

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142791635 7.00 ENST00000633705.1
TRBC1
T cell receptor beta constant 1
chr7_+_142800957 6.87 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr14_-_106579223 6.50 ENST00000390626.2
IGHV5-51
immunoglobulin heavy variable 5-51
chr14_+_22320128 5.06 ENST00000390468.1
TRAV41
T cell receptor alpha variable 41
chr19_+_3178756 4.32 ENST00000246115.5
S1PR4
sphingosine-1-phosphate receptor 4
chr22_+_22887780 4.29 ENST00000532223.2
ENST00000526893.6
ENST00000531372.1
IGLL5
immunoglobulin lambda like polypeptide 5
chr6_-_159044980 4.26 ENST00000367066.8
TAGAP
T cell activation RhoGTPase activating protein
chr6_-_159045104 4.22 ENST00000326965.7
TAGAP
T cell activation RhoGTPase activating protein
chr22_-_37486357 4.20 ENST00000356998.8
ENST00000416983.7
ENST00000424765.2
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_-_159045010 4.08 ENST00000338313.5
TAGAP
T cell activation RhoGTPase activating protein
chr17_-_31318818 4.06 ENST00000578584.5
ENSG00000265118.5
novel protein
chr14_-_106762576 3.99 ENST00000624687.1
IGHV1-69D
immunoglobulin heavy variable 1-69D
chr3_-_121660892 3.94 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr11_-_111379268 3.91 ENST00000393067.8
POU2AF1
POU class 2 homeobox associating factor 1
chr22_-_23754376 3.87 ENST00000398465.3
ENST00000248948.4
VPREB3
V-set pre-B cell surrogate light chain 3
chr22_+_44181732 3.87 ENST00000415224.5
PARVG
parvin gamma
chr14_-_59870752 3.82 ENST00000611068.1
ENST00000267484.10
RTN1
reticulon 1
chr12_-_14950606 3.62 ENST00000536592.5
ARHGDIB
Rho GDP dissociation inhibitor beta
chr6_+_32439866 3.43 ENST00000374982.5
ENST00000395388.7
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr3_+_114294020 3.38 ENST00000383671.8
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr14_-_105940235 3.04 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr15_+_81182579 2.95 ENST00000302987.9
IL16
interleukin 16
chr14_-_106108453 2.81 ENST00000632950.2
IGHV5-10-1
immunoglobulin heavy variable 5-10-1
chr2_-_181657096 2.78 ENST00000410087.8
ENST00000409440.7
CERKL
ceramide kinase like
chr6_-_33009568 2.75 ENST00000374813.1
ENST00000229829.7
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr1_-_169703329 2.74 ENST00000497295.1
SELL
selectin L
chr3_+_186996444 2.51 ENST00000676633.1
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr22_+_44181357 2.38 ENST00000417767.1
PARVG
parvin gamma
chr17_+_4932248 2.34 ENST00000329125.6
GP1BA
glycoprotein Ib platelet subunit alpha
chr14_-_106211453 2.33 ENST00000390606.3
IGHV3-20
immunoglobulin heavy variable 3-20
chr1_+_158289916 2.33 ENST00000368170.8
CD1C
CD1c molecule
chr17_+_4932285 2.19 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr15_-_55270874 2.14 ENST00000567380.5
ENST00000565972.5
ENST00000569493.5
RAB27A
RAB27A, member RAS oncogene family
chr2_-_174597728 2.12 ENST00000409891.5
ENST00000410117.5
WIPF1
WAS/WASL interacting protein family member 1
chr2_-_174597795 2.05 ENST00000679041.1
WIPF1
WAS/WASL interacting protein family member 1
chr4_-_48080172 2.04 ENST00000507351.1
TXK
TXK tyrosine kinase
chr11_+_1870252 2.01 ENST00000612798.4
LSP1
lymphocyte specific protein 1
chr2_+_69915041 2.00 ENST00000540449.5
MXD1
MAX dimerization protein 1
chr1_+_109619827 1.99 ENST00000667949.2
ENST00000342115.8
ENST00000528667.7
AMPD2
adenosine monophosphate deaminase 2
chr3_-_46208304 1.99 ENST00000296140.4
CCR1
C-C motif chemokine receptor 1
chr17_-_59151794 1.98 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr2_+_69915100 1.94 ENST00000264444.7
MXD1
MAX dimerization protein 1
chr11_-_65862026 1.92 ENST00000532134.5
CFL1
cofilin 1
chr2_-_174598206 1.90 ENST00000392546.6
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family member 1
chr8_+_27311620 1.89 ENST00000522338.5
PTK2B
protein tyrosine kinase 2 beta
chr22_+_44181844 1.86 ENST00000466375.2
PARVG
parvin gamma
chr22_+_22395005 1.83 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr12_-_75209701 1.83 ENST00000350228.6
ENST00000298972.5
KCNC2
potassium voltage-gated channel subfamily C member 2
chr17_+_59729702 1.83 ENST00000587259.5
VMP1
vacuole membrane protein 1
chr11_-_62754141 1.82 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chr11_-_65857007 1.80 ENST00000527344.5
CFL1
cofilin 1
chr8_+_55102012 1.75 ENST00000327381.7
XKR4
XK related 4
chr14_+_61485391 1.75 ENST00000640011.1
PRKCH
protein kinase C eta
chr11_-_65856944 1.72 ENST00000524553.5
CFL1
cofilin 1
chr1_+_158930778 1.66 ENST00000458222.5
PYHIN1
pyrin and HIN domain family member 1
chr3_+_122055355 1.66 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr19_+_54874218 1.64 ENST00000355524.8
ENST00000391726.7
FCAR
Fc fragment of IgA receptor
chr22_-_50085378 1.63 ENST00000442311.1
MLC1
modulator of VRAC current 1
chr7_+_150801695 1.63 ENST00000475536.5
ENST00000468689.2
TMEM176A
transmembrane protein 176A
chr2_-_100105339 1.61 ENST00000424600.5
ENST00000441400.5
ENST00000673328.1
AFF3
AF4/FMR2 family member 3
chr14_+_21797272 1.61 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr1_+_158254414 1.59 ENST00000289429.6
CD1A
CD1a molecule
chr3_+_122077850 1.57 ENST00000482356.5
ENST00000393627.6
CD86
CD86 molecule
chr13_+_48653921 1.57 ENST00000682523.1
CYSLTR2
cysteinyl leukotriene receptor 2
chr12_+_14408482 1.56 ENST00000541056.1
ATF7IP
activating transcription factor 7 interacting protein
chr11_+_122838492 1.56 ENST00000227348.9
CRTAM
cytotoxic and regulatory T cell molecule
chr2_-_100104530 1.53 ENST00000432037.5
ENST00000673232.1
ENST00000423966.6
ENST00000409236.6
AFF3
AF4/FMR2 family member 3
chr1_-_107688492 1.53 ENST00000415432.6
VAV3
vav guanine nucleotide exchange factor 3
chr16_+_8712943 1.50 ENST00000561870.5
ENST00000396600.6
ABAT
4-aminobutyrate aminotransferase
chr11_+_118883884 1.50 ENST00000292174.5
CXCR5
C-X-C motif chemokine receptor 5
chr19_+_7637099 1.48 ENST00000595950.5
ENST00000221283.10
ENST00000441779.6
ENST00000414284.6
STXBP2
syntaxin binding protein 2
chr3_+_122077776 1.46 ENST00000264468.9
CD86
CD86 molecule
chr19_+_54874275 1.42 ENST00000469767.5
ENST00000391725.7
ENST00000345937.8
ENST00000353758.8
ENST00000359272.8
ENST00000391723.7
ENST00000391724.3
FCAR
Fc fragment of IgA receptor
chr17_-_74531467 1.40 ENST00000314401.3
ENST00000392621.6
CD300LB
CD300 molecule like family member b
chr5_-_1523900 1.39 ENST00000283415.4
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr22_-_50085331 1.38 ENST00000395876.6
MLC1
modulator of VRAC current 1
chr1_+_109620578 1.38 ENST00000531203.6
ENST00000256578.8
AMPD2
adenosine monophosphate deaminase 2
chr17_-_28576882 1.33 ENST00000395319.7
ENST00000581807.5
ENST00000226253.9
ENST00000584086.5
ENST00000395321.6
ALDOC
aldolase, fructose-bisphosphate C
chr19_-_43670153 1.31 ENST00000601723.5
ENST00000339082.7
ENST00000340093.8
PLAUR
plasminogen activator, urokinase receptor
chr11_-_6619353 1.31 ENST00000642892.1
ENST00000645620.1
ENST00000533371.6
ENST00000647152.1
ENST00000644810.1
ENST00000299427.12
ENST00000682424.1
ENST00000644218.1
ENST00000528657.2
ENST00000531754.2
TPP1
tripeptidyl peptidase 1
chr3_-_56916379 1.25 ENST00000496106.5
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr6_+_31571957 1.25 ENST00000454783.5
LTA
lymphotoxin alpha
chr13_+_48653711 1.21 ENST00000614739.4
ENST00000617562.4
ENST00000621321.1
ENST00000622559.4
CYSLTR2
cysteinyl leukotriene receptor 2
chr22_-_50085414 1.13 ENST00000311597.10
MLC1
modulator of VRAC current 1
chr14_+_71321379 1.13 ENST00000557151.5
SIPA1L1
signal induced proliferation associated 1 like 1
chr9_+_122370523 1.13 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr17_+_42998779 1.12 ENST00000586277.5
RPL27
ribosomal protein L27
chr1_-_20786610 1.09 ENST00000375000.5
ENST00000312239.10
ENST00000419490.5
ENST00000414993.1
ENST00000443615.1
HP1BP3
heterochromatin protein 1 binding protein 3
chr9_+_122371036 1.08 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr8_+_41529242 1.04 ENST00000523277.6
ENST00000276533.4
GINS4
GINS complex subunit 4
chr16_+_8712831 1.04 ENST00000568847.5
ABAT
4-aminobutyrate aminotransferase
chr9_+_122371014 1.04 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr12_-_89526011 1.02 ENST00000313546.8
POC1B
POC1 centriolar protein B
chr12_-_89526164 1.01 ENST00000548729.5
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr4_-_46388713 0.98 ENST00000507069.5
GABRA2
gamma-aminobutyric acid type A receptor subunit alpha2
chr8_-_144012748 0.96 ENST00000530478.5
PARP10
poly(ADP-ribose) polymerase family member 10
chr1_-_1832282 0.95 ENST00000437146.1
GNB1
G protein subunit beta 1
chr2_+_17541157 0.94 ENST00000406397.1
VSNL1
visinin like 1
chr5_-_111756245 0.93 ENST00000447165.6
NREP
neuronal regeneration related protein
chr17_+_42998264 0.92 ENST00000589037.5
RPL27
ribosomal protein L27
chr8_-_100950549 0.90 ENST00000395951.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr4_-_46124046 0.89 ENST00000295452.5
GABRG1
gamma-aminobutyric acid type A receptor subunit gamma1
chr1_-_77979054 0.87 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
FUBP1
far upstream element binding protein 1
chr1_-_31065671 0.84 ENST00000440538.6
ENST00000424085.6
ENST00000257075.9
ENST00000373747.7
ENST00000426105.7
ENST00000525843.5
ENST00000373742.6
PUM1
pumilio RNA binding family member 1
chr7_+_31687208 0.83 ENST00000409146.3
ENST00000342032.8
PPP1R17
protein phosphatase 1 regulatory subunit 17
chr2_-_201433545 0.83 ENST00000440597.1
TRAK2
trafficking kinesin protein 2
chr1_+_16440700 0.83 ENST00000504551.6
ENST00000457722.6
ENST00000337132.10
ENST00000443980.6
NECAP2
NECAP endocytosis associated 2
chr11_-_56614874 0.82 ENST00000641076.1
OR5M1
olfactory receptor family 5 subfamily M member 1
chr17_-_58529277 0.81 ENST00000579371.5
SEPTIN4
septin 4
chr2_-_69643152 0.80 ENST00000606389.7
AAK1
AP2 associated kinase 1
chrX_-_153321759 0.80 ENST00000436629.3
PNMA6F
PNMA family member 6F
chr19_-_2282168 0.79 ENST00000342063.5
PEAK3
PEAK family member 3
chr6_+_28267107 0.79 ENST00000621053.1
ENST00000617168.4
ENST00000421553.7
ENST00000611552.2
ENST00000623276.3
ENSG00000276302.1
ZSCAN26
novel protein
zinc finger and SCAN domain containing 26
chr4_+_17577487 0.78 ENST00000606142.5
LAP3
leucine aminopeptidase 3
chr17_-_51260032 0.78 ENST00000586178.6
MBTD1
mbt domain containing 1
chr12_-_89526253 0.78 ENST00000547474.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr2_+_102311502 0.77 ENST00000404917.6
ENST00000410040.5
IL1RL1
IL18R1
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr12_-_262828 0.76 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
SLC6A13
solute carrier family 6 member 13
chr12_+_118016690 0.75 ENST00000537315.5
ENST00000454402.7
ENST00000484086.6
ENST00000420967.5
ENST00000392542.6
ENST00000535092.1
RFC5
replication factor C subunit 5
chr6_-_89315291 0.75 ENST00000402938.4
GABRR2
gamma-aminobutyric acid type A receptor subunit rho2
chr1_+_158999963 0.74 ENST00000566111.5
IFI16
interferon gamma inducible protein 16
chrX_-_53281609 0.73 ENST00000638630.1
ENST00000375365.2
IQSEC2
IQ motif and Sec7 domain ArfGEF 2
chr7_+_121873089 0.72 ENST00000651065.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr2_-_181656974 0.72 ENST00000374969.6
ENST00000339098.9
ENST00000374970.6
CERKL
ceramide kinase like
chr20_-_1393074 0.71 ENST00000614856.2
ENST00000678408.1
ENST00000618612.5
ENST00000439640.5
ENST00000381719.8
ENST00000677533.1
FKBP1A
FKBP prolyl isomerase 1A
chr11_-_790062 0.69 ENST00000330106.5
CEND1
cell cycle exit and neuronal differentiation 1
chr20_-_1393045 0.68 ENST00000400137.9
ENST00000381715.4
FKBP1A
FKBP prolyl isomerase 1A
chr12_+_59689337 0.66 ENST00000261187.8
SLC16A7
solute carrier family 16 member 7
chr17_-_58529303 0.65 ENST00000580844.5
SEPTIN4
septin 4
chr11_+_63369779 0.65 ENST00000279178.4
SLC22A9
solute carrier family 22 member 9
chr17_-_58529344 0.64 ENST00000317268.7
SEPTIN4
septin 4
chrX_-_47659128 0.62 ENST00000333119.7
ENST00000335890.3
UXT
ubiquitously expressed prefoldin like chaperone
chr9_+_124261427 0.61 ENST00000373596.5
ENST00000425237.5
NEK6
NIMA related kinase 6
chrX_-_154409278 0.60 ENST00000369808.7
DNASE1L1
deoxyribonuclease 1 like 1
chr21_-_29939532 0.57 ENST00000327783.8
ENST00000389124.6
ENST00000389125.7
ENST00000399913.5
GRIK1
glutamate ionotropic receptor kainate type subunit 1
chr14_-_106875069 0.57 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr21_-_44230089 0.57 ENST00000643466.1
ICOSLG
inducible T cell costimulator ligand
chr6_+_28267044 0.57 ENST00000316606.10
ZSCAN26
zinc finger and SCAN domain containing 26
chrX_-_47482529 0.55 ENST00000313116.11
ZNF41
zinc finger protein 41
chr12_+_32106762 0.54 ENST00000551848.1
ENST00000652176.1
BICD1
BICD cargo adaptor 1
chr1_-_149813687 0.53 ENST00000331491.2
H3C13
H3 clustered histone 13
chr2_+_115064660 0.53 ENST00000393146.6
DPP10
dipeptidyl peptidase like 10
chr17_+_42998379 0.52 ENST00000253788.12
ENST00000589913.6
RPL27
ribosomal protein L27
chr19_-_51108365 0.52 ENST00000421832.3
CTU1
cytosolic thiouridylase subunit 1
chr4_+_168497113 0.50 ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr7_-_91880672 0.49 ENST00000456229.1
ENST00000442961.1
ENST00000406735.6
ENST00000419292.1
ENST00000351870.8
MTERF1
mitochondrial transcription termination factor 1
chr12_+_54280842 0.49 ENST00000678077.1
ENST00000548688.5
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr12_-_43758748 0.48 ENST00000416848.6
ENST00000550784.5
ENST00000547156.1
ENST00000549868.1
ENST00000551923.5
ENST00000344862.10
ENST00000431332.7
PUS7L
pseudouridine synthase 7 like
chr3_+_171843337 0.48 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
TMEM212
transmembrane protein 212
chrY_-_23694579 0.48 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr12_+_54280663 0.48 ENST00000677375.1
ENST00000677210.1
ENST00000677385.1
ENST00000677249.1
ENST00000550482.2
ENST00000679101.1
ENST00000340913.11
ENST00000547708.5
ENST00000551702.5
ENST00000676794.1
ENST00000330752.12
ENST00000678690.1
ENST00000678919.1
ENST00000547276.5
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr11_-_129947576 0.48 ENST00000423662.6
PRDM10
PR/SET domain 10
chr4_-_170003738 0.47 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibril associated protein 3 like
chr7_+_141764097 0.47 ENST00000247879.2
TAS2R3
taste 2 receptor member 3
chr1_-_120051714 0.47 ENST00000579475.7
NOTCH2
notch receptor 2
chrX_-_154409246 0.46 ENST00000369807.6
DNASE1L1
deoxyribonuclease 1 like 1
chr12_+_43758936 0.44 ENST00000440781.6
ENST00000431837.5
ENST00000550616.5
ENST00000613694.5
ENST00000551736.5
IRAK4
interleukin 1 receptor associated kinase 4
chr6_+_125781108 0.44 ENST00000368357.7
NCOA7
nuclear receptor coactivator 7
chr9_-_101738640 0.43 ENST00000361820.6
GRIN3A
glutamate ionotropic receptor NMDA type subunit 3A
chr8_+_22066489 0.43 ENST00000522340.5
ENST00000519333.6
DMTN
dematin actin binding protein
chr22_+_29205877 0.43 ENST00000334018.11
ENST00000429226.5
ENST00000404755.7
ENST00000404820.7
ENST00000430127.1
EMID1
EMI domain containing 1
chr8_-_133258387 0.42 ENST00000676222.1
NDRG1
N-myc downstream regulated 1
chr12_-_75209422 0.42 ENST00000393288.2
ENST00000540018.5
KCNC2
potassium voltage-gated channel subfamily C member 2
chr21_-_45544392 0.42 ENST00000443742.1
ENST00000528477.1
ENST00000567670.5
SLC19A1
solute carrier family 19 member 1
chr1_-_173824322 0.42 ENST00000356198.6
CENPL
centromere protein L
chr1_+_159826860 0.41 ENST00000289707.10
SLAMF8
SLAM family member 8
chr5_-_134174765 0.40 ENST00000520417.1
SKP1
S-phase kinase associated protein 1
chr7_-_30682473 0.40 ENST00000506074.6
CRHR2
corticotropin releasing hormone receptor 2
chr7_+_70766172 0.40 ENST00000644949.1
AUTS2
activator of transcription and developmental regulator AUTS2
chr12_-_7936177 0.40 ENST00000544291.1
ENST00000075120.12
SLC2A3
solute carrier family 2 member 3
chr1_-_70354673 0.39 ENST00000370944.9
ENST00000262346.6
ANKRD13C
ankyrin repeat domain 13C
chr11_+_4903783 0.39 ENST00000641490.1
OR51A7
olfactory receptor family 51 subfamily A member 7
chr12_-_38906269 0.38 ENST00000550863.1
CPNE8
copine 8
chr2_-_27323072 0.38 ENST00000428910.5
ENST00000402722.5
ENST00000380044.6
ENST00000399052.8
ENST00000405076.5
MPV17
mitochondrial inner membrane protein MPV17
chr7_+_121873152 0.38 ENST00000650826.1
ENST00000650728.1
ENST00000393386.7
ENST00000651390.1
ENST00000651842.1
ENST00000650681.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr1_-_173824107 0.36 ENST00000345664.10
ENST00000367710.7
CENPL
centromere protein L
chr5_-_131994225 0.36 ENST00000543479.5
ENST00000431707.5
ACSL6
acyl-CoA synthetase long chain family member 6
chr18_+_13443720 0.35 ENST00000678309.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr11_+_65860394 0.35 ENST00000308110.9
MUS81
MUS81 structure-specific endonuclease subunit
chr1_-_109613070 0.35 ENST00000351050.8
GNAT2
G protein subunit alpha transducin 2
chr9_-_19065084 0.35 ENST00000415524.1
HAUS6
HAUS augmin like complex subunit 6
chr19_-_12597298 0.35 ENST00000440366.1
ZNF490
zinc finger protein 490
chr8_+_84184875 0.35 ENST00000517638.5
ENST00000522647.1
RALYL
RALY RNA binding protein like
chr15_-_65286837 0.34 ENST00000444347.2
ENST00000261888.10
ENST00000649807.2
PARP16
poly(ADP-ribose) polymerase family member 16
chr15_+_67067780 0.34 ENST00000679624.1
SMAD3
SMAD family member 3
chr13_+_27424583 0.34 ENST00000381140.10
GTF3A
general transcription factor IIIA
chr17_-_36534927 0.33 ENST00000610930.4
MYO19
myosin XIX
chr19_+_51571249 0.33 ENST00000262259.7
ENST00000545217.5
ENST00000596504.1
ZNF175
zinc finger protein 175
chr1_+_205256189 0.33 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr1_+_28369705 0.32 ENST00000373839.8
PHACTR4
phosphatase and actin regulator 4
chr3_-_39154558 0.32 ENST00000514182.1
CSRNP1
cysteine and serine rich nuclear protein 1
chr10_+_119892692 0.32 ENST00000369075.8
SEC23IP
SEC23 interacting protein
chr17_+_68515082 0.32 ENST00000588178.5
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr7_-_6826275 0.32 ENST00000316731.13
CCZ1B
CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated
chr20_+_56392607 0.31 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr17_-_3063607 0.31 ENST00000575751.1
OR1D5
olfactory receptor family 1 subfamily D member 5
chr10_-_5977589 0.30 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
IL15RA
interleukin 15 receptor subunit alpha
chr6_+_28267355 0.30 ENST00000614088.1
ENST00000619937.4
ZSCAN26
zinc finger and SCAN domain containing 26
chr1_+_173824956 0.30 ENST00000648458.1
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr17_+_35587239 0.29 ENST00000621914.4
ENST00000621668.4
ENST00000616681.4
ENST00000612035.4
ENST00000610402.5
ENST00000614600.4
ENST00000590432.5
ENST00000612116.5
AP2B1
adaptor related protein complex 2 subunit beta 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0002665 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
1.1 3.4 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.9 2.7 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.8 5.4 GO:2000814 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.6 3.6 GO:0071461 cellular response to redox state(GO:0071461)
0.6 2.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.4 1.2 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.4 34.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.4 1.9 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.4 2.5 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.4 3.9 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.3 2.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.3 3.4 GO:0032264 IMP salvage(GO:0032264)
0.3 2.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.3 2.0 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.3 1.4 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.3 4.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.3 1.3 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 3.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 0.6 GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation(GO:0070145)
0.2 4.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 1.3 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.2 1.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 4.3 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.2 0.7 GO:0006393 termination of mitochondrial transcription(GO:0006393)
0.2 3.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 4.5 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.8 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 0.8 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.1 1.0 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.1 0.5 GO:1900737 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.1 3.4 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 1.6 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 2.9 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.8 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.1 0.7 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.1 1.6 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 0.3 GO:1904226 regulation of UDP-glucose catabolic process(GO:0010904) negative regulation of UDP-glucose catabolic process(GO:0010905) regulation of glycogen synthase activity, transferring glucose-1-phosphate(GO:1904226) negative regulation of glycogen synthase activity, transferring glucose-1-phosphate(GO:1904227)
0.1 0.7 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 2.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.5 GO:0034227 tRNA thio-modification(GO:0034227)
0.1 0.3 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.4 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 1.4 GO:0022417 protein maturation by protein folding(GO:0022417)
0.1 2.0 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 0.8 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 0.4 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.7 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.1 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1 1.5 GO:0048535 lymph node development(GO:0048535)
0.1 0.9 GO:0090168 Golgi reassembly(GO:0090168)
0.1 1.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.4 GO:0010265 SCF complex assembly(GO:0010265)
0.0 2.7 GO:0033198 response to ATP(GO:0033198)
0.0 0.6 GO:0015747 urate transport(GO:0015747)
0.0 0.1 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 2.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916) negative regulation of lung blood pressure(GO:0061767)
0.0 8.6 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 8.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.9 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 2.5 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 1.1 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.4 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:1990523 bone regeneration(GO:1990523)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.4 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.9 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.6 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.0 1.7 GO:0007566 embryo implantation(GO:0007566)
0.0 13.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.8 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.6 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 1.0 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 1.1 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.3 GO:0045453 bone resorption(GO:0045453)
0.0 0.1 GO:0006147 guanine catabolic process(GO:0006147)
0.0 1.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.8 GO:0043304 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 2.0 GO:0006968 cellular defense response(GO:0006968)
0.0 0.5 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.6 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.4 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.6 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 2.9 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.7 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.0 0.3 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.3 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 2.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 2.6 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.5 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 1.0 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 34.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.4 2.5 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.3 6.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.3 1.4 GO:1990425 ryanodine receptor complex(GO:1990425)
0.3 1.0 GO:0000811 GINS complex(GO:0000811)
0.2 1.1 GO:0072534 perineuronal net(GO:0072534)
0.1 1.5 GO:0044194 cytolytic granule(GO:0044194)
0.1 4.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.5 GO:0039714 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.1 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 2.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.3 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.7 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 4.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.4 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 4.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 2.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.2 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 1.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 3.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 10.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.5 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 1.1 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.3 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 2.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 3.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 3.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0031095 platelet dense tubular network(GO:0031094) platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 4.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.1 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 7.0 GO:0016607 nuclear speck(GO:0016607)
0.0 2.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.8 3.1 GO:0019862 IgA binding(GO:0019862)
0.6 3.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 4.5 GO:0015057 thrombin receptor activity(GO:0015057)
0.5 34.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.4 3.9 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.4 1.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.4 2.5 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.4 6.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 3.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 2.8 GO:0004974 leukotriene receptor activity(GO:0004974)
0.3 1.4 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.3 2.7 GO:0043208 glycosphingolipid binding(GO:0043208)
0.3 3.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 4.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 3.5 GO:0046625 sphingolipid binding(GO:0046625)
0.3 0.8 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.3 2.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 1.0 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.2 5.0 GO:0005522 profilin binding(GO:0005522)
0.2 1.3 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.2 1.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 0.6 GO:0050560 aspartate-tRNA ligase activity(GO:0004815) aspartate-tRNA(Asn) ligase activity(GO:0050560)
0.2 1.8 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 0.6 GO:0048257 3'-flap endonuclease activity(GO:0048257)
0.2 0.7 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 2.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 2.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.1 1.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 1.0 GO:0060002 myosin light chain binding(GO:0032027) plus-end directed microfilament motor activity(GO:0060002)
0.1 0.4 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.8 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 0.7 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 4.7 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.4 GO:0008518 reduced folate carrier activity(GO:0008518)
0.1 2.1 GO:0031489 myosin V binding(GO:0031489)
0.1 1.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 2.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.6 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 3.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.9 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 0.5 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 5.4 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 4.6 GO:0003823 antigen binding(GO:0003823)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 3.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 12.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0008892 guanine deaminase activity(GO:0008892)
0.0 4.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 4.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.1 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 1.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 8.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 4.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.4 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 0.9 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 9.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.4 PID ALK2 PATHWAY ALK2 signaling events
0.1 4.5 PID ENDOTHELIN PATHWAY Endothelins
0.1 2.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 7.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 4.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 4.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 5.4 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.2 4.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 4.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.8 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 2.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 1.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 18.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.8 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 4.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.7 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 1.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 3.5 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 2.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 2.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis