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Illumina Body Map 2 (GSE30611)

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Results for NKX2-8

Z-value: 1.13

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Transcription factors associated with NKX2-8

Gene Symbol Gene ID Gene Info
NKX2-8
ENSG00000136327.7 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-8hg38_v1_chr14_-_36582593_36582626-0.009.9e-01Click!

Activity profile of NKX2-8 motif

Sorted Z-values of NKX2-8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_107719657 4.21 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr14_-_106235582 2.72 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr12_+_13196718 2.51 ENST00000431267.2
ENST00000542474.5
ENST00000544053.5
ENST00000256951.10
EMP1
epithelial membrane protein 1
chr14_-_106675544 2.46 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr11_-_19201976 2.34 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
CSRP3
cysteine and glycine rich protein 3
chr14_-_106130061 2.34 ENST00000390602.3
IGHV3-13
immunoglobulin heavy variable 3-13
chr14_-_106593319 2.31 ENST00000390627.3
IGHV3-53
immunoglobulin heavy variable 3-53
chr14_-_106335613 2.27 ENST00000603660.1
IGHV3-30
immunoglobulin heavy variable 3-30
chr12_+_13196777 2.14 ENST00000538364.5
ENST00000396301.7
EMP1
epithelial membrane protein 1
chr2_-_89010515 2.06 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr3_-_52454032 2.03 ENST00000232975.8
TNNC1
troponin C1, slow skeletal and cardiac type
chr14_-_106269133 1.90 ENST00000390609.3
IGHV3-23
immunoglobulin heavy variable 3-23
chr14_-_106538331 1.87 ENST00000390624.3
IGHV3-48
immunoglobulin heavy variable 3-48
chr14_-_105626066 1.83 ENST00000641978.1
ENST00000390543.3
IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr16_-_33845229 1.81 ENST00000569103.2
IGHV3OR16-17
immunoglobulin heavy variable 3/OR16-17 (non-functional)
chr14_-_106579223 1.81 ENST00000390626.2
IGHV5-51
immunoglobulin heavy variable 5-51
chr14_-_106211453 1.79 ENST00000390606.3
IGHV3-20
immunoglobulin heavy variable 3-20
chr14_-_106360320 1.74 ENST00000390615.2
IGHV3-33
immunoglobulin heavy variable 3-33
chr14_-_106811131 1.73 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr5_+_81233314 1.67 ENST00000511719.5
ENST00000437669.5
ENST00000254035.9
ENST00000424301.6
ENST00000505060.1
CKMT2
creatine kinase, mitochondrial 2
chr14_-_106088573 1.60 ENST00000632099.1
IGHV3-64D
immunoglobulin heavy variable 3-64D
chr14_-_106791226 1.55 ENST00000433072.2
IGHV3-72
immunoglobulin heavy variable 3-72
chr10_-_73641450 1.53 ENST00000359322.5
MYOZ1
myozenin 1
chr16_+_32995048 1.52 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr6_+_96563117 1.41 ENST00000450218.6
FHL5
four and a half LIM domains 5
chr14_-_106389858 1.40 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr14_-_106507476 1.32 ENST00000390621.3
IGHV1-45
immunoglobulin heavy variable 1-45
chr15_+_51681483 1.23 ENST00000542355.6
ENST00000220478.8
ENST00000558709.1
SCG3
secretogranin III
chr14_-_106875069 1.22 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr11_-_19202004 1.17 ENST00000648719.1
CSRP3
cysteine and glycine rich protein 3
chr16_+_33827140 1.11 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr14_-_106470788 1.10 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr14_-_105856183 1.07 ENST00000637539.2
ENST00000390559.6
IGHM
immunoglobulin heavy constant mu
chr4_-_175787382 1.05 ENST00000507520.5
GPM6A
glycoprotein M6A
chr6_-_131951364 1.02 ENST00000367976.4
CCN2
cellular communication network factor 2
chr17_-_3691887 1.01 ENST00000552050.5
P2RX5
purinergic receptor P2X 5
chr10_-_15719885 1.00 ENST00000378076.4
ITGA8
integrin subunit alpha 8
chr17_-_44911281 0.91 ENST00000638304.1
ENST00000591880.2
ENST00000586125.2
ENST00000639921.1
GFAP
glial fibrillary acidic protein
chr3_+_111998739 0.90 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr12_-_85836372 0.89 ENST00000361228.5
RASSF9
Ras association domain family member 9
chr17_-_15260752 0.88 ENST00000676329.1
ENST00000675551.1
ENST00000644020.1
ENST00000674947.1
PMP22
peripheral myelin protein 22
chr6_-_32763466 0.87 ENST00000427449.1
ENST00000411527.5
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr5_-_79512794 0.86 ENST00000282260.10
ENST00000508576.5
ENST00000535690.1
HOMER1
homer scaffold protein 1
chrX_+_103774385 0.85 ENST00000494475.5
PLP1
proteolipid protein 1
chr19_+_48469354 0.85 ENST00000452733.7
ENST00000641098.1
CYTH2
cytohesin 2
chr11_-_72642450 0.84 ENST00000444035.6
ENST00000544570.5
PDE2A
phosphodiesterase 2A
chr14_+_63204436 0.76 ENST00000316754.8
RHOJ
ras homolog family member J
chr18_-_58629084 0.74 ENST00000361673.4
ALPK2
alpha kinase 2
chr11_-_72642407 0.74 ENST00000376450.7
PDE2A
phosphodiesterase 2A
chr4_-_46993520 0.73 ENST00000264318.4
GABRA4
gamma-aminobutyric acid type A receptor subunit alpha4
chr18_+_45724127 0.73 ENST00000619403.4
ENST00000587601.5
SLC14A1
solute carrier family 14 member 1 (Kidd blood group)
chr3_+_111998915 0.72 ENST00000478951.6
TAGLN3
transgelin 3
chrX_+_153687918 0.71 ENST00000253122.10
SLC6A8
solute carrier family 6 member 8
chr16_+_172869 0.69 ENST00000251595.11
ENST00000397806.1
ENST00000484216.1
HBA2
hemoglobin subunit alpha 2
chr19_-_4559663 0.69 ENST00000586582.6
SEMA6B
semaphorin 6B
chr22_+_22343185 0.66 ENST00000427632.2
IGLV9-49
immunoglobulin lambda variable 9-49
chr19_-_48993300 0.66 ENST00000323798.8
ENST00000263276.6
GYS1
glycogen synthase 1
chr5_+_141094595 0.66 ENST00000622947.1
ENST00000194155.7
ENST00000624874.1
ENST00000625033.1
PCDHB2
protocadherin beta 2
chr2_-_63588390 0.64 ENST00000272321.12
ENST00000409562.7
WDPCP
WD repeat containing planar cell polarity effector
chr3_-_196515315 0.64 ENST00000397537.3
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr12_-_21657831 0.63 ENST00000450584.5
ENST00000350669.5
ENST00000673047.2
LDHB
lactate dehydrogenase B
chr5_-_176629943 0.63 ENST00000510387.5
ENST00000506696.1
SNCB
synuclein beta
chr14_+_63204859 0.63 ENST00000555125.1
RHOJ
ras homolog family member J
chr21_+_32298849 0.62 ENST00000303645.10
MRAP
melanocortin 2 receptor accessory protein
chr1_+_37807762 0.62 ENST00000373042.5
C1orf122
chromosome 1 open reading frame 122
chr12_-_21657792 0.61 ENST00000396076.5
LDHB
lactate dehydrogenase B
chr16_+_28863812 0.60 ENST00000684370.1
SH2B1
SH2B adaptor protein 1
chr8_+_66493556 0.59 ENST00000305454.8
ENST00000522977.5
ENST00000480005.1
VXN
vexin
chr16_+_176659 0.57 ENST00000320868.9
ENST00000397797.1
HBA1
hemoglobin subunit alpha 1
chr9_+_35909481 0.56 ENST00000443779.3
SPAAR
small regulatory polypeptide of amino acid response
chr17_-_44968263 0.55 ENST00000253407.4
C1QL1
complement C1q like 1
chr21_+_32298945 0.53 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr10_+_17752185 0.53 ENST00000377495.2
TMEM236
transmembrane protein 236
chr16_+_22490337 0.53 ENST00000415833.6
NPIPB5
nuclear pore complex interacting protein family member B5
chr19_+_48469306 0.53 ENST00000460595.5
CYTH2
cytohesin 2
chr19_-_33225844 0.52 ENST00000253188.8
SLC7A10
solute carrier family 7 member 10
chr6_-_56693294 0.52 ENST00000652573.1
DST
dystonin
chr10_-_13972355 0.52 ENST00000264546.10
FRMD4A
FERM domain containing 4A
chr6_+_34466059 0.51 ENST00000620693.4
ENST00000244458.7
ENST00000374043.6
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr8_-_65842051 0.50 ENST00000401827.8
PDE7A
phosphodiesterase 7A
chr3_+_66998297 0.50 ENST00000484414.5
ENST00000460576.5
ENST00000417314.2
KBTBD8
kelch repeat and BTB domain containing 8
chr3_-_8769602 0.48 ENST00000316793.8
ENST00000431493.1
OXTR
oxytocin receptor
chr3_-_180679468 0.47 ENST00000651046.1
ENST00000476379.6
CCDC39
coiled-coil domain containing 39
chr1_-_94541636 0.46 ENST00000370207.4
F3
coagulation factor III, tissue factor
chr2_+_232633551 0.46 ENST00000264059.8
EFHD1
EF-hand domain family member D1
chr11_+_27040725 0.45 ENST00000529202.5
ENST00000263182.8
BBOX1
gamma-butyrobetaine hydroxylase 1
chr19_-_11236497 0.45 ENST00000587656.5
DOCK6
dedicator of cytokinesis 6
chr1_-_109389886 0.43 ENST00000493736.5
SORT1
sortilin 1
chr9_+_35910076 0.43 ENST00000636776.1
SPAAR
small regulatory polypeptide of amino acid response
chr17_+_78214186 0.43 ENST00000301633.8
ENST00000350051.8
ENST00000374948.6
ENST00000590449.1
BIRC5
baculoviral IAP repeat containing 5
chr8_+_66493514 0.42 ENST00000521495.5
VXN
vexin
chr2_-_68319887 0.42 ENST00000409862.1
ENST00000263655.4
CNRIP1
cannabinoid receptor interacting protein 1
chr12_+_50112167 0.41 ENST00000548468.2
ENST00000552815.1
ENST00000550654.1
ENST00000550487.6
ENST00000548985.1
ENSG00000272368.2
COX14
novel transcript, antisense to CERS5
cytochrome c oxidase assembly factor COX14
chr4_+_71062642 0.41 ENST00000649996.1
SLC4A4
solute carrier family 4 member 4
chr2_+_227616998 0.41 ENST00000641801.1
SCYGR4
small cysteine and glycine repeat containing 4
chr17_-_69150062 0.40 ENST00000522787.5
ENST00000521538.5
ABCA10
ATP binding cassette subfamily A member 10
chr12_+_101568350 0.40 ENST00000550514.5
MYBPC1
myosin binding protein C1
chr5_+_157180816 0.39 ENST00000422843.8
ITK
IL2 inducible T cell kinase
chr8_-_61646807 0.39 ENST00000522919.5
ASPH
aspartate beta-hydroxylase
chr1_-_93681829 0.39 ENST00000260502.11
BCAR3
BCAR3 adaptor protein, NSP family member
chr12_+_50112028 0.38 ENST00000317943.6
COX14
cytochrome c oxidase assembly factor COX14
chr2_-_157628852 0.38 ENST00000243349.13
ACVR1C
activin A receptor type 1C
chr22_+_38468036 0.36 ENST00000409006.3
ENST00000216014.9
KDELR3
KDEL endoplasmic reticulum protein retention receptor 3
chrX_-_151974668 0.36 ENST00000370328.4
GABRE
gamma-aminobutyric acid type A receptor subunit epsilon
chr8_-_61646863 0.36 ENST00000519678.5
ASPH
aspartate beta-hydroxylase
chr5_+_77086682 0.35 ENST00000643365.1
ENST00000645183.1
ENST00000645374.1
ENST00000647364.1
ENST00000643848.1
ENST00000643603.1
ENST00000645459.1
ENST00000643269.1
ENST00000503969.6
ENST00000646262.1
ZBED3-AS1
ENSG00000284762.1
ZBED3 antisense RNA 1
phosphodiesterase 8B
chr12_-_10167591 0.35 ENST00000543993.5
ENST00000339968.6
OLR1
oxidized low density lipoprotein receptor 1
chr11_-_5249836 0.35 ENST00000632727.1
ENST00000330597.5
HBG1
hemoglobin subunit gamma 1
chr7_-_100119291 0.34 ENST00000431404.2
TAF6
TATA-box binding protein associated factor 6
chr9_-_14300231 0.34 ENST00000636735.1
NFIB
nuclear factor I B
chr8_+_124539097 0.33 ENST00000606244.2
ENST00000276689.8
ENST00000518008.5
ENST00000517367.1
NDUFB9
NADH:ubiquinone oxidoreductase subunit B9
chr9_-_22009272 0.32 ENST00000380142.5
ENST00000276925.7
CDKN2B
cyclin dependent kinase inhibitor 2B
chrX_+_630789 0.31 ENST00000381575.6
SHOX
short stature homeobox
chr2_+_203936755 0.31 ENST00000316386.11
ENST00000435193.1
ICOS
inducible T cell costimulator
chr11_+_124012997 0.31 ENST00000641521.1
ENST00000641722.1
OR10G4
olfactory receptor family 10 subfamily G member 4
chr4_+_140343443 0.31 ENST00000338517.8
ENST00000394203.7
ENST00000506322.5
SCOC
short coiled-coil protein
chr12_+_7789393 0.30 ENST00000229307.9
NANOG
Nanog homeobox
chr12_-_102197827 0.30 ENST00000329406.5
PMCH
pro-melanin concentrating hormone
chr12_-_75209814 0.29 ENST00000549446.6
KCNC2
potassium voltage-gated channel subfamily C member 2
chr11_-_17476801 0.29 ENST00000644772.1
ENST00000642271.1
ENST00000684571.1
ENST00000646902.1
ENST00000647015.1
ENST00000302539.9
ENST00000389817.8
ENST00000643260.1
ENST00000683136.1
ABCC8
ATP binding cassette subfamily C member 8
chr1_+_75786246 0.29 ENST00000319942.8
RABGGTB
Rab geranylgeranyltransferase subunit beta
chr17_-_33293247 0.28 ENST00000225823.7
ASIC2
acid sensing ion channel subunit 2
chr15_-_56465130 0.28 ENST00000260453.4
MNS1
meiosis specific nuclear structural 1
chr4_-_122456725 0.28 ENST00000226730.5
IL2
interleukin 2
chr17_+_78231310 0.27 ENST00000374946.7
ENST00000421688.5
ENST00000586400.5
TMEM235
transmembrane protein 235
chr12_+_25052732 0.27 ENST00000547044.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr12_+_59664677 0.26 ENST00000548610.5
SLC16A7
solute carrier family 16 member 7
chr19_-_43754901 0.26 ENST00000270066.11
ENST00000601170.5
SMG9
SMG9 nonsense mediated mRNA decay factor
chr12_+_56996151 0.26 ENST00000556850.1
GPR182
G protein-coupled receptor 182
chr17_-_7204502 0.26 ENST00000486626.8
ENST00000648263.1
DLG4
discs large MAGUK scaffold protein 4
chr11_-_40293102 0.25 ENST00000527150.5
LRRC4C
leucine rich repeat containing 4C
chr7_+_142345412 0.25 ENST00000390392.3
TRBV4-2
T cell receptor beta variable 4-2
chr13_-_51845169 0.25 ENST00000627246.3
ENST00000629372.3
TMEM272
transmembrane protein 272
chr2_-_157628727 0.25 ENST00000335450.7
ENST00000348328.9
ACVR1C
activin A receptor type 1C
chr12_-_6493295 0.24 ENST00000540949.1
MRPL51
mitochondrial ribosomal protein L51
chr11_+_75562056 0.24 ENST00000533603.5
SERPINH1
serpin family H member 1
chr6_-_32666648 0.24 ENST00000399082.7
ENST00000399079.7
ENST00000374943.8
ENST00000434651.6
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr17_-_78782257 0.24 ENST00000591455.5
ENST00000446868.7
ENST00000361101.8
ENST00000589296.5
CYTH1
cytohesin 1
chr3_+_173584433 0.24 ENST00000361589.8
NLGN1
neuroligin 1
chr7_-_99466148 0.23 ENST00000394186.3
ENST00000359832.8
ENST00000449683.5
ENST00000292475.8
ENST00000488775.5
ENST00000523680.1
ENST00000430982.1
ENST00000413834.5
ATP5MF
PTCD1
ATP5MF-PTCD1
ATP synthase membrane subunit f
pentatricopeptide repeat domain 1
ATP5MF-PTCD1 readthrough
chr5_-_181261078 0.23 ENST00000611618.1
TRIM52
tripartite motif containing 52
chr14_+_24070837 0.23 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
CPNE6
copine 6
chr5_+_43602648 0.23 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
NNT
nicotinamide nucleotide transhydrogenase
chr8_+_103298836 0.23 ENST00000523739.5
ENST00000358755.5
FZD6
frizzled class receptor 6
chr11_-_132943092 0.23 ENST00000612177.4
ENST00000541867.5
OPCML
opioid binding protein/cell adhesion molecule like
chr12_+_49265071 0.22 ENST00000549183.1
ENST00000639419.1
ENST00000301072.11
TUBA1C
tubulin alpha 1c
chr3_-_179266971 0.22 ENST00000349697.2
ENST00000497599.5
KCNMB3
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr1_+_75786214 0.22 ENST00000370826.3
RABGGTB
Rab geranylgeranyltransferase subunit beta
chrM_+_8489 0.22 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase membrane subunit 6
chr8_+_97887903 0.22 ENST00000520016.5
MATN2
matrilin 2
chr4_+_89894846 0.22 ENST00000264790.7
MMRN1
multimerin 1
chr16_+_28863946 0.21 ENST00000395532.8
SH2B1
SH2B adaptor protein 1
chrX_+_116436599 0.21 ENST00000598581.3
SLC6A14
solute carrier family 6 member 14
chr16_+_58392391 0.20 ENST00000426538.6
ENST00000328514.11
GINS3
GINS complex subunit 3
chr6_-_2744126 0.20 ENST00000647417.1
MYLK4
myosin light chain kinase family member 4
chr22_+_29438583 0.20 ENST00000354373.2
RFPL1
ret finger protein like 1
chr17_-_7208325 0.20 ENST00000650120.1
ENST00000648760.1
DLG4
discs large MAGUK scaffold protein 4
chr1_+_151060357 0.20 ENST00000368921.5
MLLT11
MLLT11 transcription factor 7 cofactor
chr17_+_78214286 0.20 ENST00000592734.5
ENST00000587746.5
BIRC5
baculoviral IAP repeat containing 5
chr12_+_25052512 0.20 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr12_-_10167657 0.20 ENST00000538745.5
OLR1
oxidized low density lipoprotein receptor 1
chr7_+_100219236 0.19 ENST00000317271.2
PVRIG
PVR related immunoglobulin domain containing
chr1_+_32205657 0.19 ENST00000291358.11
ENST00000537469.2
IQCC
IQ motif containing C
chrX_-_48919015 0.19 ENST00000376509.4
PIM2
Pim-2 proto-oncogene, serine/threonine kinase
chr5_+_43603163 0.19 ENST00000660752.1
ENST00000654405.1
ENST00000344920.9
ENST00000657172.1
ENST00000512996.6
ENST00000671668.1
NNT
nicotinamide nucleotide transhydrogenase
chr16_-_75267988 0.19 ENST00000393422.6
BCAR1
BCAR1 scaffold protein, Cas family member
chrX_+_123960859 0.19 ENST00000458700.5
STAG2
stromal antigen 2
chr6_+_125203639 0.18 ENST00000392482.6
TPD52L1
TPD52 like 1
chr22_+_38057200 0.18 ENST00000404072.7
ENST00000424694.5
PICK1
protein interacting with PRKCA 1
chr9_+_93289187 0.18 ENST00000453718.2
WNK2
WNK lysine deficient protein kinase 2
chr4_+_75556048 0.18 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
ODAPH
odontogenesis associated phosphoprotein
chr6_+_147508645 0.17 ENST00000367474.2
SAMD5
sterile alpha motif domain containing 5
chr15_-_28174423 0.17 ENST00000569772.1
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr9_-_14322320 0.17 ENST00000606230.2
NFIB
nuclear factor I B
chr5_+_35852695 0.17 ENST00000508941.5
IL7R
interleukin 7 receptor
chr6_-_31958935 0.16 ENST00000441998.5
ENST00000444811.6
ENST00000375429.8
NELFE
negative elongation factor complex member E
chr3_-_56468346 0.16 ENST00000288221.11
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr15_-_34754989 0.16 ENST00000290374.5
GJD2
gap junction protein delta 2
chr7_-_5959083 0.16 ENST00000539903.5
RSPH10B
radial spoke head 10 homolog B
chr10_-_14554141 0.16 ENST00000496330.5
FAM107B
family with sequence similarity 107 member B
chr2_+_135531460 0.16 ENST00000683871.1
ENST00000409478.5
ENST00000264160.8
ENST00000438014.5
R3HDM1
R3H domain containing 1
chr8_-_140800535 0.16 ENST00000521986.5
ENST00000523539.5
PTK2
protein tyrosine kinase 2
chr10_+_122192442 0.16 ENST00000514539.5
TACC2
transforming acidic coiled-coil containing protein 2
chr2_-_206159509 0.16 ENST00000423725.5
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr11_-_114595750 0.15 ENST00000424261.6
NXPE4
neurexophilin and PC-esterase domain family member 4
chr12_+_25052220 0.15 ENST00000550945.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr12_+_25052634 0.15 ENST00000548766.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chrX_+_41689006 0.15 ENST00000378138.5
ENST00000620846.1
ENST00000649219.1
GPR34
G protein-coupled receptor 34
chr5_-_108382080 0.15 ENST00000542267.7
FBXL17
F-box and leucine rich repeat protein 17
chr1_-_66801276 0.15 ENST00000304526.3
INSL5
insulin like 5
chr12_-_262828 0.15 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
SLC6A13
solute carrier family 6 member 13
chr13_-_46390042 0.15 ENST00000389908.7
RUBCNL
rubicon like autophagy enhancer
chr12_-_6493718 0.15 ENST00000543959.5
ENST00000543164.5
ENST00000543703.1
ENST00000537701.5
MRPL51
mitochondrial ribosomal protein L51
chr2_-_206159410 0.15 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr20_+_43514492 0.14 ENST00000373135.8
ENST00000373134.5
L3MBTL1
L3MBTL histone methyl-lysine binding protein 1
chr12_-_84892120 0.14 ENST00000680379.1
SLC6A15
solute carrier family 6 member 15
chr17_-_81683659 0.14 ENST00000574938.5
ENST00000570561.5
ENST00000573392.5
ENST00000576135.5
ENST00000573715.2
ARL16
ADP ribosylation factor like GTPase 16
chr22_+_31122923 0.14 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chr17_+_64507029 0.14 ENST00000553412.5
CEP95
centrosomal protein 95
chr14_-_24263162 0.13 ENST00000206765.11
ENST00000544573.5
TGM1
transglutaminase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.5 2.0 GO:0002086 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.4 3.5 GO:0035995 detection of muscle stretch(GO:0035995)
0.3 24.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 0.7 GO:1902598 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.2 0.5 GO:0002543 activation of blood coagulation via clotting cascade(GO:0002543)
0.2 1.6 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.2 0.6 GO:1901383 negative regulation of chorionic trophoblast cell proliferation(GO:1901383)
0.2 0.9 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 5.5 GO:0032060 bleb assembly(GO:0032060)
0.2 1.0 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.2 0.5 GO:0034059 response to anoxia(GO:0034059)
0.1 0.6 GO:0016476 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185)
0.1 0.8 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 1.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 1.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.7 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.4 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 9.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.3 GO:1901079 positive regulation of relaxation of muscle(GO:1901079) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.1 0.2 GO:0031104 dendrite regeneration(GO:0031104)
0.1 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.5 GO:0099558 maintenance of synapse structure(GO:0099558)
0.1 0.7 GO:2001023 regulation of response to drug(GO:2001023)
0.1 0.2 GO:0097115 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.1 1.0 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.3 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.3 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.5 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
0.0 0.8 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.9 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.5 GO:0032328 alanine transport(GO:0032328)
0.0 0.4 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 1.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.9 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.9 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.9 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.5 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.3 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.3 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.4 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.8 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 1.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.3 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.5 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.2 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455)
0.0 0.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 2.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 1.0 GO:1905103 integral component of lysosomal membrane(GO:1905103)
0.1 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.0 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.1 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.5 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.6 GO:0044301 climbing fiber(GO:0044301)
0.1 0.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 1.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 3.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.5 GO:0031143 pseudopodium(GO:0031143)
0.0 1.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.0 0.3 GO:0032021 NELF complex(GO:0032021)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.6 GO:0044447 axoneme part(GO:0044447)
0.0 4.1 GO:0030018 Z disc(GO:0030018)
0.0 5.2 GO:0043209 myelin sheath(GO:0043209)
0.0 0.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.3 24.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 5.0 GO:0031433 telethonin binding(GO:0031433)
0.2 0.7 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.2 1.7 GO:0004111 creatine kinase activity(GO:0004111)
0.2 0.6 GO:0038100 nodal binding(GO:0038100)
0.2 1.7 GO:0031013 troponin I binding(GO:0031013)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.8 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 1.6 GO:0030911 TPR domain binding(GO:0030911)
0.1 0.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.4 GO:0030379 neurotensin receptor activity, non-G-protein coupled(GO:0030379)
0.1 0.7 GO:0015265 urea channel activity(GO:0015265)
0.1 0.5 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.4 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 12.8 GO:0003823 antigen binding(GO:0003823)
0.1 0.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.7 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.5 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.9 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.3 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.9 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.5 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 4.3 GO:0051117 ATPase binding(GO:0051117)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.7 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID ARF 3PATHWAY Arf1 pathway
0.0 1.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.9 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport