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Illumina Body Map 2 (GSE30611)

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Results for NR1H4

Z-value: 0.71

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Transcription factors associated with NR1H4

Gene Symbol Gene ID Gene Info
ENSG00000012504.15 nuclear receptor subfamily 1 group H member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1H4hg38_v1_chr12_+_100473708_100473874-0.412.1e-02Click!

Activity profile of NR1H4 motif

Sorted Z-values of NR1H4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_134917872 2.80 ENST00000616356.4
ENST00000371806.4
ficolin 1
chr17_+_45241067 2.25 ENST00000587489.5
formin like 1
chr14_-_24634160 2.24 ENST00000616551.1
ENST00000382542.5
ENST00000216341.9
ENST00000526004.1
ENST00000415355.7
granzyme B
chr20_+_32052192 2.10 ENST00000375862.7
ENST00000629881.2
ENST00000375852.5
ENST00000520553.5
ENST00000518730.5
HCK proto-oncogene, Src family tyrosine kinase
chr11_-_64744102 1.60 ENST00000431822.5
ENST00000394432.8
ENST00000377486.7
RAS guanyl releasing protein 2
chr5_+_134114673 1.59 ENST00000342854.10
ENST00000395029.5
transcription factor 7
chr3_+_111542178 1.58 ENST00000283285.10
ENST00000352690.9
CD96 molecule
chr19_+_7677082 1.57 ENST00000597445.1
mast cell expressed membrane protein 1
chr19_+_1071194 1.56 ENST00000543365.5
Rho GTPase activating protein 45
chr14_-_24634266 1.56 ENST00000382540.5
granzyme B
chr3_+_111542134 1.49 ENST00000438817.6
CD96 molecule
chr17_-_75844334 1.42 ENST00000592386.5
ENST00000412096.6
ENST00000586147.1
ENST00000207549.9
unc-13 homolog D
chr19_+_19385815 1.35 ENST00000494516.6
ENST00000360315.7
GATA zinc finger domain containing 2A
chr19_+_19385919 1.24 ENST00000417582.6
GATA zinc finger domain containing 2A
chr18_-_69956924 1.23 ENST00000581982.5
ENST00000280200.8
CD226 molecule
chr2_-_181680490 1.22 ENST00000684145.1
ENST00000295108.4
ENST00000684079.1
ENST00000683430.1
ceramide kinase like
neuronal differentiation 1
chr14_+_22123318 1.21 ENST00000390455.3
T cell receptor alpha variable 26-1
chrX_-_50200358 1.17 ENST00000437370.2
ENST00000376064.7
ENST00000448865.5
A-kinase anchoring protein 4
chr1_+_27879638 1.15 ENST00000456990.1
thymocyte selection associated family member 2
chr6_-_32192630 1.15 ENST00000375040.8
G protein signaling modulator 3
chr8_-_130016536 1.12 ENST00000519020.5
CYFIP related Rac1 interactor B
chr8_-_130016414 1.07 ENST00000401979.6
ENST00000517654.5
ENST00000522361.1
ENST00000518167.5
CYFIP related Rac1 interactor B
chr17_-_75844533 1.03 ENST00000586108.1
unc-13 homolog D
chr19_-_42132465 1.01 ENST00000529067.5
ENST00000529952.5
ENST00000342301.8
ENST00000389341.9
POU class 2 homeobox 2
chr8_-_130016622 1.01 ENST00000518283.5
ENST00000519110.5
CYFIP related Rac1 interactor B
chr17_-_28711660 1.00 ENST00000439862.7
ENST00000581289.1
ENST00000301039.6
ENST00000682792.1
protein interacting with cyclin A1
chr19_-_42132391 0.99 ENST00000528894.8
ENST00000560804.6
ENST00000560558.5
ENST00000560398.5
ENST00000526816.6
ENST00000625670.2
POU class 2 homeobox 2
chr3_-_57079287 0.99 ENST00000338458.8
ENST00000468727.5
Rho guanine nucleotide exchange factor 3
chr14_+_21846534 0.96 ENST00000390434.3
T cell receptor alpha variable 8-2
chr2_+_191678967 0.95 ENST00000435931.1
nucleic acid binding protein 1
chr17_-_75843708 0.89 ENST00000590762.5
unc-13 homolog D
chr2_+_191678152 0.89 ENST00000409510.5
nucleic acid binding protein 1
chr2_+_191678122 0.88 ENST00000425611.9
ENST00000410026.7
nucleic acid binding protein 1
chr19_+_53869439 0.88 ENST00000391768.2
myeloid associated differentiation marker
chr1_+_178513103 0.85 ENST00000319416.7
ENST00000367643.7
ENST00000367642.3
ENST00000367641.7
ENST00000367639.1
testis expressed 35
chr19_+_53869623 0.85 ENST00000414489.1
myeloid associated differentiation marker
chr19_+_53869384 0.85 ENST00000391769.2
myeloid associated differentiation marker
chr2_+_157257687 0.84 ENST00000259056.5
polypeptide N-acetylgalactosaminyltransferase 5
chr8_-_56446572 0.81 ENST00000518974.5
ENST00000451791.7
ENST00000523051.5
ENST00000518770.1
proenkephalin
chr1_+_28914515 0.80 ENST00000644600.1
ENST00000643173.1
ENST00000648181.1
ENST00000650265.1
ENST00000644780.1
ENST00000343067.9
ENST00000643604.1
ENST00000373797.2
erythrocyte membrane protein band 4.1
chrX_-_119693150 0.80 ENST00000394610.7
septin 6
chr1_+_26543106 0.79 ENST00000530003.5
ribosomal protein S6 kinase A1
chr6_-_49713521 0.75 ENST00000339139.5
cysteine rich secretory protein 2
chr12_+_6789508 0.75 ENST00000011653.9
ENST00000541982.5
ENST00000539492.1
CD4 molecule
chr18_-_69956670 0.75 ENST00000583955.5
CD226 molecule
chr16_+_30664334 0.74 ENST00000287468.5
fibrosin
chr1_+_12063357 0.72 ENST00000417814.3
TNF receptor superfamily member 8
chr3_-_50345665 0.70 ENST00000442887.1
ENST00000231749.8
ENST00000360165.7
zinc finger MYND-type containing 10
chr13_+_30932638 0.70 ENST00000380473.8
testis expressed 26
chr7_+_2631978 0.69 ENST00000258796.12
tweety family member 3
chr12_+_56118241 0.69 ENST00000551790.5
ENST00000552345.1
ENST00000257940.7
ENST00000551880.1
extended synaptotagmin 1
zinc finger CCCH-type containing 10
chr17_-_64130125 0.68 ENST00000680433.1
ENST00000433197.4
endoplasmic reticulum to nucleus signaling 1
chr3_-_52231190 0.68 ENST00000494383.1
novel twinfilin, actin-binding protein, homolog 2 (Drosophila) (TWF2) and toll-like receptor 9 (TLR9) protein
chr1_+_28914597 0.66 ENST00000349460.9
erythrocyte membrane protein band 4.1
chr18_-_69957176 0.65 ENST00000580335.1
CD226 molecule
chr4_-_77819615 0.64 ENST00000512485.6
CCR4-NOT transcription complex subunit 6 like
chr15_+_89243945 0.64 ENST00000674831.1
ENST00000300027.12
ENST00000567891.5
ENST00000310775.12
ENST00000676003.1
ENST00000564920.5
ENST00000565255.5
ENST00000567996.5
ENST00000563250.5
FA complementation group I
chr1_+_12063285 0.63 ENST00000263932.7
TNF receptor superfamily member 8
chr17_-_10036741 0.62 ENST00000585266.5
growth arrest specific 7
chr17_-_45490696 0.61 ENST00000430334.8
ENST00000584420.1
ENST00000589780.5
pleckstrin homology and RUN domain containing M1
chr5_+_80319997 0.61 ENST00000296739.6
spermatogenic leucine zipper 1
chrX_+_107206632 0.58 ENST00000535523.5
ENST00000673764.1
dynein axonemal assembly factor 6
chr19_+_589873 0.56 ENST00000251287.3
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
chr19_+_10452891 0.55 ENST00000344979.7
phosphodiesterase 4A
chrX_+_107206605 0.54 ENST00000372453.8
dynein axonemal assembly factor 6
chr19_+_1205761 0.51 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr17_-_10036537 0.51 ENST00000584146.6
growth arrest specific 7
chr19_+_11435332 0.51 ENST00000591946.5
protein kinase C substrate 80K-H
chr11_-_65857007 0.50 ENST00000527344.5
cofilin 1
chr21_-_15002364 0.50 ENST00000411932.1
nuclear receptor interacting protein 1
chr2_-_218568291 0.49 ENST00000418019.5
ENST00000454775.5
ENST00000338465.5
ENST00000415516.5
ENST00000258399.8
ubiquitin specific peptidase 37
chr7_-_72337601 0.49 ENST00000446128.1
calneuron 1
chr19_-_48746797 0.49 ENST00000602105.1
ENST00000332955.7
izumo sperm-egg fusion 1
chr2_+_218568558 0.49 ENST00000627282.2
ENST00000542068.5
CCR4-NOT transcription complex subunit 9
chr1_+_205257180 0.48 ENST00000330675.12
transmembrane and coiled-coil domain family 2
chr14_+_76761453 0.48 ENST00000167106.9
vasohibin 1
chr8_-_100309368 0.47 ENST00000523167.1
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr1_-_225428813 0.47 ENST00000338179.6
ENST00000425080.1
lamin B receptor
chr19_+_11435619 0.47 ENST00000589126.5
ENST00000588269.1
ENST00000587509.5
ENST00000591462.6
ENST00000592741.5
ENST00000677123.1
ENST00000593101.5
ENST00000587327.5
protein kinase C substrate 80K-H
chr20_+_63738270 0.46 ENST00000467211.1
novel transcript, LIME1-SLC2A4RG readthrough
chr22_+_29307005 0.46 ENST00000406549.7
ENST00000610653.4
ENST00000621062.4
ENST00000611648.2
ENST00000618518.3
growth arrest specific 2 like 1
chr2_+_218568809 0.46 ENST00000273064.11
CCR4-NOT transcription complex subunit 9
chr1_-_109041986 0.45 ENST00000400794.7
ENST00000528747.1
ENST00000361054.7
WD repeat domain 47
chr22_+_30694851 0.44 ENST00000332585.11
oxysterol binding protein 2
chr17_-_75261586 0.44 ENST00000580799.2
ENST00000538886.5
ENST00000537686.6
golgi associated, gamma adaptin ear containing, ARF binding protein 3
chr3_-_49120668 0.43 ENST00000465902.1
ubiquitin specific peptidase 19
chr17_-_10036618 0.43 ENST00000580043.1
growth arrest specific 7
chr11_-_65856944 0.43 ENST00000524553.5
cofilin 1
chr17_-_3691748 0.43 ENST00000552723.1
purinergic receptor P2X 5
chr22_+_30694886 0.42 ENST00000446658.6
oxysterol binding protein 2
chr19_+_11436044 0.42 ENST00000589838.5
protein kinase C substrate 80K-H
chr22_+_44677077 0.42 ENST00000403581.5
proline rich 5
chr3_-_15333152 0.42 ENST00000426925.5
SH3 domain binding protein 5
chr1_+_36224410 0.42 ENST00000469141.6
ENST00000648638.1
ENST00000354618.10
thyroid hormone receptor associated protein 3
chr7_-_151024423 0.41 ENST00000469530.4
ENST00000639579.1
autophagy related 9B
chr2_-_74553049 0.41 ENST00000409549.5
lysyl oxidase like 3
chr5_-_177996242 0.41 ENST00000308304.2
PROP paired-like homeobox 1
chr3_-_194398354 0.41 ENST00000401815.1
glycoprotein V platelet
chr17_-_4949037 0.41 ENST00000572383.1
profilin 1
chr9_+_113580912 0.40 ENST00000471324.6
regulator of G protein signaling 3
chr17_-_61863327 0.40 ENST00000584322.2
ENST00000682369.1
ENST00000683039.1
ENST00000683381.1
BRCA1 interacting protein C-terminal helicase 1
chr5_+_150190035 0.40 ENST00000230671.7
ENST00000524041.1
solute carrier family 6 member 7
chr12_-_57742120 0.40 ENST00000257897.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr9_-_114682061 0.39 ENST00000612244.5
testis expressed 48
chr1_+_26545833 0.39 ENST00000531382.5
ribosomal protein S6 kinase A1
chr1_-_109042093 0.39 ENST00000369962.8
ENST00000357672.7
ENST00000531337.1
ENST00000529074.1
ENST00000369965.8
WD repeat domain 47
chr22_+_44677044 0.39 ENST00000006251.11
proline rich 5
chr6_-_33580229 0.39 ENST00000374467.4
ENST00000442998.6
ENST00000360661.9
BCL2 antagonist/killer 1
chrX_+_118727575 0.38 ENST00000371642.1
ENST00000371666.8
interleukin 13 receptor subunit alpha 1
chr2_+_218568865 0.38 ENST00000295701.9
CCR4-NOT transcription complex subunit 9
chr7_+_2632029 0.37 ENST00000407643.5
tweety family member 3
chr19_+_11435272 0.37 ENST00000676823.1
protein kinase C substrate 80K-H
chr5_-_16508951 0.37 ENST00000682628.1
reticulophagy regulator 1
chr6_+_44158807 0.36 ENST00000532171.5
ENST00000398776.2
calpain 11
chr19_-_633500 0.36 ENST00000588649.7
RNA polymerase mitochondrial
chr17_-_1179940 0.36 ENST00000302538.10
ABR activator of RhoGEF and GTPase
chr9_+_35042213 0.36 ENST00000378745.3
ENST00000312292.6
chromosome 9 open reading frame 131
chr17_+_47209035 0.35 ENST00000572316.5
ENST00000354968.5
ENST00000576874.5
ENST00000536623.6
myosin light chain 4
chr17_-_81870974 0.35 ENST00000541078.6
Rho GDP dissociation inhibitor alpha
chr9_-_71911183 0.35 ENST00000333421.7
abhydrolase domain containing 17B, depalmitoylase
chr19_+_40365959 0.35 ENST00000359274.5
phospholipase D family member 3
chr8_-_115492221 0.34 ENST00000518018.1
transcriptional repressor GATA binding 1
chr2_-_213150236 0.33 ENST00000442445.1
ENST00000342002.6
IKAROS family zinc finger 2
chr11_-_65857543 0.33 ENST00000534784.1
cofilin 1
chr19_-_3063101 0.33 ENST00000221561.12
TLE family member 5, transcriptional modulator
chr19_-_18274411 0.33 ENST00000595654.6
ENST00000593659.5
ENST00000599528.1
ENST00000392413.5
ENST00000608950.1
ENST00000600328.7
ENST00000600359.7
ENST00000612316.4
IQ motif containing N
chr22_+_44676808 0.32 ENST00000624862.3
proline rich 5
chr19_-_18542971 0.32 ENST00000596558.6
FKBP prolyl isomerase 8
chr2_-_85410336 0.32 ENST00000263867.9
ENST00000409921.5
capping actin protein, gelsolin like
chr2_+_237692290 0.31 ENST00000420665.5
ENST00000392000.4
LRR binding FLII interacting protein 1
chr19_-_11578937 0.31 ENST00000592659.1
ENST00000592828.6
ENST00000218758.9
ENST00000412435.6
acid phosphatase 5, tartrate resistant
chr3_-_197749688 0.30 ENST00000273582.9
rubicon autophagy regulator
chr17_-_29294141 0.30 ENST00000225388.9
nuclear FMR1 interacting protein 2
chr18_+_56651661 0.30 ENST00000593058.1
WD repeat domain 7
chr16_+_58501468 0.30 ENST00000566656.5
ENST00000566618.5
NDRG family member 4
chr5_+_68280281 0.30 ENST00000522084.5
phosphoinositide-3-kinase regulatory subunit 1
chr17_-_8162932 0.29 ENST00000488857.5
ENST00000316509.11
ENST00000481878.1
ENST00000498285.1
vesicle associated membrane protein 2
novel protein
chr9_-_114682172 0.29 ENST00000436752.3
testis expressed 48
chr18_+_56651335 0.29 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WD repeat domain 7
chr17_-_61863452 0.29 ENST00000683672.1
ENST00000682989.1
ENST00000682453.1
ENST00000259008.7
ENST00000577913.2
BRCA1 interacting protein C-terminal helicase 1
chr17_-_63931354 0.29 ENST00000647774.1
novel protein
chr22_-_43171744 0.28 ENST00000494035.1
tubulin tyrosine ligase like 12
chr5_-_16508858 0.28 ENST00000684456.1
reticulophagy regulator 1
chr1_+_25272527 0.28 ENST00000342055.9
ENST00000357542.8
ENST00000417538.6
ENST00000423810.6
ENST00000568195.5
Rh blood group D antigen
chr1_+_21440113 0.27 ENST00000454000.6
ENST00000318249.10
ENST00000342104.9
NBPF member 3
chr1_+_75134382 0.27 ENST00000356261.4
LIM homeobox 8
chr22_+_29767351 0.27 ENST00000330029.6
ENST00000401406.3
ubiquinol-cytochrome c reductase, complex III subunit X
chr1_+_156054761 0.26 ENST00000368305.9
ENST00000368304.9
ENST00000368302.3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr6_-_24719146 0.26 ENST00000378119.9
chromosome 6 open reading frame 62
chr15_-_73368951 0.26 ENST00000261917.4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
chr1_-_50023875 0.26 ENST00000371836.1
ENST00000371838.5
ATP/GTP binding protein like 4
chr11_-_62612725 0.26 ENST00000419857.1
ENST00000394773.7
EMAP like 3
chr1_+_154321076 0.26 ENST00000324978.8
aquaporin 10
chr5_+_139293939 0.26 ENST00000508689.1
ENST00000514528.5
matrin 3
chrX_+_7219431 0.26 ENST00000674499.1
ENST00000217961.5
steroid sulfatase
chr10_-_73874568 0.25 ENST00000322635.7
ENST00000322680.7
ENST00000394762.7
ENST00000680035.1
calcium/calmodulin dependent protein kinase II gamma
chr17_+_74924270 0.25 ENST00000331427.9
otopetrin 2
chr14_+_59920135 0.24 ENST00000570145.1
leucine rich repeat containing 9
chr14_+_104707253 0.24 ENST00000674602.1
inverted formin 2
chr9_+_81943500 0.24 ENST00000445385.3
SPATA31 subfamily D member 3
chr3_+_160399630 0.24 ENST00000465903.5
ENST00000485645.5
ENST00000472991.5
ENST00000467468.5
ENST00000469762.5
ENST00000357388.8
ENST00000489573.5
ENST00000462787.5
ENST00000490207.5
ENST00000485867.5
structural maintenance of chromosomes 4
chr2_-_213150387 0.24 ENST00000433134.5
IKAROS family zinc finger 2
chr11_+_7513768 0.24 ENST00000528947.5
PPFIA binding protein 2
chrX_+_153724847 0.23 ENST00000218104.6
ATP binding cassette subfamily D member 1
chr2_-_181680636 0.23 ENST00000479558.5
ceramide kinase like
chr19_-_11578917 0.23 ENST00000649386.1
acid phosphatase 5, tartrate resistant
chr11_-_58578096 0.23 ENST00000528954.5
ENST00000528489.1
leupaxin
chr5_+_163503075 0.23 ENST00000280969.9
methionine adenosyltransferase 2B
chr14_-_23286038 0.23 ENST00000673724.1
homeobox and leucine zipper encoding
chr19_-_18543556 0.23 ENST00000544835.7
ENST00000608443.6
ENST00000597960.7
FKBP prolyl isomerase 8
chr10_+_103967105 0.23 ENST00000369755.4
ENST00000335753.8
STE20 like kinase
chr5_-_73448769 0.22 ENST00000615637.3
forkhead box D1
chr19_-_42877988 0.22 ENST00000597058.1
pregnancy specific beta-1-glycoprotein 1
chr12_+_56118396 0.22 ENST00000546903.1
zinc finger CCCH-type containing 10
chr2_+_70900546 0.21 ENST00000234392.3
ventral anterior homeobox 2
chr1_+_26234157 0.21 ENST00000640292.2
ENST00000451429.8
ENST00000252992.8
centrosomal protein 85
chr5_-_16508812 0.21 ENST00000683414.1
reticulophagy regulator 1
chr14_-_74426102 0.21 ENST00000554953.1
ENST00000331628.8
synapse differentiation inducing 1 like
chr17_-_2214306 0.21 ENST00000572369.5
SMG6 nonsense mediated mRNA decay factor
chr7_-_105679089 0.20 ENST00000477775.5
ataxin 7 like 1
chr20_+_63865228 0.20 ENST00000611972.4
ENST00000615907.4
ENST00000369927.8
ENST00000346249.9
ENST00000348257.9
ENST00000352482.8
ENST00000351424.8
ENST00000217121.9
ENST00000358548.4
TPD52 like 2
chr8_+_109334317 0.20 ENST00000521662.5
ENST00000520147.5
ENST00000521688.6
ENY2 transcription and export complex 2 subunit
chr9_+_71911468 0.20 ENST00000377031.7
chromosome 9 open reading frame 85
chr19_-_18543483 0.19 ENST00000597547.1
ENST00000222308.8
FKBP prolyl isomerase 8
chr19_+_17309531 0.19 ENST00000359866.9
DET1 and DDB1 associated 1
chr1_-_149936324 0.19 ENST00000369140.7
myotubularin related protein 11
chr1_+_154321107 0.19 ENST00000484864.1
aquaporin 10
chr12_+_57520698 0.18 ENST00000548887.5
methyl-CpG binding domain protein 6
chr10_-_73874502 0.18 ENST00000372765.5
ENST00000351293.7
ENST00000441192.2
ENST00000423381.6
calcium/calmodulin dependent protein kinase II gamma
chr9_-_34381578 0.18 ENST00000379133.7
chromosome 9 open reading frame 24
chr14_+_19875142 0.18 ENST00000641885.1
olfactory receptor family 4 subfamily K member 2
chr17_-_28552549 0.17 ENST00000581945.1
ENST00000444148.1
ENST00000335765.9
ENST00000301032.8
unc-119 lipid binding chaperone
chr16_+_67873036 0.17 ENST00000358933.10
enhancer of mRNA decapping 4
chr14_-_55440616 0.17 ENST00000247219.5
TATA-box binding protein like 2
chr3_+_54123452 0.17 ENST00000620722.4
ENST00000490478.5
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr3_-_37176532 0.17 ENST00000416425.5
LRR binding FLII interacting protein 2
chr1_+_22563460 0.17 ENST00000166244.8
ENST00000374644.8
EPH receptor A8
chr12_-_16277685 0.16 ENST00000344941.3
solute carrier family 15 member 5
chr17_-_39607876 0.16 ENST00000302584.5
neuronal differentiation 2
chr3_-_49191822 0.16 ENST00000432035.2
ENST00000545770.7
chromosome 3 open reading frame 84

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0002432 granuloma formation(GO:0002432)
1.0 3.1 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.9 2.8 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.7 2.0 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.5 1.4 GO:0045556 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
0.4 2.6 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729)
0.4 3.8 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4 1.2 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.4 2.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.3 1.3 GO:2000327 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.3 0.8 GO:0035397 helper T cell enhancement of adaptive immune response(GO:0035397)
0.2 2.1 GO:0002679 respiratory burst involved in defense response(GO:0002679)
0.2 1.6 GO:0048619 embryonic genitalia morphogenesis(GO:0030538) embryonic hindgut morphogenesis(GO:0048619)
0.2 0.6 GO:0036290 protein trans-autophosphorylation(GO:0036290) peptidyl-serine trans-autophosphorylation(GO:1990579)
0.2 1.3 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.2 0.7 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.2 0.5 GO:0001543 ovarian follicle rupture(GO:0001543)
0.2 0.8 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 0.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.4 GO:0002339 B cell selection(GO:0002339)
0.1 1.0 GO:0061709 reticulophagy(GO:0061709)
0.1 0.4 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 1.0 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 2.3 GO:0051014 actin filament severing(GO:0051014)
0.1 0.4 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.5 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.1 GO:0097017 renal protein absorption(GO:0097017)
0.1 0.4 GO:0044805 late nucleophagy(GO:0044805)
0.1 0.4 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.1 0.6 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 1.1 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.8 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 0.2 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 1.1 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.9 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.2 GO:0060466 CD24 biosynthetic process(GO:0035724) activation of meiosis involved in egg activation(GO:0060466) negative regulation of monocyte extravasation(GO:2000438) regulation of CD24 biosynthetic process(GO:2000559) positive regulation of CD24 biosynthetic process(GO:2000560)
0.1 0.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.0 1.9 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:0072268 nephrogenic mesenchyme development(GO:0072076) pattern specification involved in metanephros development(GO:0072268)
0.0 1.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.3 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.1 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.5 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.0 0.4 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.3 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 2.7 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.7 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.2 GO:0060125 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.0 0.9 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 2.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.4 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 1.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.5 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.4 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.2 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.7 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.0 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.3 GO:0060973 cell migration involved in heart development(GO:0060973)
0.0 0.4 GO:0015695 organic cation transport(GO:0015695)
0.0 0.0 GO:2000314 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.4 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.4 2.7 GO:0070876 SOSS complex(GO:0070876)
0.2 0.8 GO:0098855 HCN channel complex(GO:0098855)
0.2 0.6 GO:1990332 Ire1 complex(GO:1990332)
0.2 3.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.3 GO:0032059 bleb(GO:0032059)
0.1 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.5 GO:0036398 TCR signalosome(GO:0036398)
0.1 0.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 1.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 2.6 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.2 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 3.8 GO:0001772 immunological synapse(GO:0001772)
0.0 1.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.8 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 0.9 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0071986 Ragulator complex(GO:0071986)
0.0 3.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.5 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0033691 sialic acid binding(GO:0033691)
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.8 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 2.3 GO:0005522 profilin binding(GO:0005522)
0.1 0.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.5 GO:0046625 sphingolipid binding(GO:0046625)
0.1 1.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.4 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.1 0.3 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.1 0.4 GO:0015254 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.1 0.4 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 1.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 1.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 5.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.6 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.7 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.4 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.0 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 3.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 2.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0051018 protein kinase A binding(GO:0051018)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.2 PID ARF 3PATHWAY Arf1 pathway
0.0 1.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 2.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.6 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 2.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.5 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 1.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.5 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 5.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.4 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins