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Illumina Body Map 2 (GSE30611)
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Results for NR1I2
Z-value: 1.64
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Transcription factors associated with NR1I2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1I2 | hg38_v1_chr3_+_119782094_119782114 | -0.08 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91182652 Show fit | 7.99 |
ENST00000552145.5
ENST00000546745.5 |
decorin |
|
| chr19_-_4518465 Show fit | 7.38 |
ENST00000633942.1
|
perilipin 4 |
|
| chr5_+_79689825 Show fit | 6.07 |
ENST00000446378.3
|
cardiomyopathy associated 5 |
|
| chr8_-_81483226 Show fit | 5.65 |
ENST00000256104.5
|
fatty acid binding protein 4 |
|
| chr20_+_44715360 Show fit | 5.06 |
ENST00000190983.5
|
cellular communication network factor 5 |
|
| chr1_-_229434086 Show fit | 4.83 |
ENST00000366684.7
ENST00000684723.1 ENST00000366683.4 |
actin alpha 1, skeletal muscle |
|
| chr2_+_69013170 Show fit | 4.75 |
ENST00000303714.9
|
ANTXR cell adhesion molecule 1 |
|
| chr16_-_15856994 Show fit | 4.51 |
ENST00000576790.7
ENST00000396324.7 ENST00000300036.6 ENST00000452625.7 |
myosin heavy chain 11 |
|
| chr9_-_127122623 Show fit | 4.47 |
ENST00000373417.1
ENST00000373425.8 |
angiopoietin like 2 |
|
| chr8_+_98944403 Show fit | 4.46 |
ENST00000457907.3
ENST00000523368.5 ENST00000297565.8 ENST00000435298.6 |
odd-skipped related transciption factor 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1I2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 15.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 2.5 | 12.5 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.1 | 12.1 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.0 | 10.3 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.9 | 10.0 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 9.5 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.2 | 9.2 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.2 | 8.9 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.3 | 8.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 7.4 | GO:0072189 | ureter development(GO:0072189) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 15.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 15.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 13.9 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 13.4 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.9 | 11.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 10.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.3 | 10.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 9.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 8.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 21.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 12.2 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 11.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 11.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 8.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 7.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.2 | 6.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 6.0 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.1 | 5.6 | GO:0005504 | fatty acid binding(GO:0005504) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 12.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 12.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 11.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 8.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 7.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 7.5 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 5.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.7 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 12.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.4 | 11.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 10.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 10.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 8.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 4.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 3.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 3.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |