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Illumina Body Map 2 (GSE30611)
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Results for NR4A3
Z-value: 1.37
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Transcription factors associated with NR4A3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A3 | hg38_v1_chr9_+_99821846_99821862 | -0.15 | 4.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.7 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.1 | 9.3 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.9 | 8.0 | GO:0031999 | negative regulation of fatty acid beta-oxidation(GO:0031999) |
| 0.3 | 6.7 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.6 | 6.3 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.5 | 5.7 | GO:0010269 | response to selenium ion(GO:0010269) |
| 0.3 | 5.6 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.2 | 5.1 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 0.2 | 5.0 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.7 | 4.8 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 10.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 9.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 9.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.4 | 8.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.7 | 8.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 7.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 7.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 5.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 5.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 8.4 | GO:0005179 | hormone activity(GO:0005179) |
| 0.7 | 8.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.9 | 7.3 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 7.0 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) |
| 0.0 | 5.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.2 | 4.8 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 1.5 | 4.6 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.0 | 4.4 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 4.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.4 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 5.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 5.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 4.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.7 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 3.5 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 2.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.5 | 10.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.3 | 8.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.1 | 7.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 7.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 7.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 6.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 6.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.5 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 4.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |