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Illumina Body Map 2 (GSE30611)

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Results for ONECUT1

Z-value: 2.39

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Transcription factors associated with ONECUT1

Gene Symbol Gene ID Gene Info
ENSG00000169856.9 one cut homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ONECUT1hg38_v1_chr15_-_52790324_527903520.763.9e-07Click!

Activity profile of ONECUT1 motif

Sorted Z-values of ONECUT1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_159714581 19.52 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
C-reactive protein
chr1_+_56854764 18.04 ENST00000361249.4
complement C8 alpha chain
chr17_-_28370283 17.84 ENST00000226218.9
vitronectin
chr9_-_114078293 16.88 ENST00000265132.8
alpha-1-microglobulin/bikunin precursor
chr1_+_159587817 16.82 ENST00000255040.3
amyloid P component, serum
chr13_-_46105009 16.40 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
carboxypeptidase B2
chr12_+_111034136 14.90 ENST00000261726.11
cut like homeobox 2
chr3_-_171026709 13.57 ENST00000314251.8
solute carrier family 2 member 2
chr3_+_186666003 13.24 ENST00000232003.5
histidine rich glycoprotein
chr3_+_52777580 13.14 ENST00000273283.7
inter-alpha-trypsin inhibitor heavy chain 1
chr19_+_44946043 10.24 ENST00000252490.7
ENST00000591597.5
apolipoprotein C2
chr1_+_207089233 9.82 ENST00000243611.9
ENST00000367076.7
complement component 4 binding protein beta
chr17_+_42900791 9.69 ENST00000592383.5
ENST00000253801.7
ENST00000585489.1
glucose-6-phosphatase catalytic subunit 1
chr17_-_66229380 9.66 ENST00000205948.11
apolipoprotein H
chr16_+_27203480 9.27 ENST00000286096.9
lysine demethylase 8
chrX_+_71215156 9.02 ENST00000374029.2
ENST00000675209.1
ENST00000647424.1
ENST00000675368.1
ENST00000675609.1
ENST00000646835.1
ENST00000447581.2
gap junction protein beta 1
chr10_+_113553039 8.85 ENST00000351270.4
hyaluronan binding protein 2
chr19_+_44946009 8.50 ENST00000592257.5
apolipoprotein C2
chr2_+_234050679 8.49 ENST00000373368.5
ENST00000168148.8
secreted phosphoprotein 2
chr12_-_52903648 8.32 ENST00000546900.1
keratin 8
chr1_+_207089195 8.28 ENST00000452902.6
complement component 4 binding protein beta
chr5_-_177409535 8.25 ENST00000253496.4
coagulation factor XII
chr1_+_207089283 7.48 ENST00000391923.1
complement component 4 binding protein beta
chr12_+_56752449 7.45 ENST00000554643.5
ENST00000556650.5
ENST00000554150.5
ENST00000554155.1
hydroxysteroid 17-beta dehydrogenase 6
chr19_-_58353482 7.33 ENST00000263100.8
alpha-1-B glycoprotein
chr18_-_27990256 6.29 ENST00000675173.1
cadherin 2
chr1_+_196888014 5.99 ENST00000367416.6
ENST00000608469.6
ENST00000251424.8
ENST00000367418.2
complement factor H related 4
chr12_+_56230043 5.91 ENST00000424625.5
ENST00000419753.5
ENST00000454355.7
ENST00000417965.5
ENST00000436633.5
solute carrier family 39 member 5
chr20_-_22585451 5.72 ENST00000377115.4
forkhead box A2
chr2_+_234050732 5.61 ENST00000425558.1
secreted phosphoprotein 2
chr2_+_233691607 5.51 ENST00000373424.5
ENST00000441351.1
UDP glucuronosyltransferase family 1 member A6
chr3_+_119782094 5.51 ENST00000393716.8
nuclear receptor subfamily 1 group I member 2
chr10_+_47322450 5.13 ENST00000581492.3
growth differentiation factor 2
chr12_+_56230652 5.04 ENST00000266980.8
ENST00000437277.1
solute carrier family 39 member 5
chr1_-_151831768 5.00 ENST00000318247.7
RAR related orphan receptor C
chr10_-_92243246 4.66 ENST00000412050.8
ENST00000614585.4
cytoplasmic polyadenylation element binding protein 3
chr5_+_42756811 4.58 ENST00000388827.4
ENST00000361970.10
coiled-coil domain containing 152
chr1_-_154194648 4.54 ENST00000515609.1
tropomyosin 3
chr7_-_122144231 4.51 ENST00000679511.1
ENST00000417368.7
ENST00000473553.5
aminoadipate-semialdehyde synthase
chrX_+_123184153 4.39 ENST00000616590.4
glutamate ionotropic receptor AMPA type subunit 3
chr11_-_19201976 4.34 ENST00000647990.1
ENST00000649235.1
ENST00000265968.9
ENST00000649842.1
cysteine and glycine rich protein 3
chr1_-_151831837 4.31 ENST00000652040.1
RAR related orphan receptor C
chr13_-_113364141 4.21 ENST00000620217.4
ENST00000375430.8
growth hormone regulated TBC protein 1
chr4_-_74099187 4.18 ENST00000508487.3
C-X-C motif chemokine ligand 2
chr18_+_49560684 3.91 ENST00000577628.5
lipase G, endothelial type
chr12_+_21526287 3.76 ENST00000256969.7
spexin hormone
chr3_-_165196689 3.63 ENST00000241274.3
SLIT and NTRK like family member 3
chr13_-_113364085 3.63 ENST00000375431.9
growth hormone regulated TBC protein 1
chr12_-_9115907 3.47 ENST00000318602.12
alpha-2-macroglobulin
chr10_+_68109433 3.42 ENST00000613327.4
ENST00000358913.10
ENST00000373675.3
myopalladin
chr4_+_158806069 3.39 ENST00000512986.5
folliculin interacting protein 2
chrX_+_123184260 3.33 ENST00000620443.2
ENST00000622768.5
ENST00000611689.4
glutamate ionotropic receptor AMPA type subunit 3
chr13_+_29428709 3.33 ENST00000542829.1
microtubule associated scaffold protein 2
chr1_-_197067234 3.32 ENST00000367412.2
coagulation factor XIII B chain
chr22_-_37109703 3.22 ENST00000406856.7
ENST00000676104.1
transmembrane serine protease 6
chr11_-_19202004 3.18 ENST00000648719.1
cysteine and glycine rich protein 3
chr17_-_17582417 3.14 ENST00000395783.5
phosphatidylethanolamine N-methyltransferase
chr11_+_57597563 3.13 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
serpin family G member 1
chr1_-_8015633 3.08 ENST00000467067.1
ERBB receptor feedback inhibitor 1
chr14_+_73591873 3.06 ENST00000326303.5
acyl-CoA thioesterase 4
chr2_-_85561513 3.05 ENST00000430215.7
gamma-glutamyl carboxylase
chr13_+_29428603 3.04 ENST00000380808.6
microtubule associated scaffold protein 2
chr3_+_142596385 3.00 ENST00000457734.7
ENST00000483373.5
ENST00000475296.5
ENST00000495744.5
ENST00000476044.5
ENST00000461644.5
ENST00000464320.5
plastin 1
chr20_+_44355692 2.95 ENST00000316673.8
ENST00000609795.5
ENST00000457232.5
ENST00000609262.5
hepatocyte nuclear factor 4 alpha
chr22_-_37109409 2.82 ENST00000406725.6
transmembrane serine protease 6
chr9_-_98708856 2.64 ENST00000259455.4
gamma-aminobutyric acid type B receptor subunit 2
chr7_+_55019010 2.51 ENST00000344576.7
ENST00000275493.7
ENST00000455089.5
epidermal growth factor receptor
chr1_-_209802149 2.50 ENST00000456314.1
interferon regulatory factor 6
chr14_+_73616844 2.41 ENST00000381139.1
acyl-CoA thioesterase 6
chr10_-_34815257 2.41 ENST00000374789.8
ENST00000374788.8
ENST00000346874.9
ENST00000374794.8
ENST00000350537.9
ENST00000374790.8
ENST00000374776.6
ENST00000374773.6
ENST00000545260.5
ENST00000545693.5
ENST00000340077.9
par-3 family cell polarity regulator
chr7_+_99828010 2.35 ENST00000631161.2
ENST00000354829.7
ENST00000342499.8
ENST00000417625.5
ENST00000415413.5
ENST00000444905.5
ENST00000222382.5
ENST00000312017.9
cytochrome P450 family 3 subfamily A member 43
chrX_+_10156960 2.34 ENST00000380833.9
chloride voltage-gated channel 4
chr4_+_158210444 2.33 ENST00000512481.5
transmembrane protein 144
chrM_-_14669 2.33 ENST00000361681.2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr19_-_4535221 2.23 ENST00000381848.7
ENST00000586133.1
perilipin 5
chr19_-_47512766 2.23 ENST00000598615.5
ENST00000597118.1
NSF attachment protein alpha
chr4_-_17511981 2.22 ENST00000505710.1
quinoid dihydropteridine reductase
chrX_-_132489954 2.20 ENST00000370844.5
muscleblind like splicing regulator 3
chr2_-_199851114 2.20 ENST00000420128.5
ENST00000416668.5
ENST00000622774.2
formiminotransferase cyclodeaminase N-terminal like
chr4_+_109912877 2.19 ENST00000265171.10
ENST00000509793.5
ENST00000652245.1
epidermal growth factor
chr2_+_222671651 2.18 ENST00000446656.4
monoacylglycerol O-acyltransferase 1
chr5_+_139795795 2.13 ENST00000274710.4
pleckstrin and Sec7 domain containing 2
chr1_+_113390495 2.09 ENST00000307546.14
membrane associated guanylate kinase, WW and PDZ domain containing 3
chr9_+_128068172 2.05 ENST00000373068.6
ENST00000373069.10
solute carrier family 25 member 25
chr12_-_118052597 2.03 ENST00000535496.5
WD repeat and SOCS box containing 2
chr7_+_55019032 2.02 ENST00000342916.7
ENST00000454757.6
ENST00000420316.6
epidermal growth factor receptor
chr19_+_2785481 1.99 ENST00000307741.11
ENST00000585338.1
thimet oligopeptidase 1
chr2_-_196592671 1.98 ENST00000260983.8
ENST00000644030.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr10_-_5185104 1.95 ENST00000648824.1
ENST00000650030.1
aldo-keto reductase family 1 member C8, pseudogene
chr18_+_49561013 1.93 ENST00000583083.1
lipase G, endothelial type
chr3_+_159839847 1.92 ENST00000445224.6
schwannomin interacting protein 1
chrM_+_8366 1.92 ENST00000361851.1
mitochondrially encoded ATP synthase membrane subunit 8
chr12_-_10826358 1.85 ENST00000240619.2
taste 2 receptor member 10
chr4_-_174522315 1.83 ENST00000514584.5
15-hydroxyprostaglandin dehydrogenase
chr16_+_7332839 1.82 ENST00000355637.9
RNA binding fox-1 homolog 1
chr1_+_26169891 1.75 ENST00000374266.7
ENST00000270812.6
zinc finger protein 593
chr8_-_18683932 1.75 ENST00000615573.4
pleckstrin and Sec7 domain containing 3
chr2_-_86623807 1.74 ENST00000237455.5
ring finger protein 103
chrM_+_14740 1.72 ENST00000361789.2
mitochondrially encoded cytochrome b
chr11_-_35418966 1.72 ENST00000531628.2
solute carrier family 1 member 2
chr21_-_25735026 1.68 ENST00000400099.5
ENST00000457143.6
ATP synthase peripheral stalk subunit F6
chr11_+_34977778 1.62 ENST00000526309.1
pyruvate dehydrogenase complex component X
chr21_-_25734887 1.62 ENST00000400094.5
ENST00000284971.8
ATP synthase peripheral stalk subunit F6
chr11_+_112025968 1.59 ENST00000680411.1
dihydrolipoamide S-acetyltransferase
chr11_-_30016945 1.59 ENST00000328224.7
potassium voltage-gated channel subfamily A member 4
chr1_-_177970213 1.56 ENST00000464631.6
SEC16 homolog B, endoplasmic reticulum export factor
chr1_+_232805384 1.55 ENST00000418460.4
microtubule associated protein 10
chr19_-_6501766 1.54 ENST00000596291.1
tubulin beta 4A class IVa
chrX_-_33211312 1.51 ENST00000420596.5
ENST00000448370.5
dystrophin
chr15_-_85794902 1.40 ENST00000337975.6
kelch like family member 25
chr1_-_115841116 1.39 ENST00000320238.3
nescient helix-loop-helix 2
chr5_-_61162352 1.38 ENST00000339020.8
ENST00000507416.1
small integral membrane protein 15
chr4_+_25234003 1.35 ENST00000264864.8
phosphatidylinositol 4-kinase type 2 beta
chr12_-_21334858 1.32 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
solute carrier organic anion transporter family member 1A2
chr5_-_152405277 1.31 ENST00000255262.4
neuromedin U receptor 2
chr9_+_125747345 1.30 ENST00000342287.9
ENST00000373489.10
ENST00000373487.8
PBX homeobox 3
chr20_+_21705651 1.30 ENST00000398485.6
ENST00000613128.5
paired box 1
chr1_+_156619406 1.29 ENST00000255039.6
ENST00000456112.1
hyaluronan and proteoglycan link protein 2
chr7_-_6484057 1.28 ENST00000490996.1
ENST00000258739.9
ENST00000436575.5
KDEL endoplasmic reticulum protein retention receptor 2
diacylglycerol lipase beta
chr8_+_119873710 1.28 ENST00000523492.5
ENST00000286234.6
DEP domain containing MTOR interacting protein
chr8_-_27611200 1.28 ENST00000520796.5
ENST00000520491.5
clusterin
chrM_+_8489 1.26 ENST00000361899.2
mitochondrially encoded ATP synthase membrane subunit 6
chr12_-_55966018 1.25 ENST00000548803.5
ENST00000449260.6
ENST00000550447.5
ENST00000547137.5
ENST00000546543.5
ENST00000548747.6
ENST00000550464.5
premelanosome protein
chr12_-_10909562 1.23 ENST00000390677.2
taste 2 receptor member 13
chr4_+_168497113 1.22 ENST00000511948.1
palladin, cytoskeletal associated protein
chr4_+_158210479 1.22 ENST00000504569.5
ENST00000509278.5
ENST00000514558.5
ENST00000503200.5
ENST00000296529.11
transmembrane protein 144
chr3_+_120908072 1.20 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
syntaxin binding protein 5 like
chr10_+_96304392 1.20 ENST00000630152.1
DNA nucleotidylexotransferase
chr10_+_96304425 1.20 ENST00000371174.5
DNA nucleotidylexotransferase
chr9_+_137241277 1.19 ENST00000340384.5
tubulin beta 4B class IVb
chr12_-_95942592 1.18 ENST00000546947.5
ENST00000344280.8
ENST00000546386.1
coiled-coil domain containing 38
chr3_+_32238667 1.17 ENST00000458535.6
ENST00000307526.4
CKLF like MARVEL transmembrane domain containing 8
chr1_-_202710428 1.16 ENST00000367268.5
synaptotagmin 2
chr7_+_90403506 1.16 ENST00000427904.1
claudin 12
chr3_+_58306236 1.12 ENST00000295959.10
ENST00000445193.7
ENST00000466547.1
ENST00000475412.5
ENST00000474660.5
ENST00000477305.5
ENST00000481972.5
ribonuclease P/MRP subunit p14
hydroxyacyl-thioester dehydratase type 2
chr1_+_247948858 1.09 ENST00000623922.1
olfactory receptor family 2 subfamily L member 8
chr12_+_19236880 1.08 ENST00000536974.5
pleckstrin homology domain containing A5
chr2_+_44941695 1.08 ENST00000260653.5
SIX homeobox 3
chr18_-_27185284 1.08 ENST00000580774.2
ENST00000618847.5
carbohydrate sulfotransferase 9
chr21_-_7789509 1.06 ENST00000646133.1
small integral membrane protein 34B
chr11_+_85647958 1.05 ENST00000304511.7
ENST00000528105.5
transmembrane protein 126A
chr7_-_72447061 1.04 ENST00000395276.6
ENST00000431984.5
calneuron 1
chr8_-_27611325 1.04 ENST00000523500.5
clusterin
chr9_-_73038711 1.01 ENST00000446946.1
aldehyde dehydrogenase 1 family member A1
chr11_+_61228377 1.00 ENST00000537932.5
pepsinogen A4
chrX_-_132128020 0.98 ENST00000298542.9
FERM domain containing 7
chr6_+_10694916 0.98 ENST00000379568.4
PAK1 interacting protein 1
chr13_+_110615622 0.98 ENST00000309957.3
ENST00000680505.1
NAD(P)HX dehydratase
chr19_-_13599860 0.96 ENST00000664864.1
calcium voltage-gated channel subunit alpha1 A
chr12_+_70366277 0.95 ENST00000258111.5
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr12_+_101475319 0.93 ENST00000551346.2
Spi-C transcription factor
chrX_-_111410919 0.93 ENST00000496551.2
doublecortin
chr1_+_248095184 0.91 ENST00000358120.3
ENST00000641893.1
olfactory receptor family 2 subfamily L member 13
chr2_-_58241259 0.90 ENST00000481670.2
ENST00000403676.5
ENST00000427708.6
ENST00000403295.7
ENST00000233741.9
ENST00000446381.5
ENST00000417361.1
ENST00000402135.7
ENST00000449070.5
FA complementation group L
chr17_-_17591658 0.90 ENST00000435340.6
ENST00000255389.10
ENST00000395781.6
phosphatidylethanolamine N-methyltransferase
chrX_-_33211462 0.89 ENST00000682071.1
ENST00000684237.1
dystrophin
chr7_+_141764097 0.88 ENST00000247879.2
taste 2 receptor member 3
chr11_-_5986985 0.87 ENST00000332249.4
olfactory receptor family 52 subfamily L member 1
chr3_-_191282383 0.85 ENST00000427544.6
urotensin 2B
chr5_-_20575850 0.84 ENST00000507958.5
cadherin 18
chr7_-_82005790 0.84 ENST00000443883.1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr13_+_110615516 0.82 ENST00000680254.1
ENST00000424185.7
ENST00000679389.1
NAD(P)HX dehydratase
chr6_-_138218491 0.81 ENST00000527246.3
prostate and breast cancer overexpressed 1
chr3_+_101827982 0.81 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKB inhibitor zeta
chr3_-_112974912 0.79 ENST00000440122.6
ENST00000490004.1
CD200 receptor 1
chr11_-_72674394 0.78 ENST00000418754.6
ENST00000334456.10
ENST00000542969.2
phosphodiesterase 2A
chr6_-_154247422 0.77 ENST00000519190.1
interaction protein for cytohesin exchange factors 1
chr5_+_127649018 0.76 ENST00000379445.7
cortexin 3
chr2_-_144518415 0.74 ENST00000409211.5
zinc finger E-box binding homeobox 2
chr9_+_107306459 0.74 ENST00000457811.1
RAD23 homolog B, nucleotide excision repair protein
chr17_+_41712325 0.74 ENST00000329402.4
gastrin
chr1_+_77779618 0.73 ENST00000370791.7
ENST00000443751.3
ENST00000645756.1
ENST00000643390.1
ENST00000642959.1
mitoguardin 1
chr11_-_58423313 0.72 ENST00000302581.2
olfactory receptor family 5 subfamily B member 2
chrX_-_72572794 0.72 ENST00000421523.6
ENST00000648036.1
ENST00000373559.8
ENST00000648139.1
ENST00000650636.1
ENST00000648962.1
ENST00000373560.7
ENST00000373568.7
ENST00000373573.9
ENST00000647654.1
ENST00000647859.1
ENST00000415409.6
ENST00000648298.1
ENST00000649752.1
ENST00000373571.6
ENST00000647980.1
ENST00000650126.1
ENST00000373554.6
ENST00000648870.1
ENST00000373556.8
ENST00000647886.1
ENST00000648452.1
ENST00000647594.1
ENST00000373583.6
ENST00000648922.1
histone deacetylase 8
novel protein
chr10_-_125816596 0.70 ENST00000368786.5
uroporphyrinogen III synthase
chr6_+_29111560 0.69 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr12_-_106084023 0.68 ENST00000553094.1
ENST00000549704.1
NUAK family kinase 1
chr8_-_11475902 0.66 ENST00000648766.1
family with sequence similarity 167 member A
chr15_-_99249523 0.66 ENST00000560235.1
ENST00000394132.7
ENST00000560860.5
ENST00000558078.5
ENST00000560772.5
tetratricopeptide repeat domain 23
chr8_+_32646838 0.64 ENST00000651333.1
ENST00000652592.1
neuregulin 1
chr13_-_52011337 0.64 ENST00000400366.6
ENST00000400370.8
ENST00000634844.1
ENST00000673772.1
ENST00000418097.7
ENST00000242839.10
ENST00000344297.9
ENST00000448424.7
ATPase copper transporting beta
chr4_+_75724569 0.64 ENST00000514213.7
ENST00000264904.8
USO1 vesicle transport factor
chr10_+_117197489 0.62 ENST00000334549.1
potassium two pore domain channel subfamily K member 18
chr2_-_172102893 0.61 ENST00000234198.9
ENST00000466293.2
distal-less homeobox 2
chr7_+_103297425 0.60 ENST00000428154.5
ENST00000249269.9
peptidase, mitochondrial processing subunit beta
chr13_+_31199959 0.60 ENST00000343307.5
beta 3-glucosyltransferase
chr10_+_66926028 0.60 ENST00000361320.5
leucine rich repeat transmembrane neuronal 3
chr12_+_19129779 0.60 ENST00000539256.5
ENST00000299275.10
ENST00000538714.5
pleckstrin homology domain containing A5
chr15_+_30903849 0.59 ENST00000561594.5
ENST00000658773.1
ENST00000657391.1
ENST00000656435.1
FANCD2 and FANCI associated nuclease 1
chr9_+_65700287 0.59 ENST00000489273.1
COBW domain containing 5
chr15_+_74129620 0.59 ENST00000565159.5
ENST00000567206.5
immunoglobulin superfamily containing leucine rich repeat 2
chr12_+_15322529 0.59 ENST00000348962.7
protein tyrosine phosphatase receptor type O
chr3_+_181711915 0.57 ENST00000325404.3
SRY-box transcription factor 2
chr10_-_60572599 0.57 ENST00000503366.5
ankyrin 3
chr3_+_58306505 0.56 ENST00000461393.7
hydroxyacyl-thioester dehydratase type 2
chr10_-_46019498 0.55 ENST00000583565.5
nuclear receptor coactivator 4
chr12_-_54259531 0.55 ENST00000550411.5
ENST00000439541.6
chromobox 5
chr17_+_75543149 0.55 ENST00000580925.1
LLGL scribble cell polarity complex component 2
chr15_-_88546585 0.53 ENST00000649547.1
ENST00000558413.1
ENST00000564406.5
ENST00000268148.13
novel transcript
DET1 partner of COP1 E3 ubiquitin ligase
chr2_-_99254281 0.52 ENST00000409238.5
ENST00000423800.5
lysozyme g2

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 16.8 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
4.7 18.7 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
4.1 16.4 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
3.3 13.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
2.8 25.6 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
2.7 11.0 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
2.7 13.6 GO:0070837 dehydroascorbic acid transport(GO:0070837)
2.1 8.3 GO:0051919 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
1.6 6.6 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.6 4.7 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
1.6 4.7 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
1.5 5.8 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
1.5 5.8 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
1.4 5.7 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
1.3 16.9 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
1.1 9.7 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
1.0 19.5 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
1.0 18.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.9 17.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.9 7.4 GO:0006710 androgen catabolic process(GO:0006710)
0.8 7.5 GO:0035995 detection of muscle stretch(GO:0035995)
0.7 2.2 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.6 5.5 GO:0046618 drug export(GO:0046618)
0.6 3.0 GO:1902896 terminal web assembly(GO:1902896)
0.6 3.0 GO:0019605 butyrate metabolic process(GO:0019605)
0.6 14.9 GO:0007614 short-term memory(GO:0007614)
0.6 6.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.6 5.5 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.5 3.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.5 8.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.5 3.8 GO:1904304 negative regulation of renal sodium excretion(GO:0035814) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.5 11.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.4 4.0 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.4 2.2 GO:0035359 negative regulation of triglyceride catabolic process(GO:0010897) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.4 2.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.4 1.3 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.4 9.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.4 1.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.3 2.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 3.1 GO:0042536 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.3 9.3 GO:0036315 cellular response to sterol(GO:0036315)
0.3 2.3 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 1.3 GO:0007386 compartment pattern specification(GO:0007386)
0.3 1.3 GO:0061056 sclerotome development(GO:0061056)
0.2 2.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 2.9 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.2 6.0 GO:0097264 self proteolysis(GO:0097264)
0.2 1.8 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.2 0.6 GO:0060003 copper ion export(GO:0060003)
0.2 0.8 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 3.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 13.1 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.2 0.7 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.2 3.0 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.7 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.2 5.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.2 0.6 GO:1902868 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 3.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 1.8 GO:2001300 lipoxin metabolic process(GO:2001300)
0.2 0.3 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 0.5 GO:0035038 female pronucleus assembly(GO:0035038)
0.1 2.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 2.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.5 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.8 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 1.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 7.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.8 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 1.7 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 1.0 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 12.4 GO:0046849 bone remodeling(GO:0046849)
0.1 3.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 4.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.6 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 3.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.2 GO:0071529 cementum mineralization(GO:0071529)
0.1 1.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.8 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 1.2 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 2.5 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.1 0.6 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.4 GO:0008356 asymmetric cell division(GO:0008356)
0.1 0.9 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 4.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.7 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.3 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 2.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 4.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 1.7 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.1 0.5 GO:0000270 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.6 GO:0001714 endodermal cell fate specification(GO:0001714)
0.1 0.5 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.6 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 7.8 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.5 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.4 GO:0033198 response to ATP(GO:0033198)
0.0 2.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.2 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 1.5 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.6 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 1.0 GO:0015671 oxygen transport(GO:0015671)
0.0 0.6 GO:0071435 potassium ion export(GO:0071435)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 1.3 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 1.0 GO:0005513 detection of calcium ion(GO:0005513)
0.0 2.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.9 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 1.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:2000580 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 1.8 GO:0046710 GDP metabolic process(GO:0046710)
0.0 1.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 5.4 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.7 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 1.4 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 2.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 1.2 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.3 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.0 1.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.7 GO:0032094 response to food(GO:0032094)
0.0 3.0 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.0 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.0 1.4 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.0 0.9 GO:0001824 blastocyst development(GO:0001824)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 4.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.2 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.5 GO:0021591 ventricular system development(GO:0021591)
0.0 1.3 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.5 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 1.0 GO:0086010 membrane depolarization during action potential(GO:0086010)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.8 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
2.3 18.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
2.0 18.0 GO:0005579 membrane attack complex(GO:0005579)
1.5 4.5 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
1.1 23.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.8 3.2 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.5 2.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.5 3.0 GO:1990357 terminal web(GO:1990357)
0.4 2.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.3 13.2 GO:0036019 endolysosome(GO:0036019)
0.3 4.0 GO:0033269 internode region of axon(GO:0033269)
0.3 9.0 GO:0005922 connexon complex(GO:0005922)
0.3 4.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 1.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 1.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.2 59.2 GO:0072562 blood microparticle(GO:0072562)
0.2 8.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 6.3 GO:0016342 catenin complex(GO:0016342)
0.2 25.6 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 4.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 2.3 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 2.4 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 3.8 GO:0031045 dense core granule(GO:0031045)
0.1 7.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.7 GO:0071942 XPC complex(GO:0071942)
0.1 1.1 GO:0030681 multimeric ribonuclease P complex(GO:0030681)
0.1 0.3 GO:0071817 MMXD complex(GO:0071817)
0.1 5.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.0 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 7.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 14.1 GO:0005903 brush border(GO:0005903)
0.0 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 1.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.4 GO:0000791 euchromatin(GO:0000791)
0.0 0.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 1.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.3 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 2.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 7.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.0 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0044754 autolysosome(GO:0044754)
0.0 0.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 6.4 GO:0030018 Z disc(GO:0030018)
0.0 11.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.0 2.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.2 GO:0005811 lipid particle(GO:0005811)
0.0 35.9 GO:0005615 extracellular space(GO:0005615)
0.0 2.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 7.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 12.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 19.5 GO:0033265 choline binding(GO:0033265)
4.7 28.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
2.7 13.6 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
2.4 16.9 GO:0019862 IgA binding(GO:0019862)
2.1 16.8 GO:0001849 complement component C1q binding(GO:0001849)
1.3 4.0 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.9 4.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.8 1.6 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.7 9.3 GO:0008142 oxysterol binding(GO:0008142)
0.6 18.0 GO:0001848 complement binding(GO:0001848)
0.6 18.0 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.6 3.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.6 2.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.6 2.2 GO:0070404 NADH binding(GO:0070404)
0.5 7.4 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.5 7.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.4 13.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.4 2.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 1.8 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.4 3.5 GO:0019959 interleukin-8 binding(GO:0019959) tumor necrosis factor binding(GO:0043120)
0.4 9.0 GO:0005243 gap junction channel activity(GO:0005243)
0.4 1.3 GO:0005046 KDEL sequence binding(GO:0005046)
0.4 7.5 GO:0031433 telethonin binding(GO:0031433)
0.4 16.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 5.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.4 2.2 GO:0035473 lipase binding(GO:0035473)
0.4 9.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4 1.8 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.3 10.6 GO:0051787 misfolded protein binding(GO:0051787)
0.3 0.9 GO:0070336 flap-structured DNA binding(GO:0070336)
0.3 0.8 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.3 2.2 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.3 4.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 11.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 1.6 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 0.6 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.2 5.5 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.2 6.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 1.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 1.7 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812)
0.2 4.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 0.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.2 4.7 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 1.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2 0.5 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 2.1 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.5 GO:0004102 choline O-acetyltransferase activity(GO:0004102)
0.1 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 4.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 5.5 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 1.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.0 GO:0005497 androgen binding(GO:0005497) benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 2.5 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 16.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.2 GO:0005542 folic acid binding(GO:0005542)
0.1 1.2 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 3.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.3 GO:0070330 aromatase activity(GO:0070330)
0.1 2.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 3.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 8.5 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.8 GO:0030911 TPR domain binding(GO:0030911)
0.1 1.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 9.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 0.3 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 8.3 GO:0097110 scaffold protein binding(GO:0097110)
0.1 2.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 5.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.1 1.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 4.0 GO:1901476 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 1.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.6 GO:0030955 potassium ion binding(GO:0030955)
0.0 12.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 3.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 2.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 2.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 9.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 1.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 10.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 1.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.3 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 4.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.7 GO:0035198 miRNA binding(GO:0035198)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 9.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 2.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 3.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.4 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 4.4 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 0.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.5 17.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 27.0 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 16.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 20.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 63.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 7.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 8.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 7.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 4.4 PID ALK1 PATHWAY ALK1 signaling events
0.1 4.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 5.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 2.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 1.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 3.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.3 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 19.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.1 43.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 22.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 14.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.4 11.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 9.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 11.0 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 3.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2 3.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 5.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 7.7 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 7.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 3.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 8.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.2 6.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 14.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 7.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 15.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 11.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 3.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 4.1 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.1 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 4.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.2 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.4 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 2.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 7.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 4.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 2.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.0 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport