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Illumina Body Map 2 (GSE30611)
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Results for OTX2_CRX
Z-value: 0.85
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Transcription factors associated with OTX2_CRX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| OTX2 | hg38_v1_chr14_-_56810380_56810398 | 0.42 | 1.8e-02 | Click! |
| CRX | hg38_v1_chr19_+_47821907_47821964 | -0.11 | 5.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of OTX2_CRX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.4 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 6.7 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.3 | 6.4 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.1 | 4.1 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.4 | 4.0 | GO:1902363 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.0 | 3.7 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.0 | 3.5 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.3 | 3.2 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.2 | 3.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.6 | 3.1 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 7.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 7.2 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.1 | 4.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.4 | 4.0 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.0 | 3.6 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 3.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 2.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 2.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 2.4 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.4 | 7.9 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.3 | 7.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 7.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 4.8 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 4.0 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 3.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.4 | 3.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.1 | 3.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 3.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 4.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.8 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.6 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 2.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 1.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 6.8 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 4.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 4.0 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 2.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.4 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 2.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.5 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |