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Illumina Body Map 2 (GSE30611)

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Results for OVOL1

Z-value: 0.64

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Transcription factors associated with OVOL1

Gene Symbol Gene ID Gene Info
OVOL1
ENSG00000172818.10 ovo like transcriptional repressor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OVOL1hg38_v1_chr11_+_65787056_65787075-0.144.5e-01Click!

Activity profile of OVOL1 motif

Sorted Z-values of OVOL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_161850597 2.79 ENST00000634335.1
ENST00000635880.1
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr10_-_72088972 2.14 ENST00000317376.8
ENST00000412663.5
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr10_-_72088533 1.98 ENST00000373109.7
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr10_-_72088504 1.77 ENST00000536168.2
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr6_-_83709382 1.75 ENST00000520302.5
ENST00000520213.5
ENST00000439399.6
SNAP91
synaptosome associated protein 91
chr19_-_49442360 1.65 ENST00000600601.5
SLC17A7
solute carrier family 17 member 7
chr5_-_16508788 1.63 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr5_-_16508990 1.60 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr11_+_123430259 1.55 ENST00000533341.3
ENST00000635736.2
GRAMD1B
GRAM domain containing 1B
chr5_+_68239815 1.47 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr5_-_16508858 1.46 ENST00000684456.1
RETREG1
reticulophagy regulator 1
chr5_-_16508812 1.46 ENST00000683414.1
RETREG1
reticulophagy regulator 1
chr5_-_16508951 1.43 ENST00000682628.1
RETREG1
reticulophagy regulator 1
chr18_-_5544250 1.21 ENST00000540638.6
ENST00000342933.7
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr18_-_5543960 1.10 ENST00000400111.8
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr18_-_5543988 1.01 ENST00000341928.7
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr5_+_140882116 0.88 ENST00000289272.3
ENST00000409494.5
ENST00000617769.1
PCDHA13
protocadherin alpha 13
chr1_+_174877430 0.87 ENST00000392064.6
RABGAP1L
RAB GTPase activating protein 1 like
chr2_-_152099155 0.86 ENST00000637309.1
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr2_-_182522556 0.83 ENST00000435564.5
PDE1A
phosphodiesterase 1A
chr2_-_152099023 0.62 ENST00000201943.10
ENST00000427385.6
ENST00000539935.7
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr19_+_37371152 0.58 ENST00000483919.5
ENST00000588911.5
ENST00000587349.1
ZNF527
zinc finger protein 527
chr15_+_75043263 0.42 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr11_-_75306688 0.40 ENST00000532525.1
ARRB1
arrestin beta 1
chr6_-_35688907 0.39 ENST00000539068.5
ENST00000357266.9
FKBP5
FKBP prolyl isomerase 5
chr5_+_141359970 0.38 ENST00000522605.2
ENST00000622527.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr2_-_182522703 0.34 ENST00000410103.1
PDE1A
phosphodiesterase 1A
chr19_+_6772699 0.24 ENST00000602142.6
ENST00000304076.6
ENST00000596764.5
VAV1
vav guanine nucleotide exchange factor 1
chr19_-_51501755 0.18 ENST00000291707.8
SIGLEC12
sialic acid binding Ig like lectin 12
chr4_+_75556048 0.18 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
ODAPH
odontogenesis associated phosphoprotein
chr11_+_71999927 0.14 ENST00000393707.4
IL18BP
interleukin 18 binding protein
chr9_+_122800123 0.13 ENST00000277309.3
OR1K1
olfactory receptor family 1 subfamily K member 1
chr5_-_17492076 0.12 ENST00000600799.3
H3Y2
H3.Y histone 2
chr12_-_76084666 0.11 ENST00000393263.7
ENST00000548044.5
ENST00000547704.5
ENST00000618691.5
ENST00000431879.7
ENST00000549596.5
ENST00000550934.5
ENST00000551600.5
ENST00000547479.5
ENST00000547773.5
ENST00000544816.5
ENST00000542344.5
ENST00000548273.5
NAP1L1
nucleosome assembly protein 1 like 1
chr4_-_67754335 0.09 ENST00000420975.2
ENST00000226413.5
GNRHR
gonadotropin releasing hormone receptor
chr17_-_7242156 0.07 ENST00000571129.5
ENST00000571253.1
ENST00000573928.1
ENST00000302386.10
GABARAP
GABA type A receptor-associated protein
chr20_+_56248732 0.05 ENST00000243911.2
MC3R
melanocortin 3 receptor
chr19_-_45792755 0.03 ENST00000377735.7
ENST00000270223.7
DMWD
DM1 locus, WD repeat containing

Network of associatons between targets according to the STRING database.

First level regulatory network of OVOL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.6 GO:0061709 reticulophagy(GO:0061709)
0.5 1.6 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.3 5.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 3.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 2.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.1 1.6 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 1.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.1 GO:0042309 homoiothermy(GO:0042309)
0.0 1.5 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.6 GO:0060203 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.1 3.3 GO:0033270 paranode region of axon(GO:0033270)
0.1 7.6 GO:0005801 cis-Golgi network(GO:0005801)
0.1 2.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.8 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 5.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 1.6 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0042007 interleukin-18 binding(GO:0042007)
0.0 1.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 3.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions