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Illumina Body Map 2 (GSE30611)

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Results for PAX1_PAX9

Z-value: 0.71

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
ENSG00000125813.14 paired box 1
ENSG00000198807.13 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX1hg38_v1_chr20_+_21705651_21705673-0.459.2e-03Click!
PAX9hg38_v1_chr14_+_36657664_366576770.067.5e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_22895368 3.01 ENST00000390321.2
immunoglobulin lambda constant 1
chr4_+_122826824 2.05 ENST00000608478.1
ENST00000644866.2
fibroblast growth factor 2
chr8_-_23404076 2.02 ENST00000524168.1
ENST00000389131.8
ENST00000523833.2
ENST00000519243.1
lysyl oxidase like 2
chr2_+_118942290 2.00 ENST00000412481.1
macrophage receptor with collagenous structure
chr4_+_122826679 1.98 ENST00000264498.8
fibroblast growth factor 2
chr8_-_23425282 1.63 ENST00000524144.5
lysyl oxidase like 2
chr10_+_71319249 1.37 ENST00000373189.6
ENST00000479577.2
solute carrier family 29 member 3
chr8_-_23425307 1.37 ENST00000520871.1
lysyl oxidase like 2
chr14_-_68794597 1.35 ENST00000336440.3
ZFP36 ring finger protein like 1
chr18_-_50287570 1.17 ENST00000586837.1
ENST00000412036.6
ENST00000589940.5
ENST00000587396.1
ENST00000591474.5
ENST00000285106.11
CXXC finger protein 1
chr10_-_43409160 1.14 ENST00000337970.7
ENST00000682386.1
heterogeneous nuclear ribonucleoprotein F
chr8_-_100952918 1.01 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr2_-_162074182 0.97 ENST00000360534.8
dipeptidyl peptidase 4
chr2_-_162074394 0.95 ENST00000676810.1
dipeptidyl peptidase 4
chr8_-_100953331 0.92 ENST00000353245.7
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr18_-_49492305 0.88 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
ribosomal protein L17
RPL17-C18orf32 readthrough
chr8_-_100952876 0.87 ENST00000437293.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr10_+_30434602 0.81 ENST00000413724.5
mitogen-activated protein kinase kinase kinase 8
chr10_+_30434021 0.79 ENST00000542547.5
mitogen-activated protein kinase kinase kinase 8
chr3_+_133805789 0.73 ENST00000678299.1
SRP receptor subunit beta
chr2_-_162074050 0.72 ENST00000676768.1
dipeptidyl peptidase 4
chr10_+_30434176 0.64 ENST00000263056.6
ENST00000375322.2
mitogen-activated protein kinase kinase kinase 8
chr8_-_120811988 0.64 ENST00000517992.2
syntrophin beta 1
chr4_+_74365136 0.61 ENST00000244869.3
epiregulin
chr18_-_49491586 0.61 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32 readthrough
ribosomal protein L17
chr14_-_91417805 0.60 ENST00000389857.11
ENST00000553403.1
coiled-coil domain containing 88C
chr17_+_39200275 0.58 ENST00000225430.9
ribosomal protein L19
chr6_-_137173644 0.58 ENST00000296980.7
ENST00000349184.8
ENST00000339602.3
interleukin 22 receptor subunit alpha 2
chr17_+_39200302 0.57 ENST00000579374.5
ribosomal protein L19
chr17_+_39200334 0.56 ENST00000579260.5
ENST00000582193.5
ribosomal protein L19
chr10_+_30434116 0.54 ENST00000415139.5
mitogen-activated protein kinase kinase kinase 8
chr17_+_39200507 0.52 ENST00000678573.1
ribosomal protein L19
chr11_-_126268810 0.49 ENST00000332118.11
SRP receptor subunit alpha
chr14_+_64388296 0.39 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr2_-_174847765 0.36 ENST00000443238.6
chimerin 1
chr12_+_57434778 0.33 ENST00000309668.3
inhibin subunit beta C
chr3_+_195720974 0.33 ENST00000447234.7
ENST00000320736.10
mucin 20, cell surface associated
chr9_-_122228845 0.32 ENST00000394319.8
ENST00000340587.7
LIM homeobox 6
chr11_+_61755372 0.32 ENST00000265460.9
myelin regulatory factor
chr3_-_57079287 0.30 ENST00000338458.8
ENST00000468727.5
Rho guanine nucleotide exchange factor 3
chr11_-_126268913 0.28 ENST00000532259.1
SRP receptor subunit alpha
chr22_-_17773976 0.24 ENST00000317361.11
BH3 interacting domain death agonist
chr6_+_132570322 0.24 ENST00000275198.1
trace amine associated receptor 6
chrX_-_154479253 0.23 ENST00000357360.4
L antigen family member 3
chr17_+_78378633 0.23 ENST00000262764.11
ENST00000589689.5
ENST00000592043.5
ENST00000587356.1
phosphatidylglycerophosphate synthase 1
chr17_+_41812974 0.21 ENST00000321562.9
FKBP prolyl isomerase 10
chr17_-_3557798 0.21 ENST00000301365.8
ENST00000572519.1
ENST00000576742.6
transient receptor potential cation channel subfamily V member 3
chr17_-_35487831 0.19 ENST00000260908.12
schlafen family member 12 like
chr2_-_174847250 0.19 ENST00000409089.7
chimerin 1
chr1_+_26432299 0.18 ENST00000427245.6
ENST00000236342.12
ENST00000525682.6
ENST00000526219.5
ENST00000374185.7
ENST00000360009.6
ENST00000533087.5
ENST00000531312.5
ENST00000525165.5
ENST00000525326.5
ENST00000525546.5
ENST00000436153.6
ENST00000530781.5
dehydrodolichyl diphosphate synthase subunit
chr17_-_35487739 0.17 ENST00000628453.3
schlafen family member 12 like
chr12_+_57745017 0.16 ENST00000547992.5
ENST00000552816.5
ENST00000257910.8
ENST00000547472.5
tetraspanin 31
chr12_+_131929219 0.15 ENST00000322060.9
pseudouridine synthase 1
chr7_-_144835981 0.14 ENST00000360057.7
ENST00000378099.7
ENST00000639328.1
thiamin pyrophosphokinase 1
chr2_+_68643579 0.14 ENST00000303786.5
prokineticin receptor 1
chr19_-_38847423 0.13 ENST00000647557.1
heterogeneous nuclear ribonucleoprotein L
chr12_+_131929194 0.12 ENST00000443358.6
pseudouridine synthase 1
chr1_-_1574824 0.11 ENST00000291386.4
SSU72 homolog, RNA polymerase II CTD phosphatase
chr17_+_41812673 0.11 ENST00000585664.5
ENST00000585922.5
ENST00000429461.5
FKBP prolyl isomerase 10
chrX_-_149540900 0.10 ENST00000608355.1
ENST00000651111.1
long intergenic non-protein coding RNA 893
novel protein
chr4_-_170090153 0.10 ENST00000509167.5
ENST00000353187.6
ENST00000507375.5
ENST00000515480.5
aminoadipate aminotransferase
chr7_+_142770960 0.10 ENST00000632805.1
ENST00000633969.1
ENST00000539842.6
serine protease 2
chr6_+_34889228 0.09 ENST00000360359.5
ENST00000649117.1
ENST00000650178.1
ankyrin repeat and sterile alpha motif domain containing 1A
chr3_-_57079253 0.09 ENST00000468466.1
Rho guanine nucleotide exchange factor 3
chr1_+_26432803 0.08 ENST00000430232.5
dehydrodolichyl diphosphate synthase subunit
chr2_+_241809065 0.07 ENST00000415936.5
neuraminidase 4
chr1_+_44674688 0.07 ENST00000418644.5
ENST00000458657.6
ENST00000535358.6
ENST00000441519.5
ENST00000445071.5
armadillo like helical domain containing 1
chr1_-_152115443 0.07 ENST00000614923.1
trichohyalin
chr9_+_33750669 0.04 ENST00000361005.10
ENST00000342836.9
ENST00000429677.8
serine protease 3
chrX_-_132957245 0.04 ENST00000640529.1
heparan sulfate 6-O-sulfotransferase 2
chr6_-_170584581 0.03 ENST00000392090.6
ENST00000542896.5
ENST00000453163.6
ENST00000537445.5
ENST00000541970.6
programmed cell death 2
chr3_+_31532901 0.02 ENST00000295770.4
STT3 oligosaccharyltransferase complex catalytic subunit B
chr3_+_195720867 0.02 ENST00000436408.6
mucin 20, cell surface associated
chr2_-_39187707 0.01 ENST00000451199.5
cyclin dependent kinase like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0042660 positive regulation of cell fate specification(GO:0042660)
1.3 5.0 GO:0018277 protein deamination(GO:0018277)
0.3 1.4 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.3 2.6 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716) psychomotor behavior(GO:0036343)
0.2 0.6 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 2.8 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.1 0.3 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.1 0.3 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.4 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 1.4 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 2.2 GO:0097421 liver regeneration(GO:0097421)
0.0 2.0 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 3.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 2.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.3 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 2.7 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 1.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.5 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 3.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 3.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 5.0 GO:0005604 basement membrane(GO:0005604)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.4 2.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 1.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 1.5 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 4.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.4 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.3 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.1 0.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 2.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.0 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 3.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 4.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 2.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 2.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 4.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)