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Illumina Body Map 2 (GSE30611)
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Results for PAX4
Z-value: 1.48
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Transcription factors associated with PAX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX4 | hg38_v1_chr7_-_127618137_127618145 | -0.12 | 5.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153375591 Show fit | 8.08 |
ENST00000368737.5
|
S100 calcium binding protein A12 |
|
| chr1_+_26317950 Show fit | 7.06 |
ENST00000374213.3
|
CD52 molecule |
|
| chr4_-_83109843 Show fit | 6.73 |
ENST00000411416.6
|
placenta associated 8 |
|
| chr1_+_101236860 Show fit | 5.50 |
ENST00000475821.2
|
sphingosine-1-phosphate receptor 1 |
|
| chr6_+_31586124 Show fit | 5.49 |
ENST00000418507.6
ENST00000376096.5 ENST00000376099.5 ENST00000376110.7 |
leukocyte specific transcript 1 |
|
| chr1_+_101237009 Show fit | 4.73 |
ENST00000305352.7
|
sphingosine-1-phosphate receptor 1 |
|
| chr6_+_31586269 Show fit | 4.57 |
ENST00000438075.7
|
leukocyte specific transcript 1 |
|
| chr2_-_136118142 Show fit | 4.34 |
ENST00000241393.4
|
C-X-C motif chemokine receptor 4 |
|
| chr1_-_24964984 Show fit | 4.13 |
ENST00000338888.3
ENST00000399916.5 |
RUNX family transcription factor 3 |
|
| chr19_+_54593619 Show fit | 4.12 |
ENST00000251372.8
ENST00000453777.1 |
leukocyte immunoglobulin like receptor A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.5 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 1.5 | 11.7 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway(GO:0002774) |
| 0.4 | 10.6 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.8 | 10.4 | GO:2000334 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 10.4 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 2.0 | 10.2 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.5 | 8.9 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.8 | 8.4 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.2 | 8.3 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.2 | 7.1 | GO:0045730 | respiratory burst(GO:0045730) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 13.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 12.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 10.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.5 | 9.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 8.8 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 8.1 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 7.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 6.8 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 6.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 11.7 | GO:0032396 | inhibitory MHC class I receptor activity(GO:0032396) |
| 1.8 | 10.6 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.9 | 10.4 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.5 | 10.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.5 | 9.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.6 | 8.4 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.4 | 8.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.6 | 6.8 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.0 | 6.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 6.1 | GO:0005522 | profilin binding(GO:0005522) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.9 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 11.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 8.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 6.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 5.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 4.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 3.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 11.4 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.4 | 10.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 9.7 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.4 | 8.4 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.3 | 8.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 6.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 5.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 5.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |