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Illumina Body Map 2 (GSE30611)

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Results for PAX8

Z-value: 0.78

Motif logo

Transcription factors associated with PAX8

Gene Symbol Gene ID Gene Info
ENSG00000125618.18 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX8hg38_v1_chr2_-_113241683_113241697-0.067.6e-01Click!

Activity profile of PAX8 motif

Sorted Z-values of PAX8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_51750798 2.06 ENST00000600815.1
formyl peptide receptor 1
chr10_+_133527355 1.70 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
cytochrome P450 family 2 subfamily E member 1
chr1_-_27626229 1.59 ENST00000399173.5
FGR proto-oncogene, Src family tyrosine kinase
chr1_-_27626496 1.56 ENST00000374003.7
FGR proto-oncogene, Src family tyrosine kinase
chr1_-_27626106 1.54 ENST00000457296.5
FGR proto-oncogene, Src family tyrosine kinase
chr1_-_161631152 1.45 ENST00000421702.3
ENST00000650385.1
Fc fragment of IgG receptor IIIb
chr7_+_142352802 1.42 ENST00000634605.1
T cell receptor beta variable 7-2
chr9_-_114074969 1.42 ENST00000466610.6
alpha-1-microglobulin/bikunin precursor
chr3_+_186717348 1.37 ENST00000447445.1
ENST00000287611.8
ENST00000644859.2
kininogen 1
chr6_+_160121809 1.35 ENST00000366963.9
solute carrier family 22 member 1
chr1_-_161631032 1.31 ENST00000534776.1
ENST00000613418.4
ENST00000614870.4
Fc fragment of IgG receptor IIIb
chr11_+_60455839 1.26 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr6_+_160121859 1.23 ENST00000324965.8
ENST00000457470.6
solute carrier family 22 member 1
chr19_-_7702124 1.22 ENST00000597921.6
Fc fragment of IgE receptor II
chr6_-_44265541 1.17 ENST00000619360.6
NFKB inhibitor epsilon
chr10_+_69088096 1.13 ENST00000242465.4
serglycin
chr7_+_142592928 1.11 ENST00000616518.1
T cell receptor beta variable 15
chr14_-_22819721 1.08 ENST00000554517.5
ENST00000285850.11
ENST00000397529.6
ENST00000555702.5
solute carrier family 7 member 7
chr12_-_95996302 1.08 ENST00000261208.8
ENST00000538703.5
ENST00000541929.5
histidine ammonia-lyase
chr19_-_7702139 0.94 ENST00000346664.9
Fc fragment of IgE receptor II
chr7_+_142391884 0.94 ENST00000390363.2
T cell receptor beta variable 9
chr22_-_50085414 0.94 ENST00000311597.10
modulator of VRAC current 1
chr12_-_10420550 0.93 ENST00000381903.2
ENST00000396439.7
killer cell lectin like receptor C3
chr7_+_142720652 0.92 ENST00000390400.2
T cell receptor beta variable 28
chr14_+_94619313 0.88 ENST00000621603.1
serpin family A member 3
chr6_-_24935942 0.87 ENST00000645100.1
ENST00000643898.2
ENST00000613507.4
RHO family interacting cell polarization regulator 2
chr22_-_50085331 0.86 ENST00000395876.6
modulator of VRAC current 1
chr6_+_24126186 0.85 ENST00000378478.5
ENST00000378491.9
ENST00000378477.2
neurensin 1
chr16_-_3256587 0.84 ENST00000536379.5
ENST00000541159.5
ENST00000339854.8
ENST00000219596.6
MEFV innate immuity regulator, pyrin
chr6_+_160702238 0.81 ENST00000366924.6
ENST00000308192.14
ENST00000418964.1
plasminogen
chr14_+_22462932 0.80 ENST00000390477.2
T cell receptor delta constant
chr12_+_124993633 0.79 ENST00000341446.9
ENST00000671775.2
BRI3 binding protein
chr19_+_35448251 0.78 ENST00000599180.3
free fatty acid receptor 2
chr10_+_12349685 0.78 ENST00000378845.5
calcium/calmodulin dependent protein kinase ID
chr1_+_203765168 0.77 ENST00000367217.5
ENST00000442561.7
lymphocyte transmembrane adaptor 1
chr22_-_50085378 0.76 ENST00000442311.1
modulator of VRAC current 1
chr7_-_14974773 0.75 ENST00000437998.1
diacylglycerol kinase beta
chr14_+_58331253 0.74 ENST00000417477.2
AT-rich interaction domain 4A
chr17_+_7558296 0.73 ENST00000438470.5
ENST00000436057.5
TNF superfamily member 13
chr14_+_21978440 0.73 ENST00000390443.3
T cell receptor alpha variable 8-6
chr19_+_41796616 0.72 ENST00000344550.4
CEA cell adhesion molecule 3
chr4_+_36281591 0.72 ENST00000639862.2
ENST00000357504.7
death domain containing 1
chr6_+_41228339 0.71 ENST00000448827.6
ENST00000341495.7
triggering receptor expressed on myeloid cells like 4
chr12_+_75480745 0.70 ENST00000266659.8
GLI pathogenesis related 1
chr2_+_17539964 0.70 ENST00000457525.5
visinin like 1
chr14_-_91244669 0.69 ENST00000650645.1
G protein-coupled receptor 68
chr16_-_3577288 0.68 ENST00000324659.12
NLR family CARD domain containing 3
chr7_-_144835981 0.67 ENST00000360057.7
ENST00000378099.7
ENST00000639328.1
thiamin pyrophosphokinase 1
chr17_+_7558712 0.66 ENST00000338784.9
ENST00000625791.2
TNF superfamily member 13
chr8_+_119067239 0.66 ENST00000332843.3
collectin subfamily member 10
chr4_+_118034480 0.65 ENST00000296499.6
N-deacetylase and N-sulfotransferase 3
chr6_-_32816910 0.65 ENST00000447394.1
ENST00000438763.7
major histocompatibility complex, class II, DO beta
chr9_-_89405926 0.65 ENST00000433650.5
semaphorin 4D
chr12_+_57434778 0.65 ENST00000309668.3
inhibin subunit beta C
chr11_+_60971777 0.64 ENST00000542157.5
ENST00000433107.6
ENST00000352009.9
ENST00000452451.6
CD6 molecule
chr17_+_7558774 0.62 ENST00000396545.4
TNF superfamily member 13
chr14_-_91244508 0.62 ENST00000535815.5
ENST00000529102.1
G protein-coupled receptor 68
chrX_-_153876327 0.62 ENST00000458029.1
L1 cell adhesion molecule
chr1_+_158930778 0.62 ENST00000458222.5
pyrin and HIN domain family member 1
chr8_-_52409743 0.62 ENST00000276480.11
ST18 C2H2C-type zinc finger transcription factor
chr12_+_75480800 0.61 ENST00000456650.7
GLI pathogenesis related 1
chr19_+_51225059 0.61 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chr12_-_57479848 0.59 ENST00000393791.8
ENST00000552249.1
Rho GTPase activating protein 9
chr13_-_25172278 0.59 ENST00000515384.2
ENST00000357816.2
APC membrane recruitment protein 2
chr16_-_3577375 0.59 ENST00000359128.10
NLR family CARD domain containing 3
chr1_-_84690735 0.59 ENST00000422026.1
SSX family member 2 interacting protein
chr6_-_134318097 0.59 ENST00000367858.10
ENST00000533224.1
serum/glucocorticoid regulated kinase 1
chr14_+_20781139 0.58 ENST00000304677.3
ribonuclease A family member k6
chr12_-_110445540 0.58 ENST00000547365.1
actin related protein 2/3 complex subunit 3
chr12_-_10435940 0.58 ENST00000381901.5
ENST00000381902.7
ENST00000539033.1
killer cell lectin like receptor C2
novel protein
chr22_-_43862480 0.57 ENST00000330884.9
sulfotransferase family 4A member 1
chr13_+_30735523 0.57 ENST00000380490.5
arachidonate 5-lipoxygenase activating protein
chr22_+_20774092 0.57 ENST00000215727.10
serpin family D member 1
chr3_+_190388120 0.57 ENST00000456423.2
ENST00000264734.3
claudin 16
chr4_-_69787955 0.55 ENST00000512870.1
sulfotransferase family 1B member 1
chr2_+_190469486 0.54 ENST00000444317.1
major facilitator superfamily domain containing 6
chr1_+_116372647 0.54 ENST00000418797.5
ATPase Na+/K+ transporting subunit alpha 1
chr19_-_15934410 0.54 ENST00000326742.12
cytochrome P450 family 4 subfamily F member 11
chr15_+_89088417 0.51 ENST00000569550.5
ENST00000565066.5
ENST00000565973.5
ENST00000352732.10
abhydrolase domain containing 2, acylglycerol lipase
chr17_+_7558258 0.51 ENST00000483039.5
ENST00000380535.8
ENST00000396542.5
TNF superfamily member 13
chr6_+_167122742 0.51 ENST00000341935.9
ENST00000349984.6
C-C motif chemokine receptor 6
chr1_+_160739239 0.50 ENST00000368043.8
SLAM family member 7
chr2_-_174847525 0.49 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
chimerin 1
chr7_+_95485898 0.49 ENST00000428113.5
ankyrin repeat and SOCS box containing 4
chr11_-_58575846 0.48 ENST00000395074.7
leupaxin
chr22_-_42070778 0.47 ENST00000396398.8
ENST00000403363.5
ENST00000402937.1
alpha-N-acetylgalactosaminidase
chr7_+_150514851 0.47 ENST00000313543.5
GTPase, IMAP family member 7
chr8_-_52409787 0.47 ENST00000517580.5
ST18 C2H2C-type zinc finger transcription factor
chr17_-_63931354 0.46 ENST00000647774.1
novel protein
chr19_+_41797147 0.45 ENST00000596544.1
CEA cell adhesion molecule 3
chr17_+_7558465 0.43 ENST00000349228.8
TNF superfamily member 13
chr2_-_2326210 0.43 ENST00000647755.1
myelin transcription factor 1 like
chr8_+_58411333 0.43 ENST00000399598.7
UBX domain protein 2B
chr6_+_43298326 0.43 ENST00000372574.7
solute carrier family 22 member 7
chr2_-_2326161 0.42 ENST00000649810.1
ENST00000648318.1
myelin transcription factor 1 like
chr14_-_106335613 0.42 ENST00000603660.1
immunoglobulin heavy variable 3-30
chr20_-_46684467 0.42 ENST00000372121.5
solute carrier family 13 member 3
chr1_-_198540674 0.41 ENST00000489986.1
ENST00000367382.6
ATPase H+ transporting V1 subunit G3
chr4_+_68815991 0.40 ENST00000265403.12
ENST00000458688.2
UDP glucuronosyltransferase family 2 member B10
chr1_+_89524819 0.40 ENST00000439853.6
ENST00000330947.7
ENST00000449440.5
ENST00000640258.1
leucine rich repeat containing 8 VRAC subunit B
chr19_+_35351552 0.40 ENST00000246553.3
free fatty acid receptor 1
chr12_-_57016517 0.40 ENST00000441881.5
ENST00000458521.7
tachykinin precursor 3
chr2_-_174847765 0.39 ENST00000443238.6
chimerin 1
chr14_-_106771020 0.39 ENST00000617374.2
immunoglobulin heavy variable 2-70
chr12_-_128823942 0.38 ENST00000266771.10
solute carrier family 15 member 4
chr18_-_27990256 0.38 ENST00000675173.1
cadherin 2
chr7_+_150322639 0.37 ENST00000343855.6
ZBED6 C-terminal like
chr2_+_87748087 0.37 ENST00000359481.9
plasminogen like B2
chr18_+_45825666 0.37 ENST00000389474.8
sialic acid binding Ig like lectin 15
chr1_+_89524871 0.36 ENST00000639264.1
leucine rich repeat containing 8 VRAC subunit B
chr4_+_2798564 0.36 ENST00000504294.5
SH3 domain binding protein 2
chr5_+_140868945 0.35 ENST00000398640.7
protocadherin alpha 11
chr16_-_28506826 0.35 ENST00000356897.1
interleukin 27
chr15_+_23565666 0.34 ENST00000314520.6
ENST00000679144.1
ENST00000564592.2
ENST00000677119.1
ENST00000647595.1
makorin ring finger protein 3
chr1_-_186680411 0.34 ENST00000367468.10
prostaglandin-endoperoxide synthase 2
chr2_-_2326378 0.34 ENST00000647618.1
myelin transcription factor 1 like
chr9_-_96383675 0.33 ENST00000375257.2
ENST00000375259.9
ENST00000253270.13
solute carrier family 35 member D2
chr1_-_173207322 0.33 ENST00000281834.4
TNF superfamily member 4
chr1_-_184037695 0.33 ENST00000361927.9
ENST00000649786.1
collagen beta(1-O)galactosyltransferase 2
chr2_-_37147734 0.32 ENST00000405334.5
eukaryotic translation initiation factor 2 alpha kinase 2
chr11_+_123358416 0.32 ENST00000638157.1
GRAM domain containing 1B
chr1_+_100352451 0.32 ENST00000361544.11
ENST00000370124.8
ENST00000336454.5
cell division cycle 14A
chr20_+_59996335 0.32 ENST00000244049.7
ENST00000350849.10
ENST00000456106.1
cadherin 26
chr9_-_95506601 0.31 ENST00000551630.1
ENST00000548420.1
patched 1
chr7_-_99679987 0.31 ENST00000222982.8
ENST00000439761.3
ENST00000339843.6
cytochrome P450 family 3 subfamily A member 5
chr11_+_17260353 0.31 ENST00000530527.5
nucleobindin 2
chr18_-_60372767 0.31 ENST00000299766.5
melanocortin 4 receptor
chr9_-_95507199 0.30 ENST00000553011.5
ENST00000551845.5
patched 1
chr13_+_24270841 0.30 ENST00000454083.1
spermatogenesis associated 13
chr19_+_18007182 0.30 ENST00000595712.6
arrestin domain containing 2
chr1_-_169764648 0.30 ENST00000454271.1
ENST00000609271.1
novel transcript
selectin E
chr2_+_79025678 0.29 ENST00000393897.6
regenerating family member 3 gamma
chr5_+_90640718 0.29 ENST00000640403.1
adhesion G protein-coupled receptor V1
chr11_+_63974578 0.28 ENST00000314133.4
ENST00000535431.1
cytochrome c oxidase subunit 8A
novel transcript
chr16_-_67453693 0.28 ENST00000564615.5
ATPase H+ transporting V0 subunit d1
chr2_+_79025696 0.28 ENST00000272324.10
regenerating family member 3 gamma
chr21_-_7789509 0.28 ENST00000646133.1
small integral membrane protein 34B
chrX_-_102155790 0.28 ENST00000543160.5
ENST00000333643.4
brain expressed X-linked 5
chr3_-_161372821 0.27 ENST00000617024.1
ENST00000359175.8
serine palmitoyltransferase small subunit B
chr1_+_40450053 0.27 ENST00000484445.5
ENST00000411995.6
ZFP69 zinc finger protein B
chr9_-_21228222 0.27 ENST00000413767.2
interferon alpha 17
chr20_+_4171709 0.27 ENST00000379460.6
spermine oxidase
chr19_+_41350911 0.27 ENST00000539627.5
transmembrane protein 91
chr10_+_102152380 0.27 ENST00000605788.6
ENST00000488254.6
ENST00000461421.5
ENST00000476468.5
ENST00000370007.5
nucleolar and coiled-body phosphoprotein 1
chr9_-_136996555 0.26 ENST00000494426.2
chloride intracellular channel 3
chr22_+_20116099 0.26 ENST00000430524.6
RAN binding protein 1
chr2_+_119544420 0.26 ENST00000413369.8
cilia and flagella associated protein 221
chrX_-_153875847 0.26 ENST00000361699.8
ENST00000361981.7
L1 cell adhesion molecule
chr15_-_29452799 0.25 ENST00000560082.1
family with sequence similarity 189 member A1
chr17_-_75270409 0.25 ENST00000618645.5
MIF4G domain containing
chr17_-_75270999 0.25 ENST00000579194.6
ENST00000580717.5
ENST00000577542.5
ENST00000579612.5
ENST00000245551.9
ENST00000578305.5
MIF4G domain containing
chr1_+_207034366 0.25 ENST00000545806.5
ENST00000618513.4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr21_+_43867215 0.24 ENST00000448287.5
1-acylglycerol-3-phosphate O-acyltransferase 3
chr14_+_21653835 0.24 ENST00000641524.1
olfactory receptor family 4 subfamily E member 2
chr5_-_88877967 0.23 ENST00000508610.5
ENST00000636294.1
myocyte enhancer factor 2C
chr12_-_56741535 0.23 ENST00000647707.1
novel protein
chr4_+_74365136 0.23 ENST00000244869.3
epiregulin
chrX_-_153875979 0.23 ENST00000407935.6
ENST00000439496.5
L1 cell adhesion molecule
chr5_+_55851349 0.23 ENST00000652347.2
interleukin 31 receptor A
chr11_-_129192198 0.23 ENST00000310343.13
Rho GTPase activating protein 32
chr2_-_24328113 0.23 ENST00000622089.4
intersectin 2
chr1_-_248574757 0.22 ENST00000328782.3
olfactory receptor family 2 subfamily T member 34
chr13_-_102759059 0.22 ENST00000322527.4
coiled-coil domain containing 168
chr1_-_58546693 0.22 ENST00000456980.5
ENST00000482274.2
ENST00000453710.1
ENST00000371226.8
ENST00000419242.5
ENST00000426139.5
OMA1 zinc metallopeptidase
chr17_-_75270710 0.22 ENST00000581777.2
MIF4G domain containing
chr17_-_75271223 0.22 ENST00000579297.5
ENST00000580571.5
ENST00000325102.13
MIF4G domain containing
chr2_+_79025709 0.22 ENST00000409471.1
regenerating family member 3 gamma
chr6_+_72212802 0.22 ENST00000401910.7
regulating synaptic membrane exocytosis 1
chr8_-_133256830 0.21 ENST00000674925.1
N-myc downstream regulated 1
chr10_+_102152169 0.21 ENST00000405356.5
nucleolar and coiled-body phosphoprotein 1
chr4_+_37977269 0.21 ENST00000446803.6
TBC1 domain family member 1
chr12_-_54258275 0.21 ENST00000552562.1
chromobox 5
chr5_+_140855882 0.21 ENST00000562220.2
ENST00000307360.6
ENST00000506939.6
protocadherin alpha 10
chr6_+_72212887 0.21 ENST00000523963.5
regulating synaptic membrane exocytosis 1
chr11_-_129192291 0.20 ENST00000682385.1
Rho GTPase activating protein 32
chr6_+_29306626 0.19 ENST00000377160.4
olfactory receptor family 14 subfamily J member 1
chr2_+_172860038 0.19 ENST00000538974.5
ENST00000540783.5
Rap guanine nucleotide exchange factor 4
chrX_-_132094263 0.19 ENST00000370879.5
FERM domain containing 7
chr2_-_127858107 0.19 ENST00000409955.1
ENST00000272645.9
RNA polymerase II subunit D
chr12_-_10169155 0.19 ENST00000539518.5
oxidized low density lipoprotein receptor 1
chr10_-_43397220 0.19 ENST00000477108.5
ENST00000544000.5
heterogeneous nuclear ribonucleoprotein F
chrX_-_152992195 0.19 ENST00000361887.5
ENST00000452693.5
ENST00000439251.3
PNMA family member 5
chr19_-_1513577 0.18 ENST00000585804.2
ADAMTS like 5
chr18_-_55401026 0.18 ENST00000562607.5
transcription factor 4
chr9_+_136979042 0.18 ENST00000446677.2
prostaglandin D2 synthase
chr9_-_132079856 0.18 ENST00000651555.1
ENST00000651950.1
ENST00000357028.6
ENST00000474263.1
ENST00000292035.10
mediator complex subunit 27
chr1_-_74512611 0.18 ENST00000294635.5
leucine rich repeat containing 53
chrX_-_101052054 0.18 ENST00000372939.5
ENST00000372935.5
tRNA methyltransferase 2 homolog B
chr2_+_90209873 0.18 ENST00000468879.1
immunoglobulin kappa variable 1D-43
chr13_-_46020487 0.17 ENST00000464597.2
zinc finger CCCH-type containing 13
chr21_-_34511243 0.17 ENST00000399284.1
potassium voltage-gated channel subfamily E regulatory subunit 1
chr14_-_106154113 0.17 ENST00000390603.2
immunoglobulin heavy variable 3-15
chr2_+_42169332 0.17 ENST00000402711.6
ENST00000318522.10
EMAP like 4
chr1_-_8526025 0.17 ENST00000464972.5
arginine-glutamic acid dipeptide repeats
chr2_+_170180125 0.17 ENST00000484338.6
myosin IIIB
chr17_-_75271205 0.17 ENST00000649805.1
MIF4G domain containing
chr4_+_71339014 0.17 ENST00000340595.4
solute carrier family 4 member 4
chr4_+_71339037 0.16 ENST00000512686.5
solute carrier family 4 member 4
chr5_-_135399863 0.16 ENST00000510038.1
ENST00000304332.8
macroH2A.1 histone
chr9_+_122614738 0.16 ENST00000297913.3
olfactory receptor family 1 subfamily Q member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.4 2.6 GO:0048241 epinephrine transport(GO:0048241)
0.3 1.7 GO:0010193 response to ozone(GO:0010193)
0.3 2.2 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.3 2.2 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.3 0.8 GO:0044278 cell wall disruption in other organism(GO:0044278)
0.3 0.8 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.2 0.6 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.2 0.8 GO:0052047 positive regulation of fibrinolysis(GO:0051919) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 3.0 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.2 0.5 GO:0048290 isotype switching to IgA isotypes(GO:0048290)
0.2 0.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.2 4.7 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.2 1.1 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.9 GO:2001107 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.1 2.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 0.5 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.1 1.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 2.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.3 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 1.4 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.3 GO:0020012 evasion or tolerance of host immune response(GO:0020012) evasion or tolerance of host defense response(GO:0030682) evasion or tolerance by virus of host immune response(GO:0030683) evasion or tolerance of immune response of other organism involved in symbiotic interaction(GO:0051805) evasion or tolerance of defense response of other organism involved in symbiotic interaction(GO:0051807)
0.1 0.6 GO:1900220 negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 1.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.4 GO:0071422 succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422)
0.1 0.6 GO:0010157 response to chlorate(GO:0010157)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.1 0.3 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 0.3 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.2 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.1 0.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.2 GO:0042940 serine transport(GO:0032329) D-amino acid transport(GO:0042940)
0.1 1.1 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.1 0.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 1.4 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.5 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 0.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.3 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.4 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.5 GO:0031947 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0 0.6 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.2 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.0 0.1 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.0 0.1 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0 0.4 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.3 GO:0045625 regulation of T-helper 1 cell differentiation(GO:0045625)
0.0 0.4 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.3 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.9 GO:0002438 acute inflammatory response to antigenic stimulus(GO:0002438)
0.0 0.1 GO:0002760 positive regulation of antimicrobial humoral response(GO:0002760)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.4 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0001507 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 1.1 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.6 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.6 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 1.2 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.1 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 2.8 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.4 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.8 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.1 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 1.0 GO:0006953 acute-phase response(GO:0006953)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.7 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.9 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.4 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.0 0.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 0.6 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.6 GO:0007398 ectoderm development(GO:0007398)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 1.5 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.5 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0044279 extrinsic component of external side of plasma membrane(GO:0031232) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 1.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0060171 stereocilium membrane(GO:0060171)
0.1 4.7 GO:0016235 aggresome(GO:0016235)
0.1 0.6 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0060342 photoreceptor inner segment membrane(GO:0060342)
0.0 1.1 GO:0042588 zymogen granule(GO:0042588)
0.0 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 3.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0097255 R2TP complex(GO:0097255)
0.0 0.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 2.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 2.4 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 5.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.5 4.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.3 2.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.3 0.8 GO:1904854 proteasome core complex binding(GO:1904854)
0.2 2.2 GO:0019863 IgE binding(GO:0019863)
0.2 1.4 GO:0019862 IgA binding(GO:0019862)
0.2 2.8 GO:0019864 IgG binding(GO:0019864)
0.2 1.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.6 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.4 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.1 0.3 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.7 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.6 GO:0005119 smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108)
0.1 0.3 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.1 1.7 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.7 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 0.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.1 0.3 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 3.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1 1.9 GO:0023026 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
0.0 0.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 1.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 1.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.5 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.5 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.7 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 2.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.4 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 ST GAQ PATHWAY G alpha q Pathway
0.0 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 4.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 2.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.2 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 3.0 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions