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Illumina Body Map 2 (GSE30611)
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Results for PBX3
Z-value: 2.55
Motif logo
Transcription factors associated with PBX3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PBX3
|
ENSG00000167081.18 | PBX homeobox 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg38_v1_chr9_+_125748175_125748199 | 0.50 | 3.5e-03 | Click! |
Activity profile of PBX3 motif
Sorted Z-values of PBX3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.5 | GO:0031446 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) |
| 2.2 | 19.6 | GO:0048769 | sarcomerogenesis(GO:0048769) |
| 1.5 | 4.4 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 1.1 | 6.7 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.9 | 3.5 | GO:0070894 | transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895) |
| 0.8 | 3.2 | GO:1903892 | negative regulation of ATF6-mediated unfolded protein response(GO:1903892) |
| 0.8 | 3.2 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.8 | 3.1 | GO:0002086 | diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972) |
| 0.7 | 3.7 | GO:0098904 | regulation of AV node cell action potential(GO:0098904) |
| 0.6 | 13.0 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.6 | 3.6 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.5 | 5.7 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.5 | 1.5 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) |
| 0.5 | 3.9 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.5 | 2.8 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.4 | 1.3 | GO:0018963 | phthalate metabolic process(GO:0018963) |
| 0.4 | 3.4 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.4 | 1.2 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 0.4 | 1.2 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
| 0.4 | 2.5 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.3 | 1.0 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.3 | 3.5 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.3 | 1.3 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.3 | 0.3 | GO:0098905 | regulation of bundle of His cell action potential(GO:0098905) |
| 0.3 | 1.9 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.3 | 0.9 | GO:0014034 | neural crest cell fate commitment(GO:0014034) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.3 | 0.9 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.3 | 1.5 | GO:0035513 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.3 | 1.5 | GO:0030047 | actin modification(GO:0030047) |
| 0.3 | 1.2 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.3 | 1.1 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.3 | 1.1 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.3 | 0.3 | GO:0060995 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.3 | 6.0 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.3 | 0.5 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.3 | 2.6 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.3 | 2.1 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.3 | 9.8 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.3 | 4.1 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.2 | 1.0 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 0.2 | 1.2 | GO:2000691 | regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.2 | 0.9 | GO:0051311 | meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311) |
| 0.2 | 5.4 | GO:0045199 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.2 | 1.3 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 0.2 | 2.4 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.2 | 10.3 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.2 | 2.8 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.2 | 4.0 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.2 | 0.6 | GO:1904397 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.2 | 2.6 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.2 | 1.8 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.2 | 0.8 | GO:1902617 | response to fluoride(GO:1902617) |
| 0.2 | 1.9 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.2 | 5.4 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.2 | 2.2 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.2 | 1.3 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.2 | 2.3 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.2 | 1.1 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.2 | 1.0 | GO:0048105 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) |
| 0.2 | 0.5 | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) |
| 0.2 | 0.5 | GO:0060827 | regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829) |
| 0.2 | 1.5 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.2 | 3.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 1.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.2 | 1.1 | GO:0046985 | negative regulation of megakaryocyte differentiation(GO:0045653) positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 0.2 | 0.5 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 0.2 | 6.4 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 0.6 | GO:1902310 | regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496) positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.1 | 0.6 | GO:0048205 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.1 | 0.7 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.1 | 0.9 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.1 | 0.8 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 1.7 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.4 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.5 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.1 | 0.4 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
| 0.1 | 1.2 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
| 0.1 | 0.8 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.1 | 3.9 | GO:0090312 | positive regulation of protein deacetylation(GO:0090312) |
| 0.1 | 0.7 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.1 | 1.3 | GO:0015846 | polyamine transport(GO:0015846) |
| 0.1 | 0.5 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.1 | 0.5 | GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference(GO:0033168) conversion of ds siRNA to ss siRNA(GO:0036404) |
| 0.1 | 1.6 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 0.5 | GO:1902871 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.1 | 0.2 | GO:0014717 | regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901) |
| 0.1 | 0.3 | GO:0080120 | CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120) |
| 0.1 | 1.1 | GO:0017062 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.1 | 1.3 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.1 | 0.5 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.1 | 0.6 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 0.8 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.1 | 1.3 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.1 | 1.7 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.4 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 0.1 | 3.7 | GO:0045187 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.1 | 1.4 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) |
| 0.1 | 1.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 16.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 1.5 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
| 0.1 | 1.2 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.1 | 2.0 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 2.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 13.8 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 0.1 | 0.5 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.9 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 0.1 | 1.5 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 5.3 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.1 | 1.2 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 1.8 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
| 0.1 | 1.0 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 1.2 | GO:0046855 | phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) |
| 0.1 | 0.7 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 1.0 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.1 | 0.4 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.1 | 0.2 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
| 0.1 | 0.9 | GO:0007512 | adult heart development(GO:0007512) |
| 0.1 | 3.2 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 0.8 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 3.3 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.7 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 1.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 1.4 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 2.0 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 0.2 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 3.5 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.1 | 2.0 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.1 | 2.7 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 0.5 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.4 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.0 | 0.2 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.0 | 0.4 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 0.0 | 0.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 4.4 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.4 | GO:0045040 | protein import into mitochondrial outer membrane(GO:0045040) |
| 0.0 | 2.1 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.0 | 0.8 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 1.0 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 2.0 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.6 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.0 | 0.7 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.0 | 0.9 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.0 | 2.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.2 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.0 | 1.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.5 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.0 | 3.7 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.3 | GO:0042492 | gamma-delta T cell differentiation(GO:0042492) |
| 0.0 | 2.2 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.0 | 2.0 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.5 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 2.1 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 3.0 | GO:0065002 | intracellular protein transmembrane transport(GO:0065002) |
| 0.0 | 1.6 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 0.3 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.0 | 7.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.4 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.0 | 0.4 | GO:0015871 | choline transport(GO:0015871) |
| 0.0 | 0.6 | GO:0046325 | negative regulation of glucose import(GO:0046325) |
| 0.0 | 1.8 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.0 | 1.6 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.0 | 1.0 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.8 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.4 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.1 | GO:1903753 | negative regulation of p38MAPK cascade(GO:1903753) |
| 0.0 | 0.1 | GO:0031585 | regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585) positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) |
| 0.0 | 0.2 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.0 | 0.6 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.0 | 0.1 | GO:2000174 | pro-T cell differentiation(GO:0002572) regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 0.5 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.0 | 1.7 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.6 | GO:0017004 | cytochrome complex assembly(GO:0017004) |
| 0.0 | 0.6 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.0 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) |
| 0.0 | 0.6 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.0 | 0.5 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.0 | 0.3 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.2 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.0 | 1.4 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 0.3 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 0.8 | GO:0097502 | mannosylation(GO:0097502) |
| 0.0 | 0.4 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.0 | 3.1 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 1.7 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.0 | 0.6 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.1 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.0 | 0.7 | GO:0001893 | maternal placenta development(GO:0001893) |
| 0.0 | 0.1 | GO:0051572 | negative regulation of histone H3-K36 methylation(GO:0000415) negative regulation of histone H3-K4 methylation(GO:0051572) |
| 0.0 | 0.4 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.0 | 0.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.0 | 0.7 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.0 | 1.6 | GO:0045921 | positive regulation of exocytosis(GO:0045921) |
| 0.0 | 0.2 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.0 | 0.6 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 0.3 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 1.0 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 2.0 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 0.3 | GO:0007530 | sex determination(GO:0007530) |
| 0.0 | 1.2 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.0 | 0.2 | GO:0098903 | regulation of membrane repolarization during action potential(GO:0098903) |
| 0.0 | 1.0 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.4 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.7 | GO:0010761 | fibroblast migration(GO:0010761) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 1.5 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 1.3 | 6.7 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.9 | 6.2 | GO:1990393 | 3M complex(GO:1990393) |
| 0.8 | 4.9 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.5 | 3.1 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.5 | 4.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.4 | 1.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.4 | 12.5 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.4 | 29.8 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 1.0 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 1.3 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 0.3 | 2.6 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.3 | 2.2 | GO:0070695 | FHF complex(GO:0070695) |
| 0.3 | 4.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.2 | 4.2 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.2 | 1.2 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.2 | 3.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 0.9 | GO:0005715 | late recombination nodule(GO:0005715) |
| 0.2 | 3.7 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.2 | 2.8 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.2 | 4.1 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 0.7 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.2 | 0.5 | GO:1990843 | subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844) |
| 0.2 | 0.6 | GO:0036338 | viral envelope(GO:0019031) viral membrane(GO:0036338) |
| 0.1 | 0.4 | GO:1990622 | CHOP-ATF4 complex(GO:1990617) CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 1.1 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 0.5 | GO:0033167 | ARC complex(GO:0033167) |
| 0.1 | 0.8 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.1 | 3.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 5.0 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 2.0 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.1 | 1.3 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 2.6 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 1.0 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 0.4 | GO:0030892 | mitotic cohesin complex(GO:0030892) |
| 0.1 | 1.6 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.1 | 2.7 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 1.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 1.0 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.3 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 0.9 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 11.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 0.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 2.5 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.8 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.2 | GO:0097636 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.0 | 3.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.6 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.6 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.2 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.0 | 0.5 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.0 | 0.5 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 10.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.8 | GO:0098827 | endoplasmic reticulum subcompartment(GO:0098827) |
| 0.0 | 1.9 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 0.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 1.6 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 5.2 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 2.0 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 3.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 1.2 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 3.5 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 4.0 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.6 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.8 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.3 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 6.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.3 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 0.0 | 0.3 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.2 | GO:0072379 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 2.9 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 0.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.9 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.0 | 0.5 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 1.0 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.3 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 12.0 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 2.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 8.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.6 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 1.3 | 6.5 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 1.1 | 4.3 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 0.9 | 2.8 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.9 | 15.6 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.8 | 4.2 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.7 | 3.6 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.7 | 2.7 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
| 0.6 | 1.8 | GO:0005128 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
| 0.6 | 5.7 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.5 | 1.5 | GO:0080130 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.5 | 1.4 | GO:0070975 | FHA domain binding(GO:0070975) |
| 0.5 | 9.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.4 | 4.4 | GO:0071253 | connexin binding(GO:0071253) |
| 0.4 | 4.0 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.4 | 2.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.3 | 1.0 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.3 | 3.5 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.3 | 1.3 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.3 | 12.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 0.9 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.3 | 3.7 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.3 | 0.3 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.3 | 3.1 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.3 | 1.5 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.3 | 2.5 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.3 | 5.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.3 | 3.9 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.2 | 1.3 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.2 | 0.9 | GO:1904713 | beta-catenin destruction complex binding(GO:1904713) |
| 0.2 | 0.8 | GO:0004513 | neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291) |
| 0.2 | 2.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.2 | 8.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 14.7 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.2 | 0.6 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.2 | 0.8 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.1 | 0.4 | GO:0052856 | NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857) |
| 0.1 | 2.6 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.1 | 1.2 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 2.2 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.1 | 0.9 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 1.1 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.1 | 1.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.4 | GO:0045142 | triplex DNA binding(GO:0045142) |
| 0.1 | 2.6 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 1.2 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.1 | 1.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 3.0 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 0.5 | GO:0004673 | protein histidine kinase activity(GO:0004673) |
| 0.1 | 0.5 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.1 | 1.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.6 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.1 | 2.3 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 3.0 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 2.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 3.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.1 | 0.4 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.1 | 2.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 1.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 4.2 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 2.1 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.4 | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) |
| 0.1 | 7.4 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 13.1 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.3 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 1.0 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.1 | 1.2 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
| 0.1 | 10.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 1.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 0.6 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 2.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.5 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.1 | 0.5 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 0.9 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
| 0.1 | 0.5 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.1 | 0.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 5.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.6 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.1 | 2.0 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 1.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 6.8 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 8.8 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 1.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 4.3 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.1 | 1.1 | GO:0043295 | glutathione binding(GO:0043295) |
| 0.1 | 1.4 | GO:0051864 | histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.3 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 2.7 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.1 | 1.0 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.0 | 1.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.4 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.0 | 2.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 2.0 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 5.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 4.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 1.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.3 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.0 | 2.2 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 1.2 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.6 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 1.7 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.0 | 0.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 0.9 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.8 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 0.7 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.3 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 1.8 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.6 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.0 | 0.3 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 3.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.2 | GO:1904929 | coreceptor activity involved in Wnt signaling pathway(GO:0071936) coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929) |
| 0.0 | 0.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.5 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 2.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.5 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.0 | 0.4 | GO:0030548 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.0 | 0.2 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.0 | 0.7 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 2.7 | GO:0004536 | deoxyribonuclease activity(GO:0004536) |
| 0.0 | 0.2 | GO:0015180 | hydrogen:amino acid symporter activity(GO:0005280) L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
| 0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 3.8 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 0.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 2.5 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 1.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.2 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.3 | GO:0050694 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.8 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 21.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 0.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 1.5 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 1.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.5 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.1 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.0 | 0.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.2 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 0.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 1.7 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 0.0 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.0 | 0.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.6 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.5 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 26.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 4.7 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 1.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 2.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 3.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 2.0 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 1.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 1.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 7.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 3.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.2 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 3.5 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.3 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.5 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.5 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.3 | 13.0 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.2 | 16.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 4.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 8.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 7.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 8.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 3.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 3.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 12.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 3.1 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 2.2 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 6.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 6.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 0.6 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 0.6 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 2.2 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 2.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 4.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 28.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 3.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.9 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.6 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.8 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.7 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 8.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 2.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.5 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.8 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.5 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.3 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 0.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 1.4 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |