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Illumina Body Map 2 (GSE30611)

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Results for PITX2

Z-value: 0.55

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.17 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg38_v1_chr4_-_110641920_1106421230.057.9e-01Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_5227063 4.64 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr17_-_41518878 1.85 ENST00000254043.8
KRT15
keratin 15
chr9_-_92404559 1.41 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr9_+_34458752 1.37 ENST00000614641.4
ENST00000242317.9
ENST00000437363.5
DNAI1
dynein axonemal intermediate chain 1
chr13_-_35855627 1.26 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr13_-_35855758 1.01 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr15_+_40929338 0.93 ENST00000249749.7
DLL4
delta like canonical Notch ligand 4
chr3_-_49799821 0.83 ENST00000343366.8
ENST00000487256.1
ENST00000412678.7
CDHR4
cadherin related family member 4
chr10_-_48274567 0.83 ENST00000636244.1
ENST00000374201.8
FRMPD2
FERM and PDZ domain containing 2
chr11_+_61755372 0.82 ENST00000265460.9
MYRF
myelin regulatory factor
chr11_-_119346695 0.80 ENST00000619721.6
MFRP
membrane frizzled-related protein
chr13_+_73058993 0.78 ENST00000377687.6
KLF5
Kruppel like factor 5
chr3_+_159069252 0.64 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr9_+_127678455 0.60 ENST00000494254.3
STXBP1
syntaxin binding protein 1
chr1_+_43300971 0.59 ENST00000372476.8
ENST00000538015.1
TIE1
tyrosine kinase with immunoglobulin like and EGF like domains 1
chr3_+_154121366 0.56 ENST00000465093.6
ENST00000496710.5
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor 26
chrX_-_6228835 0.55 ENST00000381095.8
NLGN4X
neuroligin 4 X-linked
chr16_-_67980483 0.54 ENST00000268793.6
ENST00000672962.1
DPEP3
dipeptidase 3
chr7_+_74453790 0.51 ENST00000265755.7
ENST00000424337.7
ENST00000455841.6
GTF2IRD1
GTF2I repeat domain containing 1
chr20_+_45722329 0.49 ENST00000279058.4
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr1_-_165445220 0.44 ENST00000619224.1
RXRG
retinoid X receptor gamma
chr10_+_102226293 0.44 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chr4_-_101347551 0.43 ENST00000525819.1
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr16_+_28711417 0.42 ENST00000395587.5
ENST00000569690.5
ENST00000331666.11
ENST00000564243.5
ENST00000566866.5
EIF3C
eukaryotic translation initiation factor 3 subunit C
chr4_-_101347327 0.42 ENST00000394853.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr4_-_101346842 0.41 ENST00000507176.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr2_-_65432591 0.40 ENST00000356388.9
SPRED2
sprouty related EVH1 domain containing 2
chr2_-_65432628 0.39 ENST00000440972.1
SPRED2
sprouty related EVH1 domain containing 2
chr1_-_165445088 0.39 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr4_-_101347492 0.39 ENST00000394854.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr1_+_91952162 0.39 ENST00000402388.1
ENST00000680541.1
BRDT
bromodomain testis associated
chr12_+_56521798 0.38 ENST00000262031.10
RBMS2
RNA binding motif single stranded interacting protein 2
chr9_-_14300231 0.37 ENST00000636735.1
NFIB
nuclear factor I B
chr10_+_17951906 0.36 ENST00000377371.3
ENST00000377369.7
SLC39A12
solute carrier family 39 member 12
chr11_-_133532493 0.35 ENST00000524381.6
OPCML
opioid binding protein/cell adhesion molecule like
chr7_-_122699108 0.35 ENST00000340112.3
RNF133
ring finger protein 133
chr4_-_101347471 0.34 ENST00000323055.10
ENST00000512215.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr6_+_46693835 0.33 ENST00000450697.1
TDRD6
tudor domain containing 6
chr1_+_202010575 0.32 ENST00000367283.7
ENST00000367284.10
ELF3
E74 like ETS transcription factor 3
chr10_+_17951825 0.32 ENST00000539911.5
SLC39A12
solute carrier family 39 member 12
chr16_-_11976611 0.32 ENST00000538896.5
ENST00000673243.1
NPIPB2
nuclear pore complex interacting protein family member B2
chr12_-_89656093 0.31 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr10_+_17951885 0.30 ENST00000377374.8
SLC39A12
solute carrier family 39 member 12
chr12_-_89656051 0.27 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr9_-_107489754 0.24 ENST00000610832.1
ENST00000374672.5
KLF4
Kruppel like factor 4
chr5_-_150758497 0.23 ENST00000521533.1
ENST00000424236.5
DCTN4
dynactin subunit 4
chr17_-_4739866 0.23 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chr8_+_48008409 0.19 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr5_+_14441043 0.19 ENST00000639876.2
TRIO
trio Rho guanine nucleotide exchange factor
chr6_+_31137646 0.17 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr22_-_30471986 0.17 ENST00000401751.5
ENST00000402286.5
ENST00000403066.5
ENST00000215812.9
SEC14L3
SEC14 like lipid binding 3
chr17_+_4740042 0.12 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr1_+_202010615 0.11 ENST00000446188.1
ELF3
E74 like ETS transcription factor 3
chr11_-_96343170 0.10 ENST00000524717.6
MAML2
mastermind like transcriptional coactivator 2
chr17_+_4740005 0.09 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr12_+_40393392 0.09 ENST00000676020.1
MUC19
mucin 19, oligomeric
chr5_+_38258373 0.09 ENST00000354891.7
EGFLAM
EGF like, fibronectin type III and laminin G domains
chr1_+_2476315 0.06 ENST00000419816.6
PLCH2
phospholipase C eta 2
chr12_+_69739370 0.05 ENST00000550536.5
ENST00000362025.9
RAB3IP
RAB3A interacting protein
chr6_+_130018565 0.05 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr19_+_2476118 0.03 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr16_-_15642488 0.02 ENST00000549219.1
MARF1
meiosis regulator and mRNA stability factor 1
chr1_+_2476284 0.02 ENST00000378486.8
PLCH2
phospholipase C eta 2
chr13_-_94479671 0.01 ENST00000377028.10
ENST00000446125.1
DCT
dopachrome tautomerase
chr6_+_35342614 0.01 ENST00000337400.6
ENST00000311565.4
PPARD
peroxisome proliferator activated receptor delta
chr6_-_159788439 0.01 ENST00000539948.5
TCP1
t-complex 1
chr6_-_111483700 0.00 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr21_-_18403754 0.00 ENST00000284885.8
TMPRSS15
transmembrane serine protease 15

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0030185 nitric oxide transport(GO:0030185)
0.4 2.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.2 0.9 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.4 GO:0001207 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.1 0.5 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.6 GO:1903294 regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
0.1 1.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.6 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.1 0.8 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 1.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.2 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 1.0 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 2.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.6 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.4 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.8 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.4 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.4 GO:0044300 cerebellar mossy fiber(GO:0044300)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.6 GO:0030492 hemoglobin binding(GO:0030492)
0.2 0.8 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 2.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0031404 chloride ion binding(GO:0031404)
0.0 1.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 1.9 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0043274 phospholipase binding(GO:0043274)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.9 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 2.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 4.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin