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Illumina Body Map 2 (GSE30611)
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Results for POU2F1
Z-value: 1.52
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Transcription factors associated with POU2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F1 | hg38_v1_chr1_+_167329148_167329175 | 0.09 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89245596 Show fit | 8.54 |
ENST00000468494.1
|
immunoglobulin kappa variable 2-30 |
|
| chr22_+_22686724 Show fit | 7.97 |
ENST00000390305.2
|
immunoglobulin lambda variable 3-25 |
|
| chr14_-_105987068 Show fit | 7.80 |
ENST00000390594.3
|
immunoglobulin heavy variable 1-2 |
|
| chr17_+_36064265 Show fit | 6.81 |
ENST00000616054.2
|
C-C motif chemokine ligand 18 |
|
| chr14_-_106185387 Show fit | 6.37 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chr2_-_88992903 Show fit | 5.94 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr14_-_106277039 Show fit | 5.92 |
ENST00000390610.2
|
immunoglobulin heavy variable 1-24 |
|
| chr14_-_106715166 Show fit | 5.85 |
ENST00000390633.2
|
immunoglobulin heavy variable 1-69 |
|
| chr2_+_89936859 Show fit | 5.73 |
ENST00000474213.1
|
immunoglobulin kappa variable 2D-30 |
|
| chr14_-_106579223 Show fit | 5.14 |
ENST00000390626.2
|
immunoglobulin heavy variable 5-51 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 84.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 18.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.1 | 6.5 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 1.1 | 5.4 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.3 | 5.4 | GO:1900227 | positive regulation of NLRP3 inflammasome complex assembly(GO:1900227) |
| 1.2 | 4.9 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.1 | 4.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 3.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.3 | 3.8 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.3 | 3.7 | GO:0002863 | positive regulation of inflammatory response to antigenic stimulus(GO:0002863) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 33.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 18.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 8.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 6.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.5 | 5.4 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 1.2 | 4.9 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 4.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 4.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 4.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 3.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 66.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 33.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 6.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.7 | 4.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 4.6 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.2 | 3.8 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.6 | 3.4 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.3 | 3.4 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 3.3 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 3.1 | GO:0015026 | coreceptor activity(GO:0015026) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 4.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 3.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 3.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 2.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 2.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 5.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 4.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.9 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 3.9 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 3.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 3.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 2.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 2.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |