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Illumina Body Map 2 (GSE30611)

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Results for POU2F2_POU3F1

Z-value: 4.21

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Transcription factors associated with POU2F2_POU3F1

Gene Symbol Gene ID Gene Info
ENSG00000028277.21 POU class 2 homeobox 2
ENSG00000185668.8 POU class 3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU2F2hg38_v1_chr19_-_42132391_421324550.672.9e-05Click!
POU3F1hg38_v1_chr1_-_38046785_38046802-0.476.9e-03Click!

Activity profile of POU2F2_POU3F1 motif

Sorted Z-values of POU2F2_POU3F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_106117159 46.05 ENST00000390601.3
immunoglobulin heavy variable 3-11
chr14_-_106538331 44.61 ENST00000390624.3
immunoglobulin heavy variable 3-48
chr14_-_106235582 41.45 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr14_-_106154113 36.09 ENST00000390603.2
immunoglobulin heavy variable 3-15
chr14_-_106803221 33.61 ENST00000390636.2
immunoglobulin heavy variable 3-73
chr14_-_106360320 30.82 ENST00000390615.2
immunoglobulin heavy variable 3-33
chr14_-_106715166 30.59 ENST00000390633.2
immunoglobulin heavy variable 1-69
chr14_-_106470788 30.42 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr2_-_89040745 30.28 ENST00000480492.1
immunoglobulin kappa variable 1-12
chr14_-_106062670 30.23 ENST00000390598.2
immunoglobulin heavy variable 3-7
chr2_+_89913982 28.80 ENST00000390265.2
immunoglobulin kappa variable 1D-33
chr14_-_106335613 27.44 ENST00000603660.1
immunoglobulin heavy variable 3-30
chr22_+_22098683 27.42 ENST00000390283.2
immunoglobulin lambda variable 8-61
chr16_+_32066065 27.40 ENST00000354689.6
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr14_-_106675544 27.38 ENST00000390632.2
immunoglobulin heavy variable 3-66
chr14_-_106211453 26.84 ENST00000390606.3
immunoglobulin heavy variable 3-20
chr22_+_22811737 25.19 ENST00000390315.3
immunoglobulin lambda variable 3-10
chr2_-_89268506 25.08 ENST00000473726.1
immunoglobulin kappa variable 1-33
chr14_-_106557465 25.01 ENST00000390625.3
immunoglobulin heavy variable 3-49
chr14_-_106088573 23.37 ENST00000632099.1
immunoglobulin heavy variable 3-64D
chr22_+_22686724 23.37 ENST00000390305.2
immunoglobulin lambda variable 3-25
chr14_-_106811131 23.34 ENST00000424969.2
immunoglobulin heavy variable 3-74
chr22_+_22357739 23.03 ENST00000390294.2
immunoglobulin lambda variable 1-47
chr2_+_90100235 21.87 ENST00000492446.1
immunoglobulin kappa variable 1D-16
chr2_+_90154073 21.63 ENST00000611391.1
immunoglobulin kappa variable 1D-13
chr14_-_106791226 21.60 ENST00000433072.2
immunoglobulin heavy variable 3-72
chr14_-_106593319 21.25 ENST00000390627.3
immunoglobulin heavy variable 3-53
chr16_+_33009175 20.85 ENST00000565407.2
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr2_+_90159840 20.42 ENST00000377032.5
immunoglobulin kappa variable 1D-12
chr16_+_33827140 20.35 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr2_-_88992903 20.00 ENST00000495489.1
immunoglobulin kappa variable 1-8
chr14_-_106108453 19.70 ENST00000632950.2
immunoglobulin heavy variable 5-10-1
chrX_-_48919015 19.59 ENST00000376509.4
Pim-2 proto-oncogene, serine/threonine kinase
chr14_-_106130061 19.06 ENST00000390602.3
immunoglobulin heavy variable 3-13
chr16_+_32995048 18.61 ENST00000425181.3
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr2_+_90082635 18.30 ENST00000483379.1
immunoglobulin kappa variable 1D-17
chr2_+_88897230 18.27 ENST00000390244.2
immunoglobulin kappa variable 5-2
chr14_-_106165730 17.74 ENST00000390604.2
immunoglobulin heavy variable 3-16 (non-functional)
chr14_-_106269133 17.73 ENST00000390609.3
immunoglobulin heavy variable 3-23
chr22_+_22880706 17.04 ENST00000390319.2
immunoglobulin lambda variable 3-1
chr14_-_106658251 16.64 ENST00000454421.2
immunoglobulin heavy variable 3-64
chr2_-_89100352 15.28 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr22_+_22668286 15.20 ENST00000390304.2
immunoglobulin lambda variable 3-27
chr14_-_106762576 15.14 ENST00000624687.1
immunoglobulin heavy variable 1-69D
chr2_-_88947820 15.10 ENST00000496168.1
immunoglobulin kappa variable 1-5
chr2_+_90172802 14.34 ENST00000390277.3
immunoglobulin kappa variable 3D-11
chr2_-_89117844 13.99 ENST00000490686.1
immunoglobulin kappa variable 1-17
chr2_-_88966767 13.97 ENST00000464162.1
immunoglobulin kappa variable 1-6
chr2_+_90038848 13.73 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr22_+_22822658 13.63 ENST00000620395.2
immunoglobulin lambda variable 2-8
chr2_-_89245596 13.40 ENST00000468494.1
immunoglobulin kappa variable 2-30
chr16_-_33845229 13.33 ENST00000569103.2
immunoglobulin heavy variable 3/OR16-17 (non-functional)
chr2_+_89862438 13.32 ENST00000448155.2
immunoglobulin kappa variable 1D-39
chr2_+_90234809 12.96 ENST00000443397.5
immunoglobulin kappa variable 3D-7
chr22_+_22758698 12.67 ENST00000390312.2
immunoglobulin lambda variable 2-14
chr22_+_22030934 12.66 ENST00000390282.2
immunoglobulin lambda variable 4-69
chr22_+_22818994 12.64 ENST00000390316.2
immunoglobulin lambda variable 3-9
chr22_+_22747383 12.57 ENST00000390311.3
immunoglobulin lambda variable 3-16
chr4_-_70666492 12.50 ENST00000254801.9
ENST00000391614.7
joining chain of multimeric IgA and IgM
chr14_-_106374129 11.96 ENST00000390616.2
immunoglobulin heavy variable 4-34
chr14_-_106389858 11.77 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chr2_+_89936859 11.46 ENST00000474213.1
immunoglobulin kappa variable 2D-30
chr4_-_70666884 11.31 ENST00000510614.5
joining chain of multimeric IgA and IgM
chr4_-_70666961 11.26 ENST00000510437.5
joining chain of multimeric IgA and IgM
chr1_+_206557157 11.21 ENST00000577571.5
Ras association domain family member 5
chr22_+_22734577 11.06 ENST00000390310.3
immunoglobulin lambda variable 2-18
chr22_+_22431949 11.02 ENST00000390301.3
immunoglobulin lambda variable 1-36
chr14_-_106277039 10.89 ENST00000390610.2
immunoglobulin heavy variable 1-24
chr16_+_23835946 10.76 ENST00000321728.12
ENST00000643927.1
protein kinase C beta
chr2_+_113406368 10.73 ENST00000453673.3
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr2_+_90209873 10.61 ENST00000468879.1
immunoglobulin kappa variable 1D-43
chr22_+_22697789 10.58 ENST00000390306.2
immunoglobulin lambda variable 2-23
chr22_+_22720615 10.50 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr2_+_89884740 10.12 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr2_+_90114838 10.04 ENST00000417279.3
immunoglobulin kappa variable 3D-15
chrX_+_12975216 9.95 ENST00000380635.5
thymosin beta 4 X-linked
chr2_-_88979016 9.89 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr8_+_55879818 9.43 ENST00000520220.6
ENST00000519728.6
LYN proto-oncogene, Src family tyrosine kinase
chr2_-_89177160 9.24 ENST00000484817.1
immunoglobulin kappa variable 2-24
chr22_+_22409755 9.07 ENST00000390299.2
immunoglobulin lambda variable 1-40
chrX_+_12975083 8.99 ENST00000451311.7
ENST00000380636.1
thymosin beta 4 X-linked
chr2_-_89320146 8.98 ENST00000498574.1
immunoglobulin kappa variable 1-39
chr2_-_89297785 8.90 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr15_-_19988117 8.56 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr21_-_10649835 8.54 ENST00000622028.1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr8_-_133102477 8.37 ENST00000522119.5
ENST00000523610.5
ENST00000338087.10
ENST00000521302.5
ENST00000519558.5
ENST00000519747.5
ENST00000517648.5
Src like adaptor
chr6_-_27146841 8.16 ENST00000356950.2
H2B clustered histone 12
chr1_-_149842736 7.90 ENST00000369159.2
H2A clustered histone 18
chr14_-_106025628 7.49 ENST00000631943.1
immunoglobulin heavy variable 7-4-1
chr6_-_31592952 7.39 ENST00000376073.8
ENST00000376072.7
natural cytotoxicity triggering receptor 3
chr1_+_149851053 7.28 ENST00000607355.2
H2A clustered histone 19
chr2_+_90004792 7.27 ENST00000462693.1
immunoglobulin kappa variable 2D-24 (non-functional)
chr1_+_149886906 7.16 ENST00000331380.4
H2A clustered histone 20
chr7_-_142813394 7.10 ENST00000417977.2
T cell receptor beta variable 30
chr2_+_90021567 7.09 ENST00000436451.2
immunoglobulin kappa variable 6D-21 (non-functional)
chr1_+_116754422 7.04 ENST00000369478.4
ENST00000369477.1
CD2 molecule
chr22_-_23754376 6.90 ENST00000398465.3
ENST00000248948.4
V-set pre-B cell surrogate light chain 3
chr8_-_133102623 6.78 ENST00000524345.5
Src like adaptor
chr2_+_89851723 6.63 ENST00000429992.2
immunoglobulin kappa variable 2D-40
chr4_-_25863537 6.59 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr8_-_133102874 6.25 ENST00000395352.7
Src like adaptor
chr5_-_141651376 6.15 ENST00000522783.5
ENST00000519800.1
ENST00000435817.7
FCH and double SH3 domains 1
chr2_-_89160329 6.00 ENST00000390256.2
immunoglobulin kappa variable 6-21 (non-functional)
chr12_-_31326111 5.79 ENST00000539409.5
SIN3-HDAC complex associated factor
chr16_-_88686453 5.63 ENST00000332281.6
snail family transcriptional repressor 3
chr14_-_106737547 5.60 ENST00000632209.1
immunoglobulin heavy variable 1-69-2
chr14_-_106005574 5.29 ENST00000390595.3
immunoglobulin heavy variable 1-3
chr6_-_31592992 5.15 ENST00000340027.10
natural cytotoxicity triggering receptor 3
chr7_+_98211431 5.12 ENST00000609256.2
basic helix-loop-helix family member a15
chr11_-_5227063 5.08 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
hemoglobin subunit beta
chr3_+_151873634 5.08 ENST00000362032.6
succinate receptor 1
chr3_+_98531965 5.05 ENST00000284311.5
G protein-coupled receptor 15
chr16_+_28931942 5.02 ENST00000324662.8
ENST00000538922.8
CD19 molecule
chr12_-_31326142 4.96 ENST00000337682.9
SIN3-HDAC complex associated factor
chr12_+_121626493 4.86 ENST00000617316.2
ORAI calcium release-activated calcium modulator 1
chr19_+_3572927 4.81 ENST00000333651.11
ENST00000417382.5
high mobility group 20B
chr19_-_18397596 4.69 ENST00000595840.1
ENST00000339007.4
leucine rich repeat containing 25
chr4_-_107283746 4.67 ENST00000510463.1
dickkopf WNT signaling pathway inhibitor 2
chr17_-_49764123 4.67 ENST00000240364.7
ENST00000506156.1
family with sequence similarity 117 member A
chr5_-_67196791 4.67 ENST00000256447.5
CD180 molecule
chr6_-_26216673 4.65 ENST00000541790.3
H2B clustered histone 8
chr14_-_106507476 4.64 ENST00000390621.3
immunoglobulin heavy variable 1-45
chr4_-_107283689 4.61 ENST00000513208.5
dickkopf WNT signaling pathway inhibitor 2
chr15_-_19965101 4.53 ENST00000338912.5
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr22_+_22395005 4.51 ENST00000390298.2
immunoglobulin lambda variable 7-43
chr1_+_207496229 4.47 ENST00000367051.6
ENST00000367053.6
ENST00000367052.6
complement C3b/C4b receptor 1 (Knops blood group)
chr6_-_149484965 4.30 ENST00000409806.8
zinc finger CCCH-type containing 12D
chr19_-_40425982 4.26 ENST00000357949.5
SERTA domain containing 1
chr6_+_37170133 4.25 ENST00000373509.6
Pim-1 proto-oncogene, serine/threonine kinase
chr4_+_40192949 4.22 ENST00000507851.5
ENST00000615577.4
ENST00000613272.4
ras homolog family member H
chr6_+_26124161 4.17 ENST00000377791.4
ENST00000602637.1
H2A clustered histone 6
chr17_+_40015428 4.09 ENST00000394149.8
ENST00000225474.6
ENST00000331769.6
ENST00000394148.7
ENST00000577675.1
colony stimulating factor 3
chr19_+_17747698 4.07 ENST00000594202.5
ENST00000252771.11
FCH and mu domain containing endocytic adaptor 1
chr19_+_17747737 4.07 ENST00000600676.5
ENST00000600209.5
ENST00000596309.5
ENST00000598539.5
ENST00000597474.5
ENST00000593385.5
ENST00000598067.5
ENST00000593833.5
FCH and mu domain containing endocytic adaptor 1
chr1_+_207496147 3.96 ENST00000400960.7
ENST00000367049.9
complement C3b/C4b receptor 1 (Knops blood group)
chr22_+_22427517 3.91 ENST00000390300.2
immunoglobulin lambda variable 5-37
chr3_+_63652663 3.88 ENST00000343837.8
ENST00000469440.5
sentan, cilia apical structure protein
chr19_-_1132208 3.87 ENST00000438103.6
strawberry notch homolog 2
chr14_-_106875069 3.83 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr8_-_133102643 3.75 ENST00000519341.5
Src like adaptor
chr3_-_112641128 3.73 ENST00000206423.8
coiled-coil domain containing 80
chr7_+_50308672 3.71 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKAROS family zinc finger 1
chrX_+_135520616 3.70 ENST00000370752.4
ENST00000639893.2
integrator complex subunit 6 like
chr7_+_18495723 3.65 ENST00000681950.1
ENST00000622668.4
ENST00000405010.7
ENST00000406451.8
ENST00000441542.7
ENST00000428307.6
ENST00000681273.1
histone deacetylase 9
chr3_-_112641292 3.62 ENST00000439685.6
coiled-coil domain containing 80
chr19_+_3572971 3.62 ENST00000453933.5
ENST00000262949.7
high mobility group 20B
chr7_-_27143672 3.55 ENST00000222726.4
homeobox A5
chr19_+_35329161 3.47 ENST00000341773.10
ENST00000600131.5
ENST00000595780.5
ENST00000597916.5
ENST00000593867.5
ENST00000600424.5
ENST00000599811.5
ENST00000536635.6
ENST00000085219.10
ENST00000544992.6
ENST00000419549.6
CD22 molecule
chr1_+_170663134 3.46 ENST00000367760.7
paired related homeobox 1
chr5_-_159099909 3.39 ENST00000313708.11
EBF transcription factor 1
chr6_-_127900958 3.26 ENST00000434358.3
ENST00000630369.2
ENST00000368248.4
thymocyte selection associated
chr19_-_43667666 3.22 ENST00000593714.5
plasminogen activator, urokinase receptor
chr6_-_11778781 3.16 ENST00000414691.8
ENST00000229583.9
androgen dependent TFPI regulating protein
chr19_-_46788586 3.12 ENST00000542575.6
solute carrier family 1 member 5
chr22_+_22588155 3.11 ENST00000390302.3
immunoglobulin lambda variable 2-33 (non-functional)
chr17_+_74737211 3.10 ENST00000392612.7
ENST00000392610.5
RAB37, member RAS oncogene family
chr4_-_153789057 3.08 ENST00000274063.5
secreted frizzled related protein 2
chr7_-_100586119 3.07 ENST00000310300.11
leucine rich repeats and calponin homology domain containing 4
chr15_-_55249029 3.06 ENST00000566877.5
RAB27A, member RAS oncogene family
chr19_-_49665603 3.04 ENST00000596756.5
interferon regulatory factor 3
chr7_+_18495697 3.01 ENST00000413380.5
ENST00000430454.5
histone deacetylase 9
chr14_+_21749163 2.99 ENST00000390427.3
T cell receptor alpha variable 5
chr7_+_16753731 2.98 ENST00000262067.5
tetraspanin 13
chr21_-_34888683 2.93 ENST00000344691.8
ENST00000358356.9
RUNX family transcription factor 1
chr19_+_54617122 2.89 ENST00000396331.5
leukocyte immunoglobulin like receptor B1
chr19_+_39412650 2.86 ENST00000425673.6
pleckstrin homology and RhoGEF domain containing G2
chr7_-_27113825 2.82 ENST00000522456.1
homeobox A3
chr6_+_26251607 2.82 ENST00000619466.2
H2B clustered histone 9
chr1_+_66332004 2.81 ENST00000371045.9
ENST00000531025.5
ENST00000526197.5
phosphodiesterase 4B
chr1_+_206406377 2.79 ENST00000605476.5
SLIT-ROBO Rho GTPase activating protein 2
chr4_-_39032922 2.73 ENST00000344606.6
transmembrane protein 156
chr12_-_98644733 2.73 ENST00000299157.5
ENST00000393042.3
IKBKB interacting protein
chr16_+_33802683 2.73 ENST00000570121.2
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr12_-_31326171 2.72 ENST00000542983.1
SIN3-HDAC complex associated factor
chr17_+_74737238 2.67 ENST00000392613.10
ENST00000613645.1
RAB37, member RAS oncogene family
chr16_-_88941801 2.67 ENST00000569464.5
ENST00000569443.5
CBFA2/RUNX1 partner transcriptional co-repressor 3
chr10_-_62236112 2.65 ENST00000315289.6
rhotekin 2
chr12_+_112906949 2.64 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
2'-5'-oligoadenylate synthetase 1
chr18_-_55322334 2.54 ENST00000630720.3
transcription factor 4
chr1_+_156150008 2.53 ENST00000355014.6
semaphorin 4A
chr17_+_40341388 2.50 ENST00000394086.7
retinoic acid receptor alpha
chr19_+_3572777 2.48 ENST00000416526.5
high mobility group 20B
chr2_-_112836702 2.47 ENST00000416750.1
ENST00000263341.7
ENST00000418817.5
interleukin 1 beta
chr1_+_207496268 2.46 ENST00000529814.1
complement C3b/C4b receptor 1 (Knops blood group)
chr1_+_23691742 2.42 ENST00000374550.8
ENST00000643754.2
ribosomal protein L11
chr4_+_26320975 2.41 ENST00000509158.6
ENST00000681856.1
ENST00000680140.1
ENST00000355476.8
ENST00000680511.1
recombination signal binding protein for immunoglobulin kappa J region
chr21_+_38272410 2.39 ENST00000398934.5
ENST00000398930.5
potassium inwardly rectifying channel subfamily J member 15
chr6_+_26158115 2.35 ENST00000377777.5
ENST00000289316.2
H2B clustered histone 5
chr2_-_174598206 2.34 ENST00000392546.6
ENST00000436221.1
WAS/WASL interacting protein family member 1
chr4_+_123399488 2.31 ENST00000394339.2
sprouty RTK signaling antagonist 1
chr5_-_179618032 2.28 ENST00000519033.5
heterogeneous nuclear ribonucleoprotein H1
chr17_+_14301069 2.27 ENST00000360954.3
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr19_-_18281612 2.22 ENST00000252818.5
JunD proto-oncogene, AP-1 transcription factor subunit
chr6_-_73521783 2.21 ENST00000331523.7
ENST00000356303.7
eukaryotic translation elongation factor 1 alpha 1
chr6_-_53148822 2.19 ENST00000259803.8
glial cells missing transcription factor 1
chr12_-_51270175 2.18 ENST00000604188.1
ENST00000398453.7
small cell adhesion glycoprotein
chr12_-_51270274 2.14 ENST00000605627.1
small cell adhesion glycoprotein
chr7_+_80646436 2.14 ENST00000419819.2
CD36 molecule
chr6_+_27808163 2.14 ENST00000358739.4
H2A clustered histone 13
chr16_+_56935371 2.14 ENST00000568358.1
homocysteine inducible ER protein with ubiquitin like domain 1

Network of associatons between targets according to the STRING database.

First level regulatory network of POU2F2_POU3F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 1149.1 GO:0006958 complement activation, classical pathway(GO:0006958)
3.9 35.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
3.1 9.4 GO:0070662 mast cell proliferation(GO:0070662)
2.5 2.5 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
2.4 18.9 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
2.1 12.5 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
1.5 10.8 GO:0035405 histone-threonine phosphorylation(GO:0035405)
1.3 5.1 GO:0030185 nitric oxide transport(GO:0030185)
1.2 285.1 GO:0002377 immunoglobulin production(GO:0002377)
1.1 3.3 GO:0043973 histone H3-K4 acetylation(GO:0043973)
1.0 3.1 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
1.0 3.9 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.9 2.7 GO:0090222 centrosome-templated microtubule nucleation(GO:0090222)
0.9 3.5 GO:0060480 bronchiole development(GO:0060435) lung goblet cell differentiation(GO:0060480)
0.9 7.0 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.8 2.5 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.8 3.1 GO:0010585 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.8 4.7 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.7 2.9 GO:2001193 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.7 2.0 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.7 1.3 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.7 2.0 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608)
0.6 1.3 GO:0031296 B cell costimulation(GO:0031296)
0.6 2.4 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.6 1.8 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.6 2.8 GO:0010159 specification of organ position(GO:0010159)
0.5 2.2 GO:0060018 astrocyte fate commitment(GO:0060018)
0.5 1.9 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.5 2.3 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.5 3.2 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.4 8.5 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.4 3.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.4 1.3 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.4 2.5 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.4 6.1 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.4 2.8 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363)
0.4 6.2 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.4 1.1 GO:1900149 positive regulation of Schwann cell migration(GO:1900149) regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
0.4 4.0 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.4 0.7 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.3 2.6 GO:0071486 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.3 2.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 2.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 10.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 7.0 GO:0043383 negative T cell selection(GO:0043383)
0.3 5.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.3 0.9 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.3 7.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.3 4.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 3.8 GO:0030223 neutrophil differentiation(GO:0030223)
0.3 2.0 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.2 1.2 GO:0035026 leading edge cell differentiation(GO:0035026)
0.2 3.2 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.2 1.6 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 2.7 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.2 1.9 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 8.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 4.0 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.2 1.1 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.2 0.9 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 2.6 GO:0048664 neuron fate determination(GO:0048664)
0.2 1.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.2 25.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 0.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 19.6 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.2 4.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 2.0 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 0.6 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.2 4.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 3.1 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 2.5 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 5.0 GO:0030449 regulation of complement activation(GO:0030449)
0.1 0.4 GO:0051097 negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.1 2.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 1.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 2.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 1.4 GO:0030728 ovulation(GO:0030728)
0.1 0.4 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.1 0.7 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.1 1.4 GO:1902748 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.9 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.1 2.4 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.5 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 0.7 GO:0000023 maltose metabolic process(GO:0000023)
0.1 1.7 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.1 5.1 GO:0072678 T cell migration(GO:0072678)
0.1 2.0 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 0.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 5.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 1.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 32.8 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.4 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.1 2.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.1 1.0 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 5.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.9 GO:0040016 embryonic cleavage(GO:0040016)
0.1 1.4 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 2.2 GO:0002076 osteoblast development(GO:0002076)
0.1 1.0 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.1 0.9 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.1 0.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 2.5 GO:0010165 response to X-ray(GO:0010165)
0.1 1.0 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 1.0 GO:0007379 segment specification(GO:0007379)
0.1 1.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.9 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.5 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.9 GO:0019532 oxalate transport(GO:0019532)
0.0 5.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 7.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 3.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 9.2 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0019075 virus maturation(GO:0019075)
0.0 0.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 1.2 GO:0010762 regulation of fibroblast migration(GO:0010762)
0.0 1.5 GO:0018126 protein hydroxylation(GO:0018126)
0.0 0.6 GO:0030903 notochord development(GO:0030903)
0.0 2.3 GO:0008154 actin polymerization or depolymerization(GO:0008154)
0.0 5.4 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.9 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0 0.5 GO:0090527 actin filament reorganization(GO:0090527)
0.0 7.8 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.0 0.2 GO:2000229 pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.6 GO:0046135 pyrimidine nucleoside catabolic process(GO:0046135)
0.0 0.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.8 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 2.0 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 2.8 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.4 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0008228 opsonization(GO:0008228)
0.0 2.0 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 35.1 GO:0071757 hexameric IgM immunoglobulin complex(GO:0071757)
8.7 478.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.6 9.4 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
1.3 5.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
1.0 213.0 GO:0072562 blood microparticle(GO:0072562)
0.4 1.3 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.3 4.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 0.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 1.1 GO:0008537 proteasome activator complex(GO:0008537)
0.3 2.1 GO:1990037 Lewy body core(GO:1990037)
0.2 2.2 GO:0035976 AP1 complex(GO:0035976)
0.2 0.7 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.2 1.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 3.2 GO:0071438 invadopodium membrane(GO:0071438)
0.2 7.3 GO:0005614 interstitial matrix(GO:0005614)
0.2 3.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 18.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 8.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.7 GO:0043293 apoptosome(GO:0043293)
0.2 3.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.8 GO:0044327 dendritic spine head(GO:0044327)
0.2 1.0 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.2 344.0 GO:0005615 extracellular space(GO:0005615)
0.2 7.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 4.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.7 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.7 GO:0031143 pseudopodium(GO:0031143)
0.1 0.5 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.8 GO:1990031 pinceau fiber(GO:1990031)
0.1 0.6 GO:0032437 cuticular plate(GO:0032437)
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 7.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 6.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 17.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 9.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 5.9 GO:0001772 immunological synapse(GO:0001772)
0.1 1.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.9 GO:0098560 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.1 0.9 GO:0031298 replication fork protection complex(GO:0031298)
0.1 1.9 GO:0000346 transcription export complex(GO:0000346)
0.1 1.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 9.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 3.2 GO:0031594 neuromuscular junction(GO:0031594)
0.1 13.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 6.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 247.7 GO:0005576 extracellular region(GO:0005576)
0.0 0.7 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 1.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 2.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 3.4 GO:0000922 spindle pole(GO:0000922)
0.0 1.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 4.4 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 513.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
4.3 933.4 GO:0003823 antigen binding(GO:0003823)
3.6 10.9 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
2.7 10.8 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
1.3 10.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.7 5.1 GO:0030492 hemoglobin binding(GO:0030492)
0.7 2.9 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.7 2.0 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.5 3.2 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.5 9.3 GO:0039706 co-receptor binding(GO:0039706)
0.5 8.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.5 1.4 GO:0017129 triglyceride binding(GO:0017129)
0.5 4.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 2.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.4 2.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.4 4.7 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.4 4.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 5.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 19.4 GO:0003785 actin monomer binding(GO:0003785)
0.3 3.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 2.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 2.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 2.4 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.2 3.3 GO:0030274 LIM domain binding(GO:0030274)
0.2 23.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 1.9 GO:0043426 MRF binding(GO:0043426)
0.2 5.9 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 4.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 7.1 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 1.8 GO:0070700 BMP receptor binding(GO:0070700)
0.2 4.3 GO:0000150 recombinase activity(GO:0000150)
0.2 7.3 GO:0038191 neuropilin binding(GO:0038191)
0.2 7.3 GO:0001968 fibronectin binding(GO:0001968)
0.2 1.4 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.2 1.3 GO:0015235 cobalamin transporter activity(GO:0015235)
0.2 1.4 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 11.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 1.3 GO:0034711 inhibin binding(GO:0034711)
0.1 1.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.6 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.9 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 2.3 GO:0005522 profilin binding(GO:0005522)
0.1 1.1 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 2.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 3.1 GO:0031489 myosin V binding(GO:0031489)
0.1 0.7 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.1 2.5 GO:0043422 protein kinase B binding(GO:0043422)
0.1 4.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 2.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 1.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 2.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 1.9 GO:0042923 neuropeptide binding(GO:0042923)
0.1 2.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 1.0 GO:0005537 mannose binding(GO:0005537)
0.1 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 3.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.9 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 1.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 3.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0050693 DBD domain binding(GO:0050692) LBD domain binding(GO:0050693)
0.0 2.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 13.6 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 3.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 3.7 GO:0070851 growth factor receptor binding(GO:0070851)
0.0 0.7 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 4.1 GO:0004519 endonuclease activity(GO:0004519)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.4 3.9 PID IL5 PATHWAY IL5-mediated signaling events
0.2 16.7 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 10.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 3.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 5.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 3.6 PID IL27 PATHWAY IL27-mediated signaling events
0.1 2.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 12.8 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 8.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.6 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 4.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 3.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 3.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 7.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 11.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.4 4.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 7.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 11.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 2.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 4.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.6 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 3.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.9 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 19.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 3.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.2 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 1.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 7.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.7 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 4.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 5.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 11.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 5.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.1 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 7.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 2.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 7.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines