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Illumina Body Map 2 (GSE30611)

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Results for PPARD

Z-value: 1.43

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.14 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg38_v1_chr6_+_35342535_35342582-0.576.6e-04Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_4153616 11.11 ENST00000078445.7
ENST00000595923.5
ENST00000602257.5
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3 like 3
chr1_-_161223559 10.49 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr1_-_119768892 10.25 ENST00000369406.8
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2
chr4_+_158672266 8.05 ENST00000684622.1
ENST00000683483.1
ENST00000684641.1
ENST00000682456.1
ENST00000684627.1
ENST00000511912.6
ENST00000684505.1
ENST00000683305.1
ENST00000684036.1
ENST00000683751.1
ENST00000684129.1
ENST00000307738.5
ETFDH
electron transfer flavoprotein dehydrogenase
chr6_+_43298254 7.55 ENST00000372585.10
ENST00000449231.5
ENST00000372589.7
SLC22A7
solute carrier family 22 member 7
chr1_-_161223408 7.12 ENST00000491350.1
APOA2
apolipoprotein A2
chr4_+_158672237 6.44 ENST00000682734.1
ETFDH
electron transfer flavoprotein dehydrogenase
chr10_-_95069489 6.32 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr3_+_186666003 6.15 ENST00000232003.5
HRG
histidine rich glycoprotein
chr6_+_43298326 5.28 ENST00000372574.7
SLC22A7
solute carrier family 22 member 7
chr1_-_145707345 5.17 ENST00000417171.6
PDZK1
PDZ domain containing 1
chr10_-_72954790 5.16 ENST00000373032.4
PLA2G12B
phospholipase A2 group XIIB
chr17_-_36001549 4.90 ENST00000617897.2
CCL15
C-C motif chemokine ligand 15
chr1_-_145707387 4.86 ENST00000451928.6
PDZK1
PDZ domain containing 1
chr1_-_11047225 4.75 ENST00000400898.3
ENST00000400897.8
MASP2
mannan binding lectin serine peptidase 2
chr18_-_49813869 4.71 ENST00000586485.5
ENST00000587994.5
ENST00000586100.1
ACAA2
acetyl-CoA acyltransferase 2
chr3_+_46497970 4.46 ENST00000296142.4
RTP3
receptor transporter protein 3
chr18_-_49813512 4.43 ENST00000285093.15
ACAA2
acetyl-CoA acyltransferase 2
chrX_+_2828808 4.20 ENST00000381163.7
GYG2
glycogenin 2
chr22_-_42130800 4.02 ENST00000645361.2
ENST00000359033.4
CYP2D6
cytochrome P450 family 2 subfamily D member 6
chr3_-_48898813 3.89 ENST00000319017.5
ENST00000430379.5
SLC25A20
solute carrier family 25 member 20
chrX_+_2828921 3.88 ENST00000398806.8
GYG2
glycogenin 2
chr12_-_52926459 3.83 ENST00000552150.5
KRT8
keratin 8
chr19_-_51366338 3.76 ENST00000596253.1
ENST00000309244.9
ETFB
electron transfer flavoprotein subunit beta
chr9_-_33402551 3.69 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
AQP7
aquaporin 7
chr9_-_33402449 3.55 ENST00000377425.8
AQP7
aquaporin 7
chr17_+_4950147 3.55 ENST00000522301.5
ENO3
enolase 3
chr17_+_7219857 3.45 ENST00000583312.5
ENST00000350303.9
ENST00000584103.5
ENST00000356839.10
ENST00000579886.2
ACADVL
acyl-CoA dehydrogenase very long chain
chr9_+_112380080 3.19 ENST00000398803.1
ENST00000398805.8
HSDL2
hydroxysteroid dehydrogenase like 2
chr20_+_43558968 3.18 ENST00000647834.1
ENST00000373100.7
ENST00000648083.1
ENST00000648530.1
SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_119367669 3.13 ENST00000393103.2
DBI
diazepam binding inhibitor, acyl-CoA binding protein
chr3_-_187291882 3.04 ENST00000392470.6
ENST00000169293.10
ENST00000439271.1
ENST00000392472.6
ENST00000392475.2
MASP1
mannan binding lectin serine peptidase 1
chr3_-_58537283 3.02 ENST00000459701.6
ACOX2
acyl-CoA oxidase 2
chr3_-_58537181 3.02 ENST00000302819.10
ACOX2
acyl-CoA oxidase 2
chr13_+_113105782 2.99 ENST00000541084.5
ENST00000346342.8
ENST00000375581.3
F7
coagulation factor VII
chr2_-_27890348 2.98 ENST00000302188.8
RBKS
ribokinase
chr4_+_139665768 2.83 ENST00000616265.4
ENST00000265498.6
ENST00000506797.5
MGST2
microsomal glutathione S-transferase 2
chr3_-_187291680 2.72 ENST00000425937.1
ENST00000337774.10
ENST00000296280.11
MASP1
mannan binding lectin serine peptidase 1
chr3_-_126517764 2.61 ENST00000290868.7
UROC1
urocanate hydratase 1
chr6_+_32038382 2.51 ENST00000478281.5
ENST00000471671.4
ENST00000435122.3
ENST00000644719.2
CYP21A2
cytochrome P450 family 21 subfamily A member 2
chr1_+_6451578 2.48 ENST00000434576.2
ENST00000477679.2
ESPN
espin
chr21_-_25735570 2.41 ENST00000400090.7
ENST00000400087.7
ENST00000400093.3
ATP5PF
ATP synthase peripheral stalk subunit F6
chr1_+_6451304 2.39 ENST00000636644.1
ESPN
espin
chr7_-_87713287 2.25 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ABCB1
ATP binding cassette subfamily B member 1
chr15_+_43593054 2.20 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
CKMT1B
creatine kinase, mitochondrial 1B
chr9_+_124011738 2.15 ENST00000373615.9
LHX2
LIM homeobox 2
chr2_+_197500371 2.13 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr21_-_25735026 1.90 ENST00000400099.5
ENST00000457143.6
ATP5PF
ATP synthase peripheral stalk subunit F6
chr12_+_120725796 1.88 ENST00000242592.9
ENST00000411593.2
ACADS
acyl-CoA dehydrogenase short chain
chr3_-_126517745 1.84 ENST00000383579.3
UROC1
urocanate hydratase 1
chr17_-_36017953 1.80 ENST00000612516.4
ENST00000615050.2
CCL23
C-C motif chemokine ligand 23
chr21_-_25734887 1.74 ENST00000400094.5
ENST00000284971.8
ATP5PF
ATP synthase peripheral stalk subunit F6
chr8_-_80030232 1.70 ENST00000518271.1
ENST00000276585.9
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr6_+_33204645 1.67 ENST00000374662.4
HSD17B8
hydroxysteroid 17-beta dehydrogenase 8
chr2_+_218419114 1.61 ENST00000454069.5
ENST00000392114.6
ENST00000248444.10
VIL1
villin 1
chr17_+_50532713 1.45 ENST00000503690.5
ENST00000514874.5
ENST00000268933.8
EPN3
epsin 3
chr15_+_43692886 1.45 ENST00000434505.5
ENST00000411750.5
CKMT1A
creatine kinase, mitochondrial 1A
chr8_-_80029904 1.43 ENST00000521434.5
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr11_+_17260353 1.41 ENST00000530527.5
NUCB2
nucleobindin 2
chr8_-_80029826 1.39 ENST00000519386.5
MRPS28
mitochondrial ribosomal protein S28
chr19_+_10086305 1.33 ENST00000253110.16
ENST00000591813.5
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr1_-_197067234 1.32 ENST00000367412.2
F13B
coagulation factor XIII B chain
chr10_-_92291063 1.28 ENST00000265997.5
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr2_-_206159509 1.28 ENST00000423725.5
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr3_-_53844617 1.24 ENST00000481668.5
ENST00000467802.1
CHDH
choline dehydrogenase
chr2_-_206159410 1.23 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NDUFS1
NADH:ubiquinone oxidoreductase core subunit S1
chr12_-_56333893 1.22 ENST00000547572.1
ENST00000257931.9
ENST00000610546.4
ENST00000440411.7
PAN2
poly(A) specific ribonuclease subunit PAN2
chr11_+_34438900 1.20 ENST00000241052.5
CAT
catalase
chr1_-_109426410 1.16 ENST00000271308.9
PSMA5
proteasome 20S subunit alpha 5
chr2_-_197499857 1.14 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
HSPD1
heat shock protein family D (Hsp60) member 1
chr2_-_197499826 1.13 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
HSPD1
heat shock protein family D (Hsp60) member 1
chr10_-_50251500 1.08 ENST00000682911.1
ASAH2
N-acylsphingosine amidohydrolase 2
chr17_+_50532681 1.06 ENST00000503246.1
EPN3
epsin 3
chr17_+_39737923 1.04 ENST00000577695.5
ENST00000309156.9
GRB7
growth factor receptor bound protein 7
chr12_-_56333693 1.04 ENST00000425394.7
ENST00000548043.5
PAN2
poly(A) specific ribonuclease subunit PAN2
chr1_-_160284205 0.97 ENST00000392220.2
PEX19
peroxisomal biogenesis factor 19
chr6_+_142147162 0.95 ENST00000452973.6
ENST00000620996.4
ENST00000367621.1
ENST00000367630.9
VTA1
vesicle trafficking 1
chr20_+_43559060 0.94 ENST00000485914.2
SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_197500398 0.90 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr11_+_64306227 0.90 ENST00000405666.5
ENST00000468670.2
ESRRA
estrogen related receptor alpha
chr20_+_41340780 0.89 ENST00000373257.8
LPIN3
lipin 3
chr20_+_41340878 0.82 ENST00000632009.1
LPIN3
lipin 3
chr4_-_7068033 0.78 ENST00000264954.5
GRPEL1
GrpE like 1, mitochondrial
chrX_+_38352573 0.78 ENST00000039007.5
OTC
ornithine transcarbamylase
chr12_+_18242955 0.75 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr8_-_144063951 0.73 ENST00000567871.2
OPLAH
5-oxoprolinase, ATP-hydrolysing
chr1_+_61952036 0.71 ENST00000646453.1
ENST00000635137.1
PATJ
PATJ crumbs cell polarity complex component
chr16_-_4351283 0.68 ENST00000318059.8
PAM16
presequence translocase associated motor 16
chr8_+_95024977 0.66 ENST00000396124.9
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr6_+_72212802 0.64 ENST00000401910.7
RIMS1
regulating synaptic membrane exocytosis 1
chr19_+_10086787 0.62 ENST00000590378.5
ENST00000397881.7
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr17_+_4899528 0.62 ENST00000381365.4
C17orf107
chromosome 17 open reading frame 107
chr5_+_173057374 0.59 ENST00000523161.1
CREBRF
CREB3 regulatory factor
chr17_-_41572052 0.58 ENST00000588431.1
ENST00000246662.9
KRT9
keratin 9
chr17_+_9842469 0.56 ENST00000304773.5
GLP2R
glucagon like peptide 2 receptor
chr17_+_4899418 0.50 ENST00000521575.1
C17orf107
chromosome 17 open reading frame 107
chr6_-_142147122 0.46 ENST00000258042.2
NMBR
neuromedin B receptor
chr16_-_4351257 0.46 ENST00000577031.5
PAM16
presequence translocase associated motor 16
chr6_-_87589961 0.44 ENST00000369536.10
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr1_+_61952283 0.44 ENST00000307297.8
PATJ
PATJ crumbs cell polarity complex component
chr2_+_95274439 0.42 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
PROM2
prominin 2
chr13_-_52739352 0.35 ENST00000431550.1
CNMD
chondromodulin
chr11_-_57311456 0.33 ENST00000530920.1
TNKS1BP1
tankyrase 1 binding protein 1
chr16_-_75251482 0.32 ENST00000393420.10
ENST00000162330.10
BCAR1
BCAR1 scaffold protein, Cas family member
chr1_+_202348727 0.28 ENST00000356764.6
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr5_-_16508990 0.26 ENST00000399793.6
RETREG1
reticulophagy regulator 1
chr20_-_775979 0.24 ENST00000676154.1
ENST00000674666.1
ENST00000217254.11
SLC52A3
solute carrier family 52 member 3
chr7_+_7182526 0.22 ENST00000436587.7
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
chr17_-_35943662 0.19 ENST00000618542.4
LYZL6
lysozyme like 6
chr6_+_87590067 0.18 ENST00000546266.5
ENST00000257789.4
ENST00000392844.8
ORC3
origin recognition complex subunit 3
chr6_+_72212887 0.17 ENST00000523963.5
RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_16508788 0.16 ENST00000682142.1
RETREG1
reticulophagy regulator 1
chr19_+_49363923 0.14 ENST00000597546.1
DKKL1
dickkopf like acrosomal protein 1
chr2_-_158456702 0.14 ENST00000409889.1
ENST00000283233.10
CCDC148
coiled-coil domain containing 148
chr1_+_165895583 0.13 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr17_-_35943707 0.13 ENST00000615905.5
LYZL6
lysozyme like 6
chr8_+_133017693 0.10 ENST00000518108.1
TG
thyroglobulin
chr5_-_144170607 0.06 ENST00000448443.6
ENST00000513112.5
ENST00000519064.5
ENST00000274496.10
ENST00000522203.5
YIPF5
Yip1 domain family member 5
chr19_+_50770464 0.05 ENST00000270590.4
GPR32
G protein-coupled receptor 32
chr16_+_29814418 0.04 ENST00000636902.1
PRRT2
proline rich transmembrane protein 2
chr11_+_7573905 0.04 ENST00000529575.5
PPFIBP2
PPFIA binding protein 2
chr20_+_48921701 0.03 ENST00000371917.5
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr17_+_76000906 0.02 ENST00000448471.2
CDK3
cyclin dependent kinase 3
chr20_-_63499170 0.02 ENST00000645357.1
ENST00000646335.1
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr14_+_74084947 0.02 ENST00000674221.1
ENST00000554938.2
LIN52
lin-52 DREAM MuvB core complex component
chr3_-_125375249 0.00 ENST00000484491.5
ENST00000492394.5
ENST00000471196.1
ENST00000468369.5
ENST00000485866.5
ENST00000360647.9
ZNF148
zinc finger protein 148

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 17.6 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
1.6 6.3 GO:0002933 lipid hydroxylation(GO:0002933)
1.5 6.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
1.3 3.9 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
1.2 27.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
1.1 9.1 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
1.0 4.0 GO:0033076 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076)
1.0 3.0 GO:0019303 D-ribose catabolic process(GO:0019303)
0.8 2.3 GO:0002368 B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.7 7.2 GO:0015793 glycerol transport(GO:0015793)
0.6 10.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.6 4.5 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.6 3.0 GO:1905225 response to thyrotropin-releasing hormone(GO:1905225)
0.6 11.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.6 10.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 1.3 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.3 1.6 GO:1902896 cytoplasmic actin-based contraction involved in cell motility(GO:0060327) terminal web assembly(GO:1902896)
0.3 1.2 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.3 9.7 GO:0015879 carnitine transport(GO:0015879)
0.3 12.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 0.8 GO:0097272 ammonia homeostasis(GO:0097272)
0.2 4.9 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.2 1.2 GO:0010193 response to ozone(GO:0010193)
0.2 3.8 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.2 2.3 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 8.1 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 3.1 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.4 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 5.2 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 2.5 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.1 4.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.6 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 2.8 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.1 2.2 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 1.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 6.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 0.4 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 1.4 GO:0006600 creatine metabolic process(GO:0006600)
0.1 2.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 0.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 1.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.2 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.9 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 3.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 1.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 4.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 2.3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 3.2 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0032218 riboflavin transport(GO:0032218)
0.0 1.0 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.8 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 4.1 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 1.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.6 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0061709 reticulophagy(GO:0061709)
0.0 0.7 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.9 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 1.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 17.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.8 2.3 GO:0031251 PAN complex(GO:0031251)
0.5 2.5 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.4 1.9 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.4 14.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.3 3.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 10.5 GO:0031528 microvillus membrane(GO:0031528)
0.2 2.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2 4.9 GO:0032426 stereocilium tip(GO:0032426)
0.2 6.2 GO:0036019 endolysosome(GO:0036019)
0.1 4.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 6.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.6 GO:0032433 filopodium tip(GO:0032433)
0.1 0.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 3.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 30.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 8.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.3 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 2.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 10.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.0 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 6.7 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 21.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 7.6 GO:0005911 cell-cell junction(GO:0005911)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.5 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
3.5 17.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
3.4 10.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
2.0 6.0 GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity(GO:0033791)
1.6 8.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.3 3.9 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
1.3 6.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
1.3 10.0 GO:0005124 scavenger receptor binding(GO:0005124)
1.2 4.8 GO:0001855 complement component C4b binding(GO:0001855)
1.0 3.1 GO:0030156 benzodiazepine receptor binding(GO:0030156)
1.0 7.2 GO:0015254 glycerol channel activity(GO:0015254)
0.8 2.5 GO:1990175 EH domain binding(GO:1990175)
0.8 9.1 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.8 2.3 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.6 3.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.6 2.8 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.6 4.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.6 1.7 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.4 2.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.4 1.8 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.3 11.1 GO:0035497 cAMP response element binding(GO:0035497)
0.3 12.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.3 3.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 6.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 1.2 GO:0004096 catalase activity(GO:0004096)
0.2 1.4 GO:0004111 creatine kinase activity(GO:0004111)
0.2 1.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 6.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.6 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 1.9 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 4.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 5.2 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 4.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 1.1 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.4 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 2.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.2 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.1 0.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 3.0 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 4.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 5.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.8 GO:0042301 phosphate ion binding(GO:0042301)
0.0 1.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 3.8 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 2.0 GO:0097110 scaffold protein binding(GO:0097110)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 ST ADRENERGIC Adrenergic Pathway
0.1 2.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 9.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 17.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.0 PID EPHB FWD PATHWAY EPHB forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 10.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 17.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.6 10.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.5 12.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 7.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 5.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 8.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 20.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 5.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.2 2.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 3.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 1.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 3.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 4.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 11.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 3.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 6.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 10.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 3.6 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.8 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex