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Illumina Body Map 2 (GSE30611)
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Results for PRDM1
Z-value: 1.93
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Transcription factors associated with PRDM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM1 | hg38_v1_chr6_+_106086316_106086349 | 0.35 | 5.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 16.6 | GO:0030421 | defecation(GO:0030421) |
| 3.9 | 11.8 | GO:0035759 | mesangial cell-matrix adhesion(GO:0035759) regulation of dendritic cell dendrite assembly(GO:2000547) |
| 2.3 | 11.5 | GO:0097403 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 2.2 | 11.0 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.5 | 9.9 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 1.3 | 8.9 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.2 | 8.7 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 8.6 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.2 | 6.4 | GO:1900116 | extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 1.2 | 6.2 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 20.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 14.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 1.4 | 11.0 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.6 | 8.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 8.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 6.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 5.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 1.3 | 5.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 5.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.5 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 16.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 12.1 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.1 | 11.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.4 | 11.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 1.4 | 11.0 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 1.1 | 9.9 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.6 | 8.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.3 | 8.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 2.1 | 6.4 | GO:0042007 | interleukin-18 binding(GO:0042007) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 11.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 10.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.1 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 5.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 5.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 5.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 5.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 5.0 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 3.0 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 11.5 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.5 | 9.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 9.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 8.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 5.2 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 5.0 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 5.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 4.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |