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Illumina Body Map 2 (GSE30611)

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Results for PRDM4

Z-value: 0.70

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.12 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg38_v1_chr12_-_107760928_1077609990.468.4e-03Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_40611863 3.03 ENST00000601032.5
LTBP4
latent transforming growth factor beta binding protein 4
chr7_+_91264426 2.59 ENST00000287934.4
FZD1
frizzled class receptor 1
chr14_+_105486867 2.11 ENST00000409393.6
ENST00000392531.4
CRIP1
cysteine rich protein 1
chr17_+_44557476 1.90 ENST00000315323.5
FZD2
frizzled class receptor 2
chr1_-_42766978 1.67 ENST00000372526.2
ENST00000236040.8
ENST00000296388.10
ENST00000397054.7
P3H1
prolyl 3-hydroxylase 1
chr19_-_48868590 1.57 ENST00000263265.11
PLEKHA4
pleckstrin homology domain containing A4
chr2_+_218400039 1.52 ENST00000452977.5
CTDSP1
CTD small phosphatase 1
chr2_+_218399838 1.47 ENST00000273062.7
CTDSP1
CTD small phosphatase 1
chr19_-_48868454 1.43 ENST00000355496.9
PLEKHA4
pleckstrin homology domain containing A4
chr7_-_5423826 1.38 ENST00000430969.6
TNRC18
trinucleotide repeat containing 18
chr13_+_51861963 1.19 ENST00000242819.7
CCDC70
coiled-coil domain containing 70
chr17_+_7884783 1.17 ENST00000380358.9
CHD3
chromodomain helicase DNA binding protein 3
chr22_+_38468036 1.14 ENST00000409006.3
ENST00000216014.9
KDELR3
KDEL endoplasmic reticulum protein retention receptor 3
chr11_+_47257953 1.09 ENST00000437276.1
ENST00000436029.5
ENST00000467728.5
ENST00000441012.7
ENST00000405853.7
NR1H3
nuclear receptor subfamily 1 group H member 3
chr7_+_143381907 1.09 ENST00000392910.6
ZYX
zyxin
chr1_-_68050615 1.08 ENST00000646789.1
DIRAS3
DIRAS family GTPase 3
chr10_+_86968432 1.02 ENST00000416348.1
ENST00000372013.8
ADIRF
adipogenesis regulatory factor
chr12_+_80444228 1.01 ENST00000644991.3
PTPRQ
protein tyrosine phosphatase receptor type Q
chr7_+_143381561 0.95 ENST00000354434.8
ZYX
zyxin
chr12_-_57846686 0.92 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chr10_-_103452384 0.85 ENST00000369788.7
CALHM2
calcium homeostasis modulator family member 2
chr1_+_172533104 0.84 ENST00000616058.4
ENST00000263688.4
ENST00000610051.5
SUCO
SUN domain containing ossification factor
chr20_-_62937936 0.81 ENST00000266070.8
ENST00000370371.8
DIDO1
death inducer-obliterator 1
chr9_+_136665745 0.78 ENST00000371698.3
EGFL7
EGF like domain multiple 7
chr11_-_441964 0.76 ENST00000332826.7
ANO9
anoctamin 9
chr9_-_124500986 0.71 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5 group A member 1
chr19_-_34773184 0.71 ENST00000588760.1
ENST00000329285.13
ENST00000587354.6
ZNF599
zinc finger protein 599
chr21_+_34073569 0.69 ENST00000399312.3
ENST00000381151.5
ENST00000362077.4
MRPS6
SLC5A3
ENSG00000272657.1
mitochondrial ribosomal protein S6
solute carrier family 5 member 3
novel transcript
chr5_-_181261078 0.60 ENST00000611618.1
TRIM52
tripartite motif containing 52
chr19_+_42220283 0.57 ENST00000301215.8
ENST00000597945.1
ZNF526
zinc finger protein 526
chr4_-_10116845 0.56 ENST00000382451.6
ENST00000382452.6
WDR1
WD repeat domain 1
chr21_+_33403391 0.56 ENST00000290219.11
ENST00000381995.5
IFNGR2
interferon gamma receptor 2
chr12_-_10723307 0.51 ENST00000279550.11
ENST00000228251.9
YBX3
Y-box binding protein 3
chr2_+_203706475 0.51 ENST00000374481.7
ENST00000458610.6
CD28
CD28 molecule
chr1_+_26787926 0.50 ENST00000674202.1
ENST00000674222.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr1_+_6451578 0.49 ENST00000434576.2
ENST00000477679.2
ESPN
espin
chr11_+_19117123 0.48 ENST00000399351.7
ENST00000446113.7
ZDHHC13
zinc finger DHHC-type palmitoyltransferase 13
chr16_-_67936808 0.48 ENST00000358514.9
PSMB10
proteasome 20S subunit beta 10
chr14_-_95516616 0.42 ENST00000682763.1
SYNE3
spectrin repeat containing nuclear envelope family member 3
chr8_+_93700667 0.42 ENST00000523453.5
ENST00000520955.5
CIBAR1
CBY1 interacting BAR domain containing 1
chr1_+_26788166 0.41 ENST00000374145.6
ENST00000431541.6
ENST00000674273.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr20_-_51023081 0.41 ENST00000433903.5
ENST00000424171.5
ENST00000371571.5
ENST00000439216.5
KCNG1
potassium voltage-gated channel modifier subfamily G member 1
chr6_-_32192845 0.41 ENST00000487761.5
GPSM3
G protein signaling modulator 3
chr1_-_224433776 0.40 ENST00000678879.1
ENST00000651911.2
WDR26
WD repeat domain 26
chr9_+_93576557 0.38 ENST00000359246.9
ENST00000375376.8
PHF2
PHD finger protein 2
chr4_-_10116779 0.37 ENST00000499869.7
WDR1
WD repeat domain 1
chr8_+_93700524 0.37 ENST00000522324.5
ENST00000518322.6
ENST00000522803.5
ENST00000423990.6
ENST00000620645.1
CIBAR1
CBY1 interacting BAR domain containing 1
chr15_+_66505289 0.35 ENST00000565627.5
ENST00000564179.5
ENST00000307897.10
ZWILCH
zwilch kinetochore protein
chr15_+_66504959 0.34 ENST00000535141.6
ENST00000613446.4
ENST00000446801.6
ZWILCH
zwilch kinetochore protein
chr15_-_66504832 0.34 ENST00000569438.2
ENST00000569696.5
ENST00000307961.11
RPL4
ribosomal protein L4
chr6_-_32192630 0.32 ENST00000375040.8
GPSM3
G protein signaling modulator 3
chr1_+_222737283 0.31 ENST00000360827.6
FAM177B
family with sequence similarity 177 member B
chr4_-_82373946 0.31 ENST00000352301.8
ENST00000509107.1
ENST00000353341.8
ENST00000313899.12
HNRNPD
heterogeneous nuclear ribonucleoprotein D
chr16_+_14974974 0.30 ENST00000535621.6
ENST00000396410.9
ENST00000566426.1
PDXDC1
pyridoxal dependent decarboxylase domain containing 1
chr20_+_31968141 0.29 ENST00000562532.3
XKR7
XK related 7
chr9_+_17135017 0.28 ENST00000380641.4
ENST00000380647.8
CNTLN
centlein
chr2_+_233388146 0.27 ENST00000409813.7
DGKD
diacylglycerol kinase delta
chr8_-_134639808 0.27 ENST00000522257.5
ZFAT
zinc finger and AT-hook domain containing
chr1_+_26787667 0.26 ENST00000674335.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr4_-_82374143 0.23 ENST00000507010.5
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D
chr5_+_103120314 0.19 ENST00000613674.4
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr12_+_69585666 0.19 ENST00000543146.2
CCT2
chaperonin containing TCP1 subunit 2
chr16_+_14975098 0.18 ENST00000569715.5
ENST00000627450.2
PDXDC1
pyridoxal dependent decarboxylase domain containing 1
chr16_+_14975061 0.18 ENST00000455313.6
PDXDC1
pyridoxal dependent decarboxylase domain containing 1
chr14_-_105065422 0.18 ENST00000329797.8
ENST00000539291.6
ENST00000392585.2
GPR132
G protein-coupled receptor 132
chr10_+_102226293 0.18 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chrX_+_49235460 0.18 ENST00000376227.4
CCDC22
coiled-coil domain containing 22
chrX_+_15790446 0.17 ENST00000380308.7
ENST00000307771.8
ZRSR2
zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
chr16_+_14975149 0.17 ENST00000325823.11
PDXDC1
pyridoxal dependent decarboxylase domain containing 1
chr12_+_104288889 0.13 ENST00000527335.5
TXNRD1
thioredoxin reductase 1
chr4_+_673518 0.12 ENST00000506838.5
MYL5
myosin light chain 5
chr22_-_21002081 0.11 ENST00000215742.9
ENST00000399133.2
THAP7
THAP domain containing 7
chr1_+_171781635 0.11 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr20_+_62938111 0.11 ENST00000266069.5
GID8
GID complex subunit 8 homolog
chrX_-_135296024 0.10 ENST00000370764.1
ZNF75D
zinc finger protein 75D
chr19_-_53132873 0.10 ENST00000601493.5
ENST00000599261.5
ENST00000597503.5
ENST00000500065.8
ENST00000594011.5
ENST00000595193.5
ENST00000595813.5
ENST00000600574.5
ENST00000596051.1
ENST00000601110.5
ENST00000243643.9
ENST00000421033.5
ZNF415
zinc finger protein 415
chr19_-_11529094 0.06 ENST00000588998.5
ENST00000586149.1
ECSIT
ECSIT signaling integrator
chrX_+_116436599 0.03 ENST00000598581.3
SLC6A14
solute carrier family 6 member 14
chr5_+_159916475 0.01 ENST00000306675.5
ADRA1B
adrenoceptor alpha 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0035425 autocrine signaling(GO:0035425)
0.6 1.7 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.5 2.1 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 0.9 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.2 1.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.2 0.8 GO:2001226 negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.2 1.9 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 0.7 GO:0007538 primary sex determination(GO:0007538)
0.1 1.0 GO:0072719 cellular response to cisplatin(GO:0072719)
0.1 0.7 GO:0015798 myo-inositol transport(GO:0015798)
0.1 1.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.5 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 0.4 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 1.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 2.5 GO:0030252 growth hormone secretion(GO:0030252)
0.0 1.2 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.7 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.5 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0 1.1 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.5 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.4 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 1.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 3.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 3.0 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.4 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.6 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.4 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.2 0.9 GO:0042643 actomyosin, actin portion(GO:0042643)
0.2 0.7 GO:1990423 RZZ complex(GO:1990423)
0.1 2.6 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.9 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.3 1.7 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.3 3.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 4.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.1 GO:0032810 sterol response element binding(GO:0032810)
0.1 2.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.6 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 3.0 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 0.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 3.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0 0.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 3.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 4.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)