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Illumina Body Map 2 (GSE30611)

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Results for REST

Z-value: 4.19

Motif logo

Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
ENSG00000084093.19 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg38_v1_chr4_+_56908894_56909016-0.476.9e-03Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_155070317 25.49 ENST00000287907.3
5-hydroxytryptamine receptor 5A
chr1_+_32886456 24.33 ENST00000373467.4
hippocalcin
chr5_+_175871570 23.69 ENST00000512824.5
ENST00000393745.8
complexin 2
chr9_+_137139481 23.41 ENST00000371546.8
ENST00000371550.8
ENST00000371553.7
ENST00000371555.8
ENST00000371559.8
ENST00000371560.4
glutamate ionotropic receptor NMDA type subunit 1
chr17_+_44308573 22.79 ENST00000590941.5
ENST00000225441.11
ENST00000426726.8
RUN domain containing 3A
chr20_+_46029165 22.77 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
solute carrier family 12 member 5
chr18_-_43277482 22.18 ENST00000255224.8
ENST00000590752.5
ENST00000596867.1
synaptotagmin 4
chrX_-_49200174 21.36 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
synaptophysin
chr16_+_24256313 20.48 ENST00000005284.4
calcium voltage-gated channel auxiliary subunit gamma 3
chrX_-_47619850 20.44 ENST00000295987.13
ENST00000340666.5
synapsin I
chr8_-_144336451 20.05 ENST00000569446.3
scratch family transcriptional repressor 1
chr12_+_112791933 19.49 ENST00000551052.5
ENST00000415485.7
rabphilin 3A
chr14_-_104604741 18.37 ENST00000615704.1
ENST00000415614.6
ENST00000556573.6
transmembrane protein 179
chr14_+_92923143 18.31 ENST00000216492.10
ENST00000334654.4
chromogranin A
chr1_-_175743529 18.12 ENST00000367674.7
ENST00000263525.6
tenascin R
chr12_+_112791738 17.70 ENST00000389385.9
rabphilin 3A
chr14_-_51095091 17.59 ENST00000684578.1
tripartite motif containing 9
chr20_+_5911501 17.07 ENST00000378961.9
ENST00000455042.1
chromogranin B
chr5_+_71719267 16.90 ENST00000296777.5
CART prepropeptide
chr10_+_59177161 16.47 ENST00000373878.3
phytanoyl-CoA 2-hydroxylase interacting protein like
chr4_+_157220691 16.04 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
glutamate ionotropic receptor AMPA type subunit 2
chr1_+_65309517 16.01 ENST00000371069.5
DnaJ heat shock protein family (Hsp40) member C6
chr10_+_97849824 16.00 ENST00000370602.6
golgin A7 family member B
chr19_-_40218339 15.90 ENST00000311308.6
tetratricopeptide repeat domain 9B
chr14_-_51095066 15.37 ENST00000360392.4
tripartite motif containing 9
chr2_-_51032091 15.35 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
neurexin 1
chr9_+_137139139 15.22 ENST00000371561.8
glutamate ionotropic receptor NMDA type subunit 1
chr17_+_32486975 15.21 ENST00000313401.4
cyclin dependent kinase 5 regulatory subunit 1
chr1_-_101996919 15.16 ENST00000370103.9
olfactomedin 3
chr2_-_51032536 15.10 ENST00000626899.1
ENST00000406316.6
neurexin 1
chr10_+_26216766 14.99 ENST00000376261.8
glutamate decarboxylase 2
chr10_+_26216665 14.88 ENST00000259271.7
glutamate decarboxylase 2
chr20_+_46029206 14.65 ENST00000243964.7
solute carrier family 12 member 5
chr4_+_157220654 14.51 ENST00000393815.6
glutamate ionotropic receptor AMPA type subunit 2
chrX_-_153875847 14.38 ENST00000361699.8
ENST00000361981.7
L1 cell adhesion molecule
chr2_+_114442616 14.23 ENST00000410059.6
dipeptidyl peptidase like 10
chr12_+_118981531 13.84 ENST00000267260.5
serine/arginine repetitive matrix 4
chr1_+_154567770 13.84 ENST00000368476.4
cholinergic receptor nicotinic beta 2 subunit
chr9_-_133609325 13.82 ENST00000673969.1
family with sequence similarity 163 member B
chr16_+_4958289 13.54 ENST00000251170.12
SEC14 like lipid binding 5
chr15_-_82709859 13.39 ENST00000542200.2
ENST00000535359.6
ENST00000668990.2
ENST00000652847.1
adaptor related protein complex 3 subunit beta 2
chr5_+_175871670 13.08 ENST00000514150.5
complexin 2
chr2_-_51032390 12.85 ENST00000404971.5
neurexin 1
chr19_-_55180104 12.71 ENST00000537500.5
synaptotagmin 5
chr5_-_176610104 12.36 ENST00000303991.5
G protein regulated inducer of neurite outgrowth 1
chr1_-_241357085 11.98 ENST00000366564.5
regulator of G protein signaling 7
chr14_-_51095314 11.95 ENST00000338969.9
tripartite motif containing 9
chr1_-_241357171 11.95 ENST00000440928.6
regulator of G protein signaling 7
chr19_-_55180242 11.89 ENST00000592470.1
ENST00000354308.8
synaptotagmin 5
chr8_-_90082871 11.84 ENST00000265431.7
calbindin 1
chr3_+_9703826 11.78 ENST00000613455.4
ENST00000383831.7
ENST00000383832.8
copine family member 9
chr12_+_66755 11.46 ENST00000538872.6
IQ motif and Sec7 domain ArfGEF 3
chr1_-_151716782 11.41 ENST00000420342.1
ENST00000290583.9
CUGBP Elav-like family member 3
chr7_+_8433602 10.90 ENST00000405863.6
neurexophilin 1
chr15_-_82709823 10.79 ENST00000666973.1
ENST00000664460.1
ENST00000669930.1
adaptor related protein complex 3 subunit beta 2
chr15_-_82709886 10.48 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
adaptor related protein complex 3 subunit beta 2
chr11_+_125903320 10.38 ENST00000525943.1
DEAD-box helicase 25
chr10_-_49762335 10.31 ENST00000419399.4
ENST00000432695.2
oxoglutarate dehydrogenase L
chr3_-_42701513 10.22 ENST00000310417.9
hedgehog acyltransferase like
chr6_+_152750789 10.10 ENST00000367244.8
ENST00000367243.7
vasoactive intestinal peptide
chr3_-_132035004 10.09 ENST00000429747.6
copine 4
chr12_+_112791903 9.80 ENST00000550901.5
rabphilin 3A
chr18_-_43277364 9.33 ENST00000593720.1
synaptotagmin 4
chr17_-_29005913 9.16 ENST00000442608.7
ENST00000317338.17
ENST00000335960.10
seizure related 6 homolog
chr20_-_62220267 8.95 ENST00000317393.10
ENST00000611492.1
ENST00000340177.10
histamine receptor H3
chr19_-_55180010 8.73 ENST00000589172.5
synaptotagmin 5
chr12_+_112791920 8.54 ENST00000551198.5
rabphilin 3A
chr7_-_101165558 8.42 ENST00000611537.1
ENST00000249330.3
VGF nerve growth factor inducible
chr16_+_2969307 8.39 ENST00000576565.1
ENST00000318782.9
progestin and adipoQ receptor family member 4
chr2_+_130756291 8.33 ENST00000458606.5
ENST00000423981.1
APC membrane recruitment protein 3
chr15_-_82709775 8.24 ENST00000535348.5
adaptor related protein complex 3 subunit beta 2
chr10_-_49762276 8.19 ENST00000374103.9
oxoglutarate dehydrogenase L
chr11_-_66347560 8.16 ENST00000311181.5
beta-1,4-glucuronyltransferase 1
chr1_+_154567820 8.12 ENST00000637900.1
cholinergic receptor nicotinic beta 2 subunit
chr11_+_45885625 8.07 ENST00000241014.6
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_64505981 7.97 ENST00000334025.3
regulator of G protein signaling 7 binding protein
chr16_+_2969270 7.88 ENST00000293978.12
progestin and adipoQ receptor family member 4
chr3_+_62319037 7.69 ENST00000494481.5
chromosome 3 open reading frame 14
chr12_+_112791532 7.65 ENST00000552667.5
rabphilin 3A
chr3_+_62318983 7.62 ENST00000232519.9
ENST00000462069.6
ENST00000465142.5
chromosome 3 open reading frame 14
chr3_+_120908072 7.55 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
syntaxin binding protein 5 like
chr16_+_285680 7.54 ENST00000435833.1
protein disulfide isomerase family A member 2
chr7_-_101165114 7.52 ENST00000445482.2
VGF nerve growth factor inducible
chr18_-_5197241 7.37 ENST00000434239.4
A-kinase anchor inhibitor 1
chr1_+_209938169 7.04 ENST00000367019.5
ENST00000537238.5
ENST00000637265.1
synaptotagmin 14
chr6_+_25652201 6.88 ENST00000612225.4
ENST00000377961.3
secretagogin, EF-hand calcium binding protein
chr10_-_101031095 6.20 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZ domain containing 7
chrX_-_153875979 6.20 ENST00000407935.6
ENST00000439496.5
L1 cell adhesion molecule
chr19_+_40530464 6.16 ENST00000392023.1
spectrin beta, non-erythrocytic 4
chr15_-_26773737 5.96 ENST00000299267.8
gamma-aminobutyric acid type A receptor subunit beta3
chr14_-_74426102 5.96 ENST00000554953.1
ENST00000331628.8
synapse differentiation inducing 1 like
chr2_+_214411048 5.82 ENST00000312504.10
ENST00000427124.1
von Willebrand factor C domain containing 2 like
chr12_+_71439976 5.69 ENST00000536515.5
ENST00000540815.2
leucine rich repeat containing G protein-coupled receptor 5
chr14_+_93430853 5.69 ENST00000553484.5
unc-79 homolog, NALCN channel complex subunit
chr4_-_174829212 5.65 ENST00000340217.5
ENST00000274093.8
glycine receptor alpha 3
chr1_+_37793865 5.63 ENST00000397631.7
mannosidase endo-alpha like
chr20_+_46029009 5.36 ENST00000608944.5
solute carrier family 12 member 5
chr15_-_31870651 5.32 ENST00000307050.6
ENST00000560598.2
OTU deubiquitinase 7A
chr11_+_62613236 5.11 ENST00000278833.4
retinal outer segment membrane protein 1
chr21_-_32728030 4.95 ENST00000382499.7
ENST00000433931.7
ENST00000382491.7
synaptojanin 1
chr1_+_37793787 4.94 ENST00000373045.11
mannosidase endo-alpha like
chr14_+_93430927 4.90 ENST00000393151.6
unc-79 homolog, NALCN channel complex subunit
chr17_+_74671096 4.74 ENST00000402449.8
RAB37, member RAS oncogene family
chr17_-_29006145 4.69 ENST00000360295.13
seizure related 6 homolog
chr12_-_12684490 4.67 ENST00000540510.1
G protein-coupled receptor 19
chr3_+_75906666 4.38 ENST00000487694.7
ENST00000602589.5
roundabout guidance receptor 2
chr9_+_114329869 4.27 ENST00000431067.4
orosomucoid 2
chr2_+_206642487 4.25 ENST00000441223.4
family with sequence similarity 237 member A
chr12_+_71439789 4.23 ENST00000266674.10
leucine rich repeat containing G protein-coupled receptor 5
chr8_-_56445941 4.20 ENST00000517415.1
ENST00000314922.3
proenkephalin
chr9_+_135714582 4.06 ENST00000630792.2
potassium sodium-activated channel subfamily T member 1
chr2_+_114442299 4.05 ENST00000436732.5
dipeptidyl peptidase like 10
chr3_-_48662877 3.93 ENST00000164024.5
cadherin EGF LAG seven-pass G-type receptor 3
chr9_+_135714425 3.88 ENST00000473941.5
ENST00000486577.6
potassium sodium-activated channel subfamily T member 1
chr2_-_51032151 3.79 ENST00000628515.2
neurexin 1
chr9_-_121050264 3.70 ENST00000223642.3
complement C5
chr6_+_109978256 3.66 ENST00000414000.3
G protein-coupled receptor 6
chr14_-_94293024 3.55 ENST00000393096.5
serpin family A member 10
chr14_-_94293071 3.52 ENST00000554723.5
serpin family A member 10
chr14_-_94293260 3.39 ENST00000261994.9
serpin family A member 10
chr6_+_35805347 3.08 ENST00000360215.3
LHFPL tetraspan subfamily member 5
chr4_+_95091462 3.02 ENST00000264568.8
bone morphogenetic protein receptor type 1B
chr6_+_109978297 2.87 ENST00000275169.5
G protein-coupled receptor 6
chr20_+_31968141 2.86 ENST00000562532.3
XK related 7
chr9_-_71446835 2.82 ENST00000357533.6
transient receptor potential cation channel subfamily M member 3
chr20_-_63653413 2.68 ENST00000370053.3
stathmin 3
chr6_+_35805392 2.56 ENST00000651676.1
LHFPL tetraspan subfamily member 5
chr6_+_25652272 2.47 ENST00000334979.6
secretagogin, EF-hand calcium binding protein
chr8_+_6708626 2.32 ENST00000285518.11
1-acylglycerol-3-phosphate O-acyltransferase 5
chr20_+_63696643 2.27 ENST00000369996.3
TNF receptor superfamily member 6b
chr4_+_157220795 2.15 ENST00000506284.5
glutamate ionotropic receptor AMPA type subunit 2
chr2_-_47570905 2.05 ENST00000327876.5
potassium two pore domain channel subfamily K member 12
chr8_+_6708685 1.94 ENST00000518327.1
1-acylglycerol-3-phosphate O-acyltransferase 5
chr19_+_39268394 1.93 ENST00000331982.6
interferon lambda 2
chr7_+_146115974 1.92 ENST00000625365.2
contactin associated protein 2
chr1_+_209938207 1.78 ENST00000472886.5
synaptotagmin 14
chr11_-_93197932 1.62 ENST00000326402.9
solute carrier family 36 member 4
chr18_-_5197502 1.62 ENST00000580650.1
A-kinase anchor inhibitor 1
chr6_+_154039102 1.52 ENST00000360422.8
ENST00000330432.12
opioid receptor mu 1
chr12_-_57050102 1.47 ENST00000300119.8
myosin IA
chr8_-_92966129 1.47 ENST00000522925.5
ENST00000522903.5
ENST00000537541.1
ENST00000521988.6
ENST00000518748.5
ENST00000519069.5
triple QxxK/R motif containing
chr17_-_29006293 1.27 ENST00000585644.1
seizure related 6 homolog
chrX_+_7147675 1.05 ENST00000674429.1
steroid sulfatase
chr3_+_149813806 0.97 ENST00000468648.5
ENST00000459632.5
ring finger protein 13
chr19_-_11529116 0.82 ENST00000592312.5
ENST00000590480.1
ENST00000585318.5
ENST00000270517.12
ENST00000252440.11
ENST00000417981.6
ECSIT signaling integrator
chrX_+_7147237 0.74 ENST00000666110.2
steroid sulfatase
chr15_+_67825504 0.71 ENST00000380035.3
ENST00000554054.5
SKI family transcriptional corepressor 1
chr19_+_840991 0.71 ENST00000234347.10
proteinase 3
chr8_-_92966105 0.53 ENST00000524037.5
ENST00000520430.5
ENST00000521617.5
ENST00000523580.5
triple QxxK/R motif containing
chr8_-_92965988 0.53 ENST00000517751.5
ENST00000524107.5
triple QxxK/R motif containing
chr1_+_171781635 0.43 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
eEF1A lysine and N-terminal methyltransferase
chr8_-_92966081 0.42 ENST00000517858.5
ENST00000378861.9
triple QxxK/R motif containing
chr10_-_77638369 0.42 ENST00000372443.6
potassium calcium-activated channel subfamily M alpha 1
chr16_+_31459950 0.41 ENST00000564900.1
armadillo repeat containing 5
chr11_+_92969651 0.24 ENST00000257068.3
ENST00000528076.1
melatonin receptor 1B
chr19_-_11529094 0.20 ENST00000588998.5
ENST00000586149.1
ECSIT signaling integrator
chr19_-_38912177 0.16 ENST00000571838.2
coiled-coil glutamate rich protein 2
chr1_+_212432891 0.15 ENST00000366988.5
neudesin neurotrophic factor
chr2_+_225399684 0.10 ENST00000636099.1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr11_-_125903190 0.07 ENST00000227474.8
ENST00000613398.4
ENST00000534158.5
ENST00000529801.1
pseudouridine synthase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.9 38.6 GO:0043449 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
10.7 42.8 GO:0040040 thermosensory behavior(GO:0040040)
9.0 44.9 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
6.1 18.3 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
5.6 16.9 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
5.1 25.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
5.1 15.2 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
4.3 29.9 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
3.9 31.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
3.7 22.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
3.6 18.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
3.1 47.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
3.0 24.3 GO:1902075 cellular response to salt(GO:1902075)
2.6 10.2 GO:1903060 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
2.0 9.9 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
1.7 10.5 GO:0008218 bioluminescence(GO:0008218)
1.6 16.0 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.5 21.0 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.5 9.0 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
1.3 11.8 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.3 36.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
1.3 42.9 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.2 105.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.2 22.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
1.2 8.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.0 21.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.8 4.2 GO:0051866 general adaptation syndrome(GO:0051866)
0.8 20.4 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.7 20.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.7 4.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.7 5.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.6 10.1 GO:0070459 prolactin secretion(GO:0070459)
0.6 7.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.6 3.7 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.6 11.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.6 3.9 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.5 32.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5 8.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.4 15.1 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.4 6.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.4 15.9 GO:0002021 response to dietary excess(GO:0002021)
0.4 11.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.4 11.4 GO:0030575 nuclear body organization(GO:0030575)
0.4 18.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.4 3.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.3 2.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 4.3 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.3 20.3 GO:0001754 eye photoreceptor cell differentiation(GO:0001754)
0.3 11.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 6.5 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.2 6.7 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 4.2 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.2 1.9 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 18.3 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 2.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 20.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.2 9.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 4.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 1.6 GO:0015808 L-alanine transport(GO:0015808)
0.1 7.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 10.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 11.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.7 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.1 6.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 7.4 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 2.8 GO:0016048 detection of temperature stimulus(GO:0016048)
0.1 4.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.9 GO:0002385 mucosal immune response(GO:0002385)
0.1 23.9 GO:0006457 protein folding(GO:0006457)
0.0 1.8 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.4 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 1.5 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.2 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 7.9 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 2.6 GO:0007631 feeding behavior(GO:0007631)
0.0 10.3 GO:0043687 post-translational protein modification(GO:0043687)
0.0 5.8 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 1.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 2.3 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 1.0 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 31.5 GO:0032127 dense core granule membrane(GO:0032127)
5.6 33.3 GO:1990769 proximal neuron projection(GO:1990769)
4.7 32.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
4.6 36.8 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
3.6 18.1 GO:0072534 perineuronal net(GO:0072534)
3.0 15.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
2.5 42.9 GO:0030123 AP-3 adaptor complex(GO:0030123)
2.1 38.6 GO:0043083 synaptic cleft(GO:0043083)
2.1 6.2 GO:0002141 stereocilia ankle link(GO:0002141) USH2 complex(GO:1990696)
1.7 24.3 GO:0044327 dendritic spine head(GO:0044327)
1.7 18.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.7 40.1 GO:0060077 inhibitory synapse(GO:0060077)
0.9 21.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 16.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.8 10.4 GO:0070852 cell body fiber(GO:0070852)
0.8 18.3 GO:0042583 chromaffin granule(GO:0042583)
0.7 8.1 GO:0044294 dendritic growth cone(GO:0044294)
0.7 41.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 22.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.6 57.9 GO:0043198 dendritic shaft(GO:0043198)
0.6 20.6 GO:0044295 axonal growth cone(GO:0044295)
0.6 10.4 GO:0033391 chromatoid body(GO:0033391)
0.5 63.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 70.1 GO:0008021 synaptic vesicle(GO:0008021)
0.4 3.7 GO:0005579 membrane attack complex(GO:0005579)
0.3 47.1 GO:0042734 presynaptic membrane(GO:0042734)
0.3 5.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 23.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 16.8 GO:0043195 terminal bouton(GO:0043195)
0.2 5.6 GO:0032426 stereocilium tip(GO:0032426)
0.2 25.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 3.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 6.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.9 GO:0033010 paranodal junction(GO:0033010)
0.1 8.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 52.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 9.0 GO:0098793 presynapse(GO:0098793)
0.1 9.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 9.3 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 4.4 GO:0030673 axolemma(GO:0030673)
0.1 15.0 GO:0030426 growth cone(GO:0030426)
0.0 8.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 13.1 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.5 GO:0031941 basal plasma membrane(GO:0009925) filamentous actin(GO:0031941)
0.0 21.8 GO:0016604 nuclear body(GO:0016604)
0.0 116.3 GO:0016021 integral component of membrane(GO:0016021)
0.0 10.2 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
4.3 38.6 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
3.7 29.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
3.5 63.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
3.2 31.5 GO:0030348 syntaxin-3 binding(GO:0030348)
2.6 18.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
2.5 42.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
2.5 32.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.3 22.8 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
2.1 25.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
1.5 11.8 GO:0005499 vitamin D binding(GO:0005499)
1.5 47.1 GO:0097109 neuroligin family protein binding(GO:0097109)
1.2 8.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
1.1 45.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.0 20.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.9 11.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.9 4.4 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.8 36.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 9.0 GO:0004969 histamine receptor activity(GO:0004969)
0.7 22.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.6 5.0 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.5 94.4 GO:0000149 SNARE binding(GO:0000149)
0.5 18.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.5 6.0 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.4 8.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 1.8 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.4 1.6 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.4 7.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.4 4.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 16.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 6.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 20.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 9.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 11.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 18.5 GO:0042169 SH2 domain binding(GO:0042169)
0.2 3.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 8.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 17.1 GO:0005179 hormone activity(GO:0005179)
0.1 6.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 5.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 2.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 10.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 4.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 8.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 16.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 12.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 2.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 2.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 10.6 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 3.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 10.5 GO:0008201 heparin binding(GO:0008201)
0.0 13.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 25.8 GO:0003779 actin binding(GO:0003779)
0.0 50.6 GO:0005215 transporter activity(GO:0005215)
0.0 10.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 20.5 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 32.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.4 23.3 PID REELIN PATHWAY Reelin signaling pathway
0.2 20.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 18.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.0 PID BMP PATHWAY BMP receptor signaling
0.0 4.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 10.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 25.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
1.5 71.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.0 22.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.0 29.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.7 20.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.5 10.1 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.5 26.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 15.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 16.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 20.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 42.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 10.3 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 33.3 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 44.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 3.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 5.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 3.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 4.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 10.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events