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Illumina Body Map 2 (GSE30611)

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Results for RFX5

Z-value: 1.65

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.18 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg38_v1_chr1_-_151346806_1513468280.551.0e-03Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_32530268 10.63 ENST00000374975.4
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_-_32666648 8.66 ENST00000399082.7
ENST00000399079.7
ENST00000374943.8
ENST00000434651.6
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_-_32816910 8.37 ENST00000447394.1
ENST00000438763.7
HLA-DOB
major histocompatibility complex, class II, DO beta
chr6_-_32763522 7.62 ENST00000435145.6
ENST00000437316.7
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_-_32589833 7.00 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32763466 6.99 ENST00000427449.1
ENST00000411527.5
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr22_+_44180915 6.73 ENST00000444313.8
ENST00000416291.5
PARVG
parvin gamma
chr6_+_30489501 6.68 ENST00000376630.5
HLA-E
major histocompatibility complex, class I, E
chr6_+_33075952 6.43 ENST00000418931.7
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr6_-_32941018 6.17 ENST00000418107.3
HLA-DMB
major histocompatibility complex, class II, DM beta
chr5_-_150412743 6.10 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74
CD74 molecule
chr6_-_32953017 6.02 ENST00000395305.7
ENST00000374843.9
ENST00000395303.7
ENST00000429234.1
HLA-DMA
ENSG00000248993.1
major histocompatibility complex, class II, DM alpha
novel protein
chr6_+_32844789 5.15 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr6_-_30690968 5.12 ENST00000376420.9
ENST00000376421.7
NRM
nurim
chr6_-_31357171 4.84 ENST00000412585.7
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr6_+_26383090 4.52 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chr6_-_32853813 4.44 ENST00000643049.2
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_+_26383176 4.39 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chr6_-_32844643 4.34 ENST00000374881.3
PSMB8
proteasome 20S subunit beta 8
chr6_-_32853618 4.32 ENST00000354258.5
TAP1
transporter 1, ATP binding cassette subfamily B member
chr6_+_26402237 4.27 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
BTN3A1
butyrophilin subfamily 3 member A1
chr6_-_132757883 4.25 ENST00000525289.5
ENST00000326499.11
VNN2
vanin 2
chr6_+_32854179 3.80 ENST00000374859.3
PSMB9
proteasome 20S subunit beta 9
chr15_+_44711487 3.76 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
B2M
beta-2-microglobulin
chr2_-_241149435 3.56 ENST00000358649.8
ENST00000452907.1
ENST00000403638.7
ENST00000234040.9
ENST00000415234.1
PASK
PAS domain containing serine/threonine kinase
chr6_+_26402289 3.50 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr6_+_26457941 3.22 ENST00000493173.1
ENST00000312541.10
ENST00000429381.5
ENST00000469185.5
BTN2A1
butyrophilin subfamily 2 member A1
chr6_+_26457904 2.99 ENST00000541522.5
BTN2A1
butyrophilin subfamily 2 member A1
chr22_+_44181357 2.95 ENST00000417767.1
PARVG
parvin gamma
chr6_+_26365159 2.90 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
BTN3A2
butyrophilin subfamily 3 member A2
chr6_+_26365215 2.80 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chr1_+_181033887 2.66 ENST00000684662.1
ENST00000434571.7
ENST00000367580.6
ENST00000617803.5
ENST00000683652.1
ENST00000367579.7
ENST00000282990.10
MR1
major histocompatibility complex, class I-related
chr6_+_26365176 2.58 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr4_-_142305935 2.36 ENST00000511838.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr6_+_26440472 2.21 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr15_-_44711306 2.20 ENST00000682850.1
PATL2
PAT1 homolog 2
chr11_+_7987314 2.18 ENST00000531572.2
ENST00000651655.1
EIF3F
eukaryotic translation initiation factor 3 subunit F
chr4_-_142305826 2.14 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr1_-_208244375 1.87 ENST00000367033.4
PLXNA2
plexin A2
chr19_-_50511203 1.79 ENST00000595669.5
JOSD2
Josephin domain containing 2
chr3_+_196739839 1.79 ENST00000327134.7
PAK2
p21 (RAC1) activated kinase 2
chr11_-_6619353 1.68 ENST00000642892.1
ENST00000645620.1
ENST00000533371.6
ENST00000647152.1
ENST00000644810.1
ENST00000299427.12
ENST00000682424.1
ENST00000644218.1
ENST00000528657.2
ENST00000531754.2
TPP1
tripeptidyl peptidase 1
chr12_-_52652207 1.45 ENST00000309680.4
KRT2
keratin 2
chr5_+_120464236 1.23 ENST00000407149.7
ENST00000379551.2
PRR16
proline rich 16
chr11_-_85719045 1.21 ENST00000533057.6
ENST00000533892.5
SYTL2
synaptotagmin like 2
chr11_+_111514772 1.14 ENST00000375618.9
ENST00000529167.5
ENST00000332814.6
HOATZ
HOATZ cilia and flagella associated protein
chr1_+_248838211 1.12 ENST00000306562.8
ZNF672
zinc finger protein 672
chr1_-_53142577 1.12 ENST00000620347.5
ENST00000611397.5
SLC1A7
solute carrier family 1 member 7
chr19_-_50511146 1.02 ENST00000594350.1
ENST00000601423.5
JOSD2
Josephin domain containing 2
chr19_-_48615050 0.94 ENST00000263266.4
FAM83E
family with sequence similarity 83 member E
chr10_+_80356754 0.89 ENST00000616870.4
ENST00000411538.5
ENST00000256039.3
DYDC2
DPY30 domain containing 2
chr8_+_100158029 0.83 ENST00000251809.4
SPAG1
sperm associated antigen 1
chr19_-_50511173 0.77 ENST00000598418.6
JOSD2
Josephin domain containing 2
chr19_+_49527988 0.75 ENST00000270645.8
RCN3
reticulocalbin 3
chr19_+_35612729 0.73 ENST00000203166.10
HAUS5
HAUS augmin like complex subunit 5
chr19_+_49528290 0.71 ENST00000597801.1
RCN3
reticulocalbin 3
chr1_-_53142617 0.70 ENST00000371491.4
ENST00000371494.9
SLC1A7
solute carrier family 1 member 7
chr1_+_248838312 0.70 ENST00000505503.5
ZNF672
zinc finger protein 672
chr3_+_9809700 0.68 ENST00000419081.5
ENST00000438596.5
ENST00000417065.5
ENST00000439814.5
ENST00000418745.5
TTLL3
tubulin tyrosine ligase like 3
chr5_-_60488055 0.68 ENST00000505507.6
ENST00000515835.2
ENST00000502484.6
PDE4D
phosphodiesterase 4D
chr17_+_32021005 0.66 ENST00000327564.11
ENST00000584368.5
ENST00000394713.7
ENST00000341671.11
LRRC37B
leucine rich repeat containing 37B
chr10_-_25062279 0.57 ENST00000615958.4
ENKUR
enkurin, TRPC channel interacting protein
chr1_+_36084079 0.54 ENST00000207457.8
TEKT2
tektin 2
chr8_-_98294195 0.50 ENST00000430223.7
NIPAL2
NIPA like domain containing 2
chr19_+_44914702 0.47 ENST00000592885.5
ENST00000589781.1
APOC1
apolipoprotein C1
chr8_+_100158576 0.46 ENST00000388798.7
SPAG1
sperm associated antigen 1
chr1_+_113930728 0.44 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr10_-_80172839 0.41 ENST00000265447.8
ANXA11
annexin A11
chr1_-_8878018 0.38 ENST00000646660.1
ENST00000646906.1
ENO1
enolase 1
chr17_+_28725874 0.33 ENST00000579671.5
ENST00000579060.5
NEK8
NIMA related kinase 8
chr7_-_14974773 0.30 ENST00000437998.1
DGKB
diacylglycerol kinase beta
chr19_-_6057271 0.26 ENST00000592281.5
RFX2
regulatory factor X2
chr12_-_123081287 0.24 ENST00000546049.5
PITPNM2
phosphatidylinositol transfer protein membrane associated 2
chr19_-_48614805 0.23 ENST00000593772.1
FAM83E
family with sequence similarity 83 member E
chr1_-_27012837 0.17 ENST00000289166.6
TENT5B
terminal nucleotidyltransferase 5B
chr8_-_98294339 0.14 ENST00000341166.3
NIPAL2
NIPA like domain containing 2
chr9_+_83980757 0.12 ENST00000325875.7
ENST00000445877.6
RMI1
RecQ mediated genome instability 1
chr11_+_57667974 0.11 ENST00000528177.5
ENST00000287169.8
ZDHHC5
zinc finger DHHC-type palmitoyltransferase 5
chr4_+_87608529 0.06 ENST00000651931.1
DSPP
dentin sialophosphoprotein
chr4_-_99290975 0.04 ENST00000209668.3
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr7_+_726682 0.03 ENST00000297440.11
DNAAF5
dynein axonemal assembly factor 5
chr9_+_133061981 0.03 ENST00000372080.8
CEL
carboxyl ester lipase

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 19.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
4.4 8.8 GO:0046967 cytosol to ER transport(GO:0046967)
3.5 10.4 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
2.8 8.4 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
2.0 6.1 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
0.6 4.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.5 2.2 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.5 8.9 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.4 3.6 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.4 16.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 1.8 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.3 40.3 GO:0031295 T cell costimulation(GO:0031295)
0.2 4.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 12.3 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 1.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 2.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 2.7 GO:0032620 interleukin-17 production(GO:0032620)
0.1 1.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 1.5 GO:0051546 keratinocyte migration(GO:0051546)
0.1 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 1.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 4.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.0 8.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.4 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.1 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.0 0.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.6 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 1.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 2.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.4 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 74.0 GO:0042613 MHC class II protein complex(GO:0042613)
1.7 13.3 GO:1990111 spermatoproteasome complex(GO:1990111)
1.6 17.9 GO:0042611 MHC protein complex(GO:0042611)
1.3 8.8 GO:0042825 TAP complex(GO:0042825)
0.2 2.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 1.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.7 GO:0070652 HAUS complex(GO:0070652)
0.0 5.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.5 GO:0001533 cornified envelope(GO:0001533)
0.0 4.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 31.6 GO:0032395 MHC class II receptor activity(GO:0032395)
1.2 44.3 GO:0042605 peptide antigen binding(GO:0042605)
1.2 6.1 GO:0042289 MHC class II protein binding(GO:0042289)
1.1 4.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.7 4.5 GO:0034597 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.4 13.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 12.6 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 1.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 2.7 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 1.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 5.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.8 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 9.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.8 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.8 PID MYC PATHWAY C-MYC pathway
0.0 8.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 24.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.8 8.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.4 8.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 4.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.2 26.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 12.3 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 3.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)