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Illumina Body Map 2 (GSE30611)
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Results for RORA
Z-value: 0.71
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Transcription factors associated with RORA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RORA | hg38_v1_chr15_-_61229297_61229306 | 0.46 | 7.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_21758097 Show fit | 4.27 |
ENST00000379494.4
|
small muscle protein X-linked |
|
| chr18_-_58629084 Show fit | 2.94 |
ENST00000361673.4
|
alpha kinase 2 |
|
| chr17_+_4951758 Show fit | 2.80 |
ENST00000518175.1
|
enolase 3 |
|
| chr1_-_154192058 Show fit | 2.35 |
ENST00000271850.11
ENST00000368530.7 ENST00000651641.1 |
tropomyosin 3 |
|
| chrX_-_21758021 Show fit | 2.21 |
ENST00000646008.1
|
small muscle protein X-linked |
|
| chr6_+_54083423 Show fit | 1.45 |
ENST00000460844.6
ENST00000370876.6 |
muscular LMNA interacting protein |
|
| chr4_-_23881282 Show fit | 1.33 |
ENST00000613098.4
|
PPARG coactivator 1 alpha |
|
| chr11_-_64759967 Show fit | 1.30 |
ENST00000377432.7
ENST00000164139.4 |
glycogen phosphorylase, muscle associated |
|
| chr2_+_218607914 Show fit | 1.27 |
ENST00000417849.5
|
phospholipase C delta 4 |
|
| chr7_+_123601815 Show fit | 1.24 |
ENST00000451215.6
|
ankyrin repeat and SOCS box containing 15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RORA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.1 | 4.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 3.5 | GO:0034982 | mitochondrial protein processing(GO:0034982) |
| 0.3 | 3.1 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.0 | 2.8 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 2.6 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 2.3 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.5 | 2.1 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 0.0 | 1.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 1.5 | GO:1990034 | calcium ion export from cell(GO:1990034) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.5 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 3.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 2.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 2.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 2.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 2.1 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.4 | 2.0 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.4 | 1.7 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 1.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.4 | 1.3 | GO:1990843 | subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 3.1 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.0 | 2.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 2.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 2.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 2.1 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 1.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 1.5 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.3 | 1.3 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 2.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.5 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 1.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.9 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.7 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.7 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |