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Illumina Body Map 2 (GSE30611)

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Results for RORC

Z-value: 0.52

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.19 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg38_v1_chr1_-_151831768_1518318330.106.0e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_7060676 7.59 ENST00000617865.4
ENST00000402681.7
ENST00000360817.10
C1S
complement C1s
chr12_+_7061206 2.66 ENST00000423384.5
ENST00000413211.5
C1S
complement C1s
chr11_-_64759967 2.23 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chrX_-_103276741 2.04 ENST00000372680.2
TCEAL5
transcription elongation factor A like 5
chr20_-_23452857 1.68 ENST00000377007.3
ENST00000377009.8
CST11
cystatin 11
chr19_-_42423100 1.19 ENST00000597001.1
LIPE
lipase E, hormone sensitive type
chr11_+_31816266 1.14 ENST00000644607.1
ENST00000646221.1
ENST00000643671.1
ENST00000643931.1
ENST00000642614.1
ENST00000642818.1
ENST00000645848.1
ENST00000506388.2
ENST00000645824.1
ENST00000532942.5
PAUPAR
ENSG00000285283.1
PAX6 upstream antisense RNA
novel protein
chr20_+_38581186 1.14 ENST00000373348.4
ENST00000537425.2
ENST00000416116.2
ADIG
adipogenin
chrX_+_70282093 1.13 ENST00000509895.5
ENST00000374473.6
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr1_-_235649734 1.04 ENST00000391854.7
GNG4
G protein subunit gamma 4
chr19_-_7633713 0.96 ENST00000311069.6
PCP2
Purkinje cell protein 2
chr19_-_7632971 0.94 ENST00000598935.5
PCP2
Purkinje cell protein 2
chr7_-_141841473 0.93 ENST00000350549.8
ENST00000438520.1
PRSS37
serine protease 37
chr6_-_46954922 0.92 ENST00000265417.7
ADGRF5
adhesion G protein-coupled receptor F5
chr11_-_47594399 0.82 ENST00000302514.4
C1QTNF4
C1q and TNF related 4
chr3_-_42410558 0.77 ENST00000441172.1
ENST00000287748.8
LYZL4
lysozyme like 4
chr3_-_50322759 0.72 ENST00000442581.1
ENST00000447092.5
HYAL2
hyaluronidase 2
chr4_+_168712159 0.71 ENST00000510998.5
PALLD
palladin, cytoskeletal associated protein
chr17_-_10804092 0.71 ENST00000581851.1
TMEM238L
transmembrane protein 238 like
chr6_-_119078642 0.69 ENST00000621231.4
ENST00000338891.12
FAM184A
family with sequence similarity 184 member A
chr20_+_46894581 0.69 ENST00000357410.7
ENST00000611592.4
EYA2
EYA transcriptional coactivator and phosphatase 2
chr3_-_50322733 0.66 ENST00000428028.1
ENST00000357750.9
HYAL2
hyaluronidase 2
chr7_-_712940 0.62 ENST00000544935.5
ENST00000430040.5
ENST00000456696.2
ENST00000406797.5
PRKAR1B
protein kinase cAMP-dependent type I regulatory subunit beta
chr8_-_94436926 0.53 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr8_+_39913881 0.51 ENST00000518237.6
IDO1
indoleamine 2,3-dioxygenase 1
chr10_-_104085847 0.50 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chr3_-_65597886 0.50 ENST00000460329.6
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_-_101818425 0.49 ENST00000361464.8
ENST00000439817.5
OGA
O-GlcNAcase
chr14_+_21317547 0.47 ENST00000557351.1
RPGRIP1
RPGR interacting protein 1
chr12_+_93570381 0.44 ENST00000549206.5
SOCS2
suppressor of cytokine signaling 2
chr12_+_93569814 0.42 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr10_-_101818405 0.40 ENST00000357797.9
ENST00000370094.7
OGA
O-GlcNAcase
chr8_+_66043413 0.39 ENST00000522619.1
DNAJC5B
DnaJ heat shock protein family (Hsp40) member C5 beta
chr6_-_136526654 0.38 ENST00000611373.1
MAP7
microtubule associated protein 7
chr8_-_126557691 0.35 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr14_+_21317535 0.35 ENST00000382933.8
RPGRIP1
RPGR interacting protein 1
chr20_-_41317602 0.34 ENST00000559234.5
ENST00000683867.1
ZHX3
zinc fingers and homeoboxes 3
chr20_+_31637905 0.34 ENST00000376075.4
COX4I2
cytochrome c oxidase subunit 4I2
chr6_-_111605859 0.34 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr1_-_157099798 0.31 ENST00000454449.3
ETV3L
ETS variant transcription factor 3 like
chr3_-_45915698 0.28 ENST00000539217.5
LZTFL1
leucine zipper transcription factor like 1
chr3_+_185586270 0.28 ENST00000296257.10
SENP2
SUMO specific peptidase 2
chr1_+_103655760 0.27 ENST00000370083.9
AMY1A
amylase alpha 1A
chr19_-_39245006 0.26 ENST00000413851.3
ENST00000613087.4
IFNL3
interferon lambda 3
chr4_-_86849366 0.25 ENST00000273905.7
SLC10A6
solute carrier family 10 member 6
chr17_-_61863327 0.25 ENST00000584322.2
ENST00000682369.1
ENST00000683039.1
ENST00000683381.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr16_+_1782940 0.24 ENST00000262302.14
ENST00000563136.5
ENST00000565987.5
ENST00000568287.5
ENST00000565134.5
NUBP2
nucleotide binding protein 2
chr14_-_23286038 0.24 ENST00000673724.1
HOMEZ
homeobox and leucine zipper encoding
chr11_+_67605488 0.23 ENST00000533876.1
ENST00000647561.1
ENSG00000255119.1
NDUFV1
novel transcript
NADH:ubiquinone oxidoreductase core subunit V1
chr19_-_46077093 0.23 ENST00000601672.5
IGFL4
IGF like family member 4
chr5_+_178130996 0.23 ENST00000515098.5
ENST00000502814.5
ENST00000313386.9
ENST00000507457.5
ENST00000508647.5
RMND5B
required for meiotic nuclear division 5 homolog B
chr6_+_43770707 0.22 ENST00000324450.11
ENST00000417285.7
ENST00000413642.8
ENST00000372055.9
ENST00000482630.7
ENST00000425836.7
ENST00000372064.9
ENST00000372077.8
ENST00000519767.5
VEGFA
vascular endothelial growth factor A
chr19_+_39268394 0.21 ENST00000331982.6
IFNL2
interferon lambda 2
chr6_+_43770202 0.21 ENST00000372067.8
ENST00000672860.2
VEGFA
vascular endothelial growth factor A
chr13_+_108596152 0.20 ENST00000356711.7
ENST00000251041.10
MYO16
myosin XVI
chr2_-_148020689 0.16 ENST00000457954.5
ENST00000392857.10
ENST00000540442.5
ENST00000535373.5
ORC4
origin recognition complex subunit 4
chr3_-_165196689 0.16 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr1_+_159826799 0.16 ENST00000368104.4
SLAMF8
SLAM family member 8
chr3_-_184378136 0.16 ENST00000445696.6
THPO
thrombopoietin
chr1_+_154567770 0.16 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr19_+_1269266 0.16 ENST00000585630.5
ENST00000589710.5
ENST00000628979.2
ENST00000586773.5
ENST00000587323.5
ENST00000589686.5
ENST00000588230.5
ENST00000413636.6
ENST00000587896.6
ENST00000320936.9
ENST00000589235.5
ENST00000591659.5
CIRBP
cold inducible RNA binding protein
chr2_-_29921580 0.16 ENST00000389048.8
ALK
ALK receptor tyrosine kinase
chr2_-_148020754 0.15 ENST00000440042.1
ENST00000536575.5
ORC4
origin recognition complex subunit 4
chr12_+_56021005 0.14 ENST00000547167.6
IKZF4
IKAROS family zinc finger 4
chr14_-_23286082 0.14 ENST00000357460.7
HOMEZ
homeobox and leucine zipper encoding
chr1_-_61725121 0.13 ENST00000371177.2
ENST00000606498.5
TM2D1
TM2 domain containing 1
chr3_-_165196369 0.13 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr14_-_53951880 0.12 ENST00000609748.1
ENST00000558961.1
BMP4
bone morphogenetic protein 4
chr22_-_32464440 0.11 ENST00000397450.2
ENST00000397452.5
ENST00000300399.8
BPIFC
BPI fold containing family C
chr2_+_148021083 0.11 ENST00000642680.2
MBD5
methyl-CpG binding domain protein 5
chr7_-_128775793 0.10 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr1_+_159826860 0.10 ENST00000289707.10
SLAMF8
SLAM family member 8
chr12_+_4562192 0.08 ENST00000543431.5
DYRK4
dual specificity tyrosine phosphorylation regulated kinase 4
chr3_+_187743654 0.08 ENST00000648485.1
ENSG00000285938.1
BCL6 antisense 1
chr10_+_100535927 0.07 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr10_-_104085793 0.04 ENST00000650263.1
COL17A1
collagen type XVII alpha 1 chain
chr16_-_69351778 0.03 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr7_-_30550761 0.01 ENST00000598361.4
ENST00000440438.6
ENSG00000281039.1
GARS1-DT
novel protein
GARS1 divergent transcript
chr12_+_12908961 0.01 ENST00000540125.1
GPRC5A
G protein-coupled receptor class C group 5 member A

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 1.4 GO:0019087 transformation of host cell by virus(GO:0019087)
0.2 1.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.2 0.7 GO:0036269 swimming behavior(GO:0036269)
0.1 0.4 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.9 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 0.2 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 2.2 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 1.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.2 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 1.7 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.0 0.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 1.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.1 0.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 10.3 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.5 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.4 1.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 1.4 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.5 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.9 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.3 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.8 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 11.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.9 GO:0051393 alpha-actinin binding(GO:0051393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.9 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters