Illumina Body Map 2 (GSE30611)
Gene | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
RUNX2 | hg38_v1_chr6_+_45422485_45422561 | 0.72 | 2.9e-06 | Click! |
RUNX1 | hg38_v1_chr21_-_34889735_34889790 | 0.59 | 4.2e-04 | Click! |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 88.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
0.1 | 87.5 | GO:0042119 | neutrophil activation(GO:0042119) |
0.6 | 60.2 | GO:0006968 | cellular defense response(GO:0006968) |
0.2 | 53.5 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
2.0 | 31.5 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
0.3 | 24.7 | GO:0031295 | T cell costimulation(GO:0031295) |
3.8 | 22.6 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
0.3 | 22.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
2.1 | 19.3 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
1.4 | 19.3 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 106.4 | GO:0016021 | integral component of membrane(GO:0016021) |
0.2 | 82.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.4 | 46.9 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
0.3 | 40.1 | GO:0035578 | azurophil granule lumen(GO:0035578) |
0.6 | 38.7 | GO:0001772 | immunological synapse(GO:0001772) |
1.2 | 38.6 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.1 | 29.8 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
0.1 | 29.5 | GO:0030667 | secretory granule membrane(GO:0030667) |
5.5 | 27.5 | GO:0071753 | IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756) |
0.7 | 26.2 | GO:0001891 | phagocytic cup(GO:0001891) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 134.5 | GO:0003823 | antigen binding(GO:0003823) |
0.1 | 35.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 31.4 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
0.3 | 31.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
3.0 | 26.9 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
0.6 | 26.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.4 | 18.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.4 | 16.4 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
2.2 | 15.4 | GO:0019862 | IgA binding(GO:0019862) |
5.0 | 15.0 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 60.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
0.9 | 41.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.7 | 30.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.3 | 29.0 | PID BCR 5PATHWAY | BCR signaling pathway |
0.4 | 28.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
0.2 | 25.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
0.4 | 22.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
0.4 | 21.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
0.4 | 20.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
0.5 | 15.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 47.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.5 | 38.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.8 | 34.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
1.1 | 31.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
0.8 | 29.0 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
0.2 | 20.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.6 | 20.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
0.8 | 20.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.7 | 19.4 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
0.4 | 18.6 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |