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Illumina Body Map 2 (GSE30611)
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Results for RXRA_NR2F6_NR2C2
Z-value: 1.30
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Transcription factors associated with RXRA_NR2F6_NR2C2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
RXRA
|
ENSG00000186350.12 | retinoid X receptor alpha |
|
NR2F6
|
ENSG00000160113.6 | nuclear receptor subfamily 2 group F member 6 |
|
NR2C2
|
ENSG00000177463.15 | nuclear receptor subfamily 2 group C member 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2C2 | hg38_v1_chr3_+_15003912_15003941 | -0.64 | 8.6e-05 | Click! |
| RXRA | hg38_v1_chr9_+_134326435_134326494 | 0.46 | 7.4e-03 | Click! |
| NR2F6 | hg38_v1_chr19_-_17245889_17245954 | 0.42 | 1.8e-02 | Click! |
Activity profile of RXRA_NR2F6_NR2C2 motif
Sorted Z-values of RXRA_NR2F6_NR2C2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRA_NR2F6_NR2C2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 13.8 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 2.7 | 2.7 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 2.0 | 2.0 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 1.7 | 6.8 | GO:0034445 | regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) |
| 1.6 | 4.8 | GO:0007199 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873) |
| 1.3 | 13.2 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.9 | 2.6 | GO:1990641 | response to iron ion starvation(GO:1990641) |
| 0.8 | 2.5 | GO:0097272 | ammonia homeostasis(GO:0097272) |
| 0.8 | 5.6 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.8 | 2.3 | GO:0061402 | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402) |
| 0.8 | 3.8 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.7 | 4.9 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.7 | 2.1 | GO:0070902 | mitochondrial tRNA pseudouridine synthesis(GO:0070902) |
| 0.7 | 2.0 | GO:1902616 | acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616) |
| 0.7 | 3.3 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 0.6 | 1.9 | GO:1990927 | calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.6 | 4.9 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.6 | 3.5 | GO:0019477 | L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440) |
| 0.6 | 1.7 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.5 | 3.6 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.5 | 1.0 | GO:1904732 | regulation of electron carrier activity(GO:1904732) |
| 0.5 | 1.4 | GO:2001027 | negative regulation of endothelial cell chemotaxis(GO:2001027) |
| 0.5 | 1.4 | GO:0045041 | B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.5 | 11.2 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.5 | 1.4 | GO:0090675 | intermicrovillar adhesion(GO:0090675) |
| 0.4 | 2.7 | GO:0021773 | striatal medium spiny neuron differentiation(GO:0021773) |
| 0.4 | 3.1 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) |
| 0.4 | 1.3 | GO:0001970 | type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) positive regulation of activation of membrane attack complex(GO:0001970) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) |
| 0.4 | 1.3 | GO:2000584 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584) |
| 0.4 | 1.2 | GO:0050787 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
| 0.4 | 1.1 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.4 | 1.1 | GO:0035674 | tricarboxylic acid transmembrane transport(GO:0035674) |
| 0.3 | 6.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.3 | 1.0 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.3 | 1.3 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.3 | 5.7 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.3 | 0.9 | GO:0032917 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 0.3 | 4.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 0.9 | GO:1903572 | coronary vein morphogenesis(GO:0003169) regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.3 | 0.9 | GO:0010728 | regulation of hydrogen peroxide biosynthetic process(GO:0010728) |
| 0.3 | 4.2 | GO:0019530 | taurine metabolic process(GO:0019530) |
| 0.3 | 1.2 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.3 | 1.5 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 0.3 | 1.8 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.3 | 4.7 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.3 | 3.2 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.3 | 2.1 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.3 | 2.9 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.3 | 1.8 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
| 0.2 | 5.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.2 | 3.2 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.2 | 0.7 | GO:2001035 | tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037) |
| 0.2 | 1.6 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.2 | 1.8 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.2 | 0.9 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.2 | 0.6 | GO:0019303 | D-ribose catabolic process(GO:0019303) |
| 0.2 | 1.0 | GO:0003070 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 0.6 | GO:0019364 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.2 | 1.2 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.2 | 1.2 | GO:0090294 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
| 0.2 | 0.6 | GO:0071962 | mitotic sister chromatid cohesion, centromeric(GO:0071962) |
| 0.2 | 0.8 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.2 | 1.4 | GO:1904100 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.2 | 0.9 | GO:1902896 | cytoplasmic actin-based contraction involved in cell motility(GO:0060327) terminal web assembly(GO:1902896) |
| 0.2 | 0.9 | GO:0061668 | mitochondrial ribosome assembly(GO:0061668) |
| 0.2 | 2.5 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.2 | 0.9 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.2 | 3.9 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.2 | 0.5 | GO:1903259 | exon-exon junction complex disassembly(GO:1903259) |
| 0.2 | 1.3 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.2 | 2.7 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.2 | 1.4 | GO:0033131 | regulation of glucokinase activity(GO:0033131) regulation of hexokinase activity(GO:1903299) |
| 0.1 | 3.0 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 0.1 | 0.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.1 | 3.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.6 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.1 | 0.4 | GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014810) |
| 0.1 | 0.7 | GO:0009439 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.1 | 0.4 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.1 | 2.2 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.1 | 0.7 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.1 | 1.3 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 1.7 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.1 | 0.9 | GO:0019556 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.1 | 0.5 | GO:0009224 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.1 | 2.0 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.1 | 1.4 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 0.1 | 3.2 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.1 | 1.0 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.1 | 1.3 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.1 | 1.0 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.1 | 0.3 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
| 0.1 | 4.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.9 | GO:0036155 | acylglycerol acyl-chain remodeling(GO:0036155) |
| 0.1 | 3.2 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.1 | 0.4 | GO:0031456 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.1 | 0.4 | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751) |
| 0.1 | 2.3 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 1.6 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 1.1 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 0.6 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.1 | 0.8 | GO:2000124 | endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 6.0 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.1 | 0.7 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 0.2 | GO:0060152 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 0.1 | 0.3 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.1 | 0.2 | GO:1904106 | protein localization to microvillus(GO:1904106) |
| 0.1 | 0.3 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 0.1 | 1.5 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 3.8 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 2.4 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
| 0.1 | 0.3 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.1 | 2.1 | GO:0050961 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 0.2 | GO:0061433 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.1 | 0.4 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 0.5 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.1 | 3.3 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 0.5 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 0.6 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.1 | 0.3 | GO:0090156 | cellular sphingolipid homeostasis(GO:0090156) |
| 0.1 | 1.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.1 | 0.3 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.1 | 2.1 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 0.8 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.1 | 1.0 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 0.3 | GO:0010159 | specification of organ position(GO:0010159) |
| 0.1 | 0.2 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.0 | 1.1 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.0 | 0.3 | GO:1901162 | primary amino compound biosynthetic process(GO:1901162) |
| 0.0 | 0.4 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.0 | 0.4 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.0 | 0.1 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.0 | 0.6 | GO:0032776 | DNA methylation on cytosine(GO:0032776) |
| 0.0 | 0.1 | GO:2000397 | regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397) |
| 0.0 | 0.4 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.0 | 0.8 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.0 | 1.0 | GO:0008212 | mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212) |
| 0.0 | 0.5 | GO:0001554 | luteolysis(GO:0001554) |
| 0.0 | 0.4 | GO:0071799 | response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799) |
| 0.0 | 0.3 | GO:0071484 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.0 | 0.3 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.0 | 0.4 | GO:0072719 | copper ion import(GO:0015677) cellular response to cisplatin(GO:0072719) |
| 0.0 | 0.2 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.0 | 0.8 | GO:0030046 | parallel actin filament bundle assembly(GO:0030046) |
| 0.0 | 1.3 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.0 | 2.8 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.0 | 0.4 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.0 | 1.3 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.5 | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) |
| 0.0 | 0.7 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 0.0 | 2.2 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.0 | 0.4 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 0.9 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.3 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.0 | 0.3 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.0 | 0.4 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.0 | 0.2 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.0 | 0.3 | GO:2001200 | positive regulation of dendritic cell differentiation(GO:2001200) |
| 0.0 | 0.4 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.0 | 1.8 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.0 | 0.6 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 0.1 | GO:0038183 | bile acid signaling pathway(GO:0038183) |
| 0.0 | 0.1 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.0 | 0.2 | GO:1902952 | positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.0 | 0.2 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.0 | 0.1 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.0 | 0.6 | GO:1901687 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.0 | 0.8 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 0.5 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.0 | 0.5 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.3 | GO:0010755 | regulation of plasminogen activation(GO:0010755) |
| 0.0 | 3.1 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.1 | GO:0044857 | plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) |
| 0.0 | 0.2 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.3 | GO:0003190 | atrioventricular valve formation(GO:0003190) |
| 0.0 | 1.0 | GO:0043586 | tongue development(GO:0043586) |
| 0.0 | 0.1 | GO:0009644 | response to high light intensity(GO:0009644) |
| 0.0 | 1.0 | GO:0001556 | oocyte maturation(GO:0001556) |
| 0.0 | 0.5 | GO:0045199 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.0 | 0.4 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.0 | 0.2 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.0 | 0.4 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.0 | 0.7 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 0.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.3 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.0 | 0.5 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.0 | 0.2 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.0 | 0.4 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.0 | 0.3 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 0.2 | GO:1902527 | female meiosis I(GO:0007144) positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) positive regulation of protein monoubiquitination(GO:1902527) |
| 0.0 | 0.2 | GO:0060372 | regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372) |
| 0.0 | 0.2 | GO:1904903 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.0 | 0.7 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.2 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.0 | 0.0 | GO:1902499 | positive regulation of protein autoubiquitination(GO:1902499) |
| 0.0 | 0.2 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 1.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.6 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.0 | 0.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.0 | 0.1 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.0 | 0.0 | GO:0014736 | regulation of muscle atrophy(GO:0014735) negative regulation of muscle atrophy(GO:0014736) response to injury involved in regulation of muscle adaptation(GO:0014876) |
| 0.0 | 0.4 | GO:0044804 | nucleophagy(GO:0044804) |
| 0.0 | 0.0 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.0 | 0.2 | GO:0002052 | positive regulation of neuroblast proliferation(GO:0002052) |
| 0.0 | 0.1 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.0 | 0.1 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.0 | 0.3 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.1 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.0 | 0.1 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.0 | 0.7 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 0.4 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 0.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.1 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.0 | 0.3 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.0 | 0.2 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.0 | 0.2 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.1 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.6 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.9 | 13.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.7 | 2.0 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.6 | 3.2 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.4 | 4.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 0.7 | GO:0031251 | PAN complex(GO:0031251) |
| 0.2 | 1.4 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 4.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 1.7 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.2 | 2.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 3.5 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 2.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.2 | 1.3 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.2 | 0.8 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.1 | 1.0 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.1 | 1.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 1.9 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 1.4 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 2.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 3.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.6 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 0.7 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 1.8 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 4.9 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.1 | 0.6 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.1 | 1.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 1.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.5 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.1 | 7.1 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.7 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
| 0.1 | 0.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 13.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 3.2 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 8.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 0.3 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.1 | 0.6 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 2.0 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 1.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.3 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 0.3 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.1 | 1.0 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 34.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 4.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.3 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.4 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.4 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 0.9 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.3 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.0 | 7.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.2 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.3 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 0.9 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 2.1 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 0.2 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 3.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.7 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.1 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.1 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.0 | 1.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.1 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.0 | 0.3 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 1.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 2.5 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 2.2 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 1.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 2.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 27.4 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 0.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.2 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.3 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 0.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.1 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
| 0.0 | 3.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.2 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.2 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 16.4 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 1.8 | 5.5 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 1.1 | 4.5 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 1.1 | 5.6 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 1.1 | 4.5 | GO:0001855 | complement component C4b binding(GO:0001855) |
| 0.8 | 2.3 | GO:0004613 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.8 | 3.8 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.7 | 2.2 | GO:0033791 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity(GO:0033791) |
| 0.7 | 2.1 | GO:0004730 | pseudouridylate synthase activity(GO:0004730) |
| 0.7 | 3.5 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.7 | 2.0 | GO:0015227 | acyl carnitine transmembrane transporter activity(GO:0015227) |
| 0.6 | 3.0 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.6 | 1.7 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.6 | 3.3 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.5 | 4.1 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.5 | 3.9 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.5 | 4.2 | GO:0005497 | androgen binding(GO:0005497) |
| 0.5 | 1.4 | GO:0052816 | medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816) |
| 0.5 | 3.2 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.5 | 3.2 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.4 | 1.3 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.4 | 4.9 | GO:0003988 | acetyl-CoA C-acyltransferase activity(GO:0003988) |
| 0.4 | 2.2 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.4 | 1.3 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.4 | 2.9 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.4 | 3.3 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.4 | 3.3 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.3 | 1.0 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.3 | 4.5 | GO:0004075 | biotin carboxylase activity(GO:0004075) |
| 0.3 | 0.9 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.3 | 1.9 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.3 | 1.1 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 0.3 | 2.7 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.3 | 0.8 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.3 | 0.8 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.2 | 6.1 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.2 | 1.4 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.2 | 1.5 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.2 | 0.9 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.2 | 0.6 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.2 | 2.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 1.2 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.2 | 4.8 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.2 | 0.6 | GO:0052858 | peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) |
| 0.2 | 1.4 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.2 | 6.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.2 | 0.9 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.2 | 0.5 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.2 | 1.1 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.2 | 1.1 | GO:0015137 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.2 | 0.7 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 0.2 | 0.5 | GO:0033981 | D-dopachrome decarboxylase activity(GO:0033981) |
| 0.2 | 2.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.2 | 1.5 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.2 | 0.6 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.2 | 1.7 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 0.4 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
| 0.1 | 0.9 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 0.9 | GO:0050252 | retinol O-fatty-acyltransferase activity(GO:0050252) |
| 0.1 | 0.4 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.1 | 0.7 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.1 | 1.5 | GO:0015288 | porin activity(GO:0015288) |
| 0.1 | 0.7 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.1 | 0.4 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.1 | 2.5 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.1 | 1.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 1.0 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 2.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 1.0 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 0.3 | GO:0047025 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.1 | 0.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 1.0 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.1 | 16.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 4.2 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 2.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 3.0 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 0.2 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.1 | 3.3 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.1 | 0.5 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.3 | GO:0050211 | procollagen galactosyltransferase activity(GO:0050211) |
| 0.1 | 0.3 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 0.1 | 1.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 0.4 | GO:0050610 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 0.1 | 0.2 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.1 | 1.1 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 0.4 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.1 | 0.3 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.1 | 0.3 | GO:0004102 | choline O-acetyltransferase activity(GO:0004102) |
| 0.1 | 1.2 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.1 | 0.9 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 0.5 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.2 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.1 | 0.2 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.1 | 0.8 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 1.8 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.4 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 19.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 0.2 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.1 | 0.2 | GO:0003978 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.1 | 0.7 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.1 | 0.2 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.1 | 2.4 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 0.4 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.0 | 2.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 2.1 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.5 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 1.0 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.1 | GO:0008434 | calcitriol receptor activity(GO:0008434) lithocholic acid receptor activity(GO:0038186) calcitriol binding(GO:1902098) lithocholic acid binding(GO:1902121) |
| 0.0 | 0.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.5 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 1.3 | GO:0016645 | oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645) |
| 0.0 | 0.3 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.0 | 2.7 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.6 | GO:0015923 | alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923) |
| 0.0 | 1.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.6 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 1.1 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 2.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.6 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.0 | 0.7 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.6 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 0.7 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.1 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.0 | 2.6 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 3.1 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.4 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 2.5 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.5 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.8 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 1.9 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.1 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.0 | 0.2 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 3.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.1 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.0 | 0.3 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 0.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.9 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.1 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.0 | 0.1 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
| 0.0 | 1.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.4 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.0 | 0.4 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.0 | 0.1 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.0 | 0.1 | GO:0015065 | uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553) |
| 0.0 | 0.6 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.0 | 0.1 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.0 | 0.2 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.1 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.4 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.6 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 40.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.9 | ST ADRENERGIC | Adrenergic Pathway |
| 0.1 | 2.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 1.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 4.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.9 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 2.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.9 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.6 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.4 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 8.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 16.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.6 | 13.2 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.6 | 10.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.6 | 13.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 4.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 5.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.2 | 3.2 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.2 | 2.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 2.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 3.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 2.8 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.8 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 6.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 7.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 7.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 8.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.7 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 2.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 2.4 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 1.3 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 1.0 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 1.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.4 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 2.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.0 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.1 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.5 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 6.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.4 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 1.3 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.6 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.7 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 5.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 0.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.3 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.3 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.3 | REACTOME PKB MEDIATED EVENTS | Genes involved in PKB-mediated events |
| 0.0 | 0.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.4 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.0 | 0.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 1.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.4 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |