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Illumina Body Map 2 (GSE30611)
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Results for SIX1_SIX3_SIX2
Z-value: 1.00
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Transcription factors associated with SIX1_SIX3_SIX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX2 | hg38_v1_chr2_-_45009401_45009457 | -0.44 | 1.1e-02 | Click! |
| SIX1 | hg38_v1_chr14_-_60649449_60649490 | -0.42 | 1.6e-02 | Click! |
| SIX3 | hg38_v1_chr2_+_44941695_44941708 | 0.11 | 5.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_58731936 Show fit | 8.62 |
ENST00000344743.8
|
glycine-N-acyltransferase |
|
| chr11_-_58731968 Show fit | 8.10 |
ENST00000278400.3
|
glycine-N-acyltransferase |
|
| chr10_+_5196831 Show fit | 6.25 |
ENST00000263126.3
|
aldo-keto reductase family 1 member C4 |
|
| chr13_-_46105009 Show fit | 5.25 |
ENST00000439329.5
ENST00000674625.1 ENST00000181383.10 |
carboxypeptidase B2 |
|
| chr3_-_42875871 Show fit | 3.36 |
ENST00000316161.6
ENST00000437102.1 |
cytochrome P450 family 8 subfamily B member 1 |
|
| chr19_-_50333504 Show fit | 3.31 |
ENST00000474951.1
|
potassium voltage-gated channel subfamily C member 3 |
|
| chr2_+_233917371 Show fit | 3.04 |
ENST00000324695.9
ENST00000433712.6 |
transient receptor potential cation channel subfamily M member 8 |
|
| chr19_+_44942230 Show fit | 2.72 |
ENST00000592954.2
ENST00000589057.5 |
apolipoprotein C4 APOC4-APOC2 readthrough (NMD candidate) |
|
| chr6_-_136526177 Show fit | 2.60 |
ENST00000617204.4
|
microtubule associated protein 7 |
|
| chr4_+_154563003 Show fit | 2.47 |
ENST00000302068.9
ENST00000509493.1 |
fibrinogen beta chain |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX1_SIX3_SIX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 18.8 | GO:0006544 | glycine metabolic process(GO:0006544) |
| 0.1 | 8.3 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 1.3 | 7.9 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 1.9 | 7.5 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.4 | 4.2 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 1.2 | 3.7 | GO:1903717 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
| 0.7 | 3.6 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.4 | 3.6 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.1 | 3.4 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.2 | 3.2 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 9.8 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 6.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 6.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.2 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 4.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 3.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 3.1 | GO:0033270 | paranode region of axon(GO:0033270) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 16.7 | GO:0047961 | glycine N-acyltransferase activity(GO:0047961) |
| 1.9 | 7.5 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) |
| 0.0 | 6.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 5.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 3.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.9 | 3.7 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.0 | 3.7 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.3 | 3.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 3.6 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 3.6 | GO:0005262 | calcium channel activity(GO:0005262) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 3.3 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.9 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.5 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 0.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.7 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.6 | 9.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.3 | 5.4 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.3 | 4.4 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 4.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 3.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.9 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.2 | 2.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.1 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.1 | 2.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |