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Illumina Body Map 2 (GSE30611)
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Results for SIX4
Z-value: 0.61
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Transcription factors associated with SIX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX4 | hg38_v1_chr14_-_60724300_60724362 | 0.15 | 4.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 3.4 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 0.0 | 2.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 1.4 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.0 | 1.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.2 | 0.9 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
| 0.2 | 0.8 | GO:0038156 | interleukin-5-mediated signaling pathway(GO:0038043) interleukin-3-mediated signaling pathway(GO:0038156) |
| 0.1 | 0.8 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 0.8 | GO:0015860 | purine nucleoside transmembrane transport(GO:0015860) coenzyme transport(GO:0051182) |
| 0.1 | 0.7 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.3 | 0.8 | GO:0030526 | granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.4 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 0.4 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 0.4 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.4 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 4.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 3.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.6 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.3 | 1.4 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.0 | 1.0 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.2 | 0.9 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.2 | 0.8 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.2 | 0.8 | GO:0004912 | interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914) |
| 0.1 | 0.8 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 0.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.8 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 0.7 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 0.7 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.0 | 0.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.4 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.4 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.4 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.3 | REACTOME OPSINS | Genes involved in Opsins |