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Illumina Body Map 2 (GSE30611)

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Results for SIX4

Z-value: 0.61

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.9 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg38_v1_chr14_-_60724300_607243620.154.2e-01Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_116754422 2.59 ENST00000369478.4
ENST00000369477.1
CD2
CD2 molecule
chr14_-_106627685 2.57 ENST00000390629.3
IGHV4-59
immunoglobulin heavy variable 4-59
chr14_-_106235582 2.27 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr14_-_106324743 2.25 ENST00000390612.3
IGHV4-28
immunoglobulin heavy variable 4-28
chr14_-_106349792 2.18 ENST00000438142.3
IGHV4-31
immunoglobulin heavy variable 4-31
chr14_-_105940235 1.93 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr14_-_106803221 1.55 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chrY_+_20575792 1.50 ENST00000382772.3
EIF1AY
eukaryotic translation initiation factor 1A Y-linked
chrY_+_20575716 1.48 ENST00000361365.7
EIF1AY
eukaryotic translation initiation factor 1A Y-linked
chr19_+_35329161 1.46 ENST00000341773.10
ENST00000600131.5
ENST00000595780.5
ENST00000597916.5
ENST00000593867.5
ENST00000600424.5
ENST00000599811.5
ENST00000536635.6
ENST00000085219.10
ENST00000544992.6
ENST00000419549.6
CD22
CD22 molecule
chr1_+_158930778 1.19 ENST00000458222.5
PYHIN1
pyrin and HIN domain family member 1
chr15_-_21742799 1.09 ENST00000622410.2
ENSG00000278263.2
novel protein, identical to IGHV4-4
chr12_-_10130143 1.04 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chrX_+_41724174 1.03 ENST00000302548.5
GPR82
G protein-coupled receptor 82
chr10_+_10798570 1.01 ENST00000638035.1
ENST00000636488.1
CELF2
CUGBP Elav-like family member 2
chr12_-_10130241 0.99 ENST00000353231.9
ENST00000525605.1
CLEC7A
C-type lectin domain containing 7A
chr17_-_74531467 0.99 ENST00000314401.3
ENST00000392621.6
CD300LB
CD300 molecule like family member b
chr19_+_35031263 0.94 ENST00000640135.1
ENST00000596348.2
SCN1B
sodium voltage-gated channel beta subunit 1
chr14_+_21924033 0.93 ENST00000390440.2
TRAV14DV4
T cell receptor alpha variable 14/delta variable 4
chr15_+_40953463 0.89 ENST00000617768.5
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr1_-_151805419 0.86 ENST00000368820.4
LINGO4
leucine rich repeat and Ig domain containing 4
chr20_+_836052 0.85 ENST00000246100.3
FAM110A
family with sequence similarity 110 member A
chr7_-_113919000 0.84 ENST00000284601.4
PPP1R3A
protein phosphatase 1 regulatory subunit 3A
chr22_+_36922040 0.82 ENST00000406230.5
CSF2RB
colony stimulating factor 2 receptor subunit beta
chr12_-_57846686 0.78 ENST00000548823.1
ENST00000398073.7
CTDSP2
CTD small phosphatase 2
chr1_-_113871665 0.78 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr19_+_19063986 0.77 ENST00000318596.8
SLC25A42
solute carrier family 25 member 42
chr19_-_46625037 0.68 ENST00000596260.1
ENST00000594275.1
ENST00000597185.1
ENST00000598865.5
ENST00000291294.7
PTGIR
prostaglandin I2 receptor
chr12_-_4379712 0.67 ENST00000237837.2
FGF23
fibroblast growth factor 23
chr12_-_57742120 0.61 ENST00000257897.7
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr12_-_10130082 0.59 ENST00000533022.5
CLEC7A
C-type lectin domain containing 7A
chr11_-_130314686 0.54 ENST00000525842.5
ZBTB44
zinc finger and BTB domain containing 44
chr6_+_53929982 0.53 ENST00000505762.1
ENST00000511369.5
ENST00000431554.2
MLIP
ENSG00000236740.6
muscular LMNA interacting protein
novel transcript
chr11_-_130314575 0.52 ENST00000397753.5
ZBTB44
zinc finger and BTB domain containing 44
chr15_+_40952962 0.51 ENST00000444189.7
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr1_-_231337830 0.50 ENST00000366645.1
EXOC8
exocyst complex component 8
chr1_-_154961720 0.44 ENST00000368457.3
PYGO2
pygopus family PHD finger 2
chr11_+_33258304 0.42 ENST00000531504.5
ENST00000456517.2
HIPK3
homeodomain interacting protein kinase 3
chr18_-_63161848 0.42 ENST00000590515.1
BCL2
BCL2 apoptosis regulator
chr1_-_16352420 0.40 ENST00000375592.8
FBXO42
F-box protein 42
chr19_+_50384323 0.40 ENST00000599857.7
ENST00000613923.6
ENST00000601098.6
ENST00000440232.7
ENST00000595904.6
ENST00000593887.1
POLD1
DNA polymerase delta 1, catalytic subunit
chr1_-_183590876 0.39 ENST00000367536.5
NCF2
neutrophil cytosolic factor 2
chr14_-_93955577 0.37 ENST00000555507.5
ASB2
ankyrin repeat and SOCS box containing 2
chr19_+_9140377 0.37 ENST00000360385.7
ENST00000247956.11
ZNF317
zinc finger protein 317
chr14_-_67515153 0.35 ENST00000555994.6
TMEM229B
transmembrane protein 229B
chr1_+_26410809 0.34 ENST00000254231.4
ENST00000326279.11
LIN28A
lin-28 homolog A
chr20_+_59300589 0.34 ENST00000337938.7
ENST00000371025.7
EDN3
endothelin 3
chr8_+_131904071 0.32 ENST00000254624.10
ENST00000522709.5
EFR3A
EFR3 homolog A
chr1_-_42335869 0.32 ENST00000372573.5
FOXJ3
forkhead box J3
chr17_+_50561010 0.31 ENST00000360761.8
ENST00000354983.8
ENST00000352832.9
CACNA1G
calcium voltage-gated channel subunit alpha1 G
chr8_+_94895763 0.31 ENST00000523378.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr1_+_231338242 0.30 ENST00000008440.9
ENST00000295050.12
SPRTN
SprT-like N-terminal domain
chr17_+_38870050 0.30 ENST00000318008.11
ENST00000435347.7
LASP1
LIM and SH3 protein 1
chr3_-_87276462 0.28 ENST00000561167.5
ENST00000560656.1
POU1F1
POU class 1 homeobox 1
chr3_-_69200711 0.28 ENST00000478263.5
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr3_-_49120785 0.27 ENST00000417901.5
ENST00000306026.5
ENST00000434032.6
USP19
ubiquitin specific peptidase 19
chr5_+_86617919 0.27 ENST00000247655.4
ENST00000509578.1
COX7C
cytochrome c oxidase subunit 7C
chr3_-_49120668 0.26 ENST00000465902.1
USP19
ubiquitin specific peptidase 19
chr20_+_59300547 0.26 ENST00000644821.1
EDN3
endothelin 3
chr15_+_58987652 0.24 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr3_-_87276577 0.24 ENST00000344265.8
ENST00000350375.7
POU1F1
POU class 1 homeobox 1
chr2_-_61017174 0.23 ENST00000407787.5
ENST00000398658.2
PUS10
pseudouridine synthase 10
chr2_-_74482914 0.23 ENST00000290418.4
ENST00000393965.8
CCDC142
coiled-coil domain containing 142
chr20_+_59300402 0.23 ENST00000311585.11
ENST00000371028.6
EDN3
endothelin 3
chr1_-_247172002 0.21 ENST00000491356.5
ENST00000472531.5
ENST00000340684.10
ENST00000543802.3
ZNF124
zinc finger protein 124
chr7_-_144403693 0.19 ENST00000645489.1
ENST00000643164.1
NOBOX
NOBOX oogenesis homeobox
chr3_-_184248935 0.19 ENST00000446569.1
ENST00000397676.8
ALG3
ALG3 alpha-1,3- mannosyltransferase
chr3_-_184249520 0.19 ENST00000455059.5
ENST00000445626.6
ALG3
ALG3 alpha-1,3- mannosyltransferase
chr2_-_113241683 0.18 ENST00000468980.3
PAX8
paired box 8
chr10_+_86654581 0.18 ENST00000443292.1
OPN4
opsin 4
chr1_-_42335189 0.18 ENST00000361776.5
ENST00000445886.5
ENST00000361346.6
FOXJ3
forkhead box J3
chr17_+_7561899 0.18 ENST00000321337.12
SENP3
SUMO specific peptidase 3
chr19_+_12687998 0.17 ENST00000640151.1
ENST00000640117.1
GNG14
G protein subunit gamma 14
chr8_+_94895837 0.17 ENST00000519136.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr15_-_42051190 0.17 ENST00000399518.3
PLA2G4E
phospholipase A2 group IVE
chr6_+_31528956 0.17 ENST00000376191.3
MCCD1
mitochondrial coiled-coil domain 1
chr6_-_27872334 0.16 ENST00000616365.2
H3C11
H3 clustered histone 11
chr11_-_46593948 0.15 ENST00000533727.5
ENST00000534300.5
ENST00000683756.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy and beclin 1 regulator 1
chr19_+_29923644 0.15 ENST00000360605.8
ENST00000570564.5
ENST00000574233.5
ENST00000585655.1
URI1
URI1 prefoldin like chaperone
chr2_+_74483067 0.14 ENST00000233623.11
ENST00000442235.6
ENST00000410003.5
TTC31
tetratricopeptide repeat domain 31
chr1_-_37595927 0.13 ENST00000373062.8
GNL2
G protein nucleolar 2
chr19_-_58381022 0.12 ENST00000427624.2
ENST00000597582.2
ZNF837
zinc finger protein 837
chr11_+_119067774 0.11 ENST00000621676.5
ENST00000614944.4
VPS11
VPS11 core subunit of CORVET and HOPS complexes
chr22_+_41833079 0.11 ENST00000612482.4
ENST00000361204.9
SREBF2
sterol regulatory element binding transcription factor 2
chr5_-_1294989 0.11 ENST00000334602.10
ENST00000310581.10
TERT
telomerase reverse transcriptase
chr19_+_859654 0.11 ENST00000592860.2
ENST00000327726.11
CFD
complement factor D
chr10_+_86654541 0.10 ENST00000241891.10
ENST00000372071.6
OPN4
opsin 4
chr1_-_158720720 0.10 ENST00000368145.2
OR6K3
olfactory receptor family 6 subfamily K member 3
chr11_-_5343524 0.09 ENST00000300773.3
OR51B5
olfactory receptor family 51 subfamily B member 5
chr16_+_590200 0.09 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr1_-_224437028 0.09 ENST00000445239.1
WDR26
WD repeat domain 26
chr5_+_86617967 0.08 ENST00000515763.1
COX7C
cytochrome c oxidase subunit 7C
chr6_+_52186373 0.08 ENST00000648244.1
IL17A
interleukin 17A
chrX_+_48828873 0.07 ENST00000338270.1
ERAS
ES cell expressed Ras
chr22_-_38872206 0.07 ENST00000407418.8
ENST00000216083.6
CBX6
chromobox 6
chr4_-_10021490 0.07 ENST00000264784.8
SLC2A9
solute carrier family 2 member 9
chr11_-_14359118 0.07 ENST00000256196.9
RRAS2
RAS related 2
chrX_+_9560465 0.07 ENST00000647060.1
TBL1X
transducin beta like 1 X-linked
chr1_-_77682639 0.04 ENST00000370801.8
ENST00000433749.5
ZZZ3
zinc finger ZZ-type containing 3
chr11_-_96343170 0.04 ENST00000524717.6
MAML2
mastermind like transcriptional coactivator 2
chr6_-_31736504 0.03 ENST00000616760.1
ENST00000375784.7
ENST00000375779.6
CLIC1
chloride intracellular channel 1
chr7_-_111788958 0.02 ENST00000417165.1
DOCK4
dedicator of cytokinesis 4
chr11_-_113773668 0.02 ENST00000200135.8
ZW10
zw10 kinetochore protein
chrX_-_11665908 0.02 ENST00000337414.9
ARHGAP6
Rho GTPase activating protein 6
chr1_+_115641945 0.02 ENST00000355485.7
ENST00000369510.8
VANGL1
VANGL planar cell polarity protein 1
chr19_+_11355386 0.00 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
PLPPR2
phospholipid phosphatase related 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.2 0.8 GO:0038156 interleukin-5-mediated signaling pathway(GO:0038043) interleukin-3-mediated signaling pathway(GO:0038156)
0.2 0.9 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.1 0.7 GO:0042369 vitamin D catabolic process(GO:0042369)
0.1 0.5 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 10.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.8 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.5 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.4 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.8 GO:0015860 purine nucleoside transmembrane transport(GO:0015860) coenzyme transport(GO:0051182)
0.1 1.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.7 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.3 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 2.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.0 0.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.5 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0006957 complement activation, alternative pathway(GO:0006957)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
0.1 8.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 2.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0032010 phagolysosome(GO:0032010)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.4 GO:0046930 pore complex(GO:0046930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.8 GO:0051185 coenzyme transporter activity(GO:0051185)
0.2 0.9 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.2 0.8 GO:0004912 interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914)
0.1 0.8 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 8.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.3 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.1 0.4 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 2.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.8 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 3.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.7 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 4.0 GO:0003823 antigen binding(GO:0003823)
0.0 0.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.2 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein