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Illumina Body Map 2 (GSE30611)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 2.70
Motif logo
Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SIX5
|
ENSG00000177045.10 | SIX homeobox 5 |
|
SMARCC2
|
ENSG00000139613.12 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 |
|
HCFC1
|
ENSG00000172534.14 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg38_v1_chr12_-_56189548_56189609 | 0.56 | 8.1e-04 | Click! |
| HCFC1 | hg38_v1_chrX_-_153971810_153971844 | 0.17 | 3.6e-01 | Click! |
| SIX5 | hg38_v1_chr19_-_45768627_45768745 | 0.11 | 5.6e-01 | Click! |
Activity profile of SIX5_SMARCC2_HCFC1 motif
Sorted Z-values of SIX5_SMARCC2_HCFC1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 9.6 | GO:0070446 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 2.0 | 5.9 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 1.0 | 11.0 | GO:2000580 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 1.0 | 2.9 | GO:0006481 | C-terminal protein methylation(GO:0006481) |
| 0.9 | 6.3 | GO:1904098 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.9 | 4.4 | GO:0042851 | L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853) |
| 0.8 | 0.8 | GO:0036090 | cleavage furrow ingression(GO:0036090) |
| 0.8 | 3.2 | GO:1903217 | regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217) |
| 0.7 | 2.7 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681) |
| 0.7 | 6.5 | GO:0071988 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 0.6 | 1.8 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.6 | 3.1 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.6 | 1.7 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) |
| 0.6 | 2.9 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.6 | 2.3 | GO:1903824 | regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824) |
| 0.5 | 8.2 | GO:0036481 | intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481) |
| 0.5 | 2.1 | GO:0051228 | mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) |
| 0.5 | 0.5 | GO:0097198 | histone H3-K36 trimethylation(GO:0097198) |
| 0.5 | 3.0 | GO:2001034 | histone H3-K36 dimethylation(GO:0097676) positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034) |
| 0.5 | 1.5 | GO:0001579 | medium-chain fatty acid transport(GO:0001579) |
| 0.5 | 2.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.5 | 1.4 | GO:0042245 | RNA repair(GO:0042245) |
| 0.5 | 4.1 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.4 | 1.3 | GO:0034471 | endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471) |
| 0.4 | 1.3 | GO:0000349 | generation of catalytic spliceosome for first transesterification step(GO:0000349) |
| 0.4 | 2.1 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.4 | 3.8 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.4 | 1.3 | GO:0010905 | regulation of UDP-glucose catabolic process(GO:0010904) negative regulation of UDP-glucose catabolic process(GO:0010905) regulation of glycogen synthase activity, transferring glucose-1-phosphate(GO:1904226) negative regulation of glycogen synthase activity, transferring glucose-1-phosphate(GO:1904227) |
| 0.4 | 1.6 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
| 0.4 | 1.2 | GO:0060086 | circadian temperature homeostasis(GO:0060086) |
| 0.4 | 1.1 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.4 | 1.1 | GO:1902824 | positive regulation of late endosome to lysosome transport(GO:1902824) |
| 0.4 | 3.6 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.3 | 2.1 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 0.3 | 1.0 | GO:1902594 | viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594) |
| 0.3 | 2.4 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.3 | 1.0 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.3 | 1.9 | GO:0070142 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) synaptic vesicle budding(GO:0070142) |
| 0.3 | 0.9 | GO:0006173 | dADP biosynthetic process(GO:0006173) |
| 0.3 | 4.0 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.3 | 0.9 | GO:0045897 | positive regulation of transcription during mitosis(GO:0045897) |
| 0.3 | 2.7 | GO:0035494 | SNARE complex disassembly(GO:0035494) |
| 0.3 | 0.9 | GO:0031445 | regulation of heterochromatin assembly(GO:0031445) positive regulation of heterochromatin assembly(GO:0031453) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.3 | 4.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.3 | 4.0 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.3 | 3.1 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.3 | 1.1 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.3 | 1.6 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.3 | 0.8 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.3 | 1.8 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.3 | 1.5 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
| 0.3 | 3.6 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.3 | 0.8 | GO:1902774 | vacuole fusion, non-autophagic(GO:0042144) late endosome to lysosome transport(GO:1902774) |
| 0.2 | 3.9 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.2 | 0.7 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.2 | 1.9 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.2 | 1.4 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.2 | 4.6 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.2 | 1.6 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.2 | 2.3 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.2 | 0.2 | GO:0016078 | tRNA catabolic process(GO:0016078) |
| 0.2 | 1.6 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.2 | 0.7 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.2 | 0.7 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.2 | 1.1 | GO:1903625 | negative regulation of DNA catabolic process(GO:1903625) |
| 0.2 | 0.6 | GO:0048213 | Golgi vesicle prefusion complex stabilization(GO:0048213) |
| 0.2 | 2.8 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.2 | 1.5 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.2 | 1.3 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.2 | 0.8 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.2 | 1.6 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.2 | 1.4 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.2 | 1.0 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.2 | 1.5 | GO:0044211 | CTP salvage(GO:0044211) |
| 0.2 | 1.1 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.2 | 0.4 | GO:1900222 | negative regulation of beta-amyloid clearance(GO:1900222) |
| 0.2 | 0.9 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.2 | 1.1 | GO:1990785 | response to water-immersion restraint stress(GO:1990785) |
| 0.2 | 2.2 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.2 | 6.9 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.2 | 3.4 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.2 | 5.1 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.2 | 7.8 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.2 | 0.5 | GO:2001311 | lysobisphosphatidic acid metabolic process(GO:2001311) |
| 0.2 | 1.5 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.2 | 2.1 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.2 | 1.6 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.2 | 0.7 | GO:0061386 | closure of optic fissure(GO:0061386) |
| 0.2 | 2.0 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.2 | 1.3 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.2 | 0.8 | GO:0048254 | snoRNA localization(GO:0048254) |
| 0.2 | 1.1 | GO:1905123 | regulation of glucosylceramidase activity(GO:1905123) |
| 0.2 | 1.9 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.2 | 3.0 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.2 | 2.6 | GO:0042407 | cristae formation(GO:0042407) |
| 0.2 | 1.5 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.1 | 1.0 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 2.1 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.1 | 0.4 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 0.1 | 4.3 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 3.1 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 2.9 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 0.3 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.1 | 1.0 | GO:0060161 | positive regulation of dopamine receptor signaling pathway(GO:0060161) |
| 0.1 | 0.4 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.1 | 0.6 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
| 0.1 | 2.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.1 | 1.4 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
| 0.1 | 0.5 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.1 | 5.8 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
| 0.1 | 1.1 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.1 | 0.6 | GO:0009236 | cobalamin biosynthetic process(GO:0009236) |
| 0.1 | 0.5 | GO:0071922 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.1 | 0.4 | GO:1902416 | regulation of mRNA binding(GO:1902415) positive regulation of mRNA binding(GO:1902416) regulation of RNA binding(GO:1905214) positive regulation of RNA binding(GO:1905216) |
| 0.1 | 1.0 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.1 | 0.4 | GO:0051793 | medium-chain fatty acid catabolic process(GO:0051793) |
| 0.1 | 1.0 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) enucleate erythrocyte differentiation(GO:0043353) |
| 0.1 | 3.4 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 1.4 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.1 | 0.3 | GO:0051805 | evasion or tolerance of host immune response(GO:0020012) evasion or tolerance of host defense response(GO:0030682) evasion or tolerance by virus of host immune response(GO:0030683) evasion or tolerance of immune response of other organism involved in symbiotic interaction(GO:0051805) evasion or tolerance of defense response of other organism involved in symbiotic interaction(GO:0051807) |
| 0.1 | 1.0 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 1.2 | GO:0000101 | sulfur amino acid transport(GO:0000101) |
| 0.1 | 0.2 | GO:0006337 | nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986) |
| 0.1 | 0.6 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.1 | 2.7 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 1.3 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.1 | 1.8 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.1 | 0.5 | GO:0030047 | actin modification(GO:0030047) |
| 0.1 | 0.9 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.1 | 0.9 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.1 | 0.9 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.1 | 0.2 | GO:0000393 | spliceosomal conformational changes to generate catalytic conformation(GO:0000393) |
| 0.1 | 1.6 | GO:1900112 | regulation of histone H3-K9 trimethylation(GO:1900112) |
| 0.1 | 0.4 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.1 | 0.7 | GO:0051415 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.1 | 1.5 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 0.6 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.1 | 0.4 | GO:0046116 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.1 | 0.3 | GO:0018008 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) |
| 0.1 | 0.3 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.1 | 0.3 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 0.1 | 4.2 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 1.7 | GO:0001767 | establishment of lymphocyte polarity(GO:0001767) |
| 0.1 | 0.5 | GO:0035624 | receptor transactivation(GO:0035624) |
| 0.1 | 2.6 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 0.4 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
| 0.1 | 0.7 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.1 | 0.2 | GO:2000275 | regulation of oxidative phosphorylation uncoupler activity(GO:2000275) |
| 0.1 | 2.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 2.5 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.1 | 1.8 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
| 0.1 | 0.4 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.1 | 0.4 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.1 | 4.1 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.1 | 0.1 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.1 | 1.6 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.1 | 4.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.2 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.1 | 1.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.1 | 0.2 | GO:0001188 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189) |
| 0.1 | 1.5 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.1 | 0.2 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.1 | 0.4 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
| 0.1 | 0.1 | GO:0031393 | negative regulation of prostaglandin biosynthetic process(GO:0031393) |
| 0.1 | 1.4 | GO:1901642 | nucleoside transmembrane transport(GO:1901642) |
| 0.1 | 0.2 | GO:0001555 | oocyte growth(GO:0001555) |
| 0.1 | 0.9 | GO:1904851 | positive regulation of establishment of protein localization to telomere(GO:1904851) |
| 0.1 | 1.0 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.1 | 0.5 | GO:0034086 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 0.1 | 0.8 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 0.1 | 0.3 | GO:0097056 | selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056) |
| 0.1 | 6.4 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.1 | 0.4 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.1 | 0.2 | GO:0009644 | response to high light intensity(GO:0009644) |
| 0.1 | 0.4 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 0.5 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.1 | 0.2 | GO:0014028 | notochord formation(GO:0014028) |
| 0.1 | 0.4 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 1.0 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 1.6 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.0 | 5.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.5 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.0 | 1.6 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.0 | 1.4 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 0.6 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.4 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.6 | GO:0015705 | iodide transport(GO:0015705) |
| 0.0 | 0.5 | GO:0045618 | positive regulation of keratinocyte differentiation(GO:0045618) |
| 0.0 | 1.2 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.0 | 1.6 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 0.4 | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering(GO:0071340) |
| 0.0 | 1.0 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.0 | 0.6 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.0 | 0.3 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 0.0 | 0.2 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.0 | 1.5 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 0.0 | 1.5 | GO:0071305 | cellular response to vitamin D(GO:0071305) |
| 0.0 | 3.0 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.0 | 0.3 | GO:0070272 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 0.0 | 0.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.1 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.0 | 0.2 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) |
| 0.0 | 3.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.2 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.0 | 0.8 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 2.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 2.7 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 2.6 | GO:0031113 | regulation of microtubule polymerization(GO:0031113) |
| 0.0 | 0.6 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 7.0 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.0 | 0.2 | GO:2001151 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 0.0 | 2.4 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.0 | 0.2 | GO:1903445 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.0 | 0.4 | GO:1904903 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 0.0 | 1.5 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 0.0 | 0.5 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
| 0.0 | 0.2 | GO:0061091 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 0.0 | 4.9 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 2.2 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.3 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.0 | 1.2 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.0 | 0.4 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.0 | 0.2 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
| 0.0 | 0.2 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.0 | 0.6 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.0 | 0.2 | GO:0009149 | pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213) |
| 0.0 | 0.2 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.7 | GO:0070072 | proton-transporting V-type ATPase complex assembly(GO:0070070) proton-transporting two-sector ATPase complex assembly(GO:0070071) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 1.4 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.0 | 1.6 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.6 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.0 | 0.1 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.0 | 0.3 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.0 | 0.1 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.0 | 0.2 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.0 | 0.4 | GO:0030638 | polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
| 0.0 | 2.0 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 1.6 | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway(GO:0033146) |
| 0.0 | 0.3 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.0 | 0.9 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.9 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.6 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 0.3 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.0 | 1.0 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.1 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.0 | 1.8 | GO:0010830 | regulation of myotube differentiation(GO:0010830) |
| 0.0 | 0.3 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.0 | 1.2 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 2.5 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 0.1 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 0.0 | 1.2 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.6 | GO:0019054 | modulation by virus of host process(GO:0019054) |
| 0.0 | 0.1 | GO:0034628 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.0 | 0.3 | GO:0070200 | establishment of protein localization to telomere(GO:0070200) |
| 0.0 | 2.1 | GO:0042274 | ribosomal small subunit biogenesis(GO:0042274) |
| 0.0 | 0.1 | GO:0040031 | snRNA modification(GO:0040031) |
| 0.0 | 1.1 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.0 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.0 | 1.3 | GO:0006482 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
| 0.0 | 2.3 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.2 | GO:1990164 | histone H2A phosphorylation(GO:1990164) |
| 0.0 | 0.7 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.0 | 0.7 | GO:0048820 | hair follicle maturation(GO:0048820) |
| 0.0 | 1.3 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 0.2 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
| 0.0 | 0.2 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.0 | 0.2 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.0 | 3.1 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 5.1 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.0 | 0.4 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.4 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.5 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.9 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.2 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.0 | 0.1 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.0 | 0.9 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 1.7 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 0.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.1 | GO:0008212 | mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212) |
| 0.0 | 0.2 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202) |
| 0.0 | 0.9 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.3 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
| 0.0 | 0.1 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.0 | 0.5 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.0 | 0.1 | GO:1901594 | detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594) |
| 0.0 | 1.0 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.2 | GO:0032815 | negative regulation of natural killer cell activation(GO:0032815) |
| 0.0 | 0.8 | GO:0035307 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.0 | 1.4 | GO:0003341 | cilium movement(GO:0003341) |
| 0.0 | 0.6 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.0 | 0.2 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.0 | 0.1 | GO:0048105 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) |
| 0.0 | 2.5 | GO:0045333 | cellular respiration(GO:0045333) |
| 0.0 | 0.2 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 2.0 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.0 | 0.2 | GO:0014904 | myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741) |
| 0.0 | 0.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.1 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 1.8 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.0 | 0.2 | GO:0097499 | protein localization to nonmotile primary cilium(GO:0097499) |
| 0.0 | 0.2 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.0 | 0.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.0 | 0.1 | GO:0002176 | male germ cell proliferation(GO:0002176) germ cell proliferation(GO:0036093) |
| 0.0 | 79.8 | GO:0006351 | transcription, DNA-templated(GO:0006351) |
| 0.0 | 0.1 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.2 | GO:0043297 | apical junction assembly(GO:0043297) |
| 0.0 | 0.1 | GO:0070266 | necroptotic process(GO:0070266) |
| 0.0 | 0.1 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.0 | 0.1 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.0 | 0.3 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.2 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.0 | 0.1 | GO:0031060 | regulation of histone methylation(GO:0031060) |
| 0.0 | 0.6 | GO:0007249 | I-kappaB kinase/NF-kappaB signaling(GO:0007249) |
| 0.0 | 0.8 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.1 | GO:0044375 | peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375) |
| 0.0 | 2.9 | GO:0000398 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.0 | 0.4 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.2 | GO:0006582 | melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438) |
| 0.0 | 0.3 | GO:1903861 | regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.8 | 4.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.7 | 3.7 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.7 | 3.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.7 | 2.7 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.7 | 6.5 | GO:0055028 | cortical microtubule(GO:0055028) |
| 0.6 | 1.9 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.6 | 2.4 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.5 | 1.5 | GO:0030689 | Noc complex(GO:0030689) |
| 0.5 | 4.1 | GO:1990745 | EARP complex(GO:1990745) |
| 0.5 | 1.5 | GO:0001534 | radial spoke(GO:0001534) |
| 0.4 | 1.3 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.4 | 2.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.4 | 13.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.4 | 3.2 | GO:0002177 | manchette(GO:0002177) |
| 0.4 | 2.4 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.4 | 1.1 | GO:0098831 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 0.4 | 1.1 | GO:1905103 | integral component of lysosomal membrane(GO:1905103) |
| 0.4 | 1.5 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.4 | 1.1 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.3 | 4.0 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.3 | 5.7 | GO:0032039 | integrator complex(GO:0032039) |
| 0.3 | 1.6 | GO:0035363 | histone locus body(GO:0035363) |
| 0.3 | 0.9 | GO:0055087 | Ski complex(GO:0055087) |
| 0.3 | 4.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.3 | 0.8 | GO:1990298 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 0.3 | 1.8 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.3 | 3.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 1.6 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.2 | 0.9 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.2 | 1.4 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.2 | 2.2 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.2 | 0.8 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.2 | 3.2 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.2 | 0.7 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.2 | 0.5 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.2 | 1.3 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 2.4 | GO:0070187 | telosome(GO:0070187) |
| 0.2 | 1.0 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.2 | 4.6 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.2 | 1.3 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.2 | 0.9 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.2 | 0.6 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.2 | 0.5 | GO:0032116 | SMC loading complex(GO:0032116) |
| 0.1 | 0.9 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.1 | 3.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.1 | 0.6 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.1 | 3.1 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 3.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 3.1 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 4.3 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.1 | 1.0 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 1.6 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 2.2 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 3.1 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 0.4 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.1 | 1.5 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.1 | 2.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 4.0 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.6 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
| 0.1 | 2.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 1.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 1.6 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 0.3 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 1.4 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 0.9 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.1 | 0.6 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.1 | 1.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 1.2 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.8 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.1 | 1.5 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 0.6 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 1.9 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 0.8 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 3.0 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) |
| 0.1 | 1.8 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 0.9 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.1 | 0.5 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 0.2 | GO:0044609 | DBIRD complex(GO:0044609) |
| 0.1 | 1.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.8 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 0.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.4 | GO:0035859 | Seh1-associated complex(GO:0035859) Iml1 complex(GO:1990130) |
| 0.1 | 0.7 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 2.1 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 4.4 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.4 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 0.4 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.1 | 0.6 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.1 | 1.1 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 6.7 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 0.5 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 1.0 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.1 | 2.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 1.3 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 2.0 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 2.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 2.2 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.7 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.3 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.6 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.4 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 3.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 1.0 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 1.5 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.7 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.4 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 2.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.2 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.6 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.6 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 2.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.0 | GO:0098798 | mitochondrial protein complex(GO:0098798) |
| 0.0 | 1.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 1.0 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.8 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 1.6 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.8 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 4.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.1 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.1 | GO:0060187 | cell pole(GO:0060187) |
| 0.0 | 0.5 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 0.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.1 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.0 | 0.2 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.0 | 0.9 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 0.3 | GO:0030891 | VCB complex(GO:0030891) |
| 0.0 | 1.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 1.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.1 | GO:0036398 | TCR signalosome(GO:0036398) |
| 0.0 | 0.7 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 4.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.2 | GO:0071014 | post-mRNA release spliceosomal complex(GO:0071014) |
| 0.0 | 1.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 2.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.8 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 6.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.1 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 0.1 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.0 | 0.3 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 0.2 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.2 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 7.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 0.4 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 1.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.7 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 2.6 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.5 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.2 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 4.0 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 2.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 4.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.3 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 9.6 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 2.5 | 7.6 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 1.5 | 4.4 | GO:0047635 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 1.4 | 4.3 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
| 1.4 | 4.1 | GO:0097363 | protein O-GlcNAc transferase activity(GO:0097363) |
| 1.4 | 4.1 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 1.0 | 2.9 | GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity(GO:0003880) |
| 1.0 | 2.9 | GO:0000994 | RNA polymerase III core binding(GO:0000994) |
| 0.9 | 6.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.8 | 3.2 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.7 | 11.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.7 | 2.7 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 0.7 | 2.7 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.6 | 2.4 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.6 | 1.7 | GO:0016005 | phospholipase A2 activator activity(GO:0016005) |
| 0.4 | 2.2 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.4 | 2.4 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.4 | 7.8 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.4 | 2.3 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.4 | 3.1 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.4 | 1.1 | GO:0050333 | thiamin-triphosphatase activity(GO:0050333) |
| 0.4 | 4.0 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.3 | 1.4 | GO:0035514 | DNA demethylase activity(GO:0035514) |
| 0.3 | 8.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.3 | 1.3 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.3 | 2.0 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.3 | 2.9 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.3 | 1.7 | GO:0031544 | peptidyl-proline 3-dioxygenase activity(GO:0031544) |
| 0.3 | 2.0 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.3 | 3.9 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.3 | 1.4 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.3 | 1.6 | GO:0070004 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.3 | 0.5 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.3 | 0.8 | GO:0071209 | U7 snRNA binding(GO:0071209) |
| 0.3 | 2.8 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.2 | 1.9 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.2 | 2.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.2 | 1.1 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.2 | 0.8 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.2 | 6.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 2.6 | GO:0034618 | arginine binding(GO:0034618) |
| 0.2 | 3.1 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.2 | 1.6 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.2 | 1.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 0.5 | GO:0052642 | lysophosphatidic acid phosphatase activity(GO:0052642) |
| 0.2 | 2.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.2 | 1.8 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.2 | 0.8 | GO:0030622 | U4atac snRNA binding(GO:0030622) |
| 0.2 | 0.6 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.2 | 1.2 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 4.3 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.9 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.1 | 1.1 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.1 | 3.1 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.1 | 0.9 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.1 | 0.7 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.1 | 0.7 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 4.0 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.1 | 0.5 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.1 | 2.7 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 0.6 | GO:0051734 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.1 | 7.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.8 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 1.0 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.1 | 0.4 | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.1 | 2.0 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.4 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.1 | 0.5 | GO:0032089 | NACHT domain binding(GO:0032089) |
| 0.1 | 0.9 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 1.7 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 1.4 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 0.4 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 3.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.9 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.1 | 0.8 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.1 | 5.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.3 | GO:0080130 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 0.1 | 0.7 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 3.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.8 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.1 | 0.9 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 0.6 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.1 | 0.3 | GO:0015182 | L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.1 | 0.6 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.1 | 0.4 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.1 | 4.9 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.1 | 0.5 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 0.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 1.6 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 1.6 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 0.3 | GO:0019107 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 0.1 | 1.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 1.5 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 0.2 | GO:0098640 | integrin binding involved in cell-matrix adhesion(GO:0098640) |
| 0.1 | 0.4 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 0.1 | 0.5 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.1 | 1.7 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 0.7 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 0.6 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.1 | 0.4 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.4 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
| 0.1 | 4.3 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 0.7 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.1 | 1.6 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.1 | 1.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 0.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 0.5 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.1 | 0.6 | GO:0031812 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.1 | 0.7 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.1 | 2.1 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 3.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 5.0 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.1 | 2.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 0.9 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 1.0 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 0.4 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.0 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 1.1 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 0.4 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.0 | 0.2 | GO:0030379 | neurotensin receptor activity, non-G-protein coupled(GO:0030379) |
| 0.0 | 1.7 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 1.1 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 2.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.9 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 1.2 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 2.2 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 1.4 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.2 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 1.4 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 1.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 3.4 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 2.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.5 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 0.4 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 1.5 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 0.0 | 1.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 5.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.9 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.2 | GO:0004803 | transposase activity(GO:0004803) |
| 0.0 | 0.7 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.2 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.0 | 1.0 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.1 | GO:0098847 | sequence-specific single stranded DNA binding(GO:0098847) |
| 0.0 | 0.2 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.0 | 1.1 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 1.2 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.4 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.5 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 4.0 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 1.0 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.1 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.0 | 0.3 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 0.3 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.0 | 1.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 0.3 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.0 | 0.1 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.0 | 0.1 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 0.0 | 1.4 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 0.2 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.2 | GO:0032138 | single base insertion or deletion binding(GO:0032138) |
| 0.0 | 1.6 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 2.4 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.2 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 0.3 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.0 | 2.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 60.8 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 3.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.4 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.0 | 1.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.2 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.0 | 0.5 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.3 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 1.1 | GO:0008378 | galactosyltransferase activity(GO:0008378) |
| 0.0 | 1.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.5 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 0.7 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
| 0.0 | 0.1 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 1.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.2 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 0.2 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.2 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.8 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.2 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
| 0.0 | 1.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 1.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.1 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.0 | 1.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.8 | GO:0032451 | demethylase activity(GO:0032451) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 25.7 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 4.6 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 0.1 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.0 | 0.2 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.0 | 3.1 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 3.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.1 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.0 | 0.7 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.6 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 0.1 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.0 | 0.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.0 | 4.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 1.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 0.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.0 | 0.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.8 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.5 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.1 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.0 | 0.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 5.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 7.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 5.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.3 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 6.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 5.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.9 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 3.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 2.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.9 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 1.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 0.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 3.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.8 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 2.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 4.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.2 | 26.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 6.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 2.4 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.2 | 5.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 4.7 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 4.6 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 0.9 | REACTOME MRNA CAPPING | Genes involved in mRNA Capping |
| 0.1 | 1.0 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 3.1 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 64.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 1.4 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.1 | 1.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.0 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 3.1 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 0.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 0.6 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 2.5 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.1 | 4.2 | REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION | Genes involved in Cleavage of Growing Transcript in the Termination Region |
| 0.1 | 4.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 2.0 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.1 | 4.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.5 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 2.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 1.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.8 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.7 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.0 | 1.1 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 2.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.7 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.8 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.5 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.1 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.0 | 0.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.1 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.9 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.3 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 3.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.4 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.2 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.2 | REACTOME TELOMERE MAINTENANCE | Genes involved in Telomere Maintenance |
| 0.0 | 2.3 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |