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Illumina Body Map 2 (GSE30611)
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Results for SIX6
Z-value: 1.30
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Transcription factors associated with SIX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX6 | hg38_v1_chr14_+_60509138_60509163 | -0.12 | 5.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 14.4 | GO:2000910 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.6 | 11.0 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 1.9 | 9.5 | GO:0015855 | pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.7 | 9.4 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.6 | 8.3 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 7.6 | GO:0045667 | regulation of osteoblast differentiation(GO:0045667) |
| 0.2 | 6.3 | GO:0031639 | plasminogen activation(GO:0031639) |
| 1.6 | 4.9 | GO:0032304 | negative regulation of icosanoid secretion(GO:0032304) |
| 0.2 | 4.6 | GO:0008228 | opsonization(GO:0008228) |
| 0.2 | 4.6 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 14.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.8 | 14.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.6 | 11.0 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 4.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.7 | 2.8 | GO:0071757 | hexameric IgM immunoglobulin complex(GO:0071757) |
| 0.0 | 1.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.1 | 1.4 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.3 | 1.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.3 | 1.1 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.0 | 1.1 | GO:0031519 | PcG protein complex(GO:0031519) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 14.4 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 1.6 | 11.0 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 10.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 1.9 | 9.5 | GO:0005350 | pyrimidine nucleobase transmembrane transporter activity(GO:0005350) |
| 0.3 | 9.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 1.6 | 4.9 | GO:0097258 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 1.2 | 4.6 | GO:0033265 | choline binding(GO:0033265) |
| 0.5 | 4.6 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 3.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 3.2 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 4.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 3.2 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 2.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.8 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 14.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 14.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 9.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.6 | 9.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 4.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.3 | 4.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 4.6 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 2.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.0 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |