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Illumina Body Map 2 (GSE30611)

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Results for SIX6

Z-value: 1.30

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.7 SIX homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg38_v1_chr14_+_60509138_60509163-0.125.1e-01Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_88128049 11.05 ENST00000393750.3
ENST00000295834.8
FABP1
fatty acid binding protein 1
chr1_-_161223559 8.86 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
APOA2
apolipoprotein A2
chr4_-_154590735 8.34 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
FGA
fibrinogen alpha chain
chr9_-_97944832 7.65 ENST00000259456.7
HEMGN
hemogen
chr4_-_154612635 6.32 ENST00000407946.5
ENST00000405164.5
ENST00000336098.8
ENST00000393846.6
ENST00000404648.7
ENST00000443553.5
FGG
fibrinogen gamma chain
chr1_-_161223408 5.50 ENST00000491350.1
APOA2
apolipoprotein A2
chr15_+_58138368 5.42 ENST00000219919.9
ENST00000536493.1
AQP9
aquaporin 9
chr19_-_15898057 4.93 ENST00000011989.11
ENST00000221700.11
CYP4F2
cytochrome P450 family 4 subfamily F member 2
chr3_+_151814102 4.77 ENST00000232892.12
AADAC
arylacetamide deacetylase
chr3_+_151814069 4.67 ENST00000488869.1
AADAC
arylacetamide deacetylase
chr1_-_159714581 4.62 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr3_+_187024614 4.57 ENST00000416235.6
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr15_+_58138169 4.13 ENST00000558772.5
AQP9
aquaporin 9
chr13_-_46105009 3.81 ENST00000439329.5
ENST00000674625.1
ENST00000181383.10
CPB2
carboxypeptidase B2
chr1_+_62597510 3.17 ENST00000371129.4
ANGPTL3
angiopoietin like 3
chr4_+_77605807 2.55 ENST00000682537.1
CXCL13
C-X-C motif chemokine ligand 13
chr6_+_25726767 2.13 ENST00000274764.5
H2BC1
H2B clustered histone 1
chr14_+_20469399 1.99 ENST00000361505.10
ENST00000553591.1
PNP
purine nucleoside phosphorylase
chr15_-_79971164 1.82 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2A1
BCL2 related protein A1
chr22_-_19150292 1.66 ENST00000086933.3
GSC2
goosecoid homeobox 2
chr4_+_73481737 1.65 ENST00000226355.5
AFM
afamin
chr6_-_25726553 1.62 ENST00000297012.5
H2AC1
H2A clustered histone 1
chr22_+_17563433 1.62 ENST00000399813.1
SLC25A18
solute carrier family 25 member 18
chr1_-_150720829 1.61 ENST00000368987.5
HORMAD1
HORMA domain containing 1
chr22_+_17563485 1.58 ENST00000327451.11
SLC25A18
solute carrier family 25 member 18
chrX_+_7843088 1.56 ENST00000341408.5
VCX
variable charge X-linked
chr4_-_70666884 1.53 ENST00000510614.5
JCHAIN
joining chain of multimeric IgA and IgM
chrY_+_14056226 1.44 ENST00000250823.5
VCY1B
variable charge Y-linked 1B
chrX_+_8465426 1.43 ENST00000381029.4
VCX3B
variable charge X-linked 3B
chr1_+_86468902 1.40 ENST00000394711.2
CLCA1
chloride channel accessory 1
chrY_-_13986473 1.27 ENST00000250825.5
VCY
variable charge Y-linked
chr4_-_70666961 1.25 ENST00000510437.5
JCHAIN
joining chain of multimeric IgA and IgM
chr6_-_107824294 1.23 ENST00000369020.8
ENST00000369022.6
SCML4
Scm polycomb group protein like 4
chr11_-_5227063 1.21 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chrX_-_143517473 1.13 ENST00000370503.2
SPANXN3
SPANX family member N3
chrX_+_12791353 1.08 ENST00000380663.7
ENST00000398491.6
ENST00000380668.10
ENST00000489404.5
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr8_+_100158029 1.07 ENST00000251809.4
SPAG1
sperm associated antigen 1
chrX_-_18220878 1.07 ENST00000380033.9
BEND2
BEN domain containing 2
chrX_+_143025918 1.04 ENST00000446864.1
ENST00000370504.3
SPANXN4
SPANX family member N4
chr12_-_21334858 1.03 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
SLCO1A2
solute carrier organic anion transporter family member 1A2
chr1_-_35769928 1.01 ENST00000373220.7
ENST00000520551.1
CLSPN
claspin
chr22_-_17221841 0.93 ENST00000449907.7
ENST00000441548.1
ENST00000399839.5
ADA2
adenosine deaminase 2
chr8_-_100145802 0.93 ENST00000428847.3
FBXO43
F-box protein 43
chr5_+_172194172 0.93 ENST00000398186.5
EFCAB9
EF-hand calcium binding domain 9
chr7_-_48029102 0.89 ENST00000297325.9
ENST00000412142.5
ENST00000395572.6
SUN3
Sad1 and UNC84 domain containing 3
chr1_-_182400660 0.88 ENST00000367565.2
TEDDM1
transmembrane epididymal protein 1
chr2_-_133568393 0.84 ENST00000317721.10
ENST00000405974.7
ENST00000409261.6
ENST00000409213.5
NCKAP5
NCK associated protein 5
chr5_-_67196791 0.83 ENST00000256447.5
CD180
CD180 molecule
chr14_-_69574845 0.83 ENST00000599174.3
CCDC177
coiled-coil domain containing 177
chr7_-_142258027 0.83 ENST00000552471.1
ENST00000547058.6
PRSS58
serine protease 58
chr5_-_83720813 0.80 ENST00000515590.1
ENST00000274341.9
HAPLN1
hyaluronan and proteoglycan link protein 1
chr18_+_52752032 0.79 ENST00000412726.5
ENST00000578080.1
ENST00000582875.1
DCC
DCC netrin 1 receptor
chr7_-_93226449 0.79 ENST00000394468.7
ENST00000453812.2
HEPACAM2
HEPACAM family member 2
chr2_+_27537380 0.78 ENST00000447166.2
C2orf16
chromosome 2 open reading frame 16
chr12_-_121580441 0.76 ENST00000377069.8
KDM2B
lysine demethylase 2B
chr8_+_100157906 0.69 ENST00000520643.5
SPAG1
sperm associated antigen 1
chr7_+_142587857 0.69 ENST00000617639.1
TRBV14
T cell receptor beta variable 14
chr1_+_160739286 0.68 ENST00000359331.8
ENST00000495334.1
SLAMF7
SLAM family member 7
chr6_-_8102046 0.68 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr6_+_47781982 0.68 ENST00000489301.6
ENST00000638973.1
ENST00000371211.6
ENST00000393699.2
OPN5
opsin 5
chr12_-_121038967 0.67 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr15_-_100341899 0.64 ENST00000568565.2
ENST00000268070.9
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif 17
chr12_-_121039204 0.63 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr7_-_81770013 0.62 ENST00000465234.2
HGF
hepatocyte growth factor
chr2_+_209771972 0.62 ENST00000439458.5
ENST00000272845.10
UNC80
unc-80 homolog, NALCN channel complex subunit
chr12_-_121039236 0.58 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_121039156 0.57 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr6_+_127577168 0.56 ENST00000329722.8
C6orf58
chromosome 6 open reading frame 58
chr1_+_160739239 0.53 ENST00000368043.8
SLAMF7
SLAM family member 7
chr11_+_122838492 0.52 ENST00000227348.9
CRTAM
cytotoxic and regulatory T cell molecule
chr5_-_157109115 0.52 ENST00000522593.5
HAVCR2
hepatitis A virus cellular receptor 2
chr8_+_24384455 0.51 ENST00000522298.1
ADAMDEC1
ADAM like decysin 1
chr16_+_21678514 0.51 ENST00000286149.8
ENST00000388958.8
OTOA
otoancorin
chr1_+_156149657 0.51 ENST00000414683.5
SEMA4A
semaphorin 4A
chr21_+_44697427 0.49 ENST00000618832.1
KRTAP10-12
keratin associated protein 10-12
chr4_+_56530600 0.48 ENST00000512175.3
THEGL
theg spermatid protein like
chr1_-_161045961 0.47 ENST00000368021.7
USF1
upstream transcription factor 1
chr1_+_156150008 0.46 ENST00000355014.6
SEMA4A
semaphorin 4A
chr7_+_117611617 0.46 ENST00000468795.1
CFTR
CF transmembrane conductance regulator
chr1_+_160739265 0.46 ENST00000368042.7
SLAMF7
SLAM family member 7
chr1_-_35769958 0.46 ENST00000251195.9
ENST00000318121.8
CLSPN
claspin
chr8_+_24384275 0.44 ENST00000256412.8
ADAMDEC1
ADAM like decysin 1
chr5_+_75512058 0.40 ENST00000514296.5
POLK
DNA polymerase kappa
chr12_+_53954870 0.40 ENST00000243103.4
HOXC12
homeobox C12
chr11_-_102625332 0.40 ENST00000260228.3
MMP20
matrix metallopeptidase 20
chr11_-_82846128 0.38 ENST00000679809.1
ENST00000680186.1
ENST00000681592.1
PRCP
prolylcarboxypeptidase
chr3_+_155083523 0.36 ENST00000680057.1
MME
membrane metalloendopeptidase
chr11_-_77301686 0.36 ENST00000315938.5
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr6_+_26240385 0.35 ENST00000244537.6
H4C6
H4 clustered histone 6
chr5_-_43043170 0.33 ENST00000314890.3
ANXA2R
annexin A2 receptor
chr12_-_121580954 0.32 ENST00000536437.5
ENST00000611216.4
ENST00000538046.6
ENST00000377071.9
KDM2B
lysine demethylase 2B
chr19_-_35563653 0.30 ENST00000262623.4
ATP4A
ATPase H+/K+ transporting subunit alpha
chr21_+_44697172 0.29 ENST00000400365.3
KRTAP10-12
keratin associated protein 10-12
chrX_+_48007796 0.29 ENST00000376940.3
SPACA5
sperm acrosome associated 5
chr16_-_1488764 0.29 ENST00000447419.7
ENST00000440447.2
PTX4
pentraxin 4
chr1_+_12791397 0.28 ENST00000332296.7
PRAMEF1
PRAME family member 1
chr13_-_19505940 0.28 ENST00000400103.6
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr7_-_99877033 0.28 ENST00000316368.3
OR2AE1
olfactory receptor family 2 subfamily AE member 1
chr4_-_122456725 0.24 ENST00000226730.5
IL2
interleukin 2
chr13_+_75549477 0.24 ENST00000618773.4
UCHL3
ubiquitin C-terminal hydrolase L3
chr2_+_85595684 0.23 ENST00000441634.5
ENST00000306368.9
ENST00000414390.5
ENST00000456023.1
RNF181
ring finger protein 181
chr5_-_157109025 0.23 ENST00000307851.9
HAVCR2
hepatitis A virus cellular receptor 2
chr5_+_55851378 0.23 ENST00000396836.6
ENST00000359040.10
IL31RA
interleukin 31 receptor A
chr20_+_56412249 0.22 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chr5_+_140821598 0.22 ENST00000614258.1
ENST00000529859.2
ENST00000529619.5
PCDHA5
protocadherin alpha 5
chr8_+_106580970 0.22 ENST00000517686.5
OXR1
oxidation resistance 1
chr3_-_146605239 0.21 ENST00000492200.5
ENST00000482567.5
ENST00000443512.2
PLSCR5
phospholipid scramblase family member 5
chr11_-_56473352 0.20 ENST00000641310.1
ENST00000641599.1
ENST00000641993.1
ENSG00000284732.1
OR5M3
novel olfactory receptor
olfactory receptor family 5 subfamily M member 3
chr1_-_13347134 0.20 ENST00000334600.7
PRAMEF14
PRAME family member 14
chr11_-_105035113 0.17 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
CASP1
caspase 1
chr13_+_42138042 0.16 ENST00000628433.2
ENST00000536612.3
DGKH
diacylglycerol kinase eta
chr20_-_5010284 0.13 ENST00000379333.5
SLC23A2
solute carrier family 23 member 2
chr13_+_102656933 0.13 ENST00000650757.1
TPP2
tripeptidyl peptidase 2
chr12_-_27970134 0.13 ENST00000534890.1
PTHLH
parathyroid hormone like hormone
chr1_-_38876351 0.12 ENST00000360786.3
GJA9
gap junction protein alpha 9
chr9_-_21351378 0.12 ENST00000380210.1
IFNA6
interferon alpha 6
chr8_+_32721753 0.12 ENST00000518084.5
NRG1
neuregulin 1
chr20_+_56412393 0.12 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr19_-_1650667 0.11 ENST00000587235.6
TCF3
transcription factor 3
chr12_+_55426254 0.10 ENST00000328314.3
OR6C76
olfactory receptor family 6 subfamily C member 76
chr12_+_55330746 0.08 ENST00000641740.2
OR6C3
olfactory receptor family 6 subfamily C member 3
chr1_-_9943314 0.08 ENST00000377223.6
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr6_+_146027662 0.08 ENST00000492807.6
ENST00000361719.6
GRM1
glutamate metabotropic receptor 1
chr16_-_20352707 0.08 ENST00000396134.6
ENST00000573567.5
ENST00000570757.5
ENST00000396138.9
ENST00000571174.5
ENST00000576688.2
UMOD
uromodulin
chr11_+_126392132 0.07 ENST00000526311.5
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr19_+_3136026 0.07 ENST00000262958.4
GNA15
G protein subunit alpha 15
chr6_-_26043704 0.07 ENST00000615966.2
H2BC3
H2B clustered histone 3
chr12_-_86838867 0.06 ENST00000621808.4
MGAT4C
MGAT4 family member C
chr21_-_18485878 0.06 ENST00000422787.1
TMPRSS15
transmembrane serine protease 15
chr3_-_3109980 0.05 ENST00000256452.7
ENST00000311981.12
ENST00000430514.6
ENST00000456302.5
IL5RA
interleukin 5 receptor subunit alpha
chr9_-_136748515 0.04 ENST00000341206.9
LCN6
lipocalin 6
chr8_+_32721823 0.04 ENST00000539990.3
ENST00000519240.5
NRG1
neuregulin 1
chr6_+_29170907 0.03 ENST00000641417.1
OR2J2
olfactory receptor family 2 subfamily J member 2
chr16_-_20352857 0.02 ENST00000577168.2
UMOD
uromodulin
chr2_+_201071984 0.02 ENST00000237889.9
ENST00000433898.5
ENST00000684175.1
ENST00000682325.1
ENST00000454214.1
ENST00000684420.1
NDUFB3
NADH:ubiquinone oxidoreductase subunit B3
chr2_+_88885397 0.02 ENST00000390243.2
IGKV4-1
immunoglobulin kappa variable 4-1
chr12_+_71686473 0.02 ENST00000549735.5
TMEM19
transmembrane protein 19
chr13_+_75549734 0.02 ENST00000563635.5
ENST00000377595.8
ENSG00000261553.5
UCHL3
novel transcript
ubiquitin C-terminal hydrolase L3
chr6_+_52186373 0.01 ENST00000648244.1
IL17A
interleukin 17A

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.4 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
1.9 9.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
1.6 4.9 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
1.0 3.8 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.7 9.4 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.6 2.5 GO:2001027 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.6 11.0 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.6 8.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 1.6 GO:0051598 meiotic recombination checkpoint(GO:0051598)
0.4 2.9 GO:0046102 inosine metabolic process(GO:0046102)
0.3 3.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.3 1.2 GO:0030185 nitric oxide transport(GO:0030185)
0.3 2.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 0.7 GO:0071656 negative regulation of interleukin-3 production(GO:0032712) negative regulation of granulocyte colony-stimulating factor production(GO:0071656) negative regulation of macrophage colony-stimulating factor production(GO:1901257)
0.2 6.3 GO:0031639 plasminogen activation(GO:0031639)
0.2 4.6 GO:0008228 opsonization(GO:0008228)
0.2 1.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 0.8 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.2 1.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 4.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 1.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.5 GO:0035377 transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 0.8 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 3.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.4 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.5 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.4 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 0.6 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.9 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:0015882 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 1.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 1.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.5 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 7.6 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 1.0 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 2.5 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 1.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.7 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 1.1 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 1.6 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.1 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 14.7 GO:0005577 fibrinogen complex(GO:0005577)
0.8 14.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.7 2.8 GO:0071757 hexameric IgM immunoglobulin complex(GO:0071757)
0.6 11.0 GO:0045179 apical cortex(GO:0045179)
0.3 1.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.5 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 1.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.5 GO:0016589 NURF complex(GO:0016589)
0.0 4.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 1.6 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 1.1 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.4 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.9 9.5 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
1.6 4.9 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
1.6 11.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.2 4.6 GO:0033265 choline binding(GO:0033265)
0.5 2.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 2.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.5 4.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 1.6 GO:0008431 vitamin E binding(GO:0008431)
0.4 2.8 GO:0019862 IgA binding(GO:0019862)
0.3 3.2 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.3 9.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.8 GO:0005042 netrin receptor activity(GO:0005042)
0.2 1.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 1.2 GO:0030492 hemoglobin binding(GO:0030492)
0.2 1.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 2.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.5 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.7 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 3.2 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.3 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1 0.3 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 3.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.9 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 1.8 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 1.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 1.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.9 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 10.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 2.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.1 GO:0004914 interleukin-5 receptor activity(GO:0004914)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 4.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 3.2 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 1.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.6 14.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.6 9.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 4.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 4.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 4.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME OPSINS Genes involved in Opsins
0.0 9.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane