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Illumina Body Map 2 (GSE30611)
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Results for SMAD2
Z-value: 1.57
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Transcription factors associated with SMAD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD2 | hg38_v1_chr18_-_47930630_47930681 | 0.52 | 2.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 11.9 | GO:1903280 | negative regulation of calcium:sodium antiporter activity(GO:1903280) |
| 1.0 | 8.3 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.6 | 6.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 6.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.8 | 5.5 | GO:0031448 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) |
| 0.0 | 5.4 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.7 | 5.1 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.2 | 5.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 5.0 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.2 | 4.6 | GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.3 | 8.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.1 | 6.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 6.3 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.2 | 5.5 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.2 | 5.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 5.2 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 5.1 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 3.8 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 3.8 | GO:0044449 | contractile fiber part(GO:0044449) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.9 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 1.4 | 8.3 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.2 | 6.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 6.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 6.0 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.2 | 5.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 5.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 1.1 | 4.5 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.0 | 4.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 4.1 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 5.1 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 3.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 3.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.4 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 2.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 2.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 6.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 5.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 4.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 4.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 4.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.8 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 3.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 3.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 2.3 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |