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Illumina Body Map 2 (GSE30611)

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Results for SMAD3

Z-value: 1.07

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.17 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg38_v1_chr15_+_67067780_67067811-0.222.3e-01Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_159714581 4.53 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
CRP
C-reactive protein
chr11_+_116829898 2.46 ENST00000227667.8
ENST00000375345.3
APOC3
apolipoprotein C3
chr11_+_116830529 2.36 ENST00000630701.1
APOC3
apolipoprotein C3
chr7_+_142656688 2.24 ENST00000390397.2
TRBV24-1
T cell receptor beta variable 24-1
chr16_+_56669807 1.94 ENST00000332374.5
MT1H
metallothionein 1H
chr7_+_50308672 1.82 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKZF1
IKAROS family zinc finger 1
chr5_+_132873660 1.80 ENST00000296877.3
LEAP2
liver enriched antimicrobial peptide 2
chr10_+_92691813 1.79 ENST00000472590.6
HHEX
hematopoietically expressed homeobox
chr1_-_160862880 1.70 ENST00000368034.9
CD244
CD244 molecule
chr1_-_160862700 1.67 ENST00000322302.7
ENST00000368033.7
CD244
CD244 molecule
chr7_+_142720652 1.63 ENST00000390400.2
TRBV28
T cell receptor beta variable 28
chr16_-_3256587 1.63 ENST00000536379.5
ENST00000541159.5
ENST00000339854.8
ENST00000219596.6
MEFV
MEFV innate immuity regulator, pyrin
chr6_-_27132750 1.58 ENST00000607124.1
ENST00000339812.3
H2BC11
H2B clustered histone 11
chr16_-_31065011 1.56 ENST00000539836.3
ENST00000535577.5
ENST00000442862.2
ZNF668
zinc finger protein 668
chr7_+_142469521 1.43 ENST00000390371.3
TRBV6-6
T cell receptor beta variable 6-6
chr1_+_89821921 1.37 ENST00000394593.7
LRRC8D
leucine rich repeat containing 8 VRAC subunit D
chr16_+_30472700 1.36 ENST00000358164.9
ITGAL
integrin subunit alpha L
chr11_+_61102465 1.31 ENST00000347785.8
ENST00000544014.1
CD5
CD5 molecule
chr16_-_31064952 1.31 ENST00000426488.6
ZNF668
zinc finger protein 668
chr19_-_40850442 1.30 ENST00000301141.10
CYP2A6
cytochrome P450 family 2 subfamily A member 6
chr7_+_142492121 1.24 ENST00000390374.3
TRBV7-6
T cell receptor beta variable 7-6
chr6_+_27133032 1.21 ENST00000359193.3
H2AC11
H2A clustered histone 11
chr5_-_128339191 1.20 ENST00000507835.5
FBN2
fibrillin 2
chr14_+_21868822 1.17 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr10_+_92691897 1.17 ENST00000492654.3
HHEX
hematopoietically expressed homeobox
chr19_+_18173148 1.17 ENST00000597802.2
IFI30
IFI30 lysosomal thiol reductase
chr6_-_27146841 1.17 ENST00000356950.2
H2BC12
H2B clustered histone 12
chr7_+_139829242 1.16 ENST00000455353.6
ENST00000458722.6
ENST00000448866.7
ENST00000411653.6
TBXAS1
thromboxane A synthase 1
chr16_+_30472733 1.12 ENST00000356798.11
ENST00000433423.2
ITGAL
integrin subunit alpha L
chr6_-_26123910 1.06 ENST00000314332.5
ENST00000396984.1
H2BC4
H2B clustered histone 4
chr3_-_120647018 1.04 ENST00000475447.2
HGD
homogentisate 1,2-dioxygenase
chr6_+_26124161 1.04 ENST00000377791.4
ENST00000602637.1
H2AC6
H2A clustered histone 6
chr6_+_25726767 1.01 ENST00000274764.5
H2BC1
H2B clustered histone 1
chr9_+_133534807 0.97 ENST00000393060.1
ADAMTSL2
ADAMTS like 2
chr7_+_142580911 0.91 ENST00000621184.1
TRBV12-5
T cell receptor beta variable 12-5
chr7_+_100720463 0.89 ENST00000252723.3
EPO
erythropoietin
chr14_+_24130659 0.87 ENST00000267426.6
FITM1
fat storage inducing transmembrane protein 1
chr19_+_51225059 0.86 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33
CD33 molecule
chr15_+_81299416 0.85 ENST00000558332.3
IL16
interleukin 16
chr1_-_225941383 0.84 ENST00000420304.6
LEFTY2
left-right determination factor 2
chr1_-_225941212 0.83 ENST00000366820.10
LEFTY2
left-right determination factor 2
chr14_+_92923143 0.82 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr6_+_26216928 0.82 ENST00000303910.4
H2AC8
H2A clustered histone 8
chr18_+_13218195 0.80 ENST00000679167.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr7_+_142587857 0.79 ENST00000617639.1
TRBV14
T cell receptor beta variable 14
chr19_+_41088450 0.78 ENST00000330436.4
CYP2A13
cytochrome P450 family 2 subfamily A member 13
chr6_-_24809798 0.78 ENST00000562221.1
ENSG00000282804.1
novel protein
chr2_-_224982420 0.77 ENST00000645028.1
DOCK10
dedicator of cytokinesis 10
chr17_-_40937445 0.75 ENST00000436344.7
ENST00000485751.1
KRT23
keratin 23
chr1_+_201190786 0.72 ENST00000335211.9
ENST00000295591.12
IGFN1
immunoglobulin like and fibronectin type III domain containing 1
chr12_-_9760893 0.72 ENST00000228434.7
ENST00000536709.1
CD69
CD69 molecule
chr20_+_57351510 0.72 ENST00000411894.5
ENST00000429339.5
RAE1
ribonucleic acid export 1
chr17_-_35868885 0.71 ENST00000604834.6
HEATR9
HEAT repeat containing 9
chr6_+_139028680 0.71 ENST00000367660.4
ABRACL
ABRA C-terminal like
chr10_-_133358006 0.70 ENST00000278025.9
ENST00000368552.7
FUOM
fucose mutarotase
chr12_+_3491189 0.70 ENST00000382622.4
PRMT8
protein arginine methyltransferase 8
chr12_+_65169546 0.69 ENST00000308330.3
LEMD3
LEM domain containing 3
chr11_-_65382632 0.68 ENST00000294187.10
ENST00000398802.6
ENST00000530936.1
SLC25A45
solute carrier family 25 member 45
chr12_+_67648737 0.68 ENST00000344096.4
ENST00000393555.3
DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
chr9_+_133534697 0.67 ENST00000651351.2
ADAMTSL2
ADAMTS like 2
chr16_+_2471284 0.67 ENST00000293973.2
NTN3
netrin 3
chr20_-_64079479 0.66 ENST00000395042.2
RGS19
regulator of G protein signaling 19
chr6_-_25726553 0.66 ENST00000297012.5
H2AC1
H2A clustered histone 1
chr17_-_35868858 0.66 ENST00000603870.5
ENST00000603218.1
HEATR9
HEAT repeat containing 9
chr20_+_57351218 0.65 ENST00000371242.6
ENST00000527947.5
ENST00000395841.7
RAE1
ribonucleic acid export 1
chr8_+_22392821 0.64 ENST00000520832.1
SLC39A14
solute carrier family 39 member 14
chrX_+_50067576 0.64 ENST00000376108.7
CLCN5
chloride voltage-gated channel 5
chr4_-_176195563 0.63 ENST00000280191.7
SPATA4
spermatogenesis associated 4
chr1_-_11858935 0.61 ENST00000376468.4
NPPB
natriuretic peptide B
chr2_-_128027273 0.58 ENST00000259235.7
ENST00000357702.9
ENST00000424298.5
SAP130
Sin3A associated protein 130
chr1_-_160647287 0.58 ENST00000235739.6
SLAMF1
signaling lymphocytic activation molecule family member 1
chr17_+_4710622 0.57 ENST00000574954.5
ENST00000269260.7
ENST00000346341.6
ENST00000572457.5
ENST00000381488.10
ENST00000412477.7
ENST00000571428.5
ENST00000575877.5
ARRB2
arrestin beta 2
chr7_+_142384328 0.55 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr2_+_219245455 0.55 ENST00000409638.7
ENST00000396738.7
ENST00000409516.7
STK16
serine/threonine kinase 16
chr15_-_82647960 0.54 ENST00000615198.4
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr20_+_57351528 0.53 ENST00000395840.6
RAE1
ribonucleic acid export 1
chr7_+_31687208 0.53 ENST00000409146.3
ENST00000342032.8
PPP1R17
protein phosphatase 1 regulatory subunit 17
chr15_+_82262781 0.53 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000682753.1
ENST00000566861.5
ENST00000565432.1
SAXO2
stabilizer of axonemal microtubules 2
chr6_+_47698538 0.52 ENST00000327753.7
ADGRF4
adhesion G protein-coupled receptor F4
chr2_-_49154507 0.51 ENST00000406846.7
FSHR
follicle stimulating hormone receptor
chr14_-_64942783 0.51 ENST00000612794.1
GPX2
glutathione peroxidase 2
chr15_-_82647123 0.51 ENST00000569257.5
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr14_-_24081986 0.51 ENST00000560550.1
NRL
neural retina leucine zipper
chr8_+_10672623 0.51 ENST00000304519.10
C8orf74
chromosome 8 open reading frame 74
chr17_-_41309253 0.50 ENST00000391352.1
KRTAP16-1
keratin associated protein 16-1
chr6_-_27831557 0.50 ENST00000611927.2
H4C12
H4 clustered histone 12
chr4_-_185775376 0.50 ENST00000456596.5
ENST00000414724.5
SORBS2
sorbin and SH3 domain containing 2
chr6_+_47698574 0.49 ENST00000283303.3
ADGRF4
adhesion G protein-coupled receptor F4
chr1_-_9069572 0.48 ENST00000377414.7
SLC2A5
solute carrier family 2 member 5
chr15_-_82647503 0.48 ENST00000567678.1
ENST00000620182.4
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr1_-_9069797 0.48 ENST00000473209.1
SLC2A5
solute carrier family 2 member 5
chr15_+_65530418 0.47 ENST00000562901.5
ENST00000261875.10
ENST00000442729.6
ENST00000565299.5
ENST00000568793.5
HACD3
3-hydroxyacyl-CoA dehydratase 3
chr14_-_24081928 0.47 ENST00000396995.1
NRL
neural retina leucine zipper
chr5_+_140450 0.47 ENST00000502646.1
PLEKHG4B
pleckstrin homology and RhoGEF domain containing G4B
chr2_-_49154433 0.47 ENST00000454032.5
ENST00000304421.8
FSHR
follicle stimulating hormone receptor
chrX_-_48470243 0.47 ENST00000429543.2
ENST00000620913.5
SLC38A5
solute carrier family 38 member 5
chrX_-_48469557 0.46 ENST00000488083.5
SLC38A5
solute carrier family 38 member 5
chr1_-_88891496 0.46 ENST00000448623.5
ENST00000370500.10
ENST00000418217.1
GTF2B
general transcription factor IIB
chr18_+_46173495 0.46 ENST00000587591.5
ENST00000588730.1
C18orf25
chromosome 18 open reading frame 25
chrX_+_9560465 0.45 ENST00000647060.1
TBL1X
transducin beta like 1 X-linked
chr16_-_375205 0.44 ENST00000448854.1
PGAP6
post-glycosylphosphatidylinositol attachment to proteins 6
chr11_-_32794610 0.44 ENST00000531481.1
ENST00000335185.10
CCDC73
coiled-coil domain containing 73
chr22_+_41560973 0.44 ENST00000306149.12
CSDC2
cold shock domain containing C2
chr20_+_57351569 0.44 ENST00000452119.1
RAE1
ribonucleic acid export 1
chr6_-_26027274 0.43 ENST00000377745.4
H4C2
H4 clustered histone 2
chr13_+_45464901 0.43 ENST00000349995.10
COG3
component of oligomeric golgi complex 3
chr15_+_63504583 0.43 ENST00000380324.8
ENST00000561442.5
ENST00000560070.5
USP3
ubiquitin specific peptidase 3
chr6_+_292050 0.42 ENST00000344450.9
DUSP22
dual specificity phosphatase 22
chr3_+_51707059 0.42 ENST00000395052.8
GRM2
glutamate metabotropic receptor 2
chr19_-_55180104 0.42 ENST00000537500.5
SYT5
synaptotagmin 5
chr17_-_40772162 0.42 ENST00000335552.4
KRT26
keratin 26
chr11_+_5691004 0.41 ENST00000414641.5
TRIM22
tripartite motif containing 22
chr11_-_64744993 0.41 ENST00000377485.5
RASGRP2
RAS guanyl releasing protein 2
chr7_+_142399860 0.40 ENST00000390364.3
TRBV10-1
T cell receptor beta variable 10-1
chr1_+_59297057 0.40 ENST00000303721.12
FGGY
FGGY carbohydrate kinase domain containing
chr6_+_27824084 0.40 ENST00000355057.3
H4C11
H4 clustered histone 11
chr5_-_133026533 0.40 ENST00000509437.6
ENST00000355372.6
ENST00000513541.5
ENST00000509008.1
ENST00000513848.5
ENST00000504170.2
ENST00000324170.7
ZCCHC10
zinc finger CCHC-type containing 10
chr22_-_35617321 0.40 ENST00000397326.7
ENST00000442617.1
MB
myoglobin
chr4_+_69051362 0.39 ENST00000502942.5
UGT2B7
UDP glucuronosyltransferase family 2 member B7
chr1_+_59296971 0.39 ENST00000371218.8
FGGY
FGGY carbohydrate kinase domain containing
chr2_-_24793382 0.38 ENST00000328379.6
PTRHD1
peptidyl-tRNA hydrolase domain containing 1
chr14_-_64942720 0.38 ENST00000557049.1
ENST00000389614.6
GPX2
glutathione peroxidase 2
chr3_-_52897541 0.38 ENST00000355083.11
ENST00000504329.1
STIMATE
STIMATE-MUSTN1
STIM activating enhancer
STIMATE-MUSTN1 readthrough
chr11_-_72434330 0.37 ENST00000542555.2
ENST00000535990.5
ENST00000294053.9
ENST00000538039.6
ENST00000340729.9
CLPB
caseinolytic mitochondrial matrix peptidase chaperone subunit B
chr12_+_67269328 0.37 ENST00000545606.6
CAND1
cullin associated and neddylation dissociated 1
chr13_+_24251686 0.37 ENST00000434675.5
ENST00000494772.5
SPATA13
spermatogenesis associated 13
chr18_+_13611764 0.36 ENST00000585931.5
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr2_-_128028114 0.36 ENST00000259234.10
SAP130
Sin3A associated protein 130
chr11_-_72070050 0.36 ENST00000535087.5
ENST00000535838.5
NUMA1
nuclear mitotic apparatus protein 1
chr15_+_63504511 0.36 ENST00000540797.5
USP3
ubiquitin specific peptidase 3
chrX_-_27463341 0.35 ENST00000412172.4
PPP4R3C
protein phosphatase 4 regulatory subunit 3C
chr2_-_128028010 0.35 ENST00000643581.2
ENST00000450957.1
SAP130
Sin3A associated protein 130
chr3_+_125969214 0.34 ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chr9_-_34637719 0.34 ENST00000378892.5
ENST00000680277.1
ENST00000277010.9
ENST00000679597.1
ENST00000680244.1
SIGMAR1
sigma non-opioid intracellular receptor 1
chr9_-_34637800 0.34 ENST00000680730.1
ENST00000477726.1
SIGMAR1
sigma non-opioid intracellular receptor 1
chr15_-_28712323 0.34 ENST00000563027.1
GOLGA8M
golgin A8 family member M
chr5_+_55851349 0.34 ENST00000652347.2
IL31RA
interleukin 31 receptor A
chr6_+_26240385 0.33 ENST00000244537.6
H4C6
H4 clustered histone 6
chr6_+_30883085 0.33 ENST00000504651.5
ENST00000512694.5
ENST00000515233.5
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_+_146598961 0.33 ENST00000522242.5
ENST00000397944.8
ADGB
androglobin
chr6_-_52577012 0.33 ENST00000182527.4
TRAM2
translocation associated membrane protein 2
chr19_-_42220109 0.32 ENST00000595337.5
DEDD2
death effector domain containing 2
chr12_+_49741802 0.32 ENST00000423828.5
ENST00000550445.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr11_-_83724922 0.32 ENST00000434967.1
ENST00000530800.5
DLG2
discs large MAGUK scaffold protein 2
chr22_-_41281621 0.31 ENST00000452543.5
ENST00000418067.1
RANGAP1
Ran GTPase activating protein 1
chr15_+_67825504 0.31 ENST00000380035.3
ENST00000554054.5
SKOR1
SKI family transcriptional corepressor 1
chr1_+_153217578 0.31 ENST00000368744.4
PRR9
proline rich 9
chr19_-_55180010 0.30 ENST00000589172.5
SYT5
synaptotagmin 5
chr17_-_1078959 0.29 ENST00000571945.5
ENST00000536794.6
ABR
ABR activator of RhoGEF and GTPase
chr1_-_60073750 0.29 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr1_+_112718880 0.28 ENST00000361886.4
TAFA3
TAFA chemokine like family member 3
chr11_-_5441514 0.28 ENST00000380211.1
OR51I1
olfactory receptor family 51 subfamily I member 1
chr6_+_144659814 0.28 ENST00000367525.3
UTRN
utrophin
chrX_+_49829260 0.28 ENST00000376141.5
ENST00000218068.7
PAGE4
PAGE family member 4
chr3_-_14178615 0.27 ENST00000511155.1
XPC
XPC complex subunit, DNA damage recognition and repair factor
chr6_+_116616467 0.27 ENST00000229554.10
ENST00000368581.8
ENST00000368580.4
RSPH4A
radial spoke head component 4A
chr11_-_133532493 0.26 ENST00000524381.6
OPCML
opioid binding protein/cell adhesion molecule like
chr11_+_124954108 0.26 ENST00000529051.5
CCDC15
coiled-coil domain containing 15
chr21_+_31659666 0.26 ENST00000389995.4
ENST00000270142.11
SOD1
superoxide dismutase 1
chr18_+_32018817 0.26 ENST00000217740.4
ENST00000583184.1
RNF125
ENSG00000263917.1
ring finger protein 125
novel transcript
chr12_+_49741565 0.25 ENST00000549445.5
ENST00000550951.5
ENST00000549385.5
ENST00000548713.5
ENST00000548201.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr15_-_82709823 0.25 ENST00000666973.1
ENST00000664460.1
ENST00000669930.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr4_-_147684114 0.24 ENST00000322396.7
PRMT9
protein arginine methyltransferase 9
chr15_-_43493076 0.24 ENST00000413546.1
TP53BP1
tumor protein p53 binding protein 1
chr17_+_82830496 0.24 ENST00000683821.1
TBCD
tubulin folding cofactor D
chr12_+_49741544 0.24 ENST00000549966.5
ENST00000547832.5
ENST00000547187.5
ENST00000548894.5
ENST00000546914.5
ENST00000552699.5
ENST00000267115.10
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_+_149832647 0.24 ENST00000578186.2
H4C14
H4 clustered histone 14
chr4_-_26490453 0.23 ENST00000295589.4
CCKAR
cholecystokinin A receptor
chr4_-_185775411 0.23 ENST00000445115.5
ENST00000451701.5
SORBS2
sorbin and SH3 domain containing 2
chrX_+_47585212 0.23 ENST00000445623.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr8_-_100106206 0.23 ENST00000519408.5
RGS22
regulator of G protein signaling 22
chr2_-_135837170 0.23 ENST00000264162.7
LCT
lactase
chr3_+_125969172 0.22 ENST00000514116.6
ENST00000513830.5
ROPN1B
rhophilin associated tail protein 1B
chr3_+_98149326 0.22 ENST00000437310.1
OR5H14
olfactory receptor family 5 subfamily H member 14
chr19_-_36916021 0.21 ENST00000520965.5
ZNF829
zinc finger protein 829
chr2_+_203867764 0.21 ENST00000648405.2
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr9_+_97307645 0.21 ENST00000529487.3
CCDC180
coiled-coil domain containing 180
chr3_+_149813806 0.21 ENST00000468648.5
ENST00000459632.5
RNF13
ring finger protein 13
chr1_-_60073733 0.21 ENST00000450089.6
C1orf87
chromosome 1 open reading frame 87
chr3_+_125969152 0.20 ENST00000251776.8
ENST00000504401.1
ROPN1B
rhophilin associated tail protein 1B
chr3_-_14178569 0.20 ENST00000285021.12
XPC
XPC complex subunit, DNA damage recognition and repair factor
chr20_+_59676661 0.20 ENST00000355648.8
PHACTR3
phosphatase and actin regulator 3
chr6_-_27873525 0.19 ENST00000618305.2
H4C13
H4 clustered histone 13
chr11_+_35189964 0.19 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr21_+_44133610 0.19 ENST00000644251.1
ENST00000427803.6
ENST00000348499.9
ENST00000291577.11
ENST00000389690.7
GATD3A
glutamine amidotransferase like class 1 domain containing 3A
chr3_-_154430184 0.18 ENST00000389740.3
GPR149
G protein-coupled receptor 149
chr1_-_160070125 0.18 ENST00000639408.1
KCNJ10
potassium inwardly rectifying channel subfamily J member 10
chr18_+_46174055 0.18 ENST00000615553.1
C18orf25
chromosome 18 open reading frame 25
chr16_-_58295019 0.17 ENST00000567164.6
ENST00000219301.8
ENST00000569727.1
PRSS54
serine protease 54
chr3_-_112846856 0.17 ENST00000488794.5
CD200R1L
CD200 receptor 1 like
chrX_-_27981449 0.17 ENST00000441525.4
DCAF8L1
DDB1 and CUL4 associated factor 8 like 1
chr3_-_123992046 0.17 ENST00000467907.5
ENST00000459660.5
ENST00000495093.1
ENST00000460743.5
ENST00000405845.7
ENST00000484329.1
ENST00000479867.1
ENST00000496145.5
ROPN1
rhophilin associated tail protein 1
chr14_+_91114388 0.17 ENST00000519019.5
ENST00000523816.5
ENST00000517518.5
DGLUCY
D-glutamate cyclase
chr14_+_91114667 0.17 ENST00000523894.5
ENST00000522322.5
ENST00000523771.5
DGLUCY
D-glutamate cyclase
chr5_-_180815528 0.16 ENST00000333055.8
MGAT1
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr5_-_69332723 0.16 ENST00000511257.1
ENST00000396496.7
ENST00000383374.6
CCDC125
coiled-coil domain containing 125
chr6_-_132798587 0.16 ENST00000275227.9
SLC18B1
solute carrier family 18 member B1
chr2_+_203867943 0.16 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr8_-_80029904 0.15 ENST00000521434.5
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr7_-_19773569 0.15 ENST00000422233.5
ENST00000433641.5
ENST00000405844.6
TMEM196
transmembrane protein 196

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
1.1 3.4 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.0 3.0 GO:0061011 hepatic duct development(GO:0061011)
0.4 1.3 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.3 0.8 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.2 1.0 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.2 1.6 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.2 1.6 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.2 4.8 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.2 1.0 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.2 0.6 GO:0035744 T-helper 1 cell cytokine production(GO:0035744)
0.2 1.0 GO:1990539 fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.2 0.8 GO:0009698 phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.2 2.3 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 2.5 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1 0.6 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 1.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.8 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.1 1.0 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.9 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.7 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.1 0.9 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 1.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.7 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.3 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.1 0.7 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.2 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.1 1.9 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 1.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.4 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.7 GO:0044821 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.4 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.5 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.0 0.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.7 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.4 GO:0032887 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.6 GO:1903874 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.8 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.8 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.3 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.7 GO:0060180 female mating behavior(GO:0060180)
0.0 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0051620 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.4 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.4 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.8 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.0 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.1 GO:0014028 notochord formation(GO:0014028)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.4 GO:0002438 acute inflammatory response to antigenic stimulus(GO:0002438)
0.0 0.3 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 1.8 GO:0019730 antimicrobial humoral response(GO:0019730)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.2 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 1.1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.1 GO:0044145 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.0 0.5 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.2 GO:0015816 glycine transport(GO:0015816)
0.0 0.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.8 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 2.5 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.1 0.8 GO:1990769 proximal neuron projection(GO:1990769)
0.1 1.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.3 GO:0001534 radial spoke(GO:0001534)
0.1 0.3 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.1 0.5 GO:0071942 XPC complex(GO:0071942)
0.1 2.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 1.1 GO:0070938 contractile ring(GO:0070938)
0.0 1.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.0 1.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.8 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 1.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.6 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 2.5 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0033265 choline binding(GO:0033265)
1.0 4.8 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.4 1.2 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.3 1.0 GO:0004411 homogentisate 1,2-dioxygenase activity(GO:0004411)
0.3 0.9 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.3 1.6 GO:0050436 microfibril binding(GO:0050436)
0.2 1.0 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.2 2.5 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.2 0.8 GO:0019150 D-ribulokinase activity(GO:0019150)
0.2 0.7 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 0.6 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 1.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.4 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.1 0.8 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 0.7 GO:0042806 fucose binding(GO:0042806)
0.1 2.1 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 3.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 3.4 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.7 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 1.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.5 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.1 0.5 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.6 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 1.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.7 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0030346 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) protein phosphatase 2B binding(GO:0030346)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 2.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 2.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.9 PID EPO PATHWAY EPO signaling pathway
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 4.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.0 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 2.3 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA