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Illumina Body Map 2 (GSE30611)
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Results for SOX10_SOX15
Z-value: 0.73
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Transcription factors associated with SOX10_SOX15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX15 | hg38_v1_chr17_-_7590072_7590101 | -0.49 | 4.7e-03 | Click! |
| SOX10 | hg38_v1_chr22_-_37984534_37984562 | -0.28 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX10_SOX15
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.1 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 0.5 | 3.7 | GO:0072011 | glomerular endothelium development(GO:0072011) |
| 0.4 | 2.5 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.2 | 2.3 | GO:1905068 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.5 | 2.2 | GO:0033606 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.2 | 2.0 | GO:0019064 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.0 | 2.0 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.0 | 2.0 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.5 | 1.9 | GO:0035284 | central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.0 | 1.9 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.4 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 2.5 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.1 | 2.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 2.1 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.7 | 2.0 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.2 | 1.9 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 1.3 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 1.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 1.2 | GO:0071141 | SMAD protein complex(GO:0071141) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 2.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 2.2 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 2.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 2.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.0 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 2.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 2.0 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 2.0 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.4 | 1.7 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 2.5 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 2.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 2.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.2 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 2.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.7 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 3.7 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 3.1 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 3.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.5 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 2.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 2.0 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.1 | 2.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 1.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |