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Illumina Body Map 2 (GSE30611)
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Results for SOX13_SOX12
Z-value: 1.06
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX12 | hg38_v1_chr20_+_325536_325565 | 0.50 | 3.4e-03 | Click! |
| SOX13 | hg38_v1_chr1_+_204073104_204073121 | 0.48 | 5.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89085787 Show fit | 4.67 |
ENST00000390252.2
|
immunoglobulin kappa variable 3-15 |
|
| chr2_+_102311502 Show fit | 3.87 |
ENST00000404917.6
ENST00000410040.5 |
interleukin 1 receptor like 1 interleukin 18 receptor 1 |
|
| chr2_+_102311546 Show fit | 3.24 |
ENST00000233954.6
ENST00000447231.5 |
interleukin 1 receptor like 1 |
|
| chr6_-_49744378 Show fit | 2.94 |
ENST00000371159.8
ENST00000263045.9 |
cysteine rich secretory protein 3 |
|
| chr2_-_89027700 Show fit | 2.82 |
ENST00000483158.1
|
immunoglobulin kappa variable 3-11 |
|
| chr5_+_93583212 Show fit | 2.82 |
ENST00000327111.8
|
nuclear receptor subfamily 2 group F member 1 |
|
| chr2_+_90114838 Show fit | 2.81 |
ENST00000417279.3
|
immunoglobulin kappa variable 3D-15 |
|
| chr6_-_49744434 Show fit | 2.64 |
ENST00000433368.6
ENST00000354620.4 |
cysteine rich secretory protein 3 |
|
| chr4_-_56681288 Show fit | 2.53 |
ENST00000556376.6
ENST00000420433.6 |
HOP homeobox |
|
| chr2_+_90172802 Show fit | 2.51 |
ENST00000390277.3
|
immunoglobulin kappa variable 3D-11 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 10.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.9 | 7.1 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.0 | 6.0 | GO:0071346 | cellular response to interferon-gamma(GO:0071346) |
| 0.0 | 4.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 4.0 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.2 | 3.1 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 3.0 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.2 | 2.6 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.6 | 2.5 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 7.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.3 | 5.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 4.3 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 3.9 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 3.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 3.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 3.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 10.3 | GO:0005518 | collagen binding(GO:0005518) |
| 2.4 | 7.1 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.0 | 4.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 3.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 2.9 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.2 | 2.8 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 2.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 2.2 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.1 | 2.0 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.0 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.5 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.2 | 4.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 3.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 3.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.0 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.7 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 1.5 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.1 | 1.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |