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Illumina Body Map 2 (GSE30611)
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Results for SOX18
Z-value: 0.86
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Transcription factors associated with SOX18
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX18 | hg38_v1_chr20_-_64049631_64049646 | -0.24 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX18
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 2.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.5 | 2.0 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.1 | 1.7 | GO:0060125 | habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125) |
| 0.1 | 1.6 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.5 | 1.5 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 0.1 | 1.2 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.2 | 1.1 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.1 | 1.1 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 1.1 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.6 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 1.2 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.3 | 1.1 | GO:0045259 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) |
| 0.1 | 1.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.9 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 0.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.6 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 0.5 | GO:0097169 | IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0005496 | steroid binding(GO:0005496) |
| 0.0 | 2.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 2.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 1.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.5 | GO:0070492 | peptidoglycan binding(GO:0042834) oligosaccharide binding(GO:0070492) |
| 0.0 | 1.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 1.2 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 1.2 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.0 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.9 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.8 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |