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Illumina Body Map 2 (GSE30611)

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Results for SOX21

Z-value: 0.86

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.6 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg38_v1_chr13_-_94712505_94712553-0.411.9e-02Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_41877267 5.32 ENST00000221972.8
ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule
chr11_+_35180279 3.92 ENST00000531873.5
CD44
CD44 molecule (Indian blood group)
chr1_+_158931539 3.91 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
PYHIN1
pyrin and HIN domain family member 1
chr14_+_21941122 3.48 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr22_+_22720615 3.45 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr22_+_38957522 3.19 ENST00000618553.1
ENST00000249116.7
APOBEC3A
apolipoprotein B mRNA editing enzyme catalytic subunit 3A
chr5_-_56233287 2.61 ENST00000513241.2
ENST00000341048.9
ANKRD55
ankyrin repeat domain 55
chr17_-_44376169 2.28 ENST00000587295.5
ITGA2B
integrin subunit alpha 2b
chr7_+_142482544 1.97 ENST00000390372.3
TRBV5-5
T cell receptor beta variable 5-5
chr12_-_10435940 1.92 ENST00000381901.5
ENST00000381902.7
ENST00000539033.1
KLRC2
ENSG00000255641.1
killer cell lectin like receptor C2
novel protein
chr3_-_71306012 1.84 ENST00000649431.1
ENST00000610810.5
FOXP1
forkhead box P1
chr6_+_131573219 1.77 ENST00000356962.2
ENST00000368087.8
ENST00000673427.1
ENST00000640973.1
ARG1
arginase 1
chr11_+_35180342 1.73 ENST00000639002.1
CD44
CD44 molecule (Indian blood group)
chr14_+_22226711 1.71 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr18_-_49492305 1.70 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr3_-_71305986 1.63 ENST00000647614.1
FOXP1
forkhead box P1
chr2_+_216498831 1.63 ENST00000491306.6
ENST00000600880.5
ENST00000446558.5
RPL37A
ribosomal protein L37a
chr1_+_144592868 1.60 ENST00000581138.3
PPIAL4F
peptidylprolyl isomerase A like 4F
chr7_+_142535763 1.54 ENST00000614171.1
TRBV13
T cell receptor beta variable 13
chr14_-_106470788 1.54 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr12_-_89352395 1.53 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr12_-_89352487 1.52 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr6_+_116399395 1.51 ENST00000644499.1
ENSG00000285446.1
novel protein
chr1_+_2556361 1.42 ENST00000355716.5
TNFRSF14
TNF receptor superfamily member 14
chr1_+_2556222 1.36 ENST00000409119.5
TNFRSF14
TNF receptor superfamily member 14
chr19_+_16197900 1.35 ENST00000429941.6
ENST00000291439.8
ENST00000444449.6
ENST00000589822.5
AP1M1
adaptor related protein complex 1 subunit mu 1
chr4_-_39032922 1.33 ENST00000344606.6
TMEM156
transmembrane protein 156
chr7_-_87220520 1.30 ENST00000455575.1
TMEM243
transmembrane protein 243
chr15_-_79971164 1.23 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2A1
BCL2 related protein A1
chr1_+_149583865 1.22 ENST00000585245.2
PPIAL4C
peptidylprolyl isomerase A like 4C
chr7_-_87220567 1.19 ENST00000433078.5
TMEM243
transmembrane protein 243
chr19_+_16197848 1.16 ENST00000590263.5
ENST00000590756.5
AP1M1
adaptor related protein complex 1 subunit mu 1
chr21_+_29300111 1.14 ENST00000451655.5
BACH1
BTB domain and CNC homolog 1
chr19_+_18571730 1.09 ENST00000596304.5
ENST00000430157.6
ENST00000596273.5
ENST00000442744.7
ENST00000595683.5
ENST00000599256.5
ENST00000595158.5
ENST00000598780.5
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr2_+_89851723 1.09 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr6_+_42563981 1.05 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr7_+_120989030 0.98 ENST00000428526.5
CPED1
cadherin like and PC-esterase domain containing 1
chr12_-_7109176 0.94 ENST00000545280.5
ENST00000543933.5
ENST00000545337.1
ENST00000266542.9
ENST00000544702.5
C1RL
complement C1r subcomponent like
chr14_-_92121902 0.87 ENST00000329559.8
NDUFB1
NADH:ubiquinone oxidoreductase subunit B1
chr14_-_92121669 0.84 ENST00000605997.6
ENST00000553514.5
ENST00000617122.1
NDUFB1
NADH:ubiquinone oxidoreductase subunit B1
chrX_-_132219439 0.81 ENST00000370874.2
RAP2C
RAP2C, member of RAS oncogene family
chr4_-_102825854 0.79 ENST00000350435.11
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr3_+_155024118 0.77 ENST00000492661.5
MME
membrane metalloendopeptidase
chr1_+_207325629 0.73 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr19_+_44613558 0.72 ENST00000402988.6
IGSF23
immunoglobulin superfamily member 23
chr6_+_31403553 0.72 ENST00000449934.7
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr3_-_45915596 0.71 ENST00000472635.5
ENST00000492333.5
LZTFL1
leucine zipper transcription factor like 1
chr7_+_138076475 0.65 ENST00000438242.1
AKR1D1
aldo-keto reductase family 1 member D1
chr8_-_141367276 0.65 ENST00000377741.4
GPR20
G protein-coupled receptor 20
chr6_-_53061740 0.60 ENST00000350082.10
ENST00000356971.3
ENST00000676107.1
CILK1
ciliogenesis associated kinase 1
chr11_+_5389377 0.59 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr18_+_32190033 0.58 ENST00000269202.11
MEP1B
meprin A subunit beta
chr1_+_152698339 0.57 ENST00000368779.2
LCE2A
late cornified envelope 2A
chr12_+_34022462 0.57 ENST00000538927.1
ENST00000266483.7
ALG10
ALG10 alpha-1,2-glucosyltransferase
chr8_-_65838730 0.57 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr7_+_7156934 0.56 ENST00000429911.5
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
chr4_-_102825526 0.54 ENST00000504211.5
ENST00000508476.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr18_+_32190015 0.50 ENST00000581447.1
MEP1B
meprin A subunit beta
chr6_-_154246850 0.50 ENST00000517438.5
IPCEF1
interaction protein for cytohesin exchange factors 1
chr3_-_186570308 0.49 ENST00000446782.5
TBCCD1
TBCC domain containing 1
chr15_+_58410543 0.47 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr3_+_100635598 0.46 ENST00000475887.1
ADGRG7
adhesion G protein-coupled receptor G7
chr17_+_68259164 0.45 ENST00000448504.6
ARSG
arylsulfatase G
chr3_+_186570663 0.45 ENST00000265028.8
DNAJB11
DnaJ heat shock protein family (Hsp40) member B11
chr12_+_55492378 0.42 ENST00000548615.1
OR6C68
olfactory receptor family 6 subfamily C member 68
chr12_-_949683 0.40 ENST00000358495.8
RAD52
RAD52 homolog, DNA repair protein
chr14_+_92121953 0.40 ENST00000298875.9
ENST00000553427.5
CPSF2
cleavage and polyadenylation specific factor 2
chr22_-_40533808 0.40 ENST00000422851.1
ENST00000651694.1
ENST00000652095.2
MRTFA
myocardin related transcription factor A
chr1_-_152089062 0.39 ENST00000368806.2
TCHHL1
trichohyalin like 1
chr4_+_68447453 0.38 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr7_+_138076453 0.37 ENST00000242375.8
ENST00000411726.6
AKR1D1
aldo-keto reductase family 1 member D1
chr1_+_147242654 0.36 ENST00000652587.1
ENST00000361293.10
ENST00000369258.8
ENST00000369259.4
ENST00000650714.1
ENST00000639534.1
CHD1L
chromodomain helicase DNA binding protein 1 like
chr1_+_200027702 0.35 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chrX_+_131083706 0.35 ENST00000370921.1
ARHGAP36
Rho GTPase activating protein 36
chr1_+_152908538 0.34 ENST00000368764.4
IVL
involucrin
chr12_-_949519 0.33 ENST00000397230.6
ENST00000542785.5
ENST00000544742.5
ENST00000536177.5
ENST00000541619.1
RAD52
RAD52 homolog, DNA repair protein
chr1_-_146344790 0.33 ENST00000584068.3
PPIAL4H
peptidylprolyl isomerase A like 4H
chr1_+_200027605 0.31 ENST00000236914.7
NR5A2
nuclear receptor subfamily 5 group A member 2
chr3_+_141384790 0.31 ENST00000507722.5
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_31760973 0.31 ENST00000436464.1
ADGRB2
adhesion G protein-coupled receptor B2
chr4_-_102825767 0.28 ENST00000505207.5
ENST00000502404.5
ENST00000507845.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr17_-_67239800 0.27 ENST00000579861.1
HELZ
helicase with zinc finger
chr4_-_88159023 0.25 ENST00000505480.6
ABCG2
ATP binding cassette subfamily G member 2 (Junior blood group)
chr16_-_18433412 0.23 ENST00000620440.4
NOMO2
NODAL modulator 2
chrX_+_11760035 0.21 ENST00000482871.6
ENST00000648013.1
MSL3
MSL complex subunit 3
chr1_-_37514743 0.21 ENST00000448519.2
ENST00000373075.6
ENST00000373073.8
ENST00000296214.10
MEAF6
MYST/Esa1 associated factor 6
chr12_-_10807286 0.21 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr7_+_34658361 0.21 ENST00000381539.3
NPSR1
neuropeptide S receptor 1
chr19_-_7040179 0.21 ENST00000381394.9
MBD3L4
methyl-CpG binding domain protein 3 like 4
chr10_-_17201580 0.21 ENST00000525762.5
ENST00000488990.5
ENST00000377799.8
TRDMT1
tRNA aspartic acid methyltransferase 1
chr8_-_142879820 0.21 ENST00000377675.3
ENST00000517471.5
ENST00000292427.10
CYP11B1
cytochrome P450 family 11 subfamily B member 1
chr1_+_67166448 0.20 ENST00000347310.10
IL23R
interleukin 23 receptor
chr8_-_86069662 0.20 ENST00000276616.3
PSKH2
protein serine kinase H2
chr15_-_34964442 0.19 ENST00000560117.1
AQR
aquarius intron-binding spliceosomal factor
chrX_-_153944655 0.18 ENST00000369997.7
RENBP
renin binding protein
chr5_+_176448363 0.18 ENST00000261942.7
FAF2
Fas associated factor family member 2
chr8_+_66775178 0.18 ENST00000396596.2
ENST00000521960.5
ENST00000522398.5
ENST00000522629.5
ENST00000520976.5
SGK3
serum/glucocorticoid regulated kinase family member 3
chr11_+_60088251 0.17 ENST00000524868.1
MS4A2
membrane spanning 4-domains A2
chr1_+_248361665 0.15 ENST00000366473.4
OR2T4
olfactory receptor family 2 subfamily T member 4
chr1_+_203795614 0.13 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr5_-_179618032 0.13 ENST00000519033.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr3_+_98463201 0.12 ENST00000642057.1
OR5K1
olfactory receptor family 5 subfamily K member 1
chr7_+_2354810 0.12 ENST00000360876.9
ENST00000413917.5
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3 subunit B
chr8_-_93017656 0.10 ENST00000520686.5
TRIQK
triple QxxK/R motif containing
chr5_-_60372714 0.10 ENST00000514552.5
PDE4D
phosphodiesterase 4D
chr11_-_8263858 0.10 ENST00000534484.1
ENST00000335790.8
LMO1
LIM domain only 1
chr10_-_13234368 0.09 ENST00000378681.8
UCMA
upper zone of growth plate and cartilage matrix associated
chrX_-_153944621 0.09 ENST00000393700.8
RENBP
renin binding protein
chr3_-_36992802 0.08 ENST00000623924.1
EPM2AIP1
EPM2A interacting protein 1
chr4_-_103719980 0.06 ENST00000304883.3
TACR3
tachykinin receptor 3
chr9_+_96928310 0.05 ENST00000354649.7
NUTM2G
NUT family member 2G
chr12_+_55314343 0.03 ENST00000642104.1
OR6C1
olfactory receptor family 6 subfamily C member 1
chr6_+_131637296 0.03 ENST00000358229.6
ENST00000357639.8
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr6_+_29396555 0.02 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr10_-_13234329 0.01 ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 1.8 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.4 5.7 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.4 3.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.3 2.8 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.2 1.0 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 1.0 GO:0030573 bile acid catabolic process(GO:0030573)
0.2 3.5 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 1.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2 0.6 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.2 0.7 GO:0035739 CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1 0.7 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.1 2.5 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.1 0.3 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.7 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 1.1 GO:0017085 response to insecticide(GO:0017085)
0.1 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.7 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 5.3 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.3 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 7.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 2.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 2.3 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 1.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 1.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.8 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 1.9 GO:0002228 natural killer cell mediated immunity(GO:0002228)
0.0 0.2 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 1.1 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:0015886 heme transport(GO:0015886)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 2.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:0019815 B cell receptor complex(GO:0019815)
0.5 5.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.2 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.0 2.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 4.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.5 GO:0042571 immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.0 1.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.8 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.5 2.3 GO:0070051 fibrinogen binding(GO:0070051)
0.4 1.9 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.2 1.0 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.2 0.6 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.2 3.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.1 5.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0070728 leucine binding(GO:0070728)
0.1 2.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.2 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.1 1.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.2 GO:0051400 BH domain binding(GO:0051400)
0.1 1.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.2 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 2.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 3.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0035473 lipase binding(GO:0035473)
0.0 6.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 4.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0019863 IgE binding(GO:0019863)
0.0 0.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) heme transporter activity(GO:0015232)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 6.4 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 2.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.7 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 3.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 5.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 2.8 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 3.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols