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Illumina Body Map 2 (GSE30611)
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Results for SOX30
Z-value: 1.05
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Transcription factors associated with SOX30
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX30 | hg38_v1_chr5_-_157652364_157652385 | 0.03 | 8.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX30
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.4 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.7 | 5.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.3 | 5.0 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.2 | 5.0 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.3 | 3.7 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.1 | 3.6 | GO:0043383 | negative T cell selection(GO:0043383) |
| 0.1 | 3.4 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.0 | 3.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.5 | 3.2 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.7 | 2.8 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 5.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 4.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 4.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 3.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 3.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 3.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 3.2 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 2.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 2.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 15.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 5.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 5.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 5.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 3.4 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 3.3 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.2 | 3.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 2.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 2.5 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 2.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 5.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 3.1 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 2.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 1.4 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 2.5 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 2.5 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 2.0 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 1.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.8 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 1.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 1.4 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.4 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |