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Illumina Body Map 2 (GSE30611)
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Results for SOX3_SOX2
Z-value: 2.54
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Transcription factors associated with SOX3_SOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX2 | hg38_v1_chr3_+_181711915_181711934 | 0.70 | 9.1e-06 | Click! |
| SOX3 | hg38_v1_chrX_-_140505058_140505076 | 0.60 | 2.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX3_SOX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 43.5 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 1.7 | 25.0 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 24.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.9 | 23.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.1 | 17.2 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.4 | 16.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 2.9 | 14.4 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.3 | 14.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 2.0 | 13.8 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
| 2.1 | 12.4 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 86.9 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 59.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 40.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 38.3 | GO:0043197 | dendritic spine(GO:0043197) |
| 2.9 | 34.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 25.6 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 19.8 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.3 | 18.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 17.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 1.5 | 16.9 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 88.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 2.9 | 58.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 55.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 23.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.6 | 18.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 18.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 17.0 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.3 | 16.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 14.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.2 | 14.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 44.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 18.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 17.6 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.3 | 12.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 12.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 9.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 8.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 8.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.2 | 8.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 8.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 30.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.8 | 30.1 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.2 | 13.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 10.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.3 | 10.0 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 8.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 8.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 8.6 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.1 | 8.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 8.2 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |