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Illumina Body Map 2 (GSE30611)
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Results for SOX6
Z-value: 1.36
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Transcription factors associated with SOX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX6 | hg38_v1_chr11_-_16356538_16356551 | -0.40 | 2.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106235582 Show fit | 4.05 |
ENST00000390607.2
|
immunoglobulin heavy variable 3-21 |
|
| chr14_-_106335613 Show fit | 3.89 |
ENST00000603660.1
|
immunoglobulin heavy variable 3-30 |
|
| chr17_-_64390852 Show fit | 3.49 |
ENST00000563924.6
|
platelet and endothelial cell adhesion molecule 1 |
|
| chr12_+_53097656 Show fit | 3.43 |
ENST00000301464.4
|
insulin like growth factor binding protein 6 |
|
| chr1_-_201507116 Show fit | 3.34 |
ENST00000340006.7
ENST00000526256.5 ENST00000526723.5 ENST00000524951.5 |
cysteine and glycine rich protein 1 |
|
| chr6_-_106974721 Show fit | 3.26 |
ENST00000606017.2
ENST00000620405.1 |
CD24 molecule |
|
| chr13_-_110307131 Show fit | 3.20 |
ENST00000543140.6
ENST00000375820.10 |
collagen type IV alpha 1 chain |
|
| chr5_-_168883333 Show fit | 3.06 |
ENST00000404867.7
|
slit guidance ligand 3 |
|
| chr17_-_64390592 Show fit | 3.06 |
ENST00000563523.5
|
platelet and endothelial cell adhesion molecule 1 |
|
| chr5_+_40909490 Show fit | 3.02 |
ENST00000313164.10
|
complement C7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 7.7 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 6.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.9 | 6.5 | GO:0072011 | glomerular endothelium development(GO:0072011) |
| 1.1 | 5.4 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.2 | 4.9 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.5 | 4.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.3 | 4.6 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 1.1 | 4.5 | GO:0032600 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.3 | 4.2 | GO:0070543 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 10.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.6 | 9.7 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.1 | 6.3 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.4 | 5.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.4 | 5.0 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 4.6 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 4.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 3.4 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.3 | 3.0 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 10.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 6.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 6.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 6.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 6.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 5.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.4 | 5.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.5 | 4.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.5 | 4.5 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 7.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 7.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 7.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 6.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 6.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 5.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 5.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 4.5 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 3.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 10.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 8.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.3 | 6.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 5.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 3.6 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.1 | 3.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 3.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 2.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |