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Illumina Body Map 2 (GSE30611)
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Results for SPIB
Z-value: 5.65
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Transcription factors associated with SPIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIB | hg38_v1_chr19_+_50418930_50418958 | 0.74 | 1.5e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 100.7 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.6 | 65.6 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 15.0 | 60.2 | GO:0045404 | positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 10.0 | 50.0 | GO:0038043 | interleukin-5-mediated signaling pathway(GO:0038043) |
| 7.1 | 50.0 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 8.3 | 49.7 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 8.0 | 48.0 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 5.9 | 47.2 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 1.8 | 47.2 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.3 | 42.6 | GO:0002819 | regulation of adaptive immune response(GO:0002819) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 264.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 233.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.3 | 112.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 85.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.4 | 77.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.3 | 60.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.4 | 59.5 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.3 | 59.3 | GO:0016605 | PML body(GO:0016605) |
| 11.1 | 55.6 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.2 | 54.6 | GO:0030667 | secretory granule membrane(GO:0030667) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 139.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.5 | 124.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.2 | 100.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 3.8 | 69.2 | GO:0019864 | IgG binding(GO:0019864) |
| 0.5 | 66.6 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 65.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.2 | 64.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 20.6 | 61.8 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 1.8 | 56.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.6 | 56.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 137.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.1 | 103.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 2.2 | 80.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 1.2 | 74.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.8 | 72.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 57.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.8 | 55.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 55.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 49.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.4 | 48.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 127.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 108.5 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 1.5 | 103.1 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 2.9 | 89.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 1.0 | 60.5 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.6 | 58.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 56.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.3 | 50.0 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 1.8 | 48.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 2.0 | 46.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |