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Illumina Body Map 2 (GSE30611)

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Results for SPIB

Z-value: 5.65

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Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
ENSG00000269404.7 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg38_v1_chr19_+_50418930_504189580.741.5e-06Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_160711803 44.00 ENST00000368045.3
ENST00000368046.8
ENST00000613788.1
CD48 molecule
chr17_-_74712911 35.38 ENST00000326165.11
ENST00000583937.5
ENST00000301573.13
ENST00000469092.5
CD300 molecule like family member f
chr22_+_36913620 30.72 ENST00000403662.8
ENST00000262825.9
colony stimulating factor 2 receptor subunit beta
chrX_-_47629845 28.61 ENST00000469388.1
ENST00000396992.8
ENST00000377005.6
complement factor properdin
chr19_+_41877267 27.50 ENST00000221972.8
ENST00000597454.1
ENST00000444740.2
CD79a molecule
chr17_-_5234801 26.93 ENST00000571800.5
ENST00000574081.6
ENST00000399600.8
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr7_+_74773962 25.59 ENST00000289473.10
neutrophil cytosolic factor 1
chr16_+_30183595 25.01 ENST00000219150.10
ENST00000570045.5
ENST00000565497.5
ENST00000570244.5
coronin 1A
chr17_-_74623730 23.85 ENST00000392619.2
CD300e molecule
chr3_-_151329539 23.36 ENST00000325602.6
purinergic receptor P2Y13
chr5_+_169637241 23.03 ENST00000520908.7
dedicator of cytokinesis 2
chrX_+_78945332 22.98 ENST00000544091.1
ENST00000171757.3
P2Y receptor family member 10
chr12_+_9971402 22.60 ENST00000304361.9
ENST00000396507.7
ENST00000434319.6
C-type lectin domain family 12 member A
chr7_-_36724457 22.14 ENST00000617537.5
ENST00000435386.1
acyloxyacyl hydrolase
chr1_+_161706949 22.02 ENST00000350710.3
ENST00000367949.6
ENST00000367959.6
ENST00000540521.5
ENST00000546024.5
ENST00000674251.1
ENST00000674323.1
Fc receptor like A
chr12_+_8123837 21.46 ENST00000345999.9
ENST00000352620.9
ENST00000360500.5
C-type lectin domain family 4 member A
chr17_-_31314040 21.45 ENST00000330927.5
ecotropic viral integration site 2B
chr11_-_67437670 21.34 ENST00000326294.4
protein tyrosine phosphatase receptor type C associated protein
chr1_+_111473792 21.30 ENST00000343534.9
chromosome 1 open reading frame 162
chr1_-_30757767 21.20 ENST00000294507.4
lysosomal protein transmembrane 5
chr19_+_16143678 21.12 ENST00000613986.4
ENST00000593031.1
hematopoietic SH2 domain containing
chr6_-_24935942 21.06 ENST00000645100.1
ENST00000643898.2
ENST00000613507.4
RHO family interacting cell polarization regulator 2
chr17_-_31314066 20.81 ENST00000577894.1
ecotropic viral integration site 2B
chr1_+_209768482 20.69 ENST00000367023.5
TRAF3 interacting protein 3
chr5_+_55102635 20.27 ENST00000274306.7
granzyme A
chr7_-_36724380 20.11 ENST00000617267.4
acyloxyacyl hydrolase
chr1_+_111473972 19.67 ENST00000369718.4
chromosome 1 open reading frame 162
chr2_+_68365274 19.65 ENST00000234313.8
pleckstrin
chr7_-_36724543 19.57 ENST00000612871.4
acyloxyacyl hydrolase
chr6_-_159045104 18.85 ENST00000326965.7
T cell activation RhoGTPase activating protein
chr1_+_26317950 18.77 ENST00000374213.3
CD52 molecule
chr6_-_159044980 18.76 ENST00000367066.8
T cell activation RhoGTPase activating protein
chr12_-_14961256 18.69 ENST00000541380.5
Rho GDP dissociation inhibitor beta
chr6_-_132757883 18.24 ENST00000525289.5
ENST00000326499.11
vanin 2
chr1_+_161505412 18.01 ENST00000367972.8
Fc fragment of IgG receptor IIa
chr5_+_35856883 17.92 ENST00000506850.5
ENST00000303115.8
ENST00000511982.1
interleukin 7 receptor
chr12_+_9971512 17.81 ENST00000350667.4
C-type lectin domain family 12 member A
chr16_-_50681289 17.68 ENST00000423026.6
ENST00000330943.9
sorting nexin 20
chr6_+_391743 17.59 ENST00000380956.9
interferon regulatory factor 4
chr7_+_50304038 17.39 ENST00000642219.1
ENST00000645066.1
IKAROS family zinc finger 1
chr17_-_8965674 17.36 ENST00000447110.6
ENST00000611902.4
ENST00000616147.4
ENST00000623421.3
phosphoinositide-3-kinase regulatory subunit 5
chr6_-_159045010 17.33 ENST00000338313.5
T cell activation RhoGTPase activating protein
chr7_+_139829242 17.13 ENST00000455353.6
ENST00000458722.6
ENST00000448866.7
ENST00000411653.6
thromboxane A synthase 1
chr19_-_54222978 16.97 ENST00000245620.13
ENST00000346401.10
ENST00000445347.1
leukocyte immunoglobulin like receptor B3
chr9_-_35618367 16.88 ENST00000378431.5
ENST00000378430.3
ENST00000259633.9
CD72 molecule
chr20_+_59163810 16.83 ENST00000371030.4
zinc finger protein 831
chr19_+_6772699 16.82 ENST00000602142.6
ENST00000304076.6
ENST00000596764.5
vav guanine nucleotide exchange factor 1
chr3_+_122055355 16.73 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86 molecule
chr6_-_41286665 16.33 ENST00000589614.5
ENST00000244709.9
ENST00000334475.10
ENST00000591620.1
triggering receptor expressed on myeloid cells 1
chr11_-_59212869 16.33 ENST00000361050.4
macrophage expressed 1
chr20_-_64079479 16.26 ENST00000395042.2
regulator of G protein signaling 19
chr22_-_37244237 16.24 ENST00000401529.3
ENST00000249071.11
Rac family small GTPase 2
chr20_-_64079906 16.19 ENST00000332298.9
regulator of G protein signaling 19
chr11_-_64745331 16.18 ENST00000377489.5
ENST00000354024.7
RAS guanyl releasing protein 2
chr12_-_54984667 16.09 ENST00000524668.5
ENST00000533607.1
ENST00000449076.6
thymocyte expressed, positive selection associated 1
chr15_+_76995118 15.82 ENST00000558012.6
ENST00000379595.7
proline-serine-threonine phosphatase interacting protein 1
chr11_-_64744811 15.57 ENST00000377497.7
ENST00000377487.5
ENST00000430645.1
RAS guanyl releasing protein 2
chr7_+_139829153 15.52 ENST00000652056.1
thromboxane A synthase 1
chr7_+_150514851 15.48 ENST00000313543.5
GTPase, IMAP family member 7
chr1_+_161707244 15.21 ENST00000349527.8
ENST00000294796.8
ENST00000309691.10
ENST00000367953.7
ENST00000367950.2
Fc receptor like A
chr16_+_3046552 15.16 ENST00000336577.9
matrix metallopeptidase 25
chr13_+_108269629 15.05 ENST00000430559.5
ENST00000375887.9
TNF superfamily member 13b
chr14_+_88005128 14.97 ENST00000267549.5
G protein-coupled receptor 65
chr9_+_90801757 14.86 ENST00000375751.8
ENST00000375754.9
spleen associated tyrosine kinase
chr12_+_54497712 14.86 ENST00000293373.11
NCK associated protein 1 like
chrX_-_30577759 14.85 ENST00000378962.4
TLR adaptor interacting with endolysosomal SLC15A4
chr5_+_58491427 14.79 ENST00000396776.6
ENST00000502276.6
ENST00000511930.2
GRB2 binding adaptor protein, transmembrane
chr12_-_14961610 14.72 ENST00000542276.1
Rho GDP dissociation inhibitor beta
chr19_+_48325522 14.65 ENST00000594198.1
ENST00000270221.11
ENST00000597279.5
ENST00000593437.1
epithelial membrane protein 3
chr1_-_160647037 14.64 ENST00000302035.11
signaling lymphocytic activation molecule family member 1
chr12_-_14961559 14.58 ENST00000228945.9
ENST00000541546.5
Rho GDP dissociation inhibitor beta
chr9_+_214843 14.57 ENST00000432829.7
dedicator of cytokinesis 8
chr12_+_6951345 14.32 ENST00000318974.14
ENST00000541698.5
ENST00000542462.1
protein tyrosine phosphatase non-receptor type 6
chr5_-_67196791 13.94 ENST00000256447.5
CD180 molecule
chr10_+_26438317 13.80 ENST00000376236.9
amyloid beta precursor protein binding family B member 1 interacting protein
chr3_+_46354072 13.76 ENST00000445132.3
ENST00000421659.1
C-C motif chemokine receptor 2
chr13_+_30735523 13.71 ENST00000380490.5
arachidonate 5-lipoxygenase activating protein
chr3_+_122077850 13.64 ENST00000482356.5
ENST00000393627.6
CD86 molecule
chr22_+_36922040 13.39 ENST00000406230.5
colony stimulating factor 2 receptor subunit beta
chr11_-_3837858 13.27 ENST00000396979.1
ras homolog family member G
chr9_+_90801909 13.24 ENST00000375747.5
spleen associated tyrosine kinase
chr2_+_143129379 13.24 ENST00000295095.11
Rho GTPase activating protein 15
chr5_+_58491451 13.17 ENST00000513924.2
ENST00000515443.2
GRB2 binding adaptor protein, transmembrane
chr3_+_32391871 13.13 ENST00000465248.1
CKLF like MARVEL transmembrane domain containing 7
chr12_+_6951271 13.05 ENST00000456013.5
protein tyrosine phosphatase non-receptor type 6
chrX_-_130110679 13.01 ENST00000335997.11
E74 like ETS transcription factor 4
chr5_+_119333151 12.96 ENST00000513374.1
TNF alpha induced protein 8
chr19_+_48325323 12.96 ENST00000596315.5
epithelial membrane protein 3
chr11_-_47378391 12.94 ENST00000227163.8
Spi-1 proto-oncogene
chr17_+_74671096 12.75 ENST00000402449.8
RAB37, member RAS oncogene family
chr11_-_47378527 12.63 ENST00000378538.8
Spi-1 proto-oncogene
chrX_-_78327604 12.49 ENST00000373304.4
cysteinyl leukotriene receptor 1
chr11_-_47378494 12.47 ENST00000533030.1
Spi-1 proto-oncogene
chr22_-_37244417 12.45 ENST00000405484.5
ENST00000441619.5
ENST00000406508.5
Rac family small GTPase 2
chrX_-_78327626 12.43 ENST00000614798.1
cysteinyl leukotriene receptor 1
chr1_+_161581339 12.40 ENST00000543859.5
ENST00000611236.1
Fc fragment of IgG receptor IIc (gene/pseudogene)
chr12_-_9733292 12.36 ENST00000621400.4
ENST00000327839.3
C-type lectin like 1
chr1_+_161505438 12.31 ENST00000271450.12
Fc fragment of IgG receptor IIa
chr6_+_37005630 12.31 ENST00000274963.13
FYVE, RhoGEF and PH domain containing 2
chr14_-_22819721 12.27 ENST00000554517.5
ENST00000285850.11
ENST00000397529.6
ENST00000555702.5
solute carrier family 7 member 7
chr19_-_10335773 12.23 ENST00000592439.1
intercellular adhesion molecule 3
chr3_+_122077776 12.20 ENST00000264468.9
CD86 molecule
chr6_+_31586124 12.19 ENST00000418507.6
ENST00000376096.5
ENST00000376099.5
ENST00000376110.7
leukocyte specific transcript 1
chr5_-_39270623 12.19 ENST00000512138.1
ENST00000646045.2
FYN binding protein 1
chr19_-_38426195 12.16 ENST00000615439.5
ENST00000614135.4
ENST00000622174.4
ENST00000587753.5
ENST00000454404.6
ENST00000617966.4
ENST00000618320.4
ENST00000293062.13
ENST00000433821.6
ENST00000426920.6
RAS guanyl releasing protein 4
chr1_-_160646958 12.08 ENST00000538290.2
signaling lymphocytic activation molecule family member 1
chr1_+_206470463 11.99 ENST00000581977.7
ENST00000578328.6
ENST00000584998.5
ENST00000579827.6
inhibitor of nuclear factor kappa B kinase subunit epsilon
chr11_-_47378479 11.95 ENST00000533968.1
Spi-1 proto-oncogene
chr12_+_6951250 11.84 ENST00000538715.5
protein tyrosine phosphatase non-receptor type 6
chr10_-_96720485 11.81 ENST00000339364.10
phosphoinositide-3-kinase adaptor protein 1
chr17_-_19046957 11.81 ENST00000284154.10
ENST00000573099.5
GRB2 related adaptor protein
chr6_+_31615215 11.81 ENST00000337917.11
ENST00000376059.8
allograft inflammatory factor 1
chr9_+_215157 11.78 ENST00000479404.5
dedicator of cytokinesis 8
chr21_-_44920892 11.71 ENST00000397846.7
ENST00000652462.1
ENST00000302347.10
ENST00000524251.1
integrin subunit beta 2
chr6_+_31586680 11.71 ENST00000339530.8
leukocyte specific transcript 1
chr20_-_36646146 11.65 ENST00000262866.9
Src like adaptor 2
chr6_+_31586835 11.59 ENST00000211921.11
leukocyte specific transcript 1
chrX_-_130110479 11.35 ENST00000308167.10
E74 like ETS transcription factor 4
chr1_+_151156627 11.30 ENST00000368910.4
TNF alpha induced protein 8 like 2
chr8_+_73991345 11.04 ENST00000284818.7
ENST00000518893.1
lymphocyte antigen 96
chr4_+_67558719 11.03 ENST00000265404.7
ENST00000396225.1
signal transducing adaptor family member 1
chr19_-_3786254 11.02 ENST00000585778.5
megakaryocyte-associated tyrosine kinase
chr19_+_51225059 10.95 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chr1_+_149782671 10.94 ENST00000444948.5
ENST00000369168.5
Fc fragment of IgG receptor Ia
chr6_+_31586269 10.87 ENST00000438075.7
leukocyte specific transcript 1
chr17_-_75393870 10.83 ENST00000582582.1
growth factor receptor bound protein 2
chr3_-_121660892 10.80 ENST00000428394.6
ENST00000314583.8
hematopoietic cell-specific Lyn substrate 1
chr2_+_233059838 10.79 ENST00000359570.9
inositol polyphosphate-5-phosphatase D
chr1_+_159302321 10.60 ENST00000368114.1
Fc fragment of IgE receptor Ia
chr21_-_44920855 10.53 ENST00000397854.7
integrin subunit beta 2
chr1_-_17439657 10.51 ENST00000375436.9
regulator of chromosome condensation 2
chr17_-_40937445 10.49 ENST00000436344.7
ENST00000485751.1
keratin 23
chr19_-_13102848 10.48 ENST00000264824.5
LYL1 basic helix-loop-helix family member
chr6_+_31587049 10.44 ENST00000376089.6
ENST00000396112.6
leukocyte specific transcript 1
chr13_+_108269880 10.34 ENST00000542136.1
TNF superfamily member 13b
chr13_+_30713477 10.20 ENST00000617770.4
arachidonate 5-lipoxygenase activating protein
chr16_-_50681206 10.19 ENST00000610485.1
sorting nexin 20
chr6_+_31587002 10.10 ENST00000376090.6
leukocyte specific transcript 1
chr17_-_40937641 10.09 ENST00000209718.8
keratin 23
chr9_-_127778659 9.89 ENST00000314830.13
SH2 domain containing 3C
chr11_+_60378475 9.86 ENST00000358246.5
membrane spanning 4-domains A7
chr19_-_3786363 9.81 ENST00000310132.11
megakaryocyte-associated tyrosine kinase
chr11_+_60378494 9.81 ENST00000534016.5
membrane spanning 4-domains A7
chr2_+_113127588 9.79 ENST00000409930.4
interleukin 1 receptor antagonist
chr1_+_161707222 9.74 ENST00000236938.12
Fc receptor like A
chr15_+_76995374 9.72 ENST00000559161.5
proline-serine-threonine phosphatase interacting protein 1
chr2_+_113173950 9.63 ENST00000245796.11
ENST00000441564.7
pleckstrin and Sec7 domain containing 4
chr17_-_75393656 9.54 ENST00000392563.5
growth factor receptor bound protein 2
chr1_+_161707205 9.34 ENST00000367957.7
Fc receptor like A
chr16_+_11965193 9.32 ENST00000053243.6
ENST00000396495.3
TNF receptor superfamily member 17
chr11_+_60378524 9.31 ENST00000530614.5
ENST00000530027.5
ENST00000300184.8
ENST00000530234.2
ENST00000528215.1
ENST00000531787.5
membrane spanning 4-domains A7
membrane spanning 4-domains A14
chr17_-_75393741 9.26 ENST00000578961.5
ENST00000392564.5
growth factor receptor bound protein 2
chr21_-_44920918 9.16 ENST00000522688.5
integrin subunit beta 2
chr8_-_100722174 9.10 ENST00000677380.1
ENST00000677478.1
poly(A) binding protein cytoplasmic 1
chr12_+_25052732 9.08 ENST00000547044.5
inositol 1,4,5-triphosphate receptor associated 2
chr19_-_51417619 9.05 ENST00000441969.7
ENST00000339313.10
ENST00000525998.5
ENST00000436984.6
sialic acid binding Ig like lectin 10
chr7_+_106865263 9.04 ENST00000440650.6
ENST00000496166.6
ENST00000473541.5
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr19_-_3786408 9.04 ENST00000395040.6
megakaryocyte-associated tyrosine kinase
chr2_+_233060295 9.03 ENST00000445964.6
inositol polyphosphate-5-phosphatase D
chr11_+_64340191 9.00 ENST00000356786.10
coiled-coil domain containing 88B
chr16_+_57542672 8.99 ENST00000615867.4
ENST00000340339.4
adhesion G protein-coupled receptor G5
chr1_+_89821921 8.97 ENST00000394593.7
leucine rich repeat containing 8 VRAC subunit D
chr19_+_54630410 8.87 ENST00000396327.7
ENST00000324602.12
leukocyte immunoglobulin like receptor B1
chr14_+_22007503 8.80 ENST00000390447.3
T cell receptor alpha variable 19
chr19_+_35154914 8.73 ENST00000423817.7
FXYD domain containing ion transport regulator 5
chr1_+_117001744 8.60 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101 molecule
chr2_-_144430934 8.53 ENST00000638087.1
ENST00000638007.1
zinc finger E-box binding homeobox 2
chr10_+_26438404 8.52 ENST00000356785.4
amyloid beta precursor protein binding family B member 1 interacting protein
chr8_-_100722036 8.51 ENST00000518196.5
ENST00000519004.5
ENST00000519363.1
ENST00000318607.10
ENST00000520142.2
poly(A) binding protein cytoplasmic 1
chr2_-_230219944 8.49 ENST00000455674.2
ENST00000392048.7
ENST00000258381.11
ENST00000358662.9
ENST00000258382.10
SP110 nuclear body protein
chr2_-_74178802 8.26 ENST00000396049.5
MOB kinase activator 1A
chr1_-_159923717 8.22 ENST00000368096.5
transgelin 2
chr2_-_144431001 8.22 ENST00000636413.1
zinc finger E-box binding homeobox 2
chr22_-_23838987 8.06 ENST00000318109.12
ENST00000404056.1
ENST00000406855.7
ENST00000476077.1
derlin 3
chr10_+_95755737 8.04 ENST00000543964.6
ectonucleoside triphosphate diphosphohydrolase 1
chr1_+_121087343 7.97 ENST00000616817.4
ENST00000623603.3
ENST00000369384.9
ENST00000369383.8
ENST00000369178.5
Fc fragment of IgG receptor Ib
chr7_-_116159886 7.85 ENST00000484212.5
transcription factor EC
chr6_-_30684744 7.85 ENST00000615892.4
protein phosphatase 1 regulatory subunit 18
chr5_-_157109025 7.84 ENST00000307851.9
hepatitis A virus cellular receptor 2
chr12_-_121802886 7.76 ENST00000545885.5
ENST00000542933.5
ENST00000428029.6
ENST00000541694.5
ENST00000536662.5
ENST00000535643.5
ENST00000541657.5
long intergenic non-protein coding RNA 1089
ras homolog family member F, filopodia associated
chr19_+_10848366 7.66 ENST00000397820.5
chromosome 19 open reading frame 38
chr17_-_45410414 7.65 ENST00000532038.5
ENST00000528677.1
Rho GTPase activating protein 27
chr15_-_34337462 7.58 ENST00000676379.1
solute carrier family 12 member 6
chr19_+_54630497 7.57 ENST00000396332.8
ENST00000427581.6
leukocyte immunoglobulin like receptor B1
chr1_+_161663147 7.56 ENST00000236937.13
ENST00000367961.8
ENST00000358671.9
Fc fragment of IgG receptor IIb
chr6_+_116461364 7.47 ENST00000368606.7
ENST00000368605.3
calcium homeostasis modulator family member 6
chr19_-_13103151 7.45 ENST00000590974.1
LYL1 basic helix-loop-helix family member
chr17_+_19127535 7.44 ENST00000577213.1
ENST00000344415.9
GRB2 related adaptor protein like
chr16_+_57542635 7.40 ENST00000349457.8
adhesion G protein-coupled receptor G5
chr10_-_119542683 7.40 ENST00000369103.3
regulator of G protein signaling 10
chr5_-_157109115 7.36 ENST00000522593.5
hepatitis A virus cellular receptor 2
chr16_+_10866247 7.26 ENST00000636238.1
class II major histocompatibility complex transactivator
chr1_-_153946652 7.24 ENST00000361217.9
DENN domain containing 4B
chrX_-_130110361 7.14 ENST00000434609.1
E74 like ETS transcription factor 4
chr19_-_54242751 7.13 ENST00000245621.6
ENST00000396365.6
leukocyte immunoglobulin like receptor A6
chr16_-_50681328 7.09 ENST00000300590.7
sorting nexin 20
chr5_-_140633639 7.00 ENST00000498971.6
CD14 molecule
chr5_-_140633690 6.97 ENST00000512545.1
ENST00000401743.6
CD14 molecule
chr8_-_100721851 6.92 ENST00000522658.6
poly(A) binding protein cytoplasmic 1
chr19_-_51417581 6.76 ENST00000442846.7
ENST00000530476.1
sialic acid binding Ig like lectin 10

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.0 60.2 GO:0045404 positive regulation of interleukin-4 biosynthetic process(GO:0045404)
13.8 13.8 GO:1902567 negative regulation of eosinophil activation(GO:1902567)
11.8 35.4 GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) regulation of interleukin-4-mediated signaling pathway(GO:1902214)
11.0 11.0 GO:1903970 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
10.0 50.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
9.7 38.7 GO:0045399 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401)
8.8 26.4 GO:0061485 memory T cell proliferation(GO:0061485)
8.3 49.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
8.0 48.0 GO:0071461 cellular response to redox state(GO:0071461)
7.1 50.0 GO:0044027 hypermethylation of CpG island(GO:0044027)
6.5 39.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
6.3 25.4 GO:0002636 positive regulation of germinal center formation(GO:0002636)
5.9 47.2 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
5.1 15.2 GO:0032672 regulation of interleukin-3 production(GO:0032672)
5.0 25.0 GO:0032796 uropod organization(GO:0032796)
5.0 19.8 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
5.0 14.9 GO:0045588 positive regulation of gamma-delta T cell differentiation(GO:0045588)
4.4 13.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
4.1 16.4 GO:0035548 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
4.1 28.6 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
3.8 7.6 GO:0002434 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
3.5 21.1 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
3.4 30.7 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
2.9 32.4 GO:0001866 NK T cell proliferation(GO:0001866)
2.9 8.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
2.8 19.6 GO:0033625 positive regulation of integrin activation(GO:0033625)
2.8 24.9 GO:0061737 leukotriene signaling pathway(GO:0061737)
2.7 16.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
2.6 15.7 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
2.6 28.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
2.5 34.8 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
2.4 11.8 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
2.3 21.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
2.3 16.3 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
2.2 17.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
2.2 22.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
2.1 6.4 GO:1904266 positive regulation of Schwann cell migration(GO:1900149) regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
2.0 4.1 GO:1901074 regulation of engulfment of apoptotic cell(GO:1901074)
1.8 27.4 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
1.8 47.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
1.7 23.9 GO:2001300 lipoxin metabolic process(GO:2001300)
1.7 11.8 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
1.6 4.9 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
1.6 35.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
1.6 28.6 GO:0036066 protein O-linked fucosylation(GO:0036066)
1.6 23.6 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
1.6 20.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
1.5 4.6 GO:0015734 taurine transport(GO:0015734)
1.5 3.0 GO:0061198 fungiform papilla formation(GO:0061198)
1.5 8.9 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
1.5 32.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
1.4 17.3 GO:0016554 cytidine to uridine editing(GO:0016554)
1.4 4.1 GO:1990637 response to prolactin(GO:1990637)
1.4 31.4 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
1.4 9.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
1.3 13.2 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
1.3 10.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
1.3 5.2 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
1.3 6.4 GO:0039516 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
1.3 5.0 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
1.2 12.3 GO:0000821 regulation of arginine metabolic process(GO:0000821)
1.2 9.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.1 29.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.1 18.2 GO:0015939 pantothenate metabolic process(GO:0015939)
1.1 12.8 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
1.1 1.1 GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production(GO:0071650)
1.0 5.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
1.0 9.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
1.0 3.0 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
1.0 14.3 GO:0043249 erythrocyte maturation(GO:0043249)
1.0 5.7 GO:0021993 initiation of neural tube closure(GO:0021993)
1.0 3.8 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.9 5.6 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.9 4.6 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.9 17.9 GO:0001955 blood vessel maturation(GO:0001955)
0.9 27.6 GO:0032060 bleb assembly(GO:0032060)
0.8 4.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.8 4.0 GO:0042989 sequestering of actin monomers(GO:0042989)
0.8 4.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.7 3.0 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.7 12.4 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.7 2.9 GO:1902530 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.7 13.6 GO:0060022 hard palate development(GO:0060022)
0.7 3.4 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.6 65.6 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.6 9.4 GO:0015871 choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536)
0.5 11.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.5 2.6 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.5 16.8 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.5 6.1 GO:0060613 fat pad development(GO:0060613)
0.5 5.8 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.5 11.6 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.5 2.4 GO:1903028 positive regulation of opsonization(GO:1903028)
0.5 17.0 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.5 18.8 GO:0045730 respiratory burst(GO:0045730)
0.5 17.9 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.5 5.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 11.7 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.4 15.0 GO:0010447 response to acidic pH(GO:0010447)
0.4 7.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 11.3 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.4 11.7 GO:0015671 oxygen transport(GO:0015671)
0.4 2.0 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.4 5.6 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.4 36.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.4 1.9 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.4 27.0 GO:0042100 B cell proliferation(GO:0042100)
0.4 4.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 2.9 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.4 3.9 GO:0032532 regulation of microvillus length(GO:0032532)
0.3 8.0 GO:0042832 defense response to protozoan(GO:0042832)
0.3 1.6 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.3 2.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.3 1.3 GO:1902463 actin filament branching(GO:0090135) protein localization to cell leading edge(GO:1902463)
0.3 2.9 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.3 3.8 GO:0018094 protein polyglycylation(GO:0018094)
0.3 18.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 3.4 GO:0032264 IMP salvage(GO:0032264)
0.3 42.6 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.3 1.2 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.3 2.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.3 3.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 2.9 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 1.7 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.3 13.3 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.3 17.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.3 6.8 GO:0006020 inositol metabolic process(GO:0006020)
0.3 3.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 7.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 3.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.2 3.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 7.0 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.2 8.5 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.2 11.1 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.2 0.7 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.2 0.9 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 9.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.9 GO:0007172 signal complex assembly(GO:0007172)
0.2 38.3 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.2 2.5 GO:0033210 leptin-mediated signaling pathway(GO:0033210) adiponectin-activated signaling pathway(GO:0033211)
0.2 3.1 GO:0010818 T cell chemotaxis(GO:0010818)
0.2 2.8 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.2 12.6 GO:0046039 GTP metabolic process(GO:0046039)
0.2 23.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 14.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 33.9 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.2 1.8 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.2 2.6 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.2 4.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.2 4.6 GO:0030225 macrophage differentiation(GO:0030225)
0.2 1.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.2 0.7 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.2 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 2.7 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 8.3 GO:0035329 hippo signaling(GO:0035329)
0.1 1.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 5.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 5.0 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.1 3.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 23.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 1.9 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.1 2.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 3.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.4 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 21.0 GO:0070268 cornification(GO:0070268)
0.1 2.0 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.4 GO:1903259 exon-exon junction complex disassembly(GO:1903259)
0.1 3.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 1.2 GO:0035973 aggrephagy(GO:0035973)
0.1 100.7 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.1 14.9 GO:0034101 erythrocyte homeostasis(GO:0034101)
0.1 13.9 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 20.7 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.1 6.4 GO:0006953 acute-phase response(GO:0006953)
0.1 9.8 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.3 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 3.6 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 1.9 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.1 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.1 1.0 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.1 3.2 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.1 1.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 3.0 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.1 3.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 1.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 6.7 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.7 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.1 0.6 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 32.9 GO:0006954 inflammatory response(GO:0006954)
0.0 29.4 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 1.7 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.9 GO:0005513 detection of calcium ion(GO:0005513)
0.0 4.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.9 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.7 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 32.3 GO:0006952 defense response(GO:0006952)
0.0 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 1.4 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.2 GO:0036071 N-glycan fucosylation(GO:0036071)
0.0 1.0 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 2.7 GO:0072431 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.0 0.8 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 4.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 6.8 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 1.2 GO:0006505 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 3.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 2.0 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 1.1 GO:0021762 substantia nigra development(GO:0021762)
0.0 4.3 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 10.3 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 1.5 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.8 GO:0002250 adaptive immune response(GO:0002250)
0.0 2.0 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.7 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 2.1 GO:0007286 spermatid development(GO:0007286)
0.0 0.6 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
14.7 44.1 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
11.1 55.6 GO:0019815 B cell receptor complex(GO:0019815)
8.3 33.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
4.1 32.5 GO:0070436 Grb2-EGFR complex(GO:0070436)
3.9 31.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
3.3 39.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
3.0 36.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.3 25.6 GO:0032010 phagolysosome(GO:0032010)
2.2 15.5 GO:0000788 nuclear nucleosome(GO:0000788)
2.1 26.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
1.8 5.4 GO:0032002 interleukin-28 receptor complex(GO:0032002)
1.8 21.1 GO:0060171 stereocilium membrane(GO:0060171)
1.6 4.8 GO:0031251 PAN complex(GO:0031251)
1.2 1.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
1.2 22.3 GO:0042101 T cell receptor complex(GO:0042101)
1.0 40.9 GO:0001891 phagocytic cup(GO:0001891)
1.0 24.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.9 14.9 GO:0031209 SCAR complex(GO:0031209)
0.8 32.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.8 13.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 3.4 GO:0071159 NF-kappaB complex(GO:0071159)
0.7 4.6 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.6 8.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.5 5.9 GO:0042788 polysomal ribosome(GO:0042788)
0.5 32.0 GO:0001772 immunological synapse(GO:0001772)
0.5 2.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.4 77.4 GO:0035579 specific granule membrane(GO:0035579)
0.4 42.0 GO:0035580 specific granule lumen(GO:0035580)
0.4 59.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 85.5 GO:0032587 ruffle membrane(GO:0032587)
0.4 32.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 1.9 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.4 4.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.4 2.2 GO:0032044 DSIF complex(GO:0032044)
0.3 53.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 13.2 GO:0030686 90S preribosome(GO:0030686)
0.3 2.9 GO:1990130 Iml1 complex(GO:1990130)
0.3 1.0 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.3 59.3 GO:0016605 PML body(GO:0016605)
0.3 60.4 GO:0031901 early endosome membrane(GO:0031901)
0.3 16.1 GO:0008180 COP9 signalosome(GO:0008180)
0.3 3.8 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 6.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.3 3.6 GO:0072487 MSL complex(GO:0072487)
0.3 112.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 1.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 5.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 4.8 GO:0005795 Golgi stack(GO:0005795)
0.2 3.5 GO:0030914 STAGA complex(GO:0030914)
0.2 5.2 GO:0031932 TORC2 complex(GO:0031932)
0.2 3.1 GO:0030008 TRAPP complex(GO:0030008)
0.2 34.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 54.6 GO:0030667 secretory granule membrane(GO:0030667)
0.2 10.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 15.4 GO:0005811 lipid particle(GO:0005811)
0.1 3.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 32.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 3.0 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 2.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 264.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 1.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 53.1 GO:0000790 nuclear chromatin(GO:0000790)
0.1 18.4 GO:0005882 intermediate filament(GO:0005882)
0.1 4.0 GO:0031519 PcG protein complex(GO:0031519)
0.1 8.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.6 GO:0097427 microtubule bundle(GO:0097427)
0.1 5.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 6.1 GO:0005876 spindle microtubule(GO:0005876)
0.1 3.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 6.8 GO:0031902 late endosome membrane(GO:0031902)
0.1 23.0 GO:0031252 cell leading edge(GO:0031252)
0.1 5.5 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.1 4.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.9 GO:0031906 late endosome lumen(GO:0031906)
0.1 2.5 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 52.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 233.6 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 7.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 10.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.7 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
20.6 61.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
10.9 32.7 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
10.0 50.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)
8.8 35.4 GO:0005136 interleukin-4 receptor binding(GO:0005136)
6.0 17.9 GO:0004917 interleukin-7 receptor activity(GO:0004917)
5.8 17.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
5.3 10.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
4.8 48.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
4.8 23.9 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
4.6 18.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
4.1 16.4 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
3.8 69.2 GO:0019864 IgG binding(GO:0019864)
3.6 50.0 GO:0051525 NFAT protein binding(GO:0051525)
3.4 13.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
3.3 9.8 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
3.1 24.9 GO:0004974 leukotriene receptor activity(GO:0004974)
3.0 12.0 GO:0008384 IkappaB kinase activity(GO:0008384)
2.9 31.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
2.8 19.8 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
2.5 19.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
2.2 8.9 GO:0001626 nociceptin receptor activity(GO:0001626)
2.0 16.3 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
2.0 47.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
1.8 25.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.8 56.4 GO:0019992 diacylglycerol binding(GO:0019992)
1.7 28.6 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.6 16.1 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.6 9.4 GO:0039552 RIG-I binding(GO:0039552)
1.5 4.6 GO:0005369 taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369)
1.5 23.0 GO:0042608 T cell receptor binding(GO:0042608)
1.5 124.8 GO:0001784 phosphotyrosine binding(GO:0001784)
1.5 10.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
1.4 4.1 GO:0034188 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
1.2 34.8 GO:0008494 translation activator activity(GO:0008494)
1.2 64.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
1.2 9.3 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.1 11.3 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
1.1 15.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
1.1 39.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.0 25.0 GO:0032036 myosin heavy chain binding(GO:0032036)
1.0 3.0 GO:0042008 interleukin-18 receptor activity(GO:0042008)
1.0 10.8 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.9 5.6 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.9 4.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.8 16.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.8 11.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.8 5.4 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.8 13.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.7 6.8 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.7 19.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.6 35.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.6 2.5 GO:0055100 adiponectin binding(GO:0055100)
0.6 9.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.6 56.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.5 2.7 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.5 4.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 12.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.5 11.7 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.5 11.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 5.6 GO:0004875 complement receptor activity(GO:0004875)
0.5 66.6 GO:0001618 virus receptor activity(GO:0001618)
0.4 2.6 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.4 3.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 5.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 23.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 23.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 3.8 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.3 14.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.3 15.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 19.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 139.2 GO:0030246 carbohydrate binding(GO:0030246)
0.3 6.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.3 3.8 GO:0051434 BH3 domain binding(GO:0051434)
0.3 4.3 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.3 3.4 GO:0097100 small ribosomal subunit rRNA binding(GO:0070181) supercoiled DNA binding(GO:0097100)
0.2 2.0 GO:0032184 SUMO polymer binding(GO:0032184)
0.2 3.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 5.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 8.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 3.7 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 7.9 GO:0003785 actin monomer binding(GO:0003785)
0.2 23.1 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 9.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 10.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 4.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 1.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.2 4.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 100.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 3.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 2.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 2.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 10.0 GO:0019843 rRNA binding(GO:0019843)
0.2 3.4 GO:0032452 histone demethylase activity(GO:0032452)
0.1 5.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 13.5 GO:0097110 scaffold protein binding(GO:0097110)
0.1 15.8 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.1 65.1 GO:0003924 GTPase activity(GO:0003924)
0.1 1.2 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.9 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 2.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.2 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 9.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 3.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 15.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.3 GO:0016436 rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 4.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.8 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 1.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 4.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 7.2 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 9.3 GO:0005525 GTP binding(GO:0005525)
0.1 8.4 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.8 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 37.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 3.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 14.1 GO:0005125 cytokine activity(GO:0005125)
0.1 3.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 1.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 3.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 2.4 GO:0043531 ADP binding(GO:0043531)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 17.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.0 1.2 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 3.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 7.7 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.0 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 7.0 GO:0016874 ligase activity(GO:0016874)
0.0 1.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 1.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 48.0 GO:0004872 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 3.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0009975 cyclase activity(GO:0009975)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.6 GO:0005283 sodium:amino acid symporter activity(GO:0005283)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 80.8 PID IL5 PATHWAY IL5-mediated signaling events
1.2 137.9 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
1.2 74.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.1 103.2 PID BCR 5PATHWAY BCR signaling pathway
1.0 36.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.9 57.8 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.8 72.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.8 55.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.5 17.4 PID EPHA FWDPATHWAY EPHA forward signaling
0.5 28.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.4 11.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.4 48.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.4 18.2 PID RAS PATHWAY Regulation of Ras family activation
0.4 49.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 11.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 4.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.3 16.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 9.8 PID IL1 PATHWAY IL1-mediated signaling events
0.3 18.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.3 24.9 PID ENDOTHELIN PATHWAY Endothelins
0.3 28.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 6.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 9.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 15.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 37.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 55.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 4.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 5.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.3 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 89.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
2.5 39.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
2.0 46.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
1.8 48.0 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
1.5 103.1 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
1.3 50.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
1.3 25.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.2 24.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.1 24.9 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
1.0 60.5 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.8 108.5 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.8 29.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.7 34.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.6 11.8 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.6 5.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.6 58.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5 6.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.5 56.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.4 32.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.4 33.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.4 127.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 16.9 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.4 33.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.4 6.4 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4 13.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.3 5.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.3 13.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.3 14.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 4.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 2.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 6.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 21.6 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.2 5.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.2 24.9 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 4.3 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.2 32.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 4.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 3.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.2 4.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 31.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 3.9 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 13.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.1 3.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 14.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.0 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.1 3.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 28.8 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.2 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 1.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 4.7 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 3.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation